pic How accurate is our picture of the pandemic? [News] By www.cmaj.ca Published On :: 2020-05-03T21:05:14-07:00 Full Article
pic Systematic Review of Whole-Genome Sequencing Data To Predict Phenotypic Drug Resistance and Susceptibility in Swedish Mycobacterium tuberculosis Isolates, 2016 to 2018 [Mechanisms of Resistance] By aac.asm.org Published On :: 2020-04-21T08:01:10-07:00 In this retrospective study, whole-genome sequencing (WGS) data generated on an Ion Torrent platform was used to predict phenotypic drug resistance profiles for first- and second-line drugs among Swedish clinical Mycobacterium tuberculosis isolates from 2016 to 2018. The accuracy was ~99% for all first-line drugs and 100% for four second-line drugs. Our analysis supports the introduction of WGS into routine diagnostics, which might, at least in Sweden, replace phenotypic drug susceptibility testing in the future. Full Article
pic Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and {beta}-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus [Susceptibility] By aac.asm.org Published On :: 2020-04-21T08:01:10-07:00 Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO3 responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of note, ~75% and ~36% of isolates displayed the NaHCO3 responsiveness phenotype to cefazolin (CFZ) and oxacillin (OXA), respectively. Neither intrinsic β-lactam MICs in standard Mueller-Hinton broth (MHB) nor population analysis profiles were predictive of this phenotype. Several genotypic markers (clonal complex 8 [CC8]; agr I and spa t008) were associated with NaHCO3 responsiveness for OXA. Full Article
pic Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress [Experimental Therapeutics] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium falciparum. First, from standard growth inhibition assays, we identified 173 molecules with antimalarial activity (50% effective concentration [EC50] ≤ 10 μM), which included 62 additional molecules over previously known antimalarial candidates from the Pathogen Box. We identified 90 molecules with EC50 of ≤1 μM, which had significant effect on the ring-trophozoite transition, while 9 molecules inhibited the trophozoite-schizont transition and 21 molecules inhibited the schizont-ring transition (with ≥50% parasites failing to proceed to the next stage) at 1 μM. We therefore rescreened all 173 molecules and validated hits in microscopy to prioritize 12 hits as selective blockers of the schizont-ring transition. Seven of these molecules inhibited the calcium ionophore-induced egress of Toxoplasma gondii, a related apicomplexan parasite, suggesting that the inhibitors may be acting via a conserved mechanism which could be further exploited for target identification studies. We demonstrate that two molecules, MMV020670 and MMV026356, identified as schizont inhibitors in our screens, induce the fragmentation of DNA in merozoites, thereby impairing their ability to egress and invade. Further mechanistic studies would facilitate the therapeutic exploitation of these molecules as broadly active inhibitors targeting late-stage development and egress of apicomplexan parasites relevant to human health. Full Article
pic River view apartment, located right in the heart of Saigon, Suitable for foreigners - Picity Hight By batdongsan.com.vn Published On :: Thu, 07 May 2020 16:37:00 GMT PiCity High Park Thanh Xuan - District 12 - Apartments worth living.- Price from only 1.5 billion / unit too attractive to invest or settle down.- The golden position is only 20 minutes from Tan Son Nhat airport.- Separate pink book, MB Bank loan support 70% for 20 years.- 4 star... Full Article
pic Video game Ancestors lets you meddle with the epic story of evolution By www.newscientist.com Published On :: Wed, 22 Jan 2020 18:00:00 +0000 Ancestors is the latest attempt to gamify millions of years of evolution but doesn't have the excitement gene, says Jacob Aron Full Article
pic AI can pick out specific odours from a combination of smells By www.newscientist.com Published On :: Mon, 16 Mar 2020 17:22:34 +0000 An AI can detect the presence of smells and even distinguish between scents like ammonia or carbon monoxide, which could be useful for detecting hazardous odours Full Article
