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[ASAP] From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules

Organic Process Research & Development
DOI: 10.1021/acs.oprd.9b00490




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[ASAP] Green Chemistry Articles of Interest to the Pharmaceutical Industry

Organic Process Research & Development
DOI: 10.1021/acs.oprd.0c00154




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[ASAP] Optimized Synthesis of 7-Azaindazole by a Diels–Alder Cascade and Associated Process Safety

Organic Process Research & Development
DOI: 10.1021/acs.oprd.0c00184




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[ASAP] Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)

Organic Process Research & Development
DOI: 10.1021/acs.oprd.9b00511




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Fine-tuning of the substrate binding mode to enhance the catalytic efficiency of an ortho-haloacetophenone-specific carbonyl reductase

Catal. Sci. Technol., 2020, 10,2462-2472
DOI: 10.1039/C9CY02335F, Paper
Aipeng Li, Xue Li, Wei Pang, Qing Tian, Ting Wang, Lianbing Zhang
Fine-tuning of the substrate binding mode was successfully applied for enhancing the catalytic efficiency of an ortho-haloacetophenone-specific carbonyl reductase.
The content of this RSS Feed (c) The Royal Society of Chemistry




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New findings and current controversies in the reaction of ruthenium red and ammonium cerium(IV) nitrate: focus on the precipitated compound

Catal. Sci. Technol., 2020, 10,2491-2502
DOI: 10.1039/C9CY02499A, Paper
Bahram Sarvi, Seyedeh Maedeh Hosseini, Bahareh Deljoo, Abdelhamid El-Sawy, Alireza Shirazi Amin, Mark Aindow, Steven L. Suib, Mohammad Mahdi Najafpour
During water-oxidation reaction in the presence of RuR and CAN, a heterogeneous nano-sized Ru-Ce compound is detected, which is formed by the interaction of [(NH3)5RuORu(NH3)4ORu(NH3)5],6+/7+ nitrate ions, and the products of the reduction of CAN.
The content of this RSS Feed (c) The Royal Society of Chemistry




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From Byju's to Swiggy: Next wave of tech unicorn listings could be in India

Mohandas Pai expects food delivery platforms Swiggy and Zomato, as well as PhonePe and Myntra to list in local markets in next few years




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Woman world / Aminder Dhaliwal ; color by Nikolas Ilic

Barker Library - PN6733.D35 W66 2018




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Stabilization of indocyanine green dye in polymeric micelles for NIR-II fluorescence imaging and cancer treatment

Biomater. Sci., 2020, 8,2245-2254
DOI: 10.1039/C9BM02010A, Paper
Gil Yeroslavsky, Masakazu Umezawa, Kyohei Okubo, Karina Nigoghossian, Doan Thi Kim Dung, Keiji Miyata, Masao Kamimura, Kohei Soga
Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fixed-point “blasting” triggered by second near-infrared window light for augmented interventional photothermal therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper
Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00466A, Paper
Peng Zhang, Yu Zhang, Xiaoya Ding, Chunsheng Xiao, Xuesi Chen
An efficient strategy to selectively promote nanoparticle accumulation in solid tumors was developed by encapsulating sildenafil in cisplatin-incorporated polymeric micelles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00147C, Paper
Open Access
Junxiong Qiu, Peng Peng, Min Xin, Zhenkang Wen, Zhong Chen, Sipeng Lin, Manyuan Kuang, Yuan Fu, Guibin Fang, Shixun Li, Changchuan Li, Jiaji Mao, Ling Qin, Yue Ding
Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Topography induced stiffness alteration of stem cells influences osteogenic differentiation

Biomater. Sci., 2020, 8,2638-2652
DOI: 10.1039/D0BM00264J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Liangliang Yang, Qi Gao, Lu Ge, Qihui Zhou, Eliza M. Warszawik, Reinier Bron, King Wai Chiu Lai, Patrick van Rijn
Topography-driven alterations to single cell stiffness rather than alterations in cell morphology, is the underlying driver for influencing cell biological processes, particularly stem cell differentiation.
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Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications

Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper
Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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A biomimetic orally targeted delivery of Bindarit for immunotherapy of atherosclerosis

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00418A, Paper
Luqi Yin, Cuiping Peng, Yue Tang, Yuchuan Yuan, Jiaxing Liu, Tingting Xiang, Feila Liu, Zhou Xing, Xiaohui Li
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage

Toxicol. Res., 2019, 8,833-841
DOI: 10.1039/C9TX00080A, Paper
Qiaoyun Liu, Longsheng Wang, Hanwen Chen, Bo Huang, Jiawei Xu, Ying Li, Paul Héroux, Xinqiang Zhu, Yihua Wu, Dajing Xia
Prometryn induces oxidative stress-mediated DNA damage; Prometryn induces S phase of cell cycle arrest; Prometryn induces Bax-dependent apoptosis in BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway

Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells

Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mice with a Sertoli cell-specific knockout of the Ctr1 gene exhibit a reduced sensitivity to cisplatin-induced testicular germ cell apoptosis

Toxicol. Res., 2019, 8,972-978
DOI: 10.1039/C9TX00142E, Paper
Open Access
Rashin Ghaffari, John H. Richburg
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats

Toxicol. Res., 2019, 8,815-832
DOI: 10.1039/C9TX00157C, Paper
Jawaid Ahmed Zai, Muhammad Rashid Khan, Zaib un Nisa Mughal, Riffat Batool, Irum Naz, Sonia Maryam, Zartash Zahra
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway

Toxicol. Res., 2019, 8,1028-1034
DOI: 10.1039/C9TX00220K, Paper
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells

