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Apr 16, 2020; 0:jcs.237628v1-jcs.237628
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As society changes, it places new demands on its surroundings. New research has found that some EU countries are better able to manage the undesirable expansion of cities, the concept known as ‘urban sprawl’, because they have a flexible spatial planning policy that can easily adapt to changes. Urban sprawl is a term used to describe the expansion of residential suburbs around city centres, driven by peoples’ desire to live in larger houses and the ease of transport made possible by cars.

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A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.

Image credit: Drew Spacht/The Ohio State University

Source: Streetwise Reports   05/05/2020

Commercial-stage biotechnology company Portola Pharmaceuticals Inc. (PTLA:NASDAQ), which focuses on blood-related disorders, and global biopharmaceuticals firm Alexion Pharmaceuticals Inc. (ALXN:NASDAQ) announced that they have entered into a definitive merger agreement for Portola to be acquired by Alexion.

The acquisition is said to provide a key addition to Alexion's diversified commercial portfolio. The report indicated that the merger agreement has already been unanimously approved each of the company's boards of directors.

The report explained that "Portola's commercialized medicine, Andexxa^® [coagulation factor Xa (recombinant), inactivated-zhzo], marketed as Ondexxya^® in Europe, is the first and only approved Factor Xa inhibitor reversal agent, and has demonstrated transformative clinical value by rapidly reversing the anticoagulant effects of Factor Xa inhibitors rivaroxaban and apixaban in severe and uncontrolled bleeding."

Portola's President and CEO Scott Garland commented, "In developing and launching Andexxa, Portola has established a strong foundation for changing the standard of care for patients receiving Factor Xa inhibitors that experience a major, life-threatening bleed. Andexxa rapidly reverses the pharmacologic effect of rivaroxaban and apixaban within two minutes, reducing anti-Factor Xa activity by 92 percent...Given their enhanced resources, global footprint and proven commercial expertise, we look forward to working with Alexion to maximize the value of Andexxa. With their commitment to commercial excellence, together, we will be able to drive stronger utilization of Andexxa, increase penetration and accelerate adoption in the critical care setting."

Ludwig Hantson, Ph.D., CEO of Alexion, remarked, "The acquisition of Portola represents an important next step in our strategy to diversify beyond C5. Andexxa is a strategic fit with our existing portfolio of transformative medicines and is well-aligned with our demonstrated expertise in hematology, neurology and critical care...We believe Andexxa has the potential to become the global standard of care for patients who experience life-threatening bleeds while taking Factor Xa inhibitors apixaban and rivaroxaban. By leveraging Alexion's strong operational and sales infrastructure and deep relationships in hospital channels, we are well positioned to expand the number of patients helped by Andexxa, while also driving value for shareholders."

The firms advised that "under the terms of the merger agreement, a subsidiary of Alexion will commence a tender offer to acquire all of the outstanding shares of Portola's common stock at a price of $18 per share in cash." Alexion plans to fund the purchase with existing cash on hand and the transaction is expected to close in Q3/20. The purchase is subject to approval by a majority interest of Portola's common stockholders tendering their shares along with ordinary closing conditions and regulatory approvals. The company noted that "following successful completion of the tender offer, Alexion will acquire all remaining shares not tendered in the offer at the same price of $18 per share through a merger."

Alexion is a global biopharmaceutical company based in Boston, Mass., with offices in 50 countries worldwide. The company states that it has been "the global leader in complement biology and inhibition for more than 20 years and that it has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome, as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor antibody-positive generalized myasthenia gravis and neuromyelitis optica spectrum disorder."

Portola is headquartered in South San Francisco, Calif., and is a commercial-stage biopharmaceutical company focused on treating patients with serious blood-related disorders. Specifically, the company is engaged in developing and commercializing novel therapeutics in order to advance the fields of thrombosis and other hematologic conditions. The firm listed that its first two commercialized products are Andexxa^® and Bevyxxa^® (betrixaban), and that it is also advancing and developing cerdulatinib, a SYK/JAK inhibitor for use in treatment of hematologic cancers.

Portola Pharmaceuticals started off the day with a market capitalization of around $609.0 million with approximately 78.5 million shares outstanding and a short interest of about 23.0%. PTLA shares opened 130% higher today at $17.85 (+$10.09, +130.03%) over yesterday's $7.85 closing price. The stock has traded today between $17.71 and $17.91 per share and is currently trading at $17.83 (+$10.07, +129.77%).

