The Chargers are scoring 2.4 points per drive, the sixth-most this season, and are only forced to go three-and-out once out of every four drives.

Baltimore has a good chance at nine wins with 10 and possibly 11 wins within reach.

Even with the Dolphins, Broncos, Bengals and Titans within striking distance, if you are hoping for a dramatic playoff push in the AFC to end the season, bad news: there won’t be any.

Here’s what we know for sure about the NFC playoff picture: the Saints, Rams and Bears can make postseason plans. The rest is up for grabs.

The Baltimore defense has produced a very effective pass rush lately.

This week’s opponent, the Arizona Cardinals, gives Aaron Rodgers and the Packers a great chance to break their losing skid.

Monday night's game figures to have a big impact on the NFC playoff race.

There are a number of players with favorable matchups this week, but none as palatable as Cowboys WR Amari Cooper.

Thursday night matchups are historically difficult on road teams like Jacksonville. Since 2016, the road team is 17-33 in these games, and that includes a 3-12 record in 2018.

The fantasy football regular season has come to an end but that doesn’t make the waiver wire any less important, especially if you have been streaming quarterbacks and defenses to make it this far.

The two teams in control of the NFC's wild-card slots battle head-to-head, while the rest of the NFL playoff picture got much clearer despite four of the AFC’s top teams losing.

Atlanta is on a five-game losing streak but their offense is scoring 2.3 points per drive in 2018, the fifth-highest rate in the NFL. That should be more than enough against Arizona's awful offense.

Alabama and Clemson appear to be on a collision course ending at the College Football Playoff championship game on Jan. 7 at Levi’s Stadium.

The Redskins need two more victories to close out the season, including one against the Eagles in the regular-season finale, just to get their playoff chances to 80 percent.

It hasn't been a great year for road favorites. Those who enjoyed a three-point advantage or more on the road have gone 21-30-2 against the spread.

You know about Beto O'Rourke on the guitar, of course, but what about Bernie Sanders's spoken-word album?

The acclaimed actress and her husband, Julius Tennon, will also serve as executive producers.

They have big dreams, but the plans aren’t backed up.

oscon: RT @build_cloud: Play poker w/ Apache #CloudStack's community members above Portland's city lights at #OSCON! Register now...

Hear about travel to Poland as the Amateur Traveler talks again to Chris Bogdon about his recent trip to Poland. Chris brought his kids and his parents to experience the country where his family came from. Chris did an overview of the country on a bus tour.

Hear about travel to California's premier wine region of Napa and Sonoma as the Amateur Traveler talks again to free lance journalist Jill Robinson about this area with more than just wine... but a lot of that

Hear about the United States UNESCO World Heritage Sites as the Amateur Traveler talks to Gary Arndt from Everything-Everywhere.com and The Global Travel Conspiracy podcast about these best of the best sites.

Hear about travel to Tokyo as the Amateur Traveler talks to family travel blogger / podcaster Jason Andrew Jenkins from AnEpicEducation.com about a city he called home for 13 years.

Hear about travel to Mantua, Verona, Padua Italy as the Amateur Traveler talks to Gina Mussio from ginamussio.com about these wonderful cities in her adopted country.

TL;DR: You don't have to buy a drum set to learn how to play the drums. Instead, just grab the Senstroke by Redison bluetooth drum kit for $189.95, on sale for 5% off as of May 9.

If you want to learn how to play the drums, then a quality set may cost you upwards of $1,000. Not only is this a hefty price to play for individuals who aren't fully committed to the instrument yet, but their massive size may be impossible to fit inside your space. Or at least your housemates may not appreciate it.

With the Senstroke by Redison Bluetooth Drum Kit and App Bundle, you can practice, play, and record on just about any surface for a much more affordable price — and it'll take up little to no space.  Read more...

With all the stress in the world — you know, a deadly, terrifying global pandemic — Spotify dropped a new service: a daily, personalized aimed at wellness. Fittingly, it's called Daily Wellness and I gave it a try. 

OK, first, let me drop my biases: I can be a cynical person and I'm pretty high energy — like hyper hyper — which has made meditation difficult for me. I can get both mentally and physically uncomfortable while trying anything resembling meditation or therapy or sincere reflection.

That being said, amid the pandemic — and battling some, let's say, serious anxiety — I've been taking active steps to try to improve my mental health. Therapy, meditation, exercise, whatever else, it all seemed like a good idea to help me get through the day. Read more...

A family in lockdown performs the Beatles' "Come Together." Read the rest

Philadelphia Phillies star Bryce Harper believes Major League Baseball should relax its "dumb" rule preventing top players from competing in the Olympics.

NZ Rugby CEO Mark Robinson says there is still no clarity on the prospects for Test rugby in 2020, but said they will explore every avenue.

Luis Spencer Freitas, digital marketing director at Pernod Ricard USA, explains what will drive greater innovation in display advertising next year.

Part of the They've got the look promo for the BBC UK Homepage

27 November 2015

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

Expert

Expert

Site-specific arrest of RNA polymerases (RNAPs) is fundamental to several technologies that assess RNA structure and function. Current in vitro transcription “roadblocking” approaches inhibit transcription elongation by blocking RNAP with a protein bound to the DNA template. One limitation of protein-mediated transcription roadblocking is that it requires inclusion of a protein factor extrinsic to the minimal in vitro transcription reaction. In this work, we developed a chemical approach for halting transcription by Escherichia coli RNAP. We first established a sequence-independent method for site-specific incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthesis. We then show that interrupting the transcribed DNA strand with an internal desthiobiotin-triethylene glycol modification or 1,N6-etheno-2'-deoxyadenosine base efficiently and stably halts Escherichia coli RNAP transcription. By encoding an intrinsic stall site within the template DNA, our chemical transcription roadblocking approach enables display of nascent RNA molecules from RNAP in a minimal in vitro transcription reaction.

Researcher: Andrew Beveridge, Macalester College
Moment Title: Dis-playing the Game of Thrones
Description: Andrew Beveridge uses math to analyze Game of Thrones.

(University of Southampton) Scientists have published highly detailed images of lab-grown neurons using Extreme Ultraviolet radiation that could aid the analysis of neurodegenerative diseases.