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Indian rice exports get delayed at ports as Customs officials hold up consignments

Exporters say they incur $70/tonne additional costs; Customs officials playing safe to verify if shipments are white or parboiled rice




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Festivals, agriculture, elections set to boost India's oil demand: S&P Global Commodity Insights

According to the commodities information services provider, India's oil demand decreased in September on a yearly basis, due to above normal rainfall, which affected road movement, construction, and mining activities




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Mountain rides, mindfulness and insightful reading

Start your day with InsuranceDekho CTO Ish Babbar’s morning mindfulness routine: deep breathing, stretching, running & more




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Syngenta signs MoUs with CSSRI and HAU on crop productivity, sustainable agriculture

MoUs aim to implement projects related to capacity building of rural youth in agriculture and allied sciences, safe use of crop protection chemicals and adoption of new technologies, among other things




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After AIX Connect merger, Air India Express sets sights on capacity and market share growth

The merger enhances operational synergies and marks a step forward in the parent company’s ambitious Vihaan transformation initiative




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Cyient DLM signs pact with Honeywell Aerospace Technologies

Cyient DLM The company signs a 16-year programme forecast to develop liquid cooling loops that will be used in select applications of Micro VCS




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Significance of the kriti

Radha Bhaskar talks about the various aspects of kriti




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Truly insightful: Gautam Adani hosts envoys from EU, Belgium, Denmark and Germany




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Insights into the photoinduced anion translocation of the Donor-π-Acceptor+(ion)- molecules

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04738A, Edge Article
Open Access
Hao-Ting Qu, Iida Partanen, Kai-Hsin Chang, Yan-Ding Lin, Igor O Koshevoy, Andrey Belyaev, Pi-Tai Chou
By strategic design and synthesis of a new series of phosphonium salts (compounds 1–7[OTf]), where [OTf]- stands for the trifluoromethanesulfonate anion, we performed comprehensive spectroscopic and dynamic studies on the...
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Bridge Editing of Spin-Flip Emitters gives Insight into Excited State Energies and Dynamics

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05860G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Florian Reichenauer, Robert Naumann, Christoph Förster, Winald Robert Robert Kitzmann, Antti-Pekka M. Reponen, Sascha Feldmann, Katja Heinze
Six-coordinate chromium(III) complexes with high spin-flip (SF) photoluminescence quantum yields and lifetimes (molecular rubies) have attracted huge interest in the past years due to their applicability in sensing, photocatalysis or...
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Ligand Cross-Links as a Design Element in Oligo- and PolyMOFs

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06109H, Edge Article
Open Access
Debobroto Sensharma, Seth M Cohen
Metal-Organic Frameworks (MOFs) constructed using cross-linked oligomeric or polymeric ligands (OligoMOFs and PolyMOFs respectively) have so far relied on a handful of canonical structural blueprints, in which the cross-links have...
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Organic dopant cyclization and significantly improved RTP properties

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06213B, Edge Article
Open Access
Shiguo Zhang, Guanyu Liu, Zhichao Mao, Shanfeng Xue, Qikun Sun, Wenjun Yang
Synthesized CDIA and ODIA via cyclization, obtained long-lived RTP polymers with lifetimes of 2146 and 2656 ms. Experimental and theoretical data show cyclization effectively restrains intramolecular rotation and stabilizes triplet populations.
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Allosteric release of cucurbit[6]uril from a rotaxane using a molecular signal

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC03970J, Edge Article
Open Access
Aneta Závodná, Petr Janovský, Václav Kolařík, Jas S. Ward, Zdeňka Prucková, Michal Rouchal, Kari Rissanen, Robert Vícha
Repulsions between portals of cucurbit[n]urils are sufficiently strong to unlock the rotaxane structure.
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Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05459H, Edge Article
Open Access
Lukas Bissegger, Theodora Alexandra Alexandra Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Clara Orbegozo, Thorsten Schaefer, Valentina Borlandelli, Thomas Bohnacker, Rohitha SriRamaratnam, Alexander Schäfer, Matthias Gstaiger, John E. Burke, Chiara Borsari, Matthias Wymann
Chemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...
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Towards real-time myocardial infarction diagnosis: a convergence of machine learning and ion-exchange membrane technologies leveraging miRNA signatures

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00640B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xiang Ren, Ruyu Zhou, George Ronan, S. Gulberk Ozcebe, Jiaying Ji, Satyajyoti Senapati, Keith L. March, Eileen Handberg, David Anderson, Carl J. Pepine, Hsueh-Chia Chang, Fang Liu, Pinar Zorlutuna
Rapid diagnosis of acute myocardial infarction (AMI) is crucial for optimal patient management.
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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00659C, Paper
Open Access
Claudia Allan, Yiling Sun, Stephen C. Whisson, Michael Porter, Petra C. Boevink, Volker Nock, Claudia-Nicole Meisrimler
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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Day 1 of Modi 3.0: PM signed file to release Kisan Nidhi, Cabinet approves 3 cr homes