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

Source: Knox Henderson for Streetwise Reports   05/07/2020

A quick update since FansUnite Entertainment Inc. (FANS:CSE) went live on Tuesday, May 5, because big things are happening in the industry, thus showing there is an enormous appetite for this kind of technology especially now, as we (very slowly) emerge out of this COVID pandemic.

On the sports front, Germany announced that its Bundesliga soccer will resume games in May, yet with tight restrictions and no fans. This is followed by the Turkish soccer league, which plans to resume playing on June 12. The Ultimate Fighting Championship (UFC), with a huge draw to the masses—the UFC 246 prelims averaged 1.767 million viewers on ESPN—will return at VyStar Veterans Memorial Arena in Jacksonville, Fla., on May 9, again featuring no live fans. So as more sports emerge in our "new reality," where will those fans be? Online, of course! In a fanless sports environment we're going to see a lot of online engagement no matter what sport or activity that may be. That's going to spawn even more online attention, which will likely hold firm even after we emerge from our home quarantine.

The industry is rapidly consolidating. On Tuesday we alluded to The Stars Group Inc. (formerly Amaya), which, according to Bloomberg, "saw record revenue in its first quarter as COVID-19 led to an increase in online activity starting in March. Indeed TSGI.T has had a great run from $18 mid-March to a high of $40 on May 1 after it confirmed shareholder approval of a friendly takeover by UK based Flutter Entertainment plc. (LSE:FLTR.L - News). The two create a £10 billion (US$12 billion) giant, according to Racing Post, and combine for more than 13 million customers, US$4.6 billion in revenue and US$1.7 billion in EBITDA.

Investors are getting on board

In our previous note we referred to DraftKings (NASDAQ:DKNG), which launched as recently as April 23, in the thick of this stay-at-home pandemic. After completing a merger with Diamond Eagle, a special purpose acquisition company, and back-end technology provider SBTech, its stock soared. DraftKings' stock jumped 14% in its first day of trading before closing up 10.38% at $19.35. The company was also able to add another half a billion dollars on the balance sheet at a time when it's not easy to raise money. That company currently has a $17 billion market capitalization.

Meanwhile there's been a noticeable correlation of trading activity in the industry from mid-March to the end of April:

• Prior to the merger with Canadian The Stars Group, Dublin, Ireland-based Flutter, trading as OTC:PDYPY in the U.S., had a good run of its own. Since mid-March it doubled from $31 to $64 by the end of April, despite any global sport-killing pandemic.

• UK-based GVC Holdings PLC (LSE:GVC) gained 23% in the last month, from $611 to $750, reaching a US$4.3 billion market capitalization.

• After falling from February highs of $30, Scientific Games (NASDAQ:SGMS) more than tripled from a $4 low mid-march to $13 by the end of April to again reach a $1 billion market valuation.

• Penn National Gaming (NASDAQ:PENN), now at a US$1.8 billion market capitalization, has a chart that mirrors SGMS. After February highs of $38, PENN rebounded through the COVID crisis. It also more than tripled from a low of $4.50 mid-March to a $17.80 high by the end of April.

• Score Media and Gaming (SCR.V,) with a market capitalization of $185 million, during that same period, ran from $0.32 to $0.42 mid-march to April 29, gaining 31%

• (are you starting to a pattern here?)

On the regulatory front, Colorado, became the next state to legalize sports bargaining following New Jersey, Nevada, Delaware and Pennsylvania. The state is poised to generate $6 billion in annual wagers and an estimated $400 million in revenue once the industry matures, according to Dustin Gouker, chief analyst for PlayColorado.com. According to the Denver Post, Colorado fans will have their pick of 17 digital sportsbooks currently licensed to operate in the state.

FansUnite Is at a Small-Cap Entry Point with Tremendous Upside.

It is in this environment that FansUnite launched on the Canadian Securities Exchange on May 5. "We are just getting started," said CEO Darius Eghdami. "We've bought a great asset in McBookie and will be continuing to focus on M&A." McBookie, the company's first acquisition, is a white-label sportsbook in the UK, focusing on the Scottish market. It offers 200,000 members active in sports and virtual games, and boasts over $100 million turnover cumulatively the last three years. "We want to be active in finding that next 'McBookie' operating in a niche market, looking at Esports assets and also creative ways to get into the U.S. market. "

After a financing at $0.35, the now-trading company rests slightly above that as a relatively new and unknown entity—so far—which is why now is great opportunity participate in a smaller scale, yet leveraged, consolidation play. "We have a great opportunity to use our stock as currency, and then grow and scale companies through our team and resources," says Eghdami.

