Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) such as TNFα muteins capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFα mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.

The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of aortic fibrosis and other associated conditions.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

A spreader assembly for a combine harvester, the assembly including a pair of disks configured to be rotated such that chaff material dropped onto the disks is spread about the combine harvester, wherein each disk is operably connected to its own motor and a spreader frame assembly. The spreader frame assembly includes a first side support pivotably connected to a frame of the combine harvester, a second side support pivotably connected to the frame of the combine harvester, and at least one disk support configured to support at least one of the pair of disks. The spreader frame assembly further defines an opening configured such that when the combine harvester is windrowing material, no portion of the spreader frame assembly interferes with the flow of windrowing material.

An energy storage composite particle is provided, which includes a carbon film, a conductive carbon component, an energy storage grain, and a conductive carbon fiber. The carbon film surrounds a space. The conductive carbon component and the energy storage grain are disposed in the space. The conductive carbon fiber is electrically connected to the conductive carbon component, the energy storage grain, and the carbon film, and the conductive carbon fiber extends from the inside of the space to the outside of the space. The energy storage composite particle has a high gravimetric capacity, a high coulomb efficiency, and a long cycle life. Furthermore, a battery negative electrode material and a battery using the energy storage composite particle are also provided.

Positive electrode active material particles for lithium ion secondary batteries include: a core particle including a first olivine-structured, lithium-containing phosphate compound which includes Fe and/or Mn and Li; and a shell layer attached to the surface of the core particle. The shell layer includes a second olivine-structured, lithium-containing phosphate compound which includes Fe and/or Mn and Li. At least the core particle includes a phosphorous compound represented by the formula (1): MemPnOp, where Me is Fe and/or Mn, 0

A composite material tape and a lithium secondary battery using the same are provided. The composite material tape includes an organic base and at least one inorganic element dispersed within the organic base. The composite material tapes of the present invention exhibit improved Insulative and heat-resistant characteristics.

A system for producing energy that includes infusing porous carbon particles produced by pyrolysis of carbon-containing materials with an off-eutectic salt composition thus producing pore-free carbon particles, and reacting the carbon particles with oxygen in a fuel cell according to the reaction C+O2=CO2 to produce electrical energy.

A carbon supported catalyst composition for solid polymer electrolyte fuel cells is disclosed that shows a high mass activity and favorable stability and durability. The catalyst composition comprises an intermetallic phase or alloy comprising Pt and a metal selected from the group consisting of Nb, Ta, V and Mo, and comprises an oxide of the metal. The carbon supported catalyst composition can be prepared at relatively low temperature either by first depositing and heating an oxide precursor of the metal on a suitable carbon to make a hybrid support, and then depositing and heating a Pt precursor on the hybrid support, or by depositing both an oxide precursor of the metal and a Pt precursor on a suitable carbon support, and directly heating to a final temperature.

Disclosed are sets of ink components, and ink compositions, useful for printing markings, on security documents, that are relatively resistant to counterfeiting. Also disclosed are the security documents formed, a method of printing and a method of authenticating the printed material. The markings, formed of the ink compositions have a spectral response that deviates from a predicted spectral response when linearly additively combining spectral responses of components of the ink composition, so that it becomes difficult to reverse-engineer the ink composition from the markings. Use of plural different markings, with each marking being a microdot, increases difficulty in counterfeiting. By forming a template of spectral responses of the original pattern, spectral responses of a pattern on an unknown document can be compared to the spectral responses on the template for determining whether the unknown document is authentic. Formation of the markings is facilitated using an inkjet printer.

A position detection encoder includes a scale and a detection head and has position detection circuits which are capable of outputting respective pieces of position information on Xf, Xs two tracks. The displacement detection encoder includes: a speed detection circuit which is provided in the detection head and detects a relative speed Xf, Xs relative to the scale; and a delay generation circuit which provides a time difference between two output request signals, the time difference being provided on the basis of a fine adjustment time tadj based on the relative speed Xf, Xs and the respective pieces of position information Xf, Xs on the two tracks, the output request signals St1, St2 urging the first and second position detection circuits to output the pieces of position information on Xf, Xs the two tracks.

