The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

Inhibition of expansion of a cereal product, such as a ready-to-eat cereal, by a particulate insoluble component such as fiber and/or calcium is avoided by pelletizing the particulate insoluble component. A binder component, such as gelatinized starch, is used to bind particles of the particulate insoluble component into a coherent mass which is formed into non-expanded pellets for fortification of the cereal product. The expanded cereal products, such as extruded puffed RTE cereals which contain the pellets, exhibit a crisp, uniform texture and cell structure, improved, prolonged bowl life, a non-gritty mouthfeel, and a smooth, uniform surface appearance even though they are fortified with high amounts of the solid or particulate insoluble nutritional components.

A tool is disclosed for separating a semiconductor die from a tape to which the die is affixed during the wafer dicing process. The tool includes a pick-up arm for positioning a vacuum tip over a semiconductor die to be removed. The vacuum tip includes a non-uniform array of vacuum holes to grip the semiconductor wafer.

A steel rule die making system produces a steel rule dies having an operative surface that form creases and cut patterns in a sheet material to form a box blank. The system includes a die manufacturing station having an indexing bench that securely holds a substrate. At least one slug driver device is disposed adjacent the die manufacturing station to drive the penetrating point of a slug into the substrate. The upper surface of the slug head defines a segment of the operative surface of the steel rule die.

A retractable stock guide has a stationary guide rail on which a retractable guide cap is operably supported. The guide rail and cap have two through holes at opposite ends through which two mounting studs extend to attach the stock guide to an associated die member. The holes in the guide cap are ovate, and the heads of the mounting studs are tapered, whereby tightening of the mounting stud shifts the guide cap relative to the guide rail from an aligned, retracted load/unload condition, to an inwardly protruding, extended run condition, wherein the stock strip is slidingly captured between two like stock guides and the mounting surface of the die. Two ball bearing guides can be substituted for the stationary guide rail.

A pressing and stripping apparatus for punch die includes a base, a pressing and striping plate, an A-type pillar, a first bolt, an elastic or pressure element, a stripping bolt, a second bolt, a die-mounting bolt, a B-type pillar, a locating pin, a cylindrical guide column, a third bolt, an outer supporting frame, and a square guide column; wherein the pressing and stripping plate is movably connected to the base via the stripping bolt, wherein the pressing and stripping plate reciprocates along the axial direction of the stripping bolt while working, and the elastic or pressure element is provided between the pressing and stripping plate and the base. The push rod used with the pressing and stripping apparatus for the punch die is a column, one end thereof is a polygonal blind hole, and the other end thereof is a stepped shaft with parallel threads. This arrangement can achieve a common pressing and stripping apparatus, making the punch die easy to be disassembled.

A method for bending a workpiece includes positioning a first bending surface adjacent to the workpiece; positioning a second bending surface adjacent to the workpiece; and moving the first bending surface and the second bending surface linearly toward the workpiece while the second bending surface rotates with respect to the first bending surface such that the first bending surface bends a first portion of the workpiece, the second bending bends a second portion of the workpiece, and the first portion of the workpiece, and the second portion of the workpiece are disposed on a first side of a bend line formed on the workpiece by the first bending surface and the second bending surface.

One aspect of the disclosure relates to a die comprising a primary plate and secondary plates. The secondary plates comprise through weld holes formed along a direction. The through weld holes of adjacent secondary plates do not overlap when viewed in the direction along which the though weld holes are formed. The primary plate is coupled to at least one secondary plate abutting the primary plate by first welds located in the through weld holes. The secondary plates abutting each other are coupled by second welds located in the through weld holes.

A device for transporting vehicle bodies, on which standardized holding components are provided. A guide device is provided for at least one continuous drive train which having a driving side and a slack side, and having a first return element and at least one second return element around which the at least one continuous drive train circulates. The at least one continuous drive train supports a plurality of coupling elements which are arranged and aligned in such a manner that they can work together with the standardized holding components provided on the vehicle body.

A heat-recovering oven system based on temperature gradient comprises: multiple chambers arranged in a sequence, the chambers configured for operating at various temperatures according to a temperature gradient arrangement that spans the sequence; a conveyor configured for transporting product through the multiple chambers in the sequence for heat treatment according to the temperature gradient arrangement; and multiple temperature-segregated heat exchanger systems, each heat exchanger system including a heat exchanger, a conduit to at least one of the chambers based on its temperature in the temperature gradient arrangement, and a return conduit from the at least one chamber to the heat exchanger.

An electronic display assembly having forced-air cooling. A thermally conductive plate or a thermally conductive backlight surface is located behind an electronic display of the electronic display assembly and within a housing thereof such that a gap is formed between the plate or backlight surface and an adjacent wall of the housing. External cooling air may be caused to flow in a top-to-bottom direction through the gap in order to remove heat from the electronic display that has been conductively transferred to the gap. A plurality of ribs may be placed within the gap and in thermal communication with the electronic display to enhance the conductive transfer of heat from the electronic display.