"We also have great investors and support, a very experienced board and management team and a clear vision of how we want to be that next gaming giant. The path has been shown by other Canadian gaming companies such as Amaya, and we want to follow that path and execute on our vision."

It's an ambitious plan: a CA$25 million market-cap company, $2 million in the bank, with a consolidation plan to attack a $1 trillion online industry. Yet FansUnite comes out of the gate with strong financial backing led by board member Shafin Diamond, CEO of Victory Square since 2015, a venture builder that builds start-ups in web, mobile, gaming, AI and AR/VR. Diamond has launched 40 start-ups in 24 countries, employed more than 350 people, and has generated over $100 million in annual revenues.

Eghdami says the immediate plan is to strengthen its UK presence with McBookie and focus on M&A activity, while continuing to develop its software platform.

The games are just beginning.

Knox Henderson is a journalist and capital markets communications consultant. He has advised for a broad range of small cap companies in the resource, life sciences and technology sectors for more than 25 years.

Disclosure:
1) 1) Knox Henderson: I, or members of my immediate household or family, own shares of the following companies mentioned in this article: None. I personally am, or members of my immediate household or family are, paid by the following companies mentioned in this article: FansUnite Entertainment Inc. My company has a financial relationship with the following companies mentioned in this article: None. I determined which companies would be included in this article based on my research and understanding of the sector.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees. As of the date of this article, an affiliate of Streetwise Reports has a consulting relationship with FansUnite. Please click here for more information. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
3) Statements and opinions expressed are the opinions of the author and not of Streetwise Reports or its officers. The author is wholly responsible for the validity of the statements. The author was not paid by Streetwise Reports for this article. Streetwise Reports was not paid by the author to publish or syndicate this article. Streetwise Reports requires contributing authors to disclose any shareholdings in, or economic relationships with, companies that they write about. Streetwise Reports relies upon the authors to accurately provide this information and Streetwise Reports has no means of verifying its accuracy.
4) This article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of FansUnite, a company mentioned in this article.

( Companies Mentioned: FANS:CSE, )

Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies.

No justification currently exists for completely abandoning chemical pesticides, says a new report from the National Academies National Research Council.

Current federal tax provisions have minimal net effect on greenhouse gas emissions, according to a new report from the National Research Council.

To improve and ensure the efficacy of restoration efforts in the Gulf of Mexico following Deepwater Horizon – the largest oil spill in U.S. history – a new report from the National Academies of Sciences, Engineering, and Medicine recommends a set of best practices for monitoring and evaluating ecological restoration activities.

In an August 18 letter, the U.S. Department of the Interior’s Office of Surface Mining Reclamation and Enforcement informed the National Academies of Sciences, Engineering, and Medicine that it should cease all work on a study of the potential health risks for people living near surface coal mine sites in Central Appalachia.

The number of patients in the U.S. awaiting organ transplantation outpaces the amount of transplants performed in the U.S., and many donated organs are not transplanted each year due to several factors, such as poor organ function, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine calls for an international, multi-institutional comprehensive campaign of research, observation, and analysis activities that would help improve understanding and prediction of the Gulf of Mexico’s Loop Current System (LCS).

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new grant opportunity focused on enhancing coastal community resilience and well-being in the Gulf of Mexico region.

To achieve goals for climate and economic growth, “negative emissions technologies” (NETs) that remove and sequester carbon dioxide from the air will need to play a significant role in mitigating climate change, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine today announced a new collaboration with Shell and others to provide $1 million in funding support for a pilot effort to convert an existing ocean mooring owned by Shell into the first long-term deep ocean observatory in the Gulf of Mexico.

Following recommendations from a National Academies of Sciences, Engineering, and Medicine report released earlier this year, the National Academies’ Gulf Research Program (GRP) is developing a long-term research campaign to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new funding opportunity to provide up to $2.5 million in grants to foster innovative approaches that support its ongoing efforts to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

Current evidence supports the classification of the contemporary red wolf as a distinct species of wolf, although additional genomic evidence from historic wolf specimens could change that assessment, says Evaluating the Taxonomic Status of the Mexican Gray Wolf and the Red Wolf, a new report from the National Academies of Sciences, Engineering, and Medicine.

