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Dietary Fats and Atherosclerosis From Childhood to Adulthood

BACKGROUND:

The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media thickness (IMT) and distensibility from childhood to young adulthood.

METHODS:

In the prospective randomized controlled Special Turku Coronary Risk Factor Intervention Project trial, personalized dietary counseling was given biannually to healthy children from infancy to young adulthood. The counseling was based on Nordic Nutrition Recommendations, with the main aim of improving the distribution of dietary fat in children’s diets. IMT and distensibility of the abdominal aorta and common carotid artery were measured repeatedly at ages 11 (n = 439), 13 (n = 499), 15 (n = 506), 17 (n = 477), and 19 years (n = 429). The targeted distribution of dietary fat was defined as a ratio of saturated fatty acids to monounsaturated and polyunsaturated fatty acids of <1:2 and as an intake of saturated fatty acids of <10% of energy intake. Participants who met ≥1 of these 2 criteria were defined to achieve the main intervention target.

RESULTS:

Individuals who achieved the main intervention target had lower aortic IMT (age- and sex-adjusted mean difference 10.4 µm; 95% confidence interval: 0.3 to 20.5 µm) and better aortic distensibility (0.13% per 10 mm Hg; 95% confidence interval: 0.00% to 0.26% per10 mm Hg) compared with their peers who did not meet the target.

CONCLUSIONS:

Achieving the main target of an infancy-onset dietary intervention, reflecting dietary guidelines, was favorably associated with aortic IMT and distensibility during the early life course. These data support the recommendation of favoring unsaturated fat to enhance arterial health.




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Validation of a Prediction Rule for Mortality in Congenital Diaphragmatic Hernia

BACKGROUND:

Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with a mortality of ~27%. The Congenital Diaphragmatic Hernia Study Group (CDHSG) developed a simple postnatal clinical prediction rule to predict mortality in newborns with CDH. Our aim for this study is to externally validate the CDHSG rule in the European population and to improve its prediction of mortality by adding prenatal variables.

METHODS:

We performed a European multicenter retrospective cohort study and included all newborns diagnosed with unilateral CDH who were born between 2008 and 2015. Newborns born from November 2011 onward were included for the external validation of the rule (n = 343). To improve the prediction rule, we included all patients born between 2008 and 2015 (n = 620) with prenatally diagnosed CDH and collected pre- and postnatal variables. We build a logistic regression model and performed bootstrap resampling and computed calibration plots.

RESULTS:

With our validation data set, the CDHSG rule had an area under the curve of 79.0%, revealing a fair predictive performance. For the new prediction rule, prenatal herniation of the liver was added, and absent 5-minute Apgar score was taken out. The new prediction rule revealed good calibration, and with an area under the curve of 84.6%, it had good discriminative abilities.

CONCLUSIONS:

In this study, we externally validated the CDHSG rule for the European population, which revealed fair predictive performance. The modified rule, with prenatal liver herniation as an additional variable, appears to further improve the model’s ability to predict mortality in a population of patients with prenatally diagnosed CDH.




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Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood

BACKGROUND:

Elevated non–high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non–HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non–HDL-C status predicts high common carotid artery intima-media thickness in adulthood.

METHODS:

We analyzed data from 4 prospective cohorts among 4582 children aged 3 to 19 years who were remeasured as adults (mean follow-up of 26 years). Non–HDL-C status in youth and adulthood was classified according to cut points of the National Heart, Lung, and Blood Institute and the National Cholesterol Education Program Adult Treatment Panel III. High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness.

RESULTS:

In a log-binomial regression analysis adjusted with age at baseline, sex, cohort, length of follow-up, baseline BMI, and systolic blood pressure, children with dyslipidemic non–HDL-C were at increased risk of high cIMT in adulthood (relative risk [RR], 1.29; 95% confidence interval [CI], 1.07–1.55). Compared with the persistent normal group, the persistent dyslipidemia group (RR, 1.80; 95% CI, 1.37–2.37) and incident dyslipidemia (normal to dyslipidemia) groups (RR, 1.45; 95% CI, 1.07–1.96) had increased risk of high cIMT in adulthood, but the risk was attenuated for the resolution (dyslipidemia to normal) group (RR, 1.17; 95% CI, 0.97–1.41).

CONCLUSIONS:

Dyslipidemic non–HDL-C levels predict youth at risk for developing high cIMT in adulthood. Those who resolve their non–HDL-C dyslipidemia by adulthood have normalized risk of developing high cIMT in adulthood.