Systems and methods are provided that may be implemented to provide a mechanical indicator to correlate magnetic disk drive IOP performance with features of mechanical and/or acoustic vibrational frequencies that are generated and captured or sensed outside of the disk drive itself. In one example, disk drive PES data may be collected concurrently with the capture of mechanical and/or acoustic vibrational data at different and progressive locations of vibration source, vibration path and vibration receiver in a disk drive operating environment, e.g., such as for disk drives installed within a server and/or storage chassis enclosure. In such case, PES threshold may be utilized to correlate performance of Drive IOP or drive servo-mechanical performance as a function of measured characteristics of vibration source/s that impart vibration to a disk drive.

In one embodiment, a system includes a robotic accessor for transporting media between multiple storage slots and one or more data storage drives; a controller for controlling the robotic accessor; a memory in communication with and/or integrated with the controller for storing information about the media and the storage slots, the information including data corresponding to a physical distribution of the media in the storage slots; and logic integrated with and/or executable by the controller, the logic being adapted to: position the robotic accessor at a computed optimal position during an idle period of the robotic accessor, the computed optimal position being based at least in part on the physical distribution of the media in the storage slots.

A suspension includes a positive write trace and a negative write trace. The positive write trace is separated into at least two positive write trace sections located at two different layers respectively, and the negative write trace is separated into at least two negative write trace sections located at two different layers respectively. Each positive write trace section and each negative write trace section are alternately arranged along a longitudinal direction on two different layers, and the positive write trace sections at different layers are connected together via conductive crossovers, and the negative write trace sections are connected together via conductive crossovers. The present invention can obtain balanced propagation time in the stacked trace structure to reduce signal distortion, and obtain widened frequency bandwidth.

A method according to one embodiment includes measuring a current position error signal, and calculating a statistical derivative using the current position error signal sample. A kurtosis value is calculated using a current position error signal sample or derivative thereof. A threshold value is adjusted using the kurtosis value. The statistical derivative is compared to the threshold value, and writing is enabled when the statistical derivative does not exceed the threshold value. A determination is made whether to enable or disable writing based on a stopwrite threshold when the statistical derivative exceeds the threshold value.

A data processing device includes a memory, an arithmetic circuit that accesses the memory by outputting an access control signal CTRL that controls access to the memory, a first data storage unit that stores first data used when a self-diagnosis is performed, a read-modify-write circuit that generates second data by replacing a part of the first data stored in the first data storage unit with modify data outputted from the arithmetic circuit, and a determination unit that diagnoses a failure of the read-modify-write circuit by comparing the second data with an expected value.

A vibration-damping plain bearing composite comprising a sliding layer, a dimensionally stable support layer and an elastic layer. In one embodiment, the dimensionally stable support layer is arranged between the sliding layer and the elastic layer; in another embodiment, the elastic layer is arranged between the sliding layer and the dimensionally stable support layer. The bearing composites are characterized that a ratio of the thickness of the elastic layer tEL to a thickness of the sliding layer tSL is at least 3.

An apparatus and a method support a selective suspend mode in a driver for any one of at least two devices constituting a composite network device. When a device of the driver requests suspend mode transition, a Physical Device Object (PDO) constituting a driver of the composite network device is identified by a PDO check part. A suspend mode transition request information of the device is sent to an operating system through the PDO. When the operating system allows the suspend mode transition, a control part sends suspend mode transition indication information to the device through the PDO.

The present invention provides a polymerizable compound represented by the following formula (I), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The polymerizable compound, polymerizable composition, and polymer have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.

A pattern-forming method includes providing a resist film on a substrate using a radiation-sensitive composition. The resist film is exposed. The exposed resist film is developed using a developer solution. The developer solution includes no less than 80% by mass of an organic solvent. The radiation-sensitive composition includes at least two components including a first polymer and a radiation-sensitive acid generator. The first polymer includes a structural unit having an acid-labile group. One or more components of the radiation-sensitive composition have a group represented by a formula (1). A− represents —N−—SO2—RD, —COO−, —O− or —SO3−. —SO3− does not directly bond to a carbon atom having a fluorine atom. RD represents a linear or branched monovalent hydrocarbon group, or the like. X+ represents an onium cation. —A−X+ (1)

The present invention relates to a process for the production of propylene polymers in the presence of a Ziegler-Natta catalyst comprising a titanium compound having at least one titanium-halogen bond, and a blend of a diether compound and a succinate compound as internal electron donor, all supported on a magnesium halide in active form, an organoaluminium compound and an optional external donor.

