A system and method of controlling a fail-safe for a vehicle is provided. The method includes determining, by a controller, that remaining hydraulic pressure exists in the clutch when the clutch is not opened and a target value of oil pressure for opening the clutch is maintained for a predetermined time period. In addition, whether a vehicle is stopped is confirmed in response to determining that remaining hydraulic pressure exists in the engine clutch. The controller is further configured to transmit a signal to shift to the vehicle to a neutral (N) stage to a transmission controller and shift to the vehicle to the N-stage in response to determining that the vehicle is stopped. Then, the engine is driven by the controller in response to determining that the vehicle is shifted to the N-stage.

A battery charge/discharge control device which performs battery charge/discharge control in a working machine with a battery capable of storing electric energy generated by a generator motor coupled to an engine and driving the generator motor or at least one of other electric actuators by the stored electric energy and a controller which controls a distribution of the electric energy among the battery, the generator motor, and the electric actuator, wherein the controller performs the charge/discharge control in which the electric energy of the battery is discharged when the engine is driven and recharging to the battery is permitted on a condition that a state in which an engine speed is equal to or lower than a predetermined engine speed is maintained for a predetermined time after the battery is completely discharged.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of kidney disease, in particular kidney fibrosis, and other associated conditions.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

Disclosed are β-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone and β-polypeptides made from such monomers. Method of generating combinatorial libraries of polypeptides containing the β-peptide residues and libraries formed thereby are disclosed.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

A cartridge drive apparatus includes a holder, a lock plate, and a drive unit. The holder is configured to hold a cartridge inserted therein. The lock plate is attached with respect to the holder to be movable in one of an insertion direction and a discharge direction of the cartridge and includes a locking mechanism configured to lock the cartridge. The drive unit is configured to drive the holder and the lock plate in one of the insertion direction and the discharge direction of the cartridge.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at a predetermined angle to the non-inclined surface and is larger than the non-inclined surface in the thin portion.

There is provided a cartridge including a plurality of optical information recording media having unique information recorded thereon, an accommodation body configured to accommodate the plurality of optical information recording media, and an identification device configured to store the unique information of the plurality of optical information recording media and supply the unique information to a changer in a non-contact manner, the identification device being provided in the accommodation body.

There is provided a cartridge including a running portion which causes both end portions of a disc-shaped recording medium to run, and a pressing portion which presses one end portion of the disc-shaped recording medium to press the other end portion against the running portion. Static friction coefficients of a portion of the pressing portion coming in contact with the one end portion and a portion of the running portion coming in contact with the other end portion are different.

A data storage media may have at least a multi-layer recording lamination with a predetermined coercivity. The multi-layer recording lamination can be configured to record at least one servo format mark for a plurality of data tracks with a solid immersion mirror and program a data bit on the multi-layer recording lamination with a near field transducer.

There is provided a disk cartridge including a case body in which a plurality of disk-shaped recording media are configured to be able to be received in an axial direction of a central shaft in parallel, and a first shell having a base surface section parallel to a recording surface of the disk-shaped recording medium and a second shell having a basal surface section parallel to the recording surface of the disk-shaped recording medium are coupled and separated through separation and connection in the axial direction, and a presser spring having a section to be attached, which is attached to the case body, and a pressing section configured to come in contact with an outer circumferential surface of the disk-shaped recording medium and to press the disk-shaped recording medium. The presser spring is formed of a resin material.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at an angle greater than or equal to 25 degrees and less than or equal to 35 degrees with respect to the non-inclined surface.

A spreader (100) has a hopper or bin (1) for storing a spreadable material (2), a plurality of spinners (5, 6) adapted to receive the material from the hopper or bin and to spread the material (2) on the ground, and a Global Positioning System (GPS) receiver (8) for sensing the position of the spreader (100) and providing an output signal indicative of a position of the spreader to a controller (7). The controller (7) calculates a required pattern and density of material (2) to be spread by the spinners (5, 6) based on a comparison of the actual position of the spreader (A) to a preferred position of the spreader (I), and controls the spinners (5, 6) in order to obtain the required pattern and density of spread material (2). A method of controlling the pattern and density of material spread by a spreader is also disclosed.

A cob conveying and cleaning system for use with a corn harvester, incorporating air induction in cooperation with an air flow from the harvester, for cleaning and separating lighter crop residue to be returned to the field from a mixed flow of the residue and cobs, such that the cleaned cobs can be collected, and the lighter residue optionally spread on the field. The air flow and induction are combined to cooperatively lift or draw the lighter residue from the mixed flow, and to optionally spread the removed lighter residue over a field. The induction apparatus can be located on the harvester, and used as a residue spreader when cobs are not collected.

