A single tweet on the weekend about a possible collaboration between dancehall princess Shenseea and US rap sensation Nicki Minaj has left fans of the Romeich Entertainment singer bursting with excitement. Rumours of a pending project between...

Nora Linscheid
Apr 14, 2020; 0:RA119.001878v1-mcp.RA119.001878
Research

Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve replacement surgery in patients with mitral valve prolapse (MVP), we set out to define inter-chamber differences, the intersect of proteomic data with genetic or genomic datasets, and the impact of left atrial dilation on the proteome of patients with no history of atrial fibrillation (AF).  We collected biopsies from right atria (RA), left atria (LA) and left ventricle (LV) of seven male patients with mitral valve regurgitation with dilated LA but no history of AF. Biopsy samples were analyzed by high-resolution mass spectrometry (MS), where peptides were pre-fractionated by reverse phase high-pressure liquid chromatography prior to MS measurement on a Q-Exactive-HF Orbitrap instrument. We identified 7,314 proteins based on 130,728 peptides. Results were confirmed in an independent set of biopsies collected from three additional individuals. Comparative analysis against data from post-mortem samples showed enhanced quantitative power and confidence level in samples collected from living hearts. Our analysis, combined with data from genome wide association studies suggested candidate gene associations to MVP, identified higher abundance in ventricle for proteins associated with cardiomyopathies and revealed the dilated LA proteome, demonstrating differential representation of molecules previously associated with AF, in non-AF hearts. This is the largest dataset of cardiac protein expression from human samples collected in vivo. It provides a comprehensive resource that allows insight into molecular fingerprints of MVP and facilitates novel inferences between genomic data and disease mechanisms. We propose that over-representation of proteins in ventricle is consequent not to redundancy but to functional need, and conclude that changes in abundance of proteins known to associate with AF are not sufficient for arrhythmogenesis.

IN AN effort to alleviate misconceptions and misinterpretations of our current COVID-19 reality, and to create the idea that human beings deserve respect, especially when they are ill, ListenMi News has collaborated with the International...

WHAT STARTED as an idea of two Barbadians – Ian Webster and Cheyne Jones – transformed into We Got This, a song which proved enough to stir the collective imagination of 25 recording artistes from 14 countries across the region, disseminating the...

It is definitely a make-or-break season for those trying to balance career and COVID-19 at home. For some, it is the ideal time to reconnect with themselves, family members and get creative with work. While with others, the cookie crumbles and they...

A new collection of articles published by The BMJ includes twelve country case studies, each an evaluation of multisectoral collaboration in action at scale on women’s, children’s, and adolescent’s health. Collectively these twelve studies inform an overarching synthesis and accompanying commentaries, drawing together lessons learned in...

Ralph A DeFronzo
Jun 1, 1988; 37:667-687
Lilly Lecture 1987

OBJECTIVE

Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes.

The ADA’s Continuing Education Recognition Program, or ADA CERP, announced in December that it is collaborating with Joint Accreditation for Interprofessional Continuing Education, in an effort to offer dentists more opportunities to participate in interprofessional education.

As the American College of Dentists celebrates its 100th anniversary, its leaders are ready to continue their mission of advancing excellence, ethics, professionalism and leadership in dentistry.

It was a Give Kids A Smile event not only for the children of the Mississippi Band of Choctaw Indians but also no fewer than 117 Indian Health Service dental programs across 24 states that were participating in GKAS with the events alone estimated to involve 14,000 American Indian/Alaska Native children.

The American College of Emergency Physicians has endorsed the American Dental Association's clinical practice guideline on the use of antibiotics for the management of pulpal- and periapical-related pain and swelling.

A federal judge on Friday declined to dismiss charges filed against Lori Loughlin and 13 others in a national college admissions case based in Massachusetts.

On May 9, 1980, a Liberian freighter rammed a bridge in Florida's Tampa Bay, collapsing part of the span and dropping 35 people to their deaths.

During a time when the world is focused on the current COVID-19 pandemic, a physical health crisis, and all those treating the physical symptoms of this pandemic, we must not...

One hundred forty-three years ago, women's suffrage advocate Elizabeth Cady Stanton faced a conundrum: With the Civil War over, Stanton had to decide whether to support the 14th and 15th amendments to the Constitution, which enabled black men to vote -- at a time when white women such as herself...

Ireland rugby captain Brian O'Driscoll has been ruled out of action for up to six months and will miss his country's Six Nations campaign when the annual tournament kicks off in February.

Darren Sammy and Devendra Bishoo shared five wickets to trigger India's collapse on the second day of the opening Test against the West Indies in New Delhi.