A polymer reactor-blend comprising at least a first component having a polydispersity index of greater than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer and a second component having a polydispersity index of less than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer wherein a molecular weight distribution of the second component lies within a molecular weight distribution of the first component.

The present application relates to novel monomers comprising polycarbosiloxane monomers useful in certain specific embodiments in the manufacture of devices. More particularly, the present application relates to certain ethylenically unsaturated free radical polymerizable monomers comprising polycarbosiloxane monomers. Even more particularly, the present application pertains to monomers comprising polycarbosiloxane monomers which further comprise at least two ethylenically unsaturated free radical polymerizable groups.

Process for the preparation of etherified melamine/formaldehyde condensates, in which first a methylolation of melamine with a formaldehyde component in the molar ratio of from 1:6 to 1:15, preferably at a pH of >7, is carried out. This is followed by an etherification of the resulting hydroxymethylation intermediate in the presence of a C1-C20-alkyl, preferably of a C1-C6-alcohol, particularly preferably of a C1-C4-alcohol, at a pH of 9.5 being established before, during and/or after the distillation. According to the invention, a plurality of hydroxymethylation, etherification and distillation steps follow in order to achieve an etherified melamine/formaldehyde condensate which is distinguished by a high degree of hydroxymethylation, a high solids content and a low viscosity.

The present invention relates to a polymer composition comprising polylactide and, based on the weight of this polymer, from 17 to 25 wt % of a chain modifier, from 30 to 55 wt % of an elastomeric polymer and from 20 to 45 wt % of a plasticizer. The invention also relates to the method of preparing said composition as well as to the method of manufacturing an article starting from said composition and the article per se.

To provide a water/oil repellent composition which can impart sufficient post-air-drying water/oil repellency to the surface of an article, and which presents a low environmental impact, and an article having its surface treated with the water/oil repellent composition. A water/oil repellent composition comprising a copolymer (A) having structural units based on a monomer (a), structural units based on a monomer (b), structural units based on a monomer (c) and/or structural units based on a monomer (d); and an aqueous medium (B) containing water, and a film-forming assistant (x) and/or a film-forming assistant (y). Monomer (a): a monomer having a C1-6 polyfluoroalkyl group, monomer (b): vinylidene chloride, monomer (c): a monomer, the homopolymer of which has a glass transition temperature of at least 20° C., monomer (d): a monomer having a crosslinkable functional group, film-forming assistant (x): a specific amide solvent, and film-forming assistant (y): a specific glycol solvent.

The present invention relates to a polymer composition that includes a polymer having at least one polymer segment represented by the following Formula (I), With reference to Formula (I): M independently for each w is a residue of a monomer; φ is a residue of a mechanochromic compound having at least two reactive groups that are each independently bonded to one monomer residue M; w, independently for each z, is an integer of at least 1; and z is an integer of at least 2. The mechanochromic compound is selected from at least one of the following, (a) a spirooxazine compound represented by the following Formula (II), and (b) an indenonaphthopyran represented by the following Formula (III),

A manhole cover assembly configured to behave as a relief valve in an explosion event, opening so that fluid, such as air or explosive gas, may vent from an underground area. The manhole cover assembly may include a manhole cover and a frame, and may be configured to limit movement of the manhole cover with respect to the frame in response to increased pressure on the manhole cover. In one embodiment, the manhole cover may include legs that are configured to enable a range of movement of a portion of the cover such that the cover can be unseated at an angle with respect to the frame to allow fluids to escape from the underground area.

A package for two liquid personal care compositions, including an applicator, a first reservoir, and a second reservoir. The applicator is non-removably connected at and extends away from the first cavity. The first and second reservoirs each hold a quantity of a liquid composition therein. The first reservoir includes an open end sized for independent insertion and removal of the applicator therethrough. The first reservoir is removable and protectively encases the applicator. The second reservoir includes a closed end an opposing open end, through which a liquid composition can be dispensed.