The supercritical water oxidation (SCWO) system is a secondary waste processing reactor of the Blue Grass Chemical Agent Destruction Pilot Plant (BGCAPP). It is perhaps second in importance behind the agent neutralization reactors, which perform base hydrolysis of chemical warfare agents stored at the Blue Grass Army Depot.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced $2 million in grant awards for seven new projects through its Understanding Gulf Ocean Systems (UGOS) Grants 2 competition.

Today the National Academies of Sciences, Engineering, and Medicine released its review of the National Toxicology Program’s (NTP) draft monograph Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.

The U.S. Department of Energy’s plan to dilute and dispose of 34 metric tons of surplus plutonium in the Waste Isolation Pilot Plant (WIPP) in New Mexico is technically viable, provided that the plan’s implementation challenges and system vulnerabilities are resolved.

The Department of Toxic Substances Control is claiming that FedEx Ground has mishandled hazardous materials in packages. ; Credit: Thomas Hawk/via Flickr

State regulators have sued FedEx Ground, claiming the company mishandled hazardous chemicals at facilities throughout California during the last 5 years.  

An investigation into a fire four years ago in San Diego prompted a wider inquiry into how FedEx handles restricted chemicals in statewide shipping at all of its facilities.

Regulators claim FedEx didn’t handle thousands of damaged and hazardous packages properly. The state’s complaint claims FedEx would remove damaged packages from shipping and store them for lengthy periods of time in salvage drums, which were moved from hubs to terminals within the company’s network of facilities.  

These packages contained goods ranging from insecticides and acids to old batteries and other flammable and toxic materials – pretty small shipments, less than 65 pounds, but investigators say they’ve found problems with more than 20 tons of goods shipped over a 5-year period.

Each violation alleged in the state’s lawsuit carries a penalty of up to 25-thousand dollars. In a written statement, FedEx spokeswoman Katie Wassmer says the company "complies with all applicable local, state and federal reporting requirements." 

The state-court complaint is the latest legal salvo in a dispute among California and local officials and FedEx.

Earlier this spring, FedEx sued the DTSC and district attorneys from three cities, including Los Angeles, seeking a declaration that federal law pre-empts California's waste handling laws, and that state officials are incorrectly interpreting laws governing FedEx. 

"To preserve our rights as a federally-registered motor carrier, FedEx Ground filed suit in federal court" said Wassmer. "We are confident that a thorough review of the regulatory framework through the judicial process will support our position."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Exide begins to remove lead-polluted soil on Monday morning at a house on the 1200 block of La Puerta Street in Boyle Heights.; Credit: Maya Sugarman/KPCC

All five members of the Los Angeles County Board of Supervisors have signed a letter imploring California Gov. Jerry Brown to intervene in the state’s handling of contamination around the Exide Technologies plant in Vernon.

The letter criticizing the state’s “piecemeal approach to an urgent environmental hazard” comes as workers paid for by Exide are removing lead-contaminated topsoil from two homes near the intersection of Olympic and Indiana avenues in L.A. 

Signed Tuesday, the letter asks for “guaranteed state funding to immediately begin testing” at 37 more homes also sampled, but to less specific degrees, during November 2013. In the words of the board, “further testing and remediation of the other 37 homes has not been confirmed and may not begin until at least October 2014 because Exide has not yet agreed to comply with DTSC directives issued last March.”

The supervisors also say the state has “reneged” on its commitments to test for lead inside the homes as well as outside.

The Department of Toxic Substances Control says that the two homes workers are at this week will be cleaned inside and out — even without indoor testing.  The DTSC’s Rizgar Ghazi said Monday that crews will use HEPA filters, vacuums and shampooing equipment on “basically any flat surface” inside the two residences.

Read the L.A. Board of Supervisors’ letter to Gov. Brown here:

http://www.scribd.com/doc/236655733/LA-County-Supervisors-Letter-to-Gov-Brown-8-12-14

This content is from Southern California Public Radio. View the original story at SCPR.org.

Peter Epstein of Epstein Research discusses the macro picture for precious metals prices and one junior that he believes will benefit from higher prices.