A flow distribution system for use with a combine spreader having an inlet opening at the top thereof for receiving crop residue, a pair of counter-rotating spreader paddles disposed generally side by side and forward of a back plate of the spreader, and a discharge opening below the spreader paddles. A flow guide element has an apex portion and a pair of opposed arm portions pivotally connected to the apex portion, the arm portions laterally extending to free end portions. An adjusting mechanism is operably connected to the arm portions to effect rotational movement of the arm portions about the apex portion, ends of spreader paddle members defining the outer swept diameters of the pair of spreader paddles and the crop residue flow surfaces of at least the arm portions defining clearance regions therebetween to controllably distribute crop residue in a desired pattern over a field.

The invention concerns a harvested crop residue chopper and distribution arrangement for a combine (10) with a straw chopper (60) with a rotor (74) that can be brought into rotation about a horizontal axis (98) with chopper blades (76) fastened thereto that define an outer envelope (96), and with at least one impeller blower (82) arranged downstream of the straw chopper (60) with impeller blades (84) that can rotate about an axis of rotation (88) that extends vertically, in which the impeller blades (84) are provided with outer edges (94) that conform to the envelope (96) of the chopper knives (76) and follow it very closely and are not in contact with it.

An agricultural combine having an adjustable spreader assembly is provided that includes a spreader with one or a pair of regulators. The spreader includes a discharge opening about its lateral side. The regulator is pivotably connected to the lateral side of the spreader such that the regulator is in fluid communication with the discharge opening. The regulator can be configured to move from a retracted position to an extended position or to vary the direction of discharge of crop residue. The spreader can be a vertical spreader, a horizontal spreader, or a spread board.

A combine side-shaking control system and a method for controlling operation of a side-shaking mechanism in a combine. The control system includes at least one sieve for separating crop material from other materials and a movable side-shaking mechanism coupled to the at least one sieve and configured to move the at least one sieve in a side-to-side motion. The control system also includes at least one sensor for sensing at least one operating condition of a combine system. The control system further includes a controller for receiving the at least one operating condition and causing the side-shaking mechanism to stop moving the at least one sieve in the side-to-side motion or start moving the at least one sieve in the side-to-side motion based on the at least one operating condition.

A combine side-shaking control system includes a sieve for separating crop material from other materials and configured to move in a fore-aft direction. At least one side-shaking assembly includes a mounting device attached to a combine chassis, a lower plate configured to rotate about a lower plate axis and an upper plate configured to (i) have an upper plate rotational motion and rotate responsive to the rotation of the lower plate and (ii) have an upper plate substantially linear motion in a substantially linear direction. A fixed arm is rotatably coupled to the upper plate and attached to the sieve. An actuation device is configured to rotate the lower plate about the lower plate axis. Responsive to the rotation of the upper plate, the sieve is controlled to move diagonal to the fore-aft direction in the substantially linear direction of the upper plate substantially linear motion.

A combine side-shaking control system that includes a sieve for separating crop material from other material, located in a plane having an X dimension and a Y dimension and configured to move in a fore-aft direction in the X dimension, in a side-to-side direction in the Y dimension and in an up-down direction in a Z dimension. The system also includes a side-shaking assembly configured to move the sieve in the side-to-side direction in the Y dimension. The fixed arm is attached to the sieve and configured to move with the sieve in (i) the fore-aft direction in the X dimension, (ii) the side-to-side direction in the Y dimension and (iii) the up-down direction in the Z dimension. The side-shaking coupling portion comprises a moving portion configured to move in a diagonal direction having a fore-aft component in the X dimension and an up-down component in the Z dimension.

A feed system for a biomass collection device uses a conveyor for dropping a flow comprising a mixture of denser or heavier biomass to be collected such as cobs, and less dense or lighter biomass residue such as leaf trash, through a space, and rotary feed apparatus below for receiving the flow, operable for propelling the received flow into a collection device, in combination with a fan configured and operable for directing a flow of air along a second path intersecting the first path in a manner to divert at least a substantial portion of the less dense or lighter biomass residue away from the feed apparatus, while allowing substantially all of the denser or heavier biomass to continue along the first path to the feed apparatus for feeding into the collection device. Distribution apparatus along the second path can then be used to spread the diverted biomass.