pic Rosie O’Donnell Reveals She’s Helping Michael Cohen With His ‘Spicy’ Trump Tell-All Book By feedproxy.google.com Published On :: Sat, 09 May 2020 08:58:46 GMT Photo Illustration by The Daily BeastOn Friday afternoon, I had a fun, wide-ranging conversation with Rosie O’Donnell, the renowned comedian, daytime TV host, philanthropist, and Trump Enemy No. 1. The occasion for our talk was I Know This Much Is True, an HBO miniseries premiering May 10 which sees the A League of Their Own star flex her dramatic muscles like never before as Lisa Sheffer, a no-nonsense social worker at a mental health facility housing Thomas Birdsey (Mark Ruffalo).Over the course of our chat—which will run Monday, May 11—we touched on not only the show (she is excellent) but Trump’s years-long vendetta against her, the Tara Reade allegations, and the untimely death of SMILF amid claims of misconduct against creator and star Frankie Shaw. Read more at The Daily Beast.Got a tip? Send it to The Daily Beast here Full Article Entertainment
pic The best picture ever taken of the sun reveals its bizarre surface By www.newscientist.com Published On :: Wed, 29 Jan 2020 19:20:04 +0000 The best picture of the sun is more than five times more detailed than the previous highest-resolution images, revealing weird structures on our star’s surface Full Article
pic Nursing Homes & Veterans' Homes Are Epicenters of Covid-19 By www.realclearpolitics.com Published On :: Sat, 09 May 2020 07:00:47 -0500 The overlooked epicenter of the Covid-19 pandemic is our nation's nursing homes, veterans' homes, and other long-term care facilities. Full Article AM Update
pic Fortnite Party Royale Event Skin 'Nightlife' available from Epic Games Item Shop By www.dailystar.co.uk Published On :: Fri, 8 May 2020 01:58:33 +0000 The new Nightlife reactive skin is now live ahead of the Fortnite Party Royale event which starts later today. Full Article Gaming
pic Fortnite Party Royale Event Warning and server Status Epic Games next live event By www.dailystar.co.uk Published On :: Fri, 8 May 2020 23:01:20 +0000 Epic Games has issued a warning ahead of the Party Royale event, but it might not be the only problem facing players this evening. Full Article Gaming
pic Fortnite Party Royale Event COUNTDOWN: Start time, Epic Games Rewards and more By www.dailystar.co.uk Published On :: Sat, 9 May 2020 00:52:00 +0000 Fortnite Party Royale event starts soon. Here's everything you need to know including start times for Deadmau5, Dillon Francis and Steve Aoki - PLUS how to claim the many live event rewards available from Epic Games as they celebrate 350 million players. Full Article Gaming
pic RPGCast – Episode 282: “RPGCast: Pumpkin Spice Latte” By feedproxy.google.com Published On :: Sat, 12 Oct 2013 19:30:21 +0000 Yeah, I’ll have a venti double dirty chai pumpkin spice latte to go, no foam. What do you mean you don’t have an espresso machine?... Full Article News Podcasts RPG Cast
pic RPGCast – Episode 317: “Everyone Gets Tropico 4!” By feedproxy.google.com Published On :: Sat, 16 Aug 2014 22:29:11 +0000 Manny and Chris report back from their recent hunting expedition. Phil teaches us about MMOs for beginners. Anna Marie does all the picrosses. And Jon... Full Article News Podcasts RPG Cast
pic Walk the line: pinstripes are the business once again – in pictures By www.theguardian.com Published On :: 2020-02-18T12:00:26Z Paired with a T-shirt or even just a vest, the classic stripe returns for men this season. Take inspiration from these high-fashion looks riffing on the boardroom stapleRead more from the spring/summer 2020 edition of The Fashion, our biannual style supplement Continue reading... Full Article Fashion Life and style
pic A round of applause: 10 fashion brands supporting the health services – in pictures By www.theguardian.com Published On :: 2020-04-13T05:00:05Z From Stay at Home T-shirts to NHS baseball caps, here’s a selection from small labels donating some or all of their profits to charities helping healthcare workers and the Covid-19 response Continue reading... Full Article Fashion Life and style
pic The best oversized dresses for all ages – in pictures By www.theguardian.com Published On :: 2020-04-24T06:00:17Z Comfortable and chic, these are perfect transitional pieces for spring. Layer a thin polo neck underneath on chillier days, or style with a fitted blazer to look smarter Continue reading... Full Article Fashion Life and style Women's dresses Women's shoes Women's coats and jackets Handbags Women's jewellery
pic Softly does it: 10 of the best lilac pieces - in pictures By www.theguardian.com Published On :: 2020-05-01T08:00:19Z This is a shade to see you through summer Continue reading... Full Article Fashion Life and style Women's tops Women's trousers Skirts Dresses Women's coats and jackets