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Trends in Pediatric Malpractice Claims 1987-2015: Results From the Periodic Survey of Fellows

BACKGROUND:

Pediatricians are less frequently sued than other physicians. When suits are successful, however, the average payout is higher. Little is known about changes in the risk of litigation over time. We sought to characterize malpractice lawsuit trends for pediatricians over time.

METHODS:

The Periodic Survey is a national random sample survey of American Academy of Pediatrics members. Seven surveys between 1987 and 2015 asked questions regarding malpractice (n = 5731). Bivariate and multivariable analyses examined trends and factors associated with risk and outcome of malpractice claims and lawsuits. Descriptive analyses examined potential change in indemnity amount over time.

RESULTS:

In 2015, 21% of pediatricians reported ever having been the subject of any claim or lawsuit, down from a peak of 33% in 1990. Report of successful outcomes in the most-recent suit trended upward between 1987 and 2015, greatest in 2015 at 58%. Median indemnity was unchanged, averaging $128 000 in 2018 dollars. In multivariate analysis, male sex, hospital-based subspecialty (neonatology, pediatric critical care, pediatric emergency medicine, and hospital medicine), longer career, and more work hours were associated with a greater risk of malpractice claim.

CONCLUSIONS:

From 1987 to 2015, the proportion of pediatricians sued has decreased and median indemnity has remained unchanged. Male pediatricians and hospital-based subspecialists were more likely to have been sued. Greater knowledge of the epidemiology of malpractice claims against pediatricians is valuable because it can impact practice arrangements, advise risk-management decisions, influence quality and safety projects, and provide data to guide advocacy for appropriate tort reform and future research.




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Champions League Fantasy popular picks and potential differentials

Ahead of Matchday 7, UEFA.com looks at some obvious selections and some lesser-owned options.




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Could Artificial Intelligence Automate Student Note-Taking?

An AI-powered digital assistant to take notes for you? It’s already happening in the workplace, but classroom note taking could prove harder to automate.




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PSU-LV faculty and staff support students during pandemic

Both in and out of the virtual classroom, Penn State Lehigh Valley departments are connecting with students during remote learning




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Practical Nursing Program moves clinicals to virtual simulations

Lehigh Valley's Practical Nursing Program has moved to the Shadow Health Digital Clinical Experience so students can continue clinical rotations through virtual simulations.




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Faculty member earns doctorate, selected as Fulbright specialist

Beth E. Michalec, lecturer of corporate communication at Penn State Lehigh Valley, earned a doctorate in rhetoric from Duquesne University. Michalec was selected as a Fulbright specialist in June 2019 by the U.S. Department of State.




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PSU-LV faculty member accepted into Fulbright Specialist Program

Although complications caused by the coronavirus pandemic have temporarily halted the Fulbright Specialist Program, Nichola D. Gutgold looks forward to officially joining the Roster after the U.S. Department of State determines that projects can resume.




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Lung Ultrasound in Children With COVID-19

Marco Denina
Apr 21, 2020; 0:peds.2020-1157v1-e20201157
Research Brief




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#WU17EURO finals: all the results

Spain won their fourth title by beating Germany in the final while Finland pipped England to the FIFA U-17 Women's World Cup.




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Bulgaria 2019: results, highlights

The story of how Germany won their seventh title, beating debut finalists the Netherlands..




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Fin24.com | Here's what SA financial experts would do with R10 000 in 2020

Fin24 asked financial experts how they would grow R10 000 in the new year. Here's what they said.




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Student Engagement Network announces newest members of Faculty Academy

The Student Engagement Network's Faculty Academy funds projects developed by Penn State faculty that result in transformative experiences that complement student engagement.




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Futsal EURO qualifying main round: full guide

Seven of the 12 places at UEFA Futsal EURO 2018 in Slovenia will be decided when the main round is played between Saturday and Tuesday, with Spain beginning their title defence.




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Futsal rules: a quick guide

The laws of futsal are similar to those of football but with some important differences: let us talk you through the rolling substitutions, accumulated fouls, double penalties and four-second count.




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UEFA Futsal EURO 2018 results, highlights

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How School Boards Should Respond to Coronavirus

It's vital that school boards make it clear that leaving students without access to meaningful instruction for 4-6 months is unacceptable, says national school board guru AJ Crabill.




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Google Pulls Open-Source Android App for Having Donation Button

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Deals: SanDisk Ultra MicroSDXC, Seagate Backup Plus Hub

Today you can save up to 30 percent on select laptops, networking devices, and storage drives at Amazon. Also, the highly anticipated game Cyberpunk 2077 is $10 off when you pre-order it.




