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<i>KRAS</i> amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy




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Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines




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Environmental determinants of cardiovascular disease: lessons learned from air pollution




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Disease-associated astrocytes in Alzheimer’s disease and aging




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Seasonal and pandemic influenza: 100 years of progress, still much to learn




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The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease




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Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma




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Parkinson disease Primer - a true team effort




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Publisher Correction: Colonic diverticular disease




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Nature Reviews Disease Primers




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Prostate Cancer and Prostatic Diseases




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npj Aging and Mechanisms of Disease




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COVID-19 outcomes in patients with hematologic disease




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Cell Death & Disease




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Mendelian neurodegenerative disease genes involved in autophagy




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Parkinson disease and the immune system — associations, mechanisms and therapeutics




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Monogenic small vessel diseases — rare but still important




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Design, implementation, and evaluation of a nurse-led intravitreal injection programme for retinal diseases in Singapore




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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease




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Genome-wide association study identifies zonisamide responsive gene in Parkinson’s disease patients




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Biomedical ethics 2.0: redefining the meaning of disease, patient and treatment




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Author Correction: Climate change: an enduring challenge for vector-borne disease prevention and control




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The ethics of genetic testing for kidney diseases




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Kidney dendritic cells: fundamental biology and functional roles in health and disease




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Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases




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Modeling and comparing central and room air conditioning ownership and cold-season in-home thermal comfort using the American Housing Survey




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Renault rounds off season in style

Robert Kubica said that finishing fifth in the Abu Dhabi Grand Prix was a good way to finish the season after fighting his way through the field from 11th on the grid




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Vettel secures third title in epic season finale

Sebastian Vettel clinched his third successive drivers' championship after an utterly absorbing final race in Brazil




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There are policy solutions that can end the war on childhood, and the discussion should start this campaign season

President Lyndon B. Johnson introduced his “war on poverty” during his State of the Union speech on Jan. 8, 1964, citing the “national disgrace” that deserved a “national response.” Today, many of the poor children of the Johnson era are poor adults with children and grandchildren of their own. Inequity has widened so that people…

       




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There are policy solutions that can end the war on childhood, and the discussion should start this campaign season

President Lyndon B. Johnson introduced his “war on poverty” during his State of the Union speech on Jan. 8, 1964, citing the “national disgrace” that deserved a “national response.” Today, many of the poor children of the Johnson era are poor adults with children and grandchildren of their own. Inequity has widened so that people…

       




seas

There are policy solutions that can end the war on childhood, and the discussion should start this campaign season

President Lyndon B. Johnson introduced his “war on poverty” during his State of the Union speech on Jan. 8, 1964, citing the “national disgrace” that deserved a “national response.” Today, many of the poor children of the Johnson era are poor adults with children and grandchildren of their own. Inequity has widened so that people…

       




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Transfer season: Lowering the barrier between community college and four-year college


Community colleges are a vital part of America’s opportunity structure, not least because they often provide a way into higher education for adults from less advantaged backgrounds. Each year there are around 10 million undergraduates enrolled at public, two-year colleges. Among first-generation students, nearly 38 percent attend community colleges, compared to 20 percent of students with college-educated parents.

Credentials from community colleges—whether short vocational courses or two-year associate degrees—can be valuable in the labor market. In theory, community colleges also provide an on-ramp for those seeking a bachelor’s degree; in fact, four out of five students enrolling intend to get a 4-year degree.

But the potential of community college is often unrealized. Many students are not ready. Quality varies. Pathways are often unclear and/or complex. Only about 40 percent of those enrolling earn a degree within six years. Just 15 percent acquire a 4-year degree, according to analyses by Doug Shapiro and Afet Dundar at the National Student Clearinghouse Research Center.

Transfers rates from community college vary dramatically by state

The degree of alignment and integration between community and four-year colleges is much greater in some states than others. Some use common course numbering for 2- and 4-year institutions, which helps students find the classes they need without racking up costly excess credits. In others, universities and community colleges have tried to align their curriculum to ensure that students’ transfer credits will be accepted.

Individual institutions like Queensborough College (part of the CUNY system) and Miami-Dade College have streamlined course sequences to help their students stay on track to transfer into 4-year schools, as Thomas Bailey, Shanna Jaggers, and Davis Jenkins describe in their book, Redesigning America’s Community Colleges. There’s some indirect evidence that these initiatives increased retention and graduation rates.

These policy differences help to explain the very different stories of transfer rates in different states, revealed in a recent study by Davis Jenkins and John Fink. One important measure is the proportion of students transferring out of community college with a certificate or associate degree already in hand:

Florida tops the list, partly because of state legislation requiring that community colleges grant eligible transfer students degrees—but also because of concerted investments at the state and institutional levels to improve 2-year institutions.

Another measure of success is the proportion of those who transfer ending up with a four-year degree. Again, there are significant variations between states:

Since community colleges serve so many more students from poor backgrounds, the importance of the transfer pathway for social mobility is clear. Many who struggle at high school may begin to flourish in the first year or two of post-secondary education. As their skills are upgraded, so their opportunities should widen. But too often they become trapped in the silos of post-secondary education. We should continue to support efforts like pathway programs that explicitly attempt to build bridges between community colleges and high-quality four year institutions through the creation of clear and consistent major-specific program maps. Such programs allow students starting out at community colleges to easily chart out the specific, clear, and coherent set of steps needed to eventually finish their post-secondary education with a four-year degree.

