Title: Single Motherhood Doesn't Seem to Hinder Happiness
Category: Health News
Created: 4/26/2014 10:35:00 AM
Last Editorial Review: 4/28/2014 12:00:00 AM

Title: Kids' Happiness Doesn't Depend on 2 Natural Parents, Says Study
Category: Health News
Created: 4/25/2014 2:35:00 PM
Last Editorial Review: 4/28/2014 12:00:00 AM

Title: Skateboarding Mishaps Send 176 U.S. Kids to ERs Every Day
Category: Health News
Created: 4/26/2016 12:00:00 AM
Last Editorial Review: 4/27/2016 12:00:00 AM

Title: Happy Mom Means Less Colicky Baby
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: AHA News: How Pregnant Woman's High Blood Pressure Can Change Shape of Baby's Heart
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

Title: 2 in 3 Women Unhappy With Their Breast Size. Could That Harm Their Health?
Category: Health News
Created: 2/6/2020 12:00:00 AM
Last Editorial Review: 2/6/2020 12:00:00 AM

Key Points

Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype.

Recent progress has been made in identifying genomic regions implicated in trait evolution on a microevolutionary scale in many species, but whether these are relevant over macroevolutionary time remains unclear. Here, we directly address this fundamental question using bird beak shape, a key evolutionary innovation linked to patterns of resource use, divergence, and speciation, as a model trait. We integrate class-wide geometric-morphometric analyses with evolutionary sequence analyses of 10,322 protein-coding genes as well as 229,001 genomic regions spanning 72 species. We identify 1434 protein-coding genes and 39,806 noncoding regions for which molecular rates were significantly related to rates of bill shape evolution. We show that homologs of the identified protein-coding genes as well as genes in close proximity to the identified noncoding regions are involved in craniofacial embryo development in mammals. They are associated with embryonic stem cell pathways, including BMP and Wnt signaling, both of which have repeatedly been implicated in the morphological development of avian beaks. This suggests that identifying genotype-phenotype association on a genome-wide scale over macroevolutionary time is feasible. Although the coding and noncoding gene sets are associated with similar pathways, the actual genes are highly distinct, with significantly reduced overlap between them and bill-related phenotype associations specific to noncoding loci. Evidence for signatures of recent diversifying selection on our identified noncoding loci in Darwin finch populations further suggests that regulatory rather than coding changes are major drivers of morphological diversification over macroevolutionary times.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex.

Sở hữu một phòng ngủ nhỏ không đồng nghĩa với việc bạn phải hy sinh sự tiện nghi và phong cách thiết kế. Trên thực tế, với những không gian nhỏ, chỉ cần lên kế hoạch thiết kế kỹ lưỡng ngay từ đầu là bạn vừa có thể tận dụng tối đa diện tích căn phòng, vừa thể hiện được cá tính của bản thân trong lối bài trí.

TP.HCM đang xây dựng đề án thành lập thành phố phía Đông trực thuộc thành phố trên cơ sở sáp nhập quận 2, quận 9 và quận Thủ Đức.

Theo Phó giám đốc NHNN chi nhánh TP.HCM Nguyễn Hoàng Minh, dư nợ cho vay bất động sản trong 11 tháng năm 2019 của các ngân hàng tại TP.HCM vẫn tăng 9,6% so với cuối năm ngoái.

Lãi suất vay mua nhà của các ngân hàng hiện nay phổ biến từ 6,79-11,5%/năm, áp dụng trong thời kỳ ưu đãi (thường là 6 tháng đến 1 năm). Trong đó, ngân hàng Standard Chartered đang có lãi suất cho vay ưu đãi thấp nhất với 6,79%/năm (gói 12 tháng).

Kể từ sau ngày 1/6, người vay gói 30.000 tỷ đồng để mua nhà sẽ không còn được hưởng ưu đãi lãi suất, theo đó lãi suất tiền vay sẽ được điều chỉnh theo sự thỏa thuận giữa ngân hàng thương mại với khách hàng. Gánh nặng trả lãi suất mua nhà khiến nhiều người lo lắng.

Theo đại diện Sở Xây dựng, các dự án nhà ở thế chấp ngân hàng có rất nhiều tình trạng khác nhau, song có thể xác định dự án nào thế chấp để bảo lãnh ngân hàng là thuộc diện an toàn.

Bên bán ít, nhu cầu từ bên mua vẫn cao là yếu tố khiến loại hình nhà ở phục vụ khách mua ở thực tăng trưởng tốt trong khi nhu cầu mua với mục đích đầu tư, đầu cơ đang giảm.

Về việc thành lập thành phố phía Đông TP.HCM, Thủ tướng Nguyễn Xuân Phúc ủng hộ việc sáp nhập 3 quận, "Còn tên gọi là gì sau khi thành lập sẽ bàn luận tiếp".

Tranh chấp đất đai và tranh chấp liên quan đến đất đai là cặp thuật ngữ rất dễ gây nhầm lẫn hoặc đánh đồng về nghĩa. Vậy làm sao để phân biệt được hai khái niệm này?

Một nghiên cứu mới đây cho thấy chi phí trang hoàng văn phòng mới tại Hồng Kông đang xếp sau 6 thành phố lớn ở Nhật và Úc. Điều này cũng phần nào an ủi những người đi thuê nhà tại nơi mà suốt 4 năm liền vẫn luôn đứng đầu bảng xếp hạng giá thuê thế giới.

मई महीने में दूसरे हफ्ते के रविवार को मदर्स डे को तौर पर मनाया जाता है। मां के लिए कोई एक दिन नहीं होता है, वो अलग बात है कि एक खास दिन को मां के नाम निश्चित कर दिया गया है।

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Researchers have made a breakthrough in understanding the structure of a key genetic molecule, called RNA, and revealing for the first time how these changes impact RNA's function. The research team developed a bioinformatics technique to resolve separate structures of RNA rather than viewing them as a 'blur' that averaged multiple structures. This underpinned their discovery that the structure of RNA can influence how cells function.

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Epic Games is finally settling its feud — kind of — with Google and putting Fortnite onto the Google Play Store, but the studio sounds pretty pissed about it. When Fortnite launched on mobile in 2018, Epic Games very notably sidestepped the Google Play Store and pushed users to download the title directly from their […]

Now that the COVID-19 pandemic has forced millions into isolation, video games are seeing a surge in usage as people seek entertainment and social interaction. When we surveyed gaming-focused VCs in October, Andreessen Horowitz partner Jonathan Lai predicted that “next-generation games will be bigger than anything we’ve seen yet,” eventually reaching “Facebook scale.” This month, […]

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CLAIM: Photo shows Joe Biden posing with former ...

As many parts of the world's biggest economy begin to reopen after weeks of stay-at-home orders that slowed the spread of the coronavirus but gutted jobs, Americans should not expect a quick return to growth, U.S. Federal Reserve officials said on Friday.

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