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A 2018 exhibit at the Billy Ireland Cartoon Library & Museum at Ohio State University celebrated the artistic legacy of MAD magazine.; Credit: Andrew Welsh-Huggins/AP

The funny, freckled face of Alfred E. Neuman is more or less retiring.

One of the last widely circulated print satirical magazines in America will leave newsstands after this year, according to sources at DC Comics, which publishes MAD magazine.

While the Harvard Lampoon remains in business, The Onion hasn't been in print since 2013. The once-influential Spy was a casualty of the 1990s.

At MAD's peak in the early 1970s, more than 2 million people subscribed to it, both for its pungent political humor and deeply adolescent jokes.

In 2017, that number had reportedly dropped to 140,000.

MAD isn't completely shutting down, but it will be radically downsized and changed.

Readers will only be able to find the 67-year-old humor magazine at comic book stores and through subscriptions.

After issue No. 10 this fall, there will no longer be new content, except for end-of-year specials which will be all new. Starting with issue No. 11, the magazine will feature classic, best-of and nostalgic content, repackaged with new covers.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Shout out to my 20 million brothers and sisters-  The one in seven U.S. taxpayers who waited until the last minute to file. 

This year, the IRS even gave us 'til April 18th-  So the 18th is when I filed- For my extension!  See you in October!

In my defense, it was not due to lack of effort.  It feels like I spent 200 hours on my taxes this year, because they were unusually complicated. 

Back when I was in my twenties?  Much effort was put into stacking red milk crates for bookshelves and trying to fold up a futon without mangling my fingers-30 years later, I'm trying to do really smart grown-up things.

To wit, my life partner and I have been business partners for almost 20 years.  We used to be young-  Now we're-ahem-"less young"-  Picture the Boomers you see in those ads, silver-haired, in wet suits, running towards the ocean with surfboards, very at peace with nature and our fully-funded 401-K plans - Except that we don't surf and, regarding those 401-K plans?

Well, what I have written on the notepad I stole from Charles Schwab is-  And I quote:
"Retirement and write it off, and something about medical." 

When I look at this enigmatic scribble, an image comes to me: A friendly thirty-something man dressed in charcoal gray business casual- And a desk, and a plant-  And that man is saying:

"Sandra, by all means, you need to form a C corp!  NOT an S corp!"

But wait, is that what he said? Maybe it was:
"Sandra, by all means, you need to form an S Corp!  NOT a C corp!"

It was like being in school and confronting a page of long division- Or sitting in a deadly after-lunch class like "US Government"-  There's this mix of incomprehension, coupled with boredom, that makes it all sound like white noise.

S corp, C corp-  These things involve a part of my brain that refuses to fire.  All I know is there was one kind that was right, it's not the one I did, at some moderate expense, and now I'm going to jail. 

Where at least I won't have to fold a futon.  I think.

Next week: Separate Bathrooms, Separate Quicken Accounts

This content is from Southern California Public Radio. View the original story at SCPR.org.

Dave Ramsey—  The financial radio talk show host—  Says every couple has two people.  One is the nerd with the calculator.   The other is the spendy free spirit. 

In my couple, I am the nerd.  I am calmed by a seven-by-seven Ken Ken and a mechanical pencil.  No surprise that I have used Quicken now for several decades.  But it seems in the last five or 10 years—  What with the Russian hackers stealing our info to get porn—  The cheapo, Windows-based laptops Quicken favors have gotten very buggy. 

So buggy, I bought a sacrificial Dell laptop just for Quicken.   But even that lasted barely six months without crashing.  So Charlie, the free spirit, took over paying the bills!  Writing checks by hand!  Notating them in a large, impressive leatherette binder!  The checks are pretty—tan and sort of antique-looking.  There's a stagecoach on them.

This was all charming until I realized it was tax time. To get all my financial info into the computer, I was going to have to hand-enter each check.  With a quill pen and a butter churn.

While in the joyous process of hand-inputting each check that went out in calendar year 2016— I learned some interesting things!

That beautiful 8-lane highway we drove on that time we visited friends in Orange County? That was a toll road that we apparently didn't pay for. 250 dollar fine! Plus--We're subscribers to something called Cook's Country Magazine, even though I am NOT into "homestyle cooking." And -- we've been paying hundreds of dollars a month for gym memberships that I didn't know we have!