The present invention relates to an applicator for applying a composition to keratinous fibers, in particular the eyelashes or the eyebrows, the applicator including a stem having a longitudinal axis and including at least one elastically-deformable flexible portion that is suitable for flexing during application and/or wiping; and an applicator element that is fastened to the stem and that includes a twisted wire core and bristles that extend transversally to the longitudinal axis of the stem.

A container adapted to contain and dispense a product and method for its use. The container comprises a hollow body, a filling opening, a dispensing opening, a valve and a resiliently deformable means for said valve. The valve may form a leak-tight engagement with the dispensing opening, and is openable by an external force acting on said valve whereby the leak-tight engagement is disengaged, allowing the product to be spread onto a fabric by the valve. The container may be used in a method for pretreating and subsequently laundering pretreated fabrics in an automatic washing machine.

A cover mechanism is provided for an opening and closing device, which includes a fixed plate arranged at a first housing; a moving plate arranged at a second housing; a hinge arm that is arranged between the two plates and rotates to move the moving plate between a closed position where the first and second housings overlap and an open position where surfaces of the first and second housings are substantially coplanar; and a recess formed at the second housing that prevents the hinge arm from interfering with the second housing in the open position. The cover mechanism includes a cover arranged at the moving plate that covers the recess when the moving plate is positioned at the closed position and moves from the covering position by engaging with and being urged by the rotating hinge arm; and an urging part that urges the cover toward the covering position.

A system for ventilating an explosion hazard region of an aircraft includes a ram-air channel, which has an air inlet for feeding ambient air into the ram-air channel as well as an air outlet. The ram-air channel is devised to feed air to a device that is to be cooled on board the aircraft. A ventilation line has an air inlet for feeding air flowing through the ram-air channel into the ventilation line as well as an air outlet. The ventilation line is devised to feed air to a region of the aircraft that is to be ventilated. An accumulator is disposed between the ram-air channel and the air inlet of the ventilation line and is devised to convert the dynamic pressure of the air flow conveyed through the ram-air channel at least partially into static pressure for regulating flow through the explosion hazard region.

A lead-free conductive paste composition contains a source of an electrically conductive metal, a fusible material, an optional additive, and an organic vehicle. An article such as a high-efficiency photovoltaic cell is formed by a process of deposition of the lead-free paste composition on a semiconductor substrate (e.g., by screen printing) and firing the paste to remove the organic vehicle and sinter the metal and fusible material.

An intervertebral fusion cage that is adapted to contain an inserter within its inner volume during insertion of the cage.

In accordance with this invention a binder composition for treating particulate material to form a solid aggregate matrix is prepared by providing a urea formaldehyde precondensate; a polar solvent; additional urea; an acid or salt thereof, the acid or salt thereof being selected such as to render the pH of the binder composition to a value from 2.0 to 5.3; providing a sugar; providing a binding promoter for enhancing the binding between the binder composition and the particulate material; and mixing the above so as to form a binder composition. The binder composition is mixed with particulate material and allowed to set into a solid aggregate matrix over a period of longer than 30 minutes from being mixed with the said particulate material.

Disclosed herein is a method for preparing a near infrared shielding fiber. The method includes the steps of preparing and compounding a composition, then pelletizing the compounded composition to obtain the near-infrared shielding masterbatch, and melt spinning the near-infrared shielding masterbatch into the near-infrared shielding fiber. The composition includes at least one metallic ionic compound powder in an amount of about 1-25 wt %, a cross-linking agent in an amount of about 0.1-2 wt %, a thermoplastic polymer in an amount of about 67-98.7 wt %, a cross-linking initiator in an amount of about 0.1-1 wt %, and a dispersing agent in an amount of about 0.1-2 wt %.

The invention relates to a method for the production of a layered or stacked inorganic/organic composite material, a predominantly inorganic material being provided and a polymer material being provided, characterized in that the predominantly inorganic material has a glass transition temperature or melting temperature lower than 500° C., that the predominantly inorganic material and the polymer material are each molten, and that the predominantly inorganic material and the polymer material are coextruded from the melt and thus form the composite material.