When we announced our v13 update, we mentioned a new feature called Email Digests that we’ll explain further in this…

Before the coronavirus pandemic, bioengineer Jim Collins and his team combined the power of AI with synthetic biology in an effort to combat a different looming crisis: antibiotic-resistant superbugs. Collins explains how they pivoted their efforts to begin developing a series of tools and antiviral compounds to help fight COVID-19 -- and shares their plan to discover seven new classes of antibiotics over the next seven years. (This ambitious plan is a part of The Audacious Project, TED's initiative to inspire and fund global change.)

The November 2019 issue of College & Research Libraries is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and follow C&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the final print issue of College & Research Libraries. The journal began an online-only publication model in January 2014. [...]

The January 2020 issue of College & Research Libraries is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and follow C&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the final print issue of College & Research Libraries. The journal began an online-only publication model [...]

The March 2020 issue of College & Research Libraries is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and followC&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the final print issue of College & Research Libraries. The journal began an online-only publication model in [...]

The April 2020 special issue of College & Research Libraries, highlighting the projects of ACRL Academic Library Impact research grant recipients, is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and followC&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the [...]

The May 2020 issue of College & Research Libraries is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and followC&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the final print issue of College & Research Libraries. The journal began an online-only publication model [...]

A measure now before Virginia's governor would let teachers bargain with local boards over wages and working conditions if a local board authorizes it.

An unusual program in Cincinnati provides academic coaches to help high school players meet eligibility requirements to stay in the game.

Fewer students are filing financial aid applications this year, as the pandemic continues to disrupt college plans for high school seniors nationwide.

Fewer students are filing financial aid applications this year, as the pandemic continues to disrupt college plans for high school seniors nationwide.

A read of California's news outlets makes clear that the state is not going to accept President-elect Donald Trump's policies without a fight, particularly those on immigration.

Five California educators last week filed a lawsuit seeking to stop the state's top teachers' union from collecting dues through mandatory paycheck deductions.

Utah Valley University offers career and technical education, associate degrees, bachelor's degrees, and master's degrees under one roof, all for the average out-of-pocket tuition of $1,700.

The NFL is indeed discussing the possibility of playing games on Saturdays in the event that college football doesn't proceed with a season from September through December. As one source with direct knowledge of the discussions tells PFT, however, the league's strong preference is for college football to happen, as scheduled. No college football season [more]

Nevada offensive lineman Nate Brown is doing his best to eat right, like many football players and other college athletes scattered around the country without access to training facilities amid the coronavirus pandemic. The 6-foot-4, 300-pound rising senior has stumbled a few times in college sports' version of Weight Watchers, with no in-person classes or spring practices. ''Maybe I would get Taco Bell because I do like Taco Bell,'' Brown said.

The NFL wants college football season to proceed as usual in 2020. It may proceed, but there's a good chance it will be very unusual. Via Sports Business Daily, commissioners of two of the Power Five conferences (Kevin Warren of the Big 10 and Greg Sankey of the SEC) have hinted in recent days at [more]

There are 130 major college football teams, spread across 41 states and competing in 10 conferences, save for a handful of independents. The goal is to have all those teams start the upcoming season at the same time - whether that's around Labor Day as scheduled or later - and play the same number of games. Despite the best intentions of conference leaders, the possibility exists of college football being played in SEC country before it begins in Pac-12 territory - or something else entirely.

Reconnecting with mentors, friends, coaches and professors, these football greats reflected on the experiences that they carried with them well beyond their college years. While they all share different stories, their journeys to the NFL were each met with adversity, and whether on or off the field, these obstacles served as tests for each individual athlete to overcome. These challenges made them stronger, earning them valuable lessons and helping them create special connections with the university they will always call ‘home.’

The NCAA is expected to formally approve rules changes that will allow athletes to get endorsement income in 2021.

Geoff Schwartz joins the latest Talkin' Ducks Podcast with host Jordan Kent

What middle ground does college football need to continue as normal this season? Here are the five biggest questions looming over the sport’s return.

"It is timely that the higher education sector examines paths forward to address and indeed engage in the new environment in which it will work in the future. This fellowship explored two approaches to engage students more deeply in their education. The first approach is generally termed 'interdisciplinary studies' where students define their own program of study; the second approach focuses on topic structure where students are given a wide range of choice and in effect can build a topic that suits their interests."--Page iv.

In 2017 the Department of the Prime Minister and Cabinet and Australian Defence Force (Australian Army) undertook a joint review of the Army Aboriginal Community Assistance Programme (AACAP) to assess its efficiency and effectiveness. The review found AACAP is a highly regarded and effective means of achieving positive environmental and primary health outcomes for Aboriginal and Torres Strait Islander communities while providing valuable training outcomes for Army. AACAP's objectives align with the Council of Australian Governments (COAG) 'Closing the Gap' targets in Indigenous disadvantage and with the Australian Government's Indigenous Advancement Strategy (IAS). The report identified areas for potential improvement, recommending greater support for the sustainability of infrastructure and project investment, enhanced employment and training opportunities and strengthening of project governance.