A package includes a device die, which includes a metal pillar at a top surface of the device die, and a solder region on a sidewall of the metal pillar. A molding material encircles the device die, wherein a top surface of the molding material is substantially level with a top surface of the device die. A dielectric layer overlaps the molding material and the device die, with a bottom surface of the dielectric layer contacting a top surface of the device die and a top surface of the molding material. A redistribution line (RDL) extends into the dielectric layer to electrically couple to the metal pillar.

A semiconductor device has a plurality of semiconductor die. A first prefabricated insulating film is disposed over the semiconductor die. A conductive layer is formed over the first prefabricated insulating film. An interconnect structure is formed over the semiconductor die and first prefabricated insulating film. The first prefabricated insulating film is laminated over the semiconductor die. The first prefabricated insulating film includes glass cloth, glass fiber, or glass fillers. The semiconductor die is embedded within the first prefabricated insulating film with the first prefabricated insulating film covering first and side surfaces of the semiconductor die. The interconnect structure is formed over a second surface of the semiconductor die opposite the first surface. A portion of the first prefabricated insulating film is removed after disposing the first prefabricated insulating film over the semiconductor die. A second prefabricated insulating film is disposed over the first prefabricated insulating film.

An example method includes providing a packaging device includes a substrate having an integrated circuit die mounting region. A plurality of microstructures, each including an outer insulating layer over a conductive material, are disposed proximate a side of the integrated circuit die mounting region. An underfill material is disposed between the substrate and the integrated circuit die, the microstructures preventing spread of the underfill. In another example method, a via can be formed in a substrate and the substrate etched to form a bump or pillar from the via. An insulating material can be formed over the bump or pillar. In another example method, a photoresist deposited over a seed layer and patterned to form openings. A conductive material is plated in the openings, forming a plurality of pillars or bumps. The photoresist and exposed seed layer are removed. The conductive material is oxidized to form an insulating material.

Provided are an apparatus and a method for rapidly producing a synthetic gas from a bio-diesel byproduct using microwave plasma, in which, while a plasma flame is generated by a plasma generator and waste glycerin, a bio-diesel byproduct, as fuel, is gasified by being supplied to the generated plasma flame of high temperature, the fuel is supplied in various types to increase the contact time or the contact area with the plasma flame and thus promote gasification thereof and the contents of steam and oxygen supplied and the plasma power are controlled to increase the collection amount of combustible gas and thus allow rapid production of the synthetic gas.

The present invention provides a shearing die having longer life and a method for manufacturing the same. The shearing die includes a pair of substrates, at least one of which has a hard film formed by an arc ion plating method and located at least on a region of a curved surface and on an adjacent region from the end part of the curved surface on the side facing to the surface of the sheet or plate material to 300 μm along the surface of the substrate. The hard film comprises Al and one or more of Ti and Cr, and has a thickness of 1 to 5 μm, such that a number of metal particles having a diameter of 20 μm or more, which are present on a line segment having a length of 10 mm on a surface of the hard film, is 2 or less.

A seal device that may be for a variable area fan nozzle (VAFN) assembly of a turbofan engine is positioned between first and second surfaces configured to move between close and distant positions. The seal device includes a first electrode engaged to the first surface and a second electrode spaced between the first and second surfaces and spaced from the first electrode. A resilient first element of the device is disposed between and engages to the first and second electrodes, and is configured to move between contracted and expanded states when the electrodes are energized. A resilient second element of the device opposes the second surface and is engaged to the second electrode. The second element is configured to move between a compressed mode when the first and second surfaces are in the close position and an extended mode when the first and second surfaces are in the distant position.

A method of processing bundles of carbon nanotubes (CNTs). Bundles of CNTs are put into a solution and unbundled using sonication and one or more surfactants that break apart and disperse at least some of the bundles into the solution such that it contains individual semiconducting CNTs, individual metallic CNTs, and remaining CNT bundles. The individual CNTs are separated from each other using agarose bead column separation using sodium dodecyl sulfate as a surfactant. Remaining CNT bundles are then separated out by performing density-gradient ultracentrifugation.

A method for obtaining diesel fuel from vegetable or animal oils through the addition of hydrogen in the presence of catalysts under suitable temperature and pressure conditions is described. The method is different from other similar methods in that it involves the use of space velocities of between 5.1 h-1 and 9 h-1, thereby enabling a reduction in the size of the reactor and in hydrogen consumption, as well as lowering construction and operating costs. The invention also relates to the products obtained using said method, which have demonstrated that in additions, even below 10%, they improve the performance of diesel engines, thereby lowering fuel consumption.