Argh!

Losing it, I throw in the towel and buy myself my own personal version of Quicken—for Mac—  There's a help line to call—  And unbelievably, an operator immediately answers.  He's a courteous gentleman with a lilting, slightly British accent.  He answers my "sign in" question, and asks: "Do you want me to stay on the line while you try it?" "Sure!" I say, surprised.

We click pleasantly through a few more windows—  He's marvelously patient, and attentive—  Wanting to be entertaining, I actually start reciting my passwords aloud as I type them.  

"Let's see—2, 3, 4—asterisk, star, Sparky Sparky, that was my first pet— "Now I'm actually going to have to go downstairs to get my purse," I say, "and maybe go to the ladies' on the way 'cause I've had a lot of coffee— "
"It's fine!" he says—
"Well you can continue playing Solitaire or whatever you're doing!" I say.  And he chuckles!
Doing your taxes?  It takes a village.  And a butter churn.

This content is from Southern California Public Radio. View the original story at SCPR.org.

A spike in texts and calls to crisis hotlines reflects Americans' growing anxiety about the coronavirus and its impact on their lives.; Credit: Richard Bailey/Getty Images

Normally, Laura Mayer helps the most acutely suicidal callers find the nearest hospital emergency room. But in a pandemic, that has become a crisis counselor's advice of last resort.

"It's a difficult decision because we do know that by sending them into an overburdened health care system, they may or may not get the treatment that they need," says Mayer, who is director of PRS CrisisLink in Oakton, Va., which also takes calls for the National Suicide Prevention Lifeline. "The resources may or may not be there, and we're exposing them to the illness."

So instead, counselors are devoting more time to each caller, offering ad hoc therapy and coaxing them to talk through their pain. These days, that pain often has many sources: lost jobs, severed relationships and sick family.

"The type of call and the seriousness of the call is very different this year than it was in previous years," Mayer says. "There's environmental issues, internal issues, family issues. ... It's never one thing."

America's crisis centers and hotlines are themselves in crisis. As people grapple with fear, loneliness and grief, on a grand scale, those stresses are showing up at crisis hotlines. Not only are the needs greater, but their clients' problems are more acute and complex and offer a window into the emotional struggles Americans face.

Across the board, hotlines of all kinds are reporting increases in volume.

The Substance Abuse and Mental Health Services Administration saw a fivefold increase at its National Helpline in March. The Crisis Text Line says its volumes are up 40% in the pandemic, to about 100,000 conversations a month.

Volunteer counselors and good Samaritans are responding by lining up to help.

But Mayer says the heaviness takes its toll. Those offering this kind of support end up needing support themselves.

"This illness is starting to impact each of our crisis workers and counselors themselves personally," she says. "So everyone is kind of a client right now, and that's been really challenging."

Nancy Lublin, CEO and co-founder of the Crisis Text Line, says she is bracing for sustained need. "This echo of the physical virus, the mental health echo, we fear it's going to last a very long time and that the intensity will remain," she says.

Over the last two months, the focal point of the emotional pain has shifted, she says. Initially, the spike in traffic was over anxiety about the virus itself. That shifted to complaints of isolation. Now, texters talk of depression and grief.

"So we've doubled the number of conversations that are about grief, and there the top two words that we see are 'grandma' and 'grandpa,' " she says.

And it's no longer just young people texting. Adults are complaining of loneliness, sexual abuse and eating disorders.

"As the quarantines go on and continue, we're seeing it's the people over the age of 35 who are increasing at a higher percentage of our volume," Lublin says. "For the first time, we're seeing people over the age of 60 texting us."

Texting is an ideal medium, she says, for those stuck at home with no personal space: "You don't have to find a quiet space where no one else can hear you."

And for some, that might be the only form of escape. The text line has seen a 74% increase in references to domestic violence. "We see words like 'trapped' [and] 'hurt,' " says Lublin.

Many shelters have shut down, and some of those in-person centers, including the Salvation Army in Philadelphia, now rely on their own hotlines instead.

Arielle Curry, director of the Salvation Army's anti-human trafficking program, says many of her clients can't afford cell phones and have lost touch; those who remain in contact are in dire straits, searching for a shorter supply of money or drugs, and are often suicidal. Curry says addressing those acute emotional needs by phone is frustrating; sometimes she doesn't even know where they are and can't send help to intervene.