Disclosed herein is a method for utilizing the exothermic energy generated by a low temperature cure reaction to access a high-temperature cure reaction, which is otherwise energetically inaccessible at a chosen tool temperature, thereby producing a cured resin matrix with properties closely matching to those produced via high-temperature cure reactions but achieved via a short cure time and low cure temperature. Also disclosed is a short-cure resin composition containing: (a) at least one multifunctional epoxy resin having an epoxy functionality of greater than 1; (b) a hardener composition containing (i) at least one aliphatic or cycloaliphatic amine curing agent having one or more amino groups per molecule; (ii) at least one aromatic amine curing agent having one or more amino groups per molecule; and optionally, (iii) an imidazole as curing accelerator. The improved properties of this resin composition include being curable at a temperature of ≦120° C. for a time period of less than 10 minutes to achieve a degree of cure higher than that derived from the same composition with just (i) aliphatic/cycloaliphatic amine or (ii) aromatic amine in isolation.

Method of manufacturing a fibre-reinforced composite moulding, the method comprising the steps of: (a) disposing at least one layer of fibrous reinforcing material within a mould; (b) disposing at least one pre-preg layer adiacent to the fibrous reinforcing material, the pre-preg layer comprising fibrous reinforcement at least partially impregnated with uncured first resin material, to form a laminar assembly of the at least one layer of fibrous reinforcing material and the at least one pre-preg layer within the mould; (c) applying a vacuum to the assembly; (d) infusing a flowable uncured second resin material, under the vacuum, into the at least one layer of fibrous reinforcing material; and (e) curing the first and second resin materials at least partially simultaneously to form the fibre-reinforced composite moulding which comprises at least one first structural portion formed from the fibrous reinforcement and the cured first resin material bonded to at least one second structural portion formed from the at least one layer of fibrous reinforcing material and the cured second resin material.

When a molded fabric body (X) is impregnated with a powder (K) of a predetermined material, there are performed a first step of dispersing the powder (K) in a liquid to prepare a slurry, and a second step of burying the molded fabric body (X) made of fiber bundles in the slurry and vibrating the slurry by use of a predetermined vibrator (M). Furthermore, in the second step, the vibrator (M) is moved along a surface of the molded fabric body (X). As a result, it is possible to improve the rate of impregnation of the powder (K) more than that in the conventional cases, irrespective of the shape of the molded fabric body (X).

A thermoplastic composition that contains a rigid renewable polyester and has a voided structure and low density is provided. To achieve such a structure, the renewable polyester is blended with a polymeric toughening additive to form a precursor material in which the toughening additive can be dispersed as discrete physical domains within a continuous matrix of the renewable polyester. The precursor material is thereafter stretched or drawn at a temperature below the glass transition temperature of the polyester (i.e., “cold drawn”). This creates a network of voids located adjacent to the discrete domains, which as a result of their proximal location, can form a bridge between the boundaries of the voids and act as internal structural “hinges” that help stabilize the network and increase its ability to dissipate energy. The present inventors have also discovered that the voids can be distributed in a substantially homogeneous fashion throughout the composition.

Compositions of thermoplastic polyesters containing dispersed nanoparticles of fibrous clay are made by polymerizing the polyester precursors in the presence of exfoliated fibrous clay that has not been organically modified. The compositions have good physical properties and can be melt molded into various articles. Many of these articles may be coated (painted) and are especially useful for appearance parts such as visible exterior automotive body parts.

Systems and methods are provided for generating a composite video based on a plurality of asynchronously recorded input video streams. A plurality of segments of the input video streams are identified. A number of the input video streams that were recording during the particular segment are determined. A video display configuration for the particular segment is determined based on the number of video streams that were recording, where the video display configuration includes a display sub-region for each of the number of video streams that was recording. A composite video is generated, where the composite video includes a portion of video associated with each of the segments, where the composite video portion associated with the particular segment is formatted according to the video display configuration and displays the video streams that were recording during the particular segment in the display sub-regions of the video display configuration.