pic Gladiator at 20: how Ridley Scott's epic rejuvenated the historical blockbuster By www.theguardian.com Published On :: 2020-05-04T08:00:15Z The Oscar-winning sword-and-sandals Russell Crowe vehicle refreshed old cliches, before ushering in a spate of copycats “Joey, do you like movies about gladiators?” the creepy pilot asks the small boy in Airplane!. To younger audiences, the joke no longer makes any sense. In Airplane!’s day, sword-and-sandals movies had become an outdated, unwittingly homoerotic joke. But then came Gladiator, and the joke was on us. Released 20 years ago this month, Ridley Scott’s Roman epic gave the old cliches a new lease of life. It was all here: Colosseum action! Rippling man-flesh! Tigers! But Gladiator had its cheesecake and ate it. It served up crowd-pleasing spectacle and airline-ad visuals but also solemn, Oscar-worthy drama (and, in retrospect, a fair degree of camp). Related: The Guide: Staying In – sign up for our home entertainment tips Continue reading... Full Article Gladiator Film Culture
pic Epic Games launches Fortnite on the Google Play Store and they’re not happy about it By feedproxy.google.com Published On :: Tue, 21 Apr 2020 19:20:18 +0000 Epic Games is finally settling its feud — kind of — with Google and putting Fortnite onto the Google Play Store, but the studio sounds pretty pissed about it. When Fortnite launched on mobile in 2018, Epic Games very notably sidestepped the Google Play Store and pushed users to download the title directly from their […] Full Article Gaming TC Epic Games fortnite
pic ‘Saturday Night Live’: Melissa McCarthy Surprises Audience With Sean Spicer Spoof By blogs.wsj.com Published On :: Sun, 05 Feb 2017 15:55:54 +0000 Alec Baldwin also returned to the 'SNL' stage as Donald Trump in the cold open. Full Article Late Night Politics TV Alec Baldwin Donald Trump Kate McKinnon Melissa McCarthy Neil Gorsuch Saturday Night Live Sean Spicer SNL Steve Bannon Vanessa Bayer
pic Gary Neville picks Paul Pogba to win Ballon d'Or for Manchester United By in.news.yahoo.com Published On :: Sat, 09 May 2020 07:28:53 -0500 Full Article
pic Neymar Jr Trolls Kylian Mbappe as French Footballer Posts Picture of Himself Playing Basketball By in.news.yahoo.com Published On :: Sat, 09 May 2020 07:55:27 -0500 Kylian Mbappe and Neymar Jr's friendship is not limited to Paris Saint Germain but also off the field. The recent example of the same could be the French footballer's recent post on social media. Mbappe posted a picture of himself on social media where he was seen playing basketball. This was quite an ideal opportunity for Neymar Jr to pull his teammate's leg and he hilariously trolled the footballer with a funny comment. Full Article
pic Final Olympic Archery Qualification Event In June Next Year By in.news.yahoo.com Published On :: Sat, 09 May 2020 10:02:00 -0500 India have so far grabbed men's full quota and one individual place in women's category for Tokyo Olympics. Full Article
pic Adele reveals her incredible weight loss in new birthday picture By www.music-news.com Published On :: Wed, 06 May 2020 15:37:00 +0100 The 'Hello' singer turned 32 on Tuesday (05.05.20) and when she took to Instagram to thank fans for their well-wishes on her special day Full Article
pic Steve McCurry Shares #Throwback Pictures From 90s Bollywood By www.mansworldindia.com Published On :: Thu, 30 Apr 2020 14:08:40 +0000 In what is one of our favourite #throwback posts to... The post Steve McCurry Shares #Throwback Pictures From 90s Bollywood appeared first on Man's World India. Full Article Uncategorized Anil Kapoor Sridevi Steve McCurry
pic 2D oxide flakes pick up surprise electrical properties By www.sciencedaily.com Published On :: Thu, 07 May 2020 13:07:08 EDT Researchers find evidence of piezoelectricity in lab-grown, two-dimensional flakes of molybdenum dioxide. Full Article
pic Swiss soldiers pick up smartphones to fight COVID-19 By feeds.reuters.com Published On :: Fri, 01 May 2020 04:38:55 -0400 In the battle against coronavirus, Swiss soldiers are using smartphones to test a new contact tracing application that could prevent infections while also protecting users' privacy. Full Article scienceNews
pic Korean economy gets its skates on after Olympic medal haul By feeds.reuters.com Published On :: Tue, 09 Mar 2010 11:21:36 +0530 Kim Yuna's stunning win at last month's Winter Games will not only boost the career of the Olympic figure skating champion, it should help add several billion dollars to the South Korean economy. Full Article worldOfSport
pic Man released from US jail amid Covid-19 outbreak arrested on suspicion of murder By www.standard.co.uk Published On :: 2020-04-15T07:39:00Z Read our live updates on coronavirus HERE Coronavirus: The symptoms Full Article
pic Pictures show Notre Dame Cathedral one year on from devastating fire By www.standard.co.uk Published On :: 2020-04-15T10:08:56Z 'Notre Dame is an old, injured lady' Full Article
pic Pharmacist and surveyor arrested on suspicion of illegally selling coronavirus tests By www.standard.co.uk Published On :: 2020-04-15T14:29:10Z Follow our live coronavius updates HERE Coronavirus: The symptoms Full Article