PM Kisan Nidhi provides income support to 14.5 crore small and marginal farmers




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BMW 620d M Sport Signature launched

Priced at ₹78.90 lakh, ex-showroom, the tech-laden car is powered by a 2-litre diesel engine




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Significant spike in air, noise pollution in Kolkata




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How to identify hidden signs of your child's depression and how to go about it

This article will highlight common signs of depression in children and offer practical steps for parents to ensure their child gets the support needed to overcome these challenges.




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Data | How significant were BJP’s deposit losses in 13.8% of Karnataka’s seats?

The BJP lost deposits in 38.4% of the seats it contested in Southern Karnataka




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Parliamentary Panel highlights significant delays in installation of telemetry systems in critical flood-prone areas

The Committee's report on the performance audit of schemes for flood control and forecasting underscores the need for urgent action to ensure timely and effective flood management




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New National champion Nandhidhaa sets sights on becoming a GM




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Kremlin says sees 'positive signals' from Trump on Ukraine

Kremlin spokesman Dmitry Pesko said it was hard to predict "to what extent he's going to stick to statements that he made on the campaign trail"




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Designated terrorist Arsh Dalla arrested by Canadian police after shooting incident, say sources

Though the police in Canada did not disclose the arrested person’s identity, sources in New Delhi claimed that he was believed to be Arsh Dalla, who ran terror modules on behalf of Hardeep Singh Nijjar.




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Israeli ministers send mixed signals over Lebanon ceasefire

"There is certain progress," Foreign Minister Gideon Saar said after being asked about a possible ceasefire.




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Justin Welby, Archbishop of Canterbury, resigns over abuse scandal

Archbishop Welby, the spiritual leader of 85 million Anglicans worldwide, had faced calls to resign after a report last week found he had taken insufficient action to stop a person it described as arguably the Church of England’s most prolific serial abuser




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Insights from data with R [electronic resource] : an introduction for the life and environmental sciences / Owen L. Petchey, Andrew P. Beckerman, Natalie Cooper, Dylan Z. Childs.

Oxford : Oxford University Press, 2021.




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The application of a self-designed microfluidic lung chip in the assessment of different inhalable aerosols

Anal. Methods, 2024, 16,2111-2119
DOI: 10.1039/D4AY00017J, Paper
Zezhi Li, Xiang Li, Boyang Feng, Junwei Zhao, Kejian Liu, Fuwei Xie, Jianping Xie
Microfluidic-based assessment platforms have recently attracted considerable attention and have been widely used for evaluating in vitro toxic effects.
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Sodium alginate hydrogelation mediated paper-based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of L-lactate

Anal. Methods, 2024, 16,2077-2084
DOI: 10.1039/D4AY00041B, Paper
Wenjuan Wang, Danrong Chen, Yujiao Cai, Zijing Liu, Hongfen Yang, Hongbin Xie, Jinquan Liu, Shengyuan Yang
Here, we show a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric dual-signal analysis to determine the concentration of L-lactate in yogurt samples.
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Dual-signal detection of tannin acid in red wines based on peroxidase activity carbon dots

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00526K, Paper
Bin Liu, Yu Yin, qianwen Li, wanwan Li, Fubing Xiao, Jinquan Liu, Yan Tan, Shengyuan Yang
Herein, a novel sort of phosphorus and iron-doped carbon dots (P,Fe-CDs) with outstanding peroxidase activity and excellent fluorescence performance was hydrothermally synthesized to colorimetrically and fluorimetrically detect tannic acid (TA)....
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

Anal. Methods, 2024, 16,2340-2348
DOI: 10.1039/D4AY00053F, Paper
Pakawat Kongpreecha, Sineenat Siri
Given paraquat's environmental health risks, there is a need for a fast and simple detection method. This study presents a novel colorimetric aptasensor with a tailored aptamer, boosting sensitivity by targeting multiple paraquat binding sites.
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A novel electrophoretic assisted hydrophobic microdevice for enhancing blood cell sorting: design and numerical simulation

Anal. Methods, 2024, 16,2368-2377
DOI: 10.1039/D4AY00196F, Paper
Xinkun Chen, Xueye Chen
Microfluidic technology has great advantages in the precise manipulation of micro–nano particles, and the hybrid microfluidic separation technology has attracted much attention due to the advantages of both active and passive separation technology at the same time.
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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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Sun signs: On extreme heat and Tamil Nadu’s policy decision

States should prepare to assist the vulnerable during extreme heat events




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article
Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article
Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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