A dehider tool has first and second blades arranged in contact with each other that rotate in opposite directions on a common blade axis. A drive assembly having a pneumatic motor and respective drive belts drives the blades in opposite directions about the common blade axis. The blades each have an outer cutting edge in the shape of a regular convex polygon, such as a decagon. The blades have an inner opening for coupling with a blade holder of the drive assembly. The inner opening has the shape of a regular convex polygon, such as a pentagon. The blades are covered with a hard surface coating to extend their service life.

A method and a system for separating the spinal column from a carcass middle part, comprising the steps of providing a digital representation of an outer surface of the carcass middle on the basis of, e.g., an optical scan, determining a cutting path (1c) for a cutting device for the separation of the spinal column from the carcass middle on the basis of digital processing of the scan, and subsequently separating the spinal column from the carcass middle by causing a relative movement between the middle and the cutting device and simultaneously causing the cutting device to engage the carcass middle, wherein the relative movement between the middle and the cutting device during the spinal column separation to achieve a cut along the predetermined cutting path (1c).

A battery pack dehumidifier system for controlling the relative humidity within a battery pack enclosure is provided, the dehumidifier system including a desiccant that absorbs/adsorbs water vapor from the battery pack enclosure. The system heats and reactivates the desiccant at predetermined time intervals or when the humidity within the system reaches a preset level, thereby allowing the desiccant to regain its potential for absorbing/adsorbing water vapor.

Provided is a method for shutting down an indirect internal reforming SOFC, in which a hydrocarbon-based fuel is reliably reformed, and the oxidative degradation of the anode can be prevented by a reformed gas. A method for shutting down an indirect internal reforming SOFC including a reformer; an SOFC; a combustion region for combusting the anode off-gas of the SOFC; and an enclosure for housing the reformer, the SOFC, and the combustion region, wherein the method includes causing the flow rate of a fuel supplied to the reformer to become FE from FS; and stopping the supply of the fuel to the reformer when an anode temperature becomes lower than the oxidative degradation temperature, where FE represents a flow rate of the fuel supplied to the reformer in a state in which the anode temperature is steady and lower than the oxidative degradation temperature, in which in the reformer the fuel is reformed and a reformed gas with a composition suitable to be supplied to an anode is produced, and in which an amount of the reformed gas produced is equal to or more than the requisite minimum flow rate for preventing the oxidative degradation of the anode when the anode temperature is a temperature equal to or higher than the oxidative degradation temperature, and FS represents a flow rate of the fuel supplied to the reformer at the start of the shutdown method. Also provided is an indirect internal reforming SOFC appropriate for this method.

A pouch or holder has a friction-enhanced surface. The pouch has an opening to receive a cardboard backing of a writing pad. The sheets of paper of the writing pad overlie the upper surface of the pouch. The friction-enhanced material is located at the lower surface of the pouch. The pouch is closed at the bottom end and the side edges. The binding of the writing pad locates on the outside of the pouch.

A server-based video game system maintains a number of video game characters having computer-simulated genetic (“digenetic”) structures that prescribe a number of physical and cognitive performance traits and characteristics for the video game characters. The system allows end users to establish remote online access to the game characters (via, e.g., the Internet). The results of competitions and training activities are based upon the game characters' digenetics, the conditions of the game environment, and the game characters' current levels of physical and cognitive development. The game characters' performance capabilities and cognition are updated continuously in response to the results of competitions and training activities. Competition and training results can be processed by the game servers and transmitted to the end user presentation devices for graphics rendering. In this manner, the video game system need not be burdened by network latency and other delays. The game system also supports game character breeding; game character evolution based upon the digenetics; and game character buying, trading, selling, and collecting.

Methods and system for presenting a plurality of attributes of a plurality of players from a plurality of teams that are part of a league includes obtaining a plurality of attributes of the plurality of players and the plurality of teams. The plurality of attributes of the plurality of the players and of the teams is populated in one or more databases along with any updates to these attributes. The databases are queried to retrieve updated plurality of attributes of the plurality of players and the plurality of teams. A roster grid is generated for the plurality of teams for rendering at a client in substantial real time. The roster grid displays the updated status of the plurality of attributes of the plurality of players and the plurality of teams simultaneously in a clean, concise and effective manner.

A gaming system used in a wager-based electronic gaming machine is described. The gaming system is configured to provide picture in a picture capabilities on the electronic gaming machine. In one embodiment, the gaming system can include a first gaming device and a second gaming device where the first gaming device controls the second gaming device. The first gaming device can be configured to receive data and/or communicate with an electronic gaming machine controller, a value input device and value output device. The second gaming device can be configured to receive touchscreen data from a touchscreen display and first video data from the first gaming device and second video data from the EGM controller. Under control of the first gaming device, the first video data and second video data can be output in various sizes and locations on the touchscreen display.