pic Hermes delivery drivers snap hilarious pictures of people with their parcels under new coronavirus measures By www.standard.co.uk Published On :: 2020-04-16T08:33:00Z Coronavirus: the symptoms Read our LIVE updates on the coronavirus here Full Article
pic London Uber driver dies with Covid-19 after trip to Heathrow to pick up passenger By www.standard.co.uk Published On :: 2020-04-16T14:57:01Z Follow our live Covid-19 updates HERE Coronavirus: The symptoms Full Article
pic Canada shooting: First picture of policewoman Heidi Stevenson who was killed in Nova Scotia attack By www.standard.co.uk Published On :: 2020-04-20T08:19:00Z At least 16 people have been killed in the deadliest mass shooting in Canada's history. Full Article
pic Three men arrested on suspicion of firearm offences after police chase in south London By www.standard.co.uk Published On :: 2020-04-20T13:58:22Z Three men have been arrested on suspicion of firearms offences after failing to stop for police. Full Article
pic Elderly couple sprayed in face with fire extinguishers during 'despicable' raid in east London By www.standard.co.uk Published On :: 2020-04-21T06:39:00Z Full Article
pic Former Olympic rower Kenny Dwan recalls emotional moment he left hospital after overcoming coronavirus By www.standard.co.uk Published On :: 2020-04-22T08:41:00Z Former Olympic rower Kenny Dwan has recalled the emotional moment he left hospital after a three-week battle with coronavirus. Full Article
pic Prince Louis birthday photos: New pictures show ruby-cheeked royal playing in garden of Norfolk home By www.standard.co.uk Published On :: 2019-04-22T20:29:00Z Adorable new photographs of Prince Louis taken by his mother Kate have been released ahead of his first birthday. Full Article
pic The Londoner: Michael Spicer writing "secret aide" book By www.standard.co.uk Published On :: 2020-04-24T08:39:00Z In today's Diary: Michael Spicer on his forthcoming book / Rupert Everett calls for help for Coram's Fields / Emma Freud on the Comic Relief t-shirts / Brandon Lewis's marathon exercise regime Full Article
pic Food For London Now: Pick your own to help feed the capital… Felix Project volunteers hit the fields By www.standard.co.uk Published On :: 2020-04-27T09:14:00Z Volunteers spent the day on a farm to harvest vegetables that would have otherwise gone to waste so the produce could be turned into meals for our Food for London Now appeal. Full Article
pic Norwegian tycoon Tom Hagen held on suspicion of killing missing wife By www.standard.co.uk Published On :: 2020-04-29T07:06:00Z One of Norway's wealthiest men is being held on suspicion of murdering his wife who has been missing since 2018. Full Article
pic Ilford stabbing: Man arrested on suspicion of murder as children killed in east London pictured By www.standard.co.uk Published On :: 2020-04-29T19:52:00Z A man has been arrested on suspicion of murder after two children were stabbed to death in Ilford. Full Article
pic Tower Bridge reopens after police investigate 'suspicious package' on London landmark By www.standard.co.uk Published On :: 2020-05-01T11:24:00Z Tower Bridge was cordoned off at around midday on Friday while police investigated reports of a "suspicious package." Full Article
pic Princess Charlotte's fifth birthday celebrated with adorable picture captured by Kate Middleton By www.standard.co.uk Published On :: 2020-05-02T07:14:00Z A new photograph of Princess Charlotte has been released by Kensington Palace to mark her fifth birthday. Full Article
pic Newham stabbing: Two arrested on suspicion of murder after young NHS worker knifed to death in east London By www.standard.co.uk Published On :: 2020-05-02T10:27:00Z Two teenagers have been arrested on suspicion of murder after a young NHS worker was stabbed to death in east London. Full Article
pic Upminster shooting: Teens arrested on suspicion of aggravated burglary after Boy, 11, shot in east London By www.standard.co.uk Published On :: 2020-05-03T15:26:00Z Two teenagers have been arrested after a young boy was shot in east London and left with potentially life-changing injuries. Full Article
pic Man arrested on suspicion of murder after woman shot inside house during lockdown By www.standard.co.uk Published On :: 2020-05-03T18:53:00Z A man has been arrested on suspicion of murder after a woman was shot inside a house during the coronavirus lockdown. Full Article
pic Girl, 13, arrested on suspicion of attempted murder as woman fights for life By www.standard.co.uk Published On :: 2020-05-04T20:47:20Z A 13-year-old girl has been arrested on suspicion of attempted murder after a woman was left fighting for her life following reports of a street fight. Full Article