Tuning an American engine of social mobility

The mission of community colleges since their inception a century ago has been to broaden access to education. Today that means providing a solid education to all students, but also providing opportunities to move on to other institutions.

Authors

Image Source: © Brian Snyder / Reuters
      
 
 




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China’s overseas investments in Europe and beyond


Event Information

April 25, 2016
2:30 PM - 4:00 PM EDT

Saul/Zilkha Rooms
Brookings Institution
1775 Massachusetts Avenue NW
Washington, DC 20036

Register for the Event

For decades Chinese companies focused their international investment on unearthing natural resources in Africa, Asia, and Latin America. In recent years, Chinese money has spread across the globe into diverse sectors including the real estate, energy, hospitality, and transportation industries. So far in 2016, Chinese investment in offshore mergers and acquisitions has already reached $101 billion, on track to surpass its $109 billion total for all of 2015. What do these investments reveal about China’s intentions in the West? How is China’s image being shaped by its muscular international investments? Should the West respond to this new wave, and if so, how?

On April 25, 2016, the Center on the United States and Europe and the John L. Thornton China Center at Brookings hosted the launch of "China’s Offensive in Europe" (Brookings Institution Press, 2016), the newly-published, revised book co-authored by Visiting Fellow Philippe Le Corre (with Alain Sepulchre). During the event, Le Corre offered an assessment of the trends, sectors, and target countries of Chinese investments on the Continent. Following the presentation, Senior Fellow Mireya Solis moderated a discussion with Le Corre and Senior Fellows Constanze Stelzenmüller and David Dollar.

 Join the conversation on Twitter using #ChinaEurope

Audio

Transcript

Event Materials

      
 
 




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The effect of COVID-19 and disease suppression policies on labor markets: A preliminary analysis of the data

World leaders are deliberating when and how to re-open business operations amidst considerable uncertainty as to the economic consequences of the coronavirus. One pressing question is whether or not countries that have remained relatively open have managed to escape at least some of the economic harm, and whether that harm is related to the spread…

       




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Coupled Contagion Dynamics of Fear and Disease: Mathematical and Computational Explorations

Published version of the CSED October 2007 Working Paper

ABSTRACT

Background

In classical mathematical epidemiology, individuals do not adapt their contact behavior during epidemics. They do not endogenously engage, for example, in social distancing based on fear. Yet, adaptive behavior is well-documented in true epidemics. We explore the effect of including such behavior in models of epidemic dynamics.

Methodology/Principal Findings

Using both nonlinear dynamical systems and agent-based computation, we model two interacting contagion processes: one of disease and one of fear of the disease. Individuals can “contract” fear through contact with individuals who are infected with the disease (the sick), infected with fear only (the scared), and infected with both fear and disease (the sick and scared). Scared individuals–whether sick or not–may remove themselves from circulation with some probability, which affects the contact dynamic, and thus the disease epidemic proper. If we allow individuals to recover from fear and return to circulation, the coupled dynamics become quite rich, and can include multiple waves of infection. We also study flight as a behavioral response.

Conclusions/Significance

In a spatially extended setting, even relatively small levels of fear-inspired flight can have a dramatic impact on spatio-temporal epidemic dynamics. Self-isolation and spatial flight are only two of many possible actions that fear-infected individuals may take. Our main point is that behavioral adaptation of some sort must be considered.”

View full paper »
View factsheet »

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Authors

Publication: PLoS One Journal
      
 
 




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Winters Were Colder in Your Parents' Day: New England Trees Get 10 Days More Growing Season Than Pre-1970

According




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On MNN: Robot hotels, over-conditioned offices, seasteading still sinks, and I Kondoed my phone!

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On MNN: Water heaters and Legionnaires' Disease

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How modern, minimalist design (and washing your hands) can fight disease

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Detecting Plant Diseases? There's an App for that

The Gene-Z app works with Apple and Android and can detect plant diseases in 10-30 minutes.




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‘Tis the season to recycle your electronics: Project Reboot

Chances are, your holiday gifts may include an electronic gadget or two, and a new initiative aims to encourage and support the proper disposal and recycling of the old ones.




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Link Between BPA and Heart Disease Seen in Urine, New Study Reports

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Beware the season of excess

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Melting ice and rising seas will make Alaskan villagers America's first climate refugees

Adapting to climate change is going to affect the lives of every human on Earth. But for some those impacts are hitting a little sooner and a little harder than they are for others.




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Roman concrete lasts a long time, but it won't stop rising seas

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Smartphones can now detect diseases in minutes

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Photo: How are seashells formed?

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A farm-to-table feast proves that Ontario has great seasonal food, even in winter

And when prepared by professional chefs, it's more delicious than any imported produce could ever be.




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Compact seaside apartment renovation is inspired by boat design

This small 355-square-foot apartment has been redesigned to be more space-efficient, enough to accommodate a family that loves to entertain and have guests sleep over.