"You can't ... comfort someone and look them in their eyes and support them face-to-face," she says. That makes it hard, Curry says, not to feel helpless and hopeless herself.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Ron Struthers of Struthers' Research Report takes a look at the investment thesis for Ridgestone Mining.

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A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.

Image credit: Drew Spacht/The Ohio State University

Source: Streetwise Reports   05/05/2020

Commercial-stage biotechnology company Portola Pharmaceuticals Inc. (PTLA:NASDAQ), which focuses on blood-related disorders, and global biopharmaceuticals firm Alexion Pharmaceuticals Inc. (ALXN:NASDAQ) announced that they have entered into a definitive merger agreement for Portola to be acquired by Alexion.

The acquisition is said to provide a key addition to Alexion's diversified commercial portfolio. The report indicated that the merger agreement has already been unanimously approved each of the company's boards of directors.

The report explained that "Portola's commercialized medicine, Andexxa^® [coagulation factor Xa (recombinant), inactivated-zhzo], marketed as Ondexxya^® in Europe, is the first and only approved Factor Xa inhibitor reversal agent, and has demonstrated transformative clinical value by rapidly reversing the anticoagulant effects of Factor Xa inhibitors rivaroxaban and apixaban in severe and uncontrolled bleeding."

Portola's President and CEO Scott Garland commented, "In developing and launching Andexxa, Portola has established a strong foundation for changing the standard of care for patients receiving Factor Xa inhibitors that experience a major, life-threatening bleed. Andexxa rapidly reverses the pharmacologic effect of rivaroxaban and apixaban within two minutes, reducing anti-Factor Xa activity by 92 percent...Given their enhanced resources, global footprint and proven commercial expertise, we look forward to working with Alexion to maximize the value of Andexxa. With their commitment to commercial excellence, together, we will be able to drive stronger utilization of Andexxa, increase penetration and accelerate adoption in the critical care setting."

Ludwig Hantson, Ph.D., CEO of Alexion, remarked, "The acquisition of Portola represents an important next step in our strategy to diversify beyond C5. Andexxa is a strategic fit with our existing portfolio of transformative medicines and is well-aligned with our demonstrated expertise in hematology, neurology and critical care...We believe Andexxa has the potential to become the global standard of care for patients who experience life-threatening bleeds while taking Factor Xa inhibitors apixaban and rivaroxaban. By leveraging Alexion's strong operational and sales infrastructure and deep relationships in hospital channels, we are well positioned to expand the number of patients helped by Andexxa, while also driving value for shareholders."

The firms advised that "under the terms of the merger agreement, a subsidiary of Alexion will commence a tender offer to acquire all of the outstanding shares of Portola's common stock at a price of $18 per share in cash." Alexion plans to fund the purchase with existing cash on hand and the transaction is expected to close in Q3/20. The purchase is subject to approval by a majority interest of Portola's common stockholders tendering their shares along with ordinary closing conditions and regulatory approvals. The company noted that "following successful completion of the tender offer, Alexion will acquire all remaining shares not tendered in the offer at the same price of $18 per share through a merger."

Alexion is a global biopharmaceutical company based in Boston, Mass., with offices in 50 countries worldwide. The company states that it has been "the global leader in complement biology and inhibition for more than 20 years and that it has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome, as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor antibody-positive generalized myasthenia gravis and neuromyelitis optica spectrum disorder."

Portola is headquartered in South San Francisco, Calif., and is a commercial-stage biopharmaceutical company focused on treating patients with serious blood-related disorders. Specifically, the company is engaged in developing and commercializing novel therapeutics in order to advance the fields of thrombosis and other hematologic conditions. The firm listed that its first two commercialized products are Andexxa^® and Bevyxxa^® (betrixaban), and that it is also advancing and developing cerdulatinib, a SYK/JAK inhibitor for use in treatment of hematologic cancers.

Portola Pharmaceuticals started off the day with a market capitalization of around $609.0 million with approximately 78.5 million shares outstanding and a short interest of about 23.0%. PTLA shares opened 130% higher today at $17.85 (+$10.09, +130.03%) over yesterday's $7.85 closing price. The stock has traded today between $17.71 and $17.91 per share and is currently trading at $17.83 (+$10.07, +129.77%).