An apparatus and method are disclosed for controlling fluid flow to a variator which responsive to separate high and low pressure fluids to control an output torque thereof. A first trim valve may be responsive to a first control signal to supply a first fluid at a fluid outlet thereof. A second trim valve may be responsive to a second control signal to supply a second fluid at a fluid outlet thereof. A variator switching sub-system may controllably supply the high pressure fluid and the low pressure fluid to the variator. A multiplex valve may be fluidly coupled to the outlets of the first and second trim valves, and may supply the first fluid as the high pressure fluid to the variator switching sub-system during at least one predefined operating condition and may otherwise supply the second fluid as the high pressure fluid to the variator switching sub-system.

A toroidal continuously variable transmission includes: an input disk; an output disk; a plurality of power rollers; a plurality of trunnions; an oil pump; a pressing hydraulic mechanism that moves and brings the input disk and output disk closer to each other; a shifting hydraulic mechanism that moves the trunnions forward and rearward; and a hydraulic control device that controls the pressing hydraulic mechanism and the shifting hydraulic mechanism by oil pressure. The hydraulic control device has an oil pressure regulation unit that sets an oil pressure in a shifting hydraulic line that is a hydraulic source of the shifting hydraulic mechanism to an oil pressure at which shifting control can be performed by the shifting hydraulic mechanism till the transmission of power between the input disk and output disk is interrupted when the operation of the oil pump is stopped.

A toroidal variable speed traction drive includes a driving disc and a driven disc. The discs have a common axis. A plurality of pairs of contacting rollers are interposed between the discs. The discs are urged together against the roller pairs (A) by a clamping force. Each of the rollers has a first rolling surface, by which it rolls on the other roller of the pair, and a second rolling surface by which it rolls on the toroidal surface of a corresponding disc. Each roller is mounted on a supporting axle about which it can rotate. The rotational axes of the rollers in a pair are supported in a plane that contains the two points where the rollers of the pair contact the discs. At least one of the rollers in each pair is adapted to be moved to adopt a stable position within the plane by the reactionary force exerted on it by the other roller of the pair.

An apparatus for controlling a variator having at least one roller between two toroidal disks may include at least one actuator responsive to fluid pressure at separate high side and low side fluid inlets thereof to control torque applied by the at least one roller to the disks. First and second variator switching valves may each receive a first fluid at a first pressure and a second fluid at a second lesser pressure. The first and second variator switching valves supply the first fluid to the high side fluid inlet and the second fluid to the low side fluid inlet during two of four different operational states together defined by the variator switching valves, and supply the second fluid to the high side fluid inlet and the first fluid to the low side fluid inlet during each of the remaining two of the four different operational states.

A toroidal continuously variable transmission of the present invention comprises: input side disks (1a, 1b) and output side disks (6) being supported concentric with each other such that the disks can rotate freely; a trunnion (9) that comprises end sections (36) on both ends on which tilt shafts (13) that are concentric with each other are provided, and a support beam section (15) that extends between both end sections (36), the trunnion (9) being capable of pivotally displacing around the tilt shafts (13); a thrust rolling bearing (17); and a power roller (8) that is supported to the inside surface of the trunnion (9) by way of the thrust rolling bearing (17) such that it rotates freely; wherein the support beam section (15) comprises an inside surface having a cylindrical convex surface (14); the thrust rolling bearing (17) comprises an outer race (18a) having an outside surface with a concave section (19a) that fits with the cylindrical convex surface (14) of the support beam section (15), and a plurality of rolling bodies (26) that are located between the power roller (8) and a track of an outer race (18a); and the concave section (19a) of the outer race (18a) has side surface sections (29) on both sides in the width direction, fits with the cylindrical convex surface (14) by the cylindrical convex surface (14) coming in contact with both side surface sections (29).

A fluid pump includes a drive shaft driven by power from an engine, a rotor adapted to be provided at a housing and rotating unitarily with the drive shaft, a driving wheel which is provided separately from the drive shaft and to which the power from the engine is always transmitted when the engine is running, a driven wheel transmitting the power from the engine to the drive shaft upon being in contact with the driving wheel, and a displacement mechanism causing the driving wheel and the driven wheel to be out of contact from each other by moving at least one of the driving wheel and the driven wheel.