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Microsoft Enhances OneDrive With a Personal Vault

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Snag a 50-Inch Sceptre 4K Ultra HD TV for Just $200

Normally $399.99, the Sceptre U515CV-U is available at Walmart right now for just $199.99. Don't miss this chance to snag it for half off.




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What Is 8K? Should You Buy a New TV or Wait?

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Rangers "incredulous" over "unfounded" SPFL claim that chairman Douglas Park threatened Neil Doncaster

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In full: Partick Thistle criticise SPFL in scathing letter and hit out at 'agenda' accusations

Partick Thistle have released, in full, a letter sent by the club to SPFL chiefs following the news that league reconstruction has been scrapped - confirming the Jags' relegation.




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Berks faculty member coordinates mask donation from Reading Chinese Association

Hongyan “Red” Yuan, an instructional designer at Penn State Berks and member of the board of the Reading Chinese Association (RCA), recently helped to coordinate the donation of 1,500 surgical masks to Penn State Health St. Joseph.




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Senior and Faculty, Staff Diversity Recognition Awards announced

The Multicultural Resource Center at Penn State has announced this year’s Senior and Faculty/Staff Diversity Recognition Awards recipients. The 2020 awards honor multicultural University Park graduating seniors who excel in academics, leadership, and service, as well as faculty and staff throughout Penn State who demonstrate a commitment to diversity, equity and inclusion efforts beyond the responsibilities of their position.




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The Efficacy of Bacillus Calmette-Guerin Vaccination of Newborns and Infants in the Prevention of Tuberculosis: Meta-Analyses of the Published Literature

Graham A. Colditz
Jul 1, 1995; 96:29-35
ARTICLES




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A SIMPLE PHENYLALANINE METHOD FOR DETECTING PHENYLKETONURIA IN LARGE POPULATIONS OF NEWBORN INFANTS

Robert Guthrie
Sep 1, 1963; 32:338-343
ARTICLES




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Validation of the National Institutes of Health Consensus Definition of Bronchopulmonary Dysplasia

Richard A. Ehrenkranz
Dec 1, 2005; 116:1353-1360
ARTICLES




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Abnormal Pulmonary Outcomes in Premature Infants: Prediction From Oxygen Requirement in the Neonatal Period

Andrew T. Shennan
Oct 1, 1988; 82:527-532
ARTICLES




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A Simple Estimate of Glomerular Filtration Rate in Children Derived From Body Length and Plasma Creatinine

G. J. Schwartz
Aug 1, 1976; 58:259-263
ARTICLES




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The Relation of Overweight to Cardiovascular Risk Factors Among Children and Adolescents: The Bogalusa Heart Study

David S. Freedman
Jun 1, 1999; 103:1175-1182
ARTICLES




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All the Under-19 EURO results

Recap all the results from Finland following Portugal's dramatic final win against Italy.




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Blood Pressure Responses to Psychosocial Stress in Young Adults With Very Low Birth Weight: Helsinki Study of Very Low Birth Weight Adults

Young adults born prematurely with very low birth weight (≤1500 g) have higher blood pressure than do their counterparts born at term. We tested whether they also have higher blood pressure reactivity to psychosocial stress, which may be a more-specific predictor of long-term cardiovascular morbidity. Systolic and diastolic blood pressure levels for 44 very low birth weight adults (mean age: 23.1 years; SD: 2.3 years) and 37 control subjects (mean age: 23.6 years; SD: 2.0 years) were measured through noninvasive finger photoplethysmography during a standardized psychosocial stress challenge (Trier Social Stress Test). Baseline and task values and their difference (ie, reactivity) served as outcome variables. In comparison with the control group, the very low birth weight group had 7.9 mm Hg higher diastolic blood pressure during the task and 4.8 mm Hg higher diastolic reactivity, with adjustment for gender and age, height, and BMI at testing. A similar trend was seen for systolic blood pressure during the baseline period and the task, but the group differences were not statistically significant. Our results indicate that very low birth weight is associated with elevated blood pressure reactivity to psychosocial stress and, therefore, may increase the risk of cardiovascular morbidity.




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Penn State Harrisburg honors retiring faculty, staff

Penn State Harrisburg this spring honored three retiring faculty and staff members.




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Penn State Harrisburg announces faculty and staff awards

Penn State Harrisburg this spring recognized outstanding employee contributions with the 2020 faculty and staff awards. Nominated by the college community, and selected by various award committees, several faculty and staff members received awards.




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Faculty support each other through remote learning challenges and triumphs

Penn State Harrisburg faculty share their experiences – the challenges, triumphs and innovations – as they are adapting lesson plans and teaching processes during this time of social distancing.