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Hypoxia (low levels of oxygen) is widespread in the coastal waters of the Baltic Sea, according to recently published research. The trend of increasing hypoxia since the 1950 is alarming, although improvements can be seen in some areas as a result of measures to reduce inputs of organic material.

Blue-green algae, or ???aquatic cyanobacteria???, can produce harmful toxins and present a serious health hazard when they bloom in large numbers. Researchers from Germany have now identified plant species that could be used to sustainably treat water by removing such cyanobacterial toxins.

A recent study has described a simple method to screen the toxicity of materials used in consumer products. Using utility meter products as examples, the study found, for example, that stainless steel and polyvinyl chloride (PVC) had high toxicity potentials and suggests less toxic, but equally effective and priced, alternatives that could be used instead.

Research into mercury has identified two genes in bacteria that appear to be required for turning the metal into its most toxic form, methylmercury. The study adds to a growing body of research that helps us to understand the transformations that mercury undergoes in the environment and the microbes involved in these transformations.

Increases in the amount of CO₂ in the atmosphere can be beneficial to crops, by providing a source of carbon for growth. However, very high levels of CO₂ have the reverse effect, decreasing the yield and quality of vegetable crops, a new study has shown. The researchers say atmospheric CO₂ concentration should be kept below 5 000 ppm to enhance the yield of leafy vegetables such as cabbage and lettuce.

Polycyclic aromatic hydrocarbons (PAHs) are a large group of toxic molecules produced by forest fires, industrial processes and the incomplete combustion of fossil fuels. The airborne particles containing these molecules are often washed into watercourses, where they can persist. This study uses long-term monitoring data from the Elbe river, Saxony, Germany, to show how changes in PAH sources affect both the concentrations of these chemicals and the corresponding environmental risks. The researchers suggest that controlling PAHs is the best prevention of harm to aquatic and human health.

Harbour sediments should be tested for their toxic effects on living organisms in addition to being subject to the chemical, physical and biological tests usually conducted to assess water quality, according to recent research from Portugal. This would provide a better environmental assessment of dredged material to help guide port authorities’ decisions on its disposa

Hispanic Mexican city of Teotihuacan may have bred rabbits and hares for food, fur and bone tools, according to a study published August 17, 2016 in the open-access journal PLOS ONE by Andrew Somerville from the University of California San Diego, US, and colleagues.

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Researchers from the University of Oxford's Bodleian Libraries and from universities in the Netherlands have used high-tech imaging to uncover the details of a rare Mexican codex dating from before the colonization of the Americas. The newly revealed codex, or book, has been hidden from view for almost 500 years, concealed beneath a layer of plaster and chalk on the back of a later manuscript known as the Codex Selden, which is housed at the Bodleian Libraries. Scientists have used hyperspectral imaging to reveal pictographic scenes from this remarkable document and have published their findings in the Journal of Archaeological Science: Reports.

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As society changes, it places new demands on its surroundings. New research has found that some EU countries are better able to manage the undesirable expansion of cities, the concept known as ‘urban sprawl’, because they have a flexible spatial planning policy that can easily adapt to changes. Urban sprawl is a term used to describe the expansion of residential suburbs around city centres, driven by peoples’ desire to live in larger houses and the ease of transport made possible by cars.

Controlling pests using their natural enemies can be an environmentally sound alternative to pesticides. However, the complex interactions between different pest control species and the landscape itself can affect the efficiency of such biological pest control, research suggests.

How environmental agencies can best engage with, and reap the benefits of, Environmental Enforcement Networks (EENs) has been identified in new research. The study used questionnaires and interviews with senior figures from eight environment agencies, spanning seven countries, to identify the key themes of, and ways of improving engagement with, EENs, to extract the maximum benefits. The input was then used to perform a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis of engaging with EENs, from which options for improved engagement could be developed.

People who are annoyed by environmental noise are also more likely to suffer from depression and anxiety, a new, large-scale study from Germany suggests. The results do not prove that noise causes mental health issues but suggest a possible link, which the study’s authors are exploring further. Of all the types of noise considered in the study, aircraft noise was reported to be the most annoying.

Several barriers to upgrading existing social housing with innovative energy systems (IES) have been identified by a study of eight large-scale renovation projects in the Netherlands. These include a lack of trust between stakeholders, opposition from tenants on grounds of increased costs or delays, or poor experience with previous energy projects.