Toxicol. Res., 2019, 8,1050-1056
DOI: 10.1039/C9TX00235A, Paper
Zahra Karimi, Maryam Ghaffari, Jafar Ezzati Nazhad Dolatabadi, Parvin Dehghan
2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry.
The content of this RSS Feed (c) The Royal Society of Chemistry




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AIIB extends $500 mn loan to India to deal with coronavirus crisis

The bank's board of directors has approved a loan to India to strengthen the preparedness of the country's national health system




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India's credit profile to face further pressure due to Covid-19: Moody's

Moody's rating on the government of India is Baa2 with negative outlook




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Nomura predicts Indian GDP to contract by 5.2% in FY21, more rate cuts

Analysts at Goldman Sachs expect the Indian economy to contract 0.4 per cent in FY21 versus consensus median 2.7 per cent




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Only 13% of industrial units resume ops after Odisha eases lockdown

Micro units in the state have not been able to resume operations to catch up with their larger peers




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Amarinder Singh asks administration to ensure welfare of migrant workers

The chief minister asked the industry ministry to "aggressively" pursue the development of the four industrial parks already announced by the state government in the budget for this fiscal.




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Working closely with states on labour reforms to help industry: Centre

The Confederation of Indian Industry (CII) suggested to the Labour Ministry to "direct workers to join back to their workplace" by issuing a circular




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Covid-19 lockdown effect: Every second Indian now on internet in cities

The data released by Nielsen and the Broadcast Audience Research Council (BARC) shows that internet usage has grown sharply in cities over the last one month, touching 54 per cent




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Wrinkle-induced highly conductive channels in graphene on SiO2/Si substrate

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR01406K, Paper
Ruisong Ma, Jiajun Ma, Jiahao Yan, Liangmei Wu, Wei Guo, Shuai Wang, Qing Huan, Lihong Bao, Sokrates T Pantelides, Hong-Jun Gao
Graphene wrinkle is a quasi-one-dimensional structure and can alter the intrinsic physical and chemical activity, modify the band structure and introduce transport anisotropy in graphene thin films. However, their quasi-one-dimensional...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pristine Graphene Induces Innate Immune Training

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/C9NR09661B, Paper
Filipa Lebre, John B Boland, Pedro Gouveia, Aoife Gorman, Mimmi Lundahl, Fergal J O'Brien, Jonathan N Coleman, Ed Lavelle
Graphene-based materials are of increasing interest for their potential use in biomedical applications. However, there is a need to gain a deeper understanding of how graphene modulates biological responses before...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Realization of high-quality optical nanoporous gradient-index filters by optimal combination of anodization conditions

Nanoscale, 2020, 12,9404-9415
DOI: 10.1039/C9NR10526C, Paper
Cheryl Suwen Law, Siew Yee Lim, Lina Liu, Andrew D. Abell, Lluis F. Marsal, Abel Santos
High-quality nanoporous anodic alumina gradient-index filters are realized by sinusoidal pulse anodization under optimized anodization conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enhanced type I photoreaction of indocyanine green via electrostatic-force-driven aggregation

Nanoscale, 2020, 12,9517-9523
DOI: 10.1039/D0NR01208D, Paper
Huizhen Fan, Yu Fan, Wenna Du, Rui Cai, Xinshuang Gao, Xinfeng Liu, Hao Wang, Lei Wang, Xiaochun Wu
ICG forms aggregates in positively charged mesoporous silica, which show an enhanced type I photoreaction pathway.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Binding patterns and dynamics of double-stranded DNA on the phosphorene surface

Nanoscale, 2020, 12,9430-9439
DOI: 10.1039/D0NR01403F, Paper
Baoyu Li, Xuejie Xie, Guangxin Duan, Serena H. Chen, Xuan-Yu Meng, Ruhong Zhou
Molecular dynamics simulations and electrophoresis experiments show that dsDNA can form a stable binding on the phosphorene surface through the terminal base pairs and adopt an upright orientation regardless of its initial configurations.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Point defect induced intervalley scattering for the enhancement of interlayer electron transport in bilayer MoS2 homojunctions

Nanoscale, 2020, 12,9859-9865
DOI: 10.1039/D0NR01339K, Paper
Yang Ou, Zhuo Kang, Qingliang Liao, Shihan Gao, Zheng Zhang, Yue Zhang
The interlayer transport of MoS2 homojunctions can be enhanced by point defect induced K–Q intervalley scattering.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Clear observation of the formation of nanoparticles inside the ablation bubble through a laser-induced flat transparent window by laser scattering

Nanoscale, 2020, 12,9640-9646
DOI: 10.1039/C9NR10560C, Paper
Kota Ando, Takashi Nakajima
We demonstrate the clear observation of laser-scattering signals from Ag nanoparticles (NPs) inside an ablation bubble.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The Music Industry: Music in the Cloud


 
Since the first edition was published in 2009, Patrik Wikström's The Music Industry has become a go-to text for students and scholars. This thoroughly updated third edition provides an international overview of the music industry and its future prospects in the world of global entertainment.

The music industry has experienced two turbulent decades of immense change brought about in part by the digital revolution. How has the industry been transformed

Read More...




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How to find a postdoc position that’s right for you

Our Letters to Young Scientists columnists share insights into the postdoc application process




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Charles S. Miley Learning Resources Center - Indian River Community College




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Timicuan Indians, of Pre-Columbus days, left clan symbols




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Hindu temple with Christian cross is meditation spot




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Indians frolicked at Florida playground area




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DeSoto and the Indians bargained under oak tree in Tampa




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Monument salutes volunteers in Indian War




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Indian chief's head dress was a lighthouse reflector




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Ancient Indian litterbugs left mound