A multi-stage reactor system for preparing biodiesel is used to increase efficiency and yield and reduce impurities. A three-stage transesterification reaction for preparing biodiesel can include one high-shear cavitation reactor and two low-shear cavitation reactors, preferably in series, and optionally one or more separation vessels for removing waste and recycling triglyceride feedstock, catalyst and alcohol to the high-shear cavitation reactor.

The present invention relates to the use of 1,1-diethoxyethane for increasing the knocking resistance of low-boiling gasoline with an initial boiling point (IBP) of 80° C. to 120° C. by at least 40 units (Research Octane Number).

The present invention relates to the use of at least 120 ppm of a nitrogen-containing detergent as a diesel fuel additive to improve the performance of a diesel engine having a high pressure fuel system.

The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

An exhaust apparatus for a diesel engine rapidly burns an unburned deposit in an upstream exhaust catalyst with heat of a heater. The exhaust apparatus includes a downstream exhaust cleaner, an upstream exhaust catalyst provided in an exhaust passage, upstream of the downstream exhaust cleaner, a heater disposed at an exhaust inlet of the upstream exhaust catalyst, and an engine starter apparatus. A control unit controls the power supply to the heater and an engine start process is performed by the engine starter apparatus. A start command unit is connected to the control unit. When the engine has been stopped and then the start command unit gives the control unit a start command, the control unit powers the heater without performing an engine start process, thereby keeping the engine stopped for a predetermined period of time after the start command has been given, and subsequently performing the engine start process.

The present invention relates to an optical clear resin and a method for producing a liquid optical clear photo-curable adhesive.

Brian Batchelor, once described by the Daily Echo as ‘the most versatile singer in the South’, has died at the age of 87.

News you don't want to miss for April 15:

1. The number of covid-19 deaths in Alameda County increased from 23 to 36 over a two-day period, SFGate reports.…

A SCHOOLBOY who was apart from his soldier dad for four months was stunned when he turned up out of the blue to pick him up from class - just in time for Christmas.

HE’S the former England cricket captain best known for his ability as an all-rounder.

A FORMER Aston Villa striker has died after he was Tasered by police.

Bournemouth manager Eddie Howe is fully committed to the club amid speculation of a move to Arsenal.

BOURNEMOUTH manager Eddie Howe has been given the full backing of chairman Jeff Mostyn.

A SOUTHAMPTON football team has scored big after being newly kitted out.

A LADIES’ night of food and fashion raised £700 for a cancer charity.

TRIBUTES have been paid to a "much loved" mum of three who died after being hit by a car.

Unexpected treat in store for girls in Race For Life

by Mike Vimpany

IT was a personal journey for each and every one of them.

AS the war in Europe continued apace, the daily reports of the Allies’ progress on the battlefronts were being forced to share the column inches of the newspaper with the reports and portraits of lost sons, whose lives had been claimed by the fighting, and were appearing with painful regularity.

TRIBUTES have been paid to a “passionate and loving” Southampton mum of five children who has died of cancer aged 33.

Described as a funny story of love and redemption, BRIGHT STAR , the Steve Martin, yes that Steve Martin, and Edie Brickell musical is being presented by Tryon Little Theatre. The same musical that's been on Broadway and presented by theatre groups across the nation, now takes the stage in Western N.C. - near the actual location where the story is depicted. TLT lead actors in the show, Hannah Searcy (Alice) and Ryan Holub (Jimmy Rae) were interviewed. Aired originally on Feb. 28, 2020. Showtimes for BRIGHT STAR are as follows: Showtimes Thu Mar 5, 2020 | 7:30PM Fri Mar 6, 2020 | 7:30PM Sat Mar 7, 2020 | 2:30PM Sat Mar 7, 2020 | 7:30PM Sun Mar 8, 2020 | 3:00PM Posted by Host and Producer of The Friday Feature Interview of the Week- Paul Foster, WNCW Senior Producer, News Director, and Morning Edition Regional Host

One thing WNCW knows about is bluegrass, old time and true country music. It's a part of our electic music format which made this Friday Feature Interview of the Week even more special - when we learned all about the East Tennessee State University Bluegrass, Old Time, and Country Music Studies Program. Interviewed on March 20, 2020 was Program Director Daniel Boner. ETSU is passing on a legacy of music history that will help keep it going strong for the future. Posted by Host and Producer of The Friday Feature- Paul Foster, WNCW Senior Producer, News Director, and Morning Edition Regional Host

The Legacy Theatre in Branford, Connecticut, isn’t technically open yet. But Artistic Director Keely Baisden Knudsen says they’ve done more than 70 performances without a building.

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him