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Three Things New Higher Education Bills Would Mean for Teachers and Students

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Truly Paying for Performance

Catherine Awsumb Nelson and Richard Wertheimer offer Pittsburgh’s City High as a case study of basing pay decisions on the quality of classroom teaching, rather than standardized-test scores.




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Creating Successful Blended-Learning Classrooms

History teacher Bill Tolley offers tips on adapting to learning environments that combine face-to-face instruction with self-directed online experiences.




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Instructions released for Alternative Grade Calculator and Request Tool

Instructions for using the new Alternative Grade Calculator and Request Tool in LionPATH are now available for undergraduates and students enrolled in the Graduate School.




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Senate updates faculty hiring policy to support diversity, equity and inclusion

At its final meeting of the 2019-20 academic year, the Penn State Faculty Senate passed landmark legislation updating its full-time faculty hiring policy for the first time in more than 20 years, as one step in continued efforts to advance the University’s commitment to diversity, equity and inclusion.




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2020 Board of Trustees election results announced

Six trustees were elected or appointed to serve on the Penn State Board of Trustees today (May 8).




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Colombian kidnapping victim says God is faithful

Bogotá, Colombia, Apr 3, 2020 / 04:04 am (CNA).- Diana María Toro Vélez was kidnapped on a September day, as she drove home from Mass in the Colombian city where she lived. She spent 453 days in captivity. And she says that God’s grace kept her hope alive during the ordeal.

“I left Mass one Thursday and was driving home in my car and when I got home they assaulted me. They asked me a few questions and took me away. They sold me to the guerrillas,” Toro told ACI Prensa, CNA’s Spanish language news partner.

Toro, the mother of three, told ACI Prensa that during her captivity, she was sometimes forced to march a lot, one time for up to 15 days in a row.

“I clung to God. I cried and prayed a lot. I really held fast to God. I taught the kidnappers how to read and write. We prayed. There was a certain coexistence, and good things came out of the bad,” she said.

Toro, 41, was kidnapped Sept. 27, 2018, in Amagá, about an hour’s drive from Medellin. Her captors were criminals, members of a gang called “The Sorcerers,” who handed her over to Marxist guerrillas from the the National Liberation Army (ELN) for 48M pesos, about $12,000. The ELN reportedly asked 3 billion pesos, about $745,000 for her return.

Toro was released from captivity on Christmas Eve, 2019.

The Catholic Church in Colombia had appealed for her release, and the release appeared to be a goodwill gesture toward achieving some kind of peace agreement between the ELN and the country’s government. Public officials credited the Church with arranging the release.

Speaking to ACI Prensa, the young mom said that she was “very devoted to Our Lady of Guadalupe. When I was kidnapped I made a rosary and prayed it every day, praying a lot to the Virgin that she would allow me to be returned to my children. And God heard me, because I was released on Dec. 24, 2019.”

It was difficult, Toro said, to be “separated from my three children, one of them 3, another 4 and one 14 years old. Separated from my husband, my parents, my siblings, my family members, relatives and friends.”

“These were 453 days of anxiety, grief, sadness and despair. 453 days of living in the middle of the jungle, sleeping under a canopy, on branches, with snakes, scorpions, mosquitos and many other animals around,” she said.

Toro told ACI Prensa she subsisted on parrot, pasta, cooked banana, and rice. She had only two sets of clothes and infrequently bathed. 

“These were really hard days without knowing anything about my family, just with the certainty that God was with me, filling me daily with his strength and fortitude and firmly believing that if I woke up okay, my family was okay too,” she said.

“And God brought me out of that really hard situation. I saw that his glory and his mercy are immense.”

Toro said the ordeal has filled her with gratitude.

“I want to tell those people who in these times feel alone or in despair because of the situation we’re going through in Colombia and the entire world, that God is with us, he never has left us alone, especially now.”

“Let’s pray the rosary, let’s pray as a family. The power of prayer is immense,” she added.

 

This story was first published by ACI Prensa, CNA's Spanish-language news partner. It has been translated and adapted by CNA.

 




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Firefox 72 to Block 'Fingerprinters' by Default

Fingerprinters collect information about the device you're accessing the internet on and attempt to build up a profile of the device.




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LG Pulls Out From Mobile World Congress Over Coronavirus Fears

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Samsung Galaxy S20 Ultra

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PHP Covid Relief Checks Calculator

Package:
Summary:
Calculate the amount of a check as Covid-19 relief
Groups:
Author:
Description:
This class can be used to calculate the amount of a check as Covid-19 relief...

Read more at https://www.phpclasses.org/package/11613-PHP-Calculate-the-amount-of-a-check-as-Covid-19-relief.html#2020-04-15-13:57:30