give me goodseed and I’ll plant it by the roadside. give me water and I will tend it, goodseed, grow it give me laughter and I will turn it, and live it with goodheart, and love it in goodlight, like softlight on bone. -♦Photo – Gottfried Helnwein♦- -short, evocative poetry-

Underneath all of our civilisation and science, we’re still primates - and the connection between patient and doctor can be reinforced by simply taking a hand. Robin Youngson, cofounder of hearts in healthcare, and Mitzi Blennerhassett, who has written extensively on patient engagement, have co-authored an editorial calling for the humanisation...

Susan Greenhalg is a research professor of chinese society in Harvard’s department of anthropology - not a natural fit for a medical journal you may think, but recently she has been looking at the influence of Coca Cola on obesity policy in China. She has written up her investigation in an article published on bmj.com this week, and joins us in...

Jönköping has been at the centre of the healthcare quality improvement movement for years - but how did a forested region of Sweden, situated between it's main cities, come to embrace the philosophy of improvement so fervently? Goran Henriks, chief executive of learning and innovation at Qulturum in Jönköping joins us to explain. He also tells...

It was not the landing the Jamaicans who arrived at Kingston’s Norman Manley International Airport on Wednesday evening would want again. The 43 Jamaican ship workers of the Marella Discovery 2 were among the 115 people aboard the TUI charter flight that touched down amid the Kingston breeze and evening sunset.

The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)–mediated β-cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the signal peptide was found to be the most prevalent in patients with recent-onset T1D. While the combined action of signal peptide peptidase and endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of the signal peptide, the mechanisms controlling signal peptide trimming and the contribution of the T1D inflammatory milieu on these mechanisms are unknown. Here, we show in human β-cells that ER stress regulates ERAP1 gene expression at posttranscriptional level via the IRE1α/miR-17-5p axis and demonstrate that inhibition of the IRE1α activity impairs processing of preproinsulin signal peptide antigen and its recognition by specific autoreactive CTLs during inflammation. These results underscore the impact of ER stress in the increased visibility of β-cells to the immune system and position the IRE1α/miR-17 pathway as a central component in β-cell destruction processes and as a potential target for the treatment of autoimmune T1D.

Members Event

Event participants

Helen Thompson, Professor of Political Economy, University of Cambridge; Host, Talking Politics
Chairs: Hans Kundnani, Senior Research Fellow, Europe Programme, Chatham House
Laura Cram, Professor of European Politics, University of Edinburgh. Co-Editor, Government and Opposition: An International Journal of Comparative Politics
 

The Trump administration took sweeping action in 2018 to slow legal immigration, make life harder for some immigrants already in the United States, rebuff would-be asylum seekers, and reduce refugee resettlement. Shaping a narrative of crisis at the border, the administration significantly changed the U.S. asylum system, deployed troops and tear gas, and separated families—yet Central American migrants continued to arrive.

The recent rise in xenophobia in Hungary stands in marked contrast with the country's rich migration history. After 390,000 migrants and asylum seekers arrived in 2015, the government of Viktor Orbán issued policies to significantly limit migration and enacted a law criminalizing humanitarian assistance to migrants. This country profile examines Hungary’s migration past and present, tracing the country’s multicultural heritage to the current wave of anti-immigrant sentiment.

How did the U.S. border enforcement picture go in the span of two years from the lowest levels of illegal immigration since 1971 to a spiraling border security and humanitarian crisis? This report draws on enforcement and other data as well as analysis of changing migration trends and policies to tell this story. The authors outline key elements for a new strategy that can succeed over the long term.

OBJECTIVE

Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes.

While much attention has been given to the move by U.S. Citizenship and Immigration Services to raise its application fees—including an 83 percent hike to apply for U.S. citizenship—the policy changes embedded in the proposed rule have been less scrutinized. The changes, including the elimination of most fee waivers for lower-income applicants, would likely reduce the number and shift the profile of those getting a green card or other immigration status.

Mexicans migrate to Canada in much smaller numbers than to the United States, yet over the last 30 years the country has become an increasingly attractive destination. Canada prioritizes highly skilled, educated Mexicans for permanent residency, but also attracts temporary workers from Mexico. This article examines Mexican migration to Canada and how it has been shaped by visa requirements, trade policy, and more.

The failure of Geert Wilders’ right-wing, anti-Islam Freedom Party (PVV) to become the top vote-getter in the Dutch parliamentary elections is being hailed as proof of the limits of anti-Muslim rhetoric and even the “waning” of the appeal of right-wing populism. But as this commentary explores, a closer reading leads one to a more nuanced interpretation of the results and the recognition that Wilders will remain a major force.

When Warren Buffett announced last week that he will be giving away more than $30 billion to improve health, nutrition and education, people all over America reflected on his remarkable generosity, pondered all the noble things the gift would achieve and asked themselves what they would do if...

The United States is awash in gloom. Overwhelming majorities of Americans say they are dissatisfied with the country's economic direction, and the intensity of unhappiness is greater than it has been in 15 years, according to a recent Washington Post-ABC News poll. The answer, pundits, politicians...

Nearly a century ago, American middle-distance runner Abel Kiviat entered the Stockholm Olympics as the odds-on favorite to win the 1,500-meter race, an event in which he held the world record. Kiviat had the lead 1,492 meters into the race but was passed in the final eight meters by Britain's...

This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Alice in Frames. www.aliceinframes.com

The public-charge rule issued by the Trump administration in August 2019 will have profound effects on future immigration and on use of public benefits by millions of legal noncitizens and their U.S.-citizen family members. Complex standards for determining when an immigrant is likely to become a public charge could cause a significant share of the nearly 23 million noncitizens and U.S. citizens in benefits-using immigrant families to disenroll, as this commentary explains.

CALL FOR PAPERSINTERNATIONAL WORKSHOP Shaping the ‘Socialist Self’? The Role of Psy-Sciences in Communist States of the Eastern Bloc (1948–1989) Date: 6 November 2020 Venue: Prague, Czech Republic Deadline for applications: 30 June 2020 Organizing institutions: CEFRES (French Research Center in Humanities and Social Sciences in Prague) Institute of Contemporary History of the Czech Academy of Sciences Collegium Carolinum … Continue reading CfP: Shaping the ‘Socialist Self’? The Role of Psy-Sciences in Communist States of the Eastern Bloc (1948–1989) →

What if the government ran more like Silicon Valley? Engineer Matt Cutts shares why he decided to leave Google (where he worked for nearly 17 years) for a career in the US government -- and makes the case that if you really want to make an impact, go where your help is needed most.

The coronavirus pandemic put India's population of 1.3 billion into an extreme and sudden lockdown. Social entrepreneur Gayathri Vasudevan explains how the situation is impacting the country's migrant workers, who are stuck far from home with limited access to food and shelter, and calls for an overhaul of India's social infrastructure in order to get people the essentials they need right now. (This virtual conversation is part of the TED Connects series, hosted by current affairs curator Whitney Pennington Rodgers. Recorded April 9, 2020)

To combat COVID-19, countries have enforced city-wide shutdowns, stay-at-home orders and mask mandates -- but the reaction (and adherence) to these rules has differed markedly in the East and West. In conversation with TED's head of curation Helen Walters, writer and publisher Huang Hung sheds light on how Chinese and American cultural values shaped their responses to the outbreak -- and provides perspective on why everyone needs to come together to end the pandemic. (Recorded April 16, 2020)

By Emily Reynolds. But self-assessed intelligence was not actually related to objective measures of intelligence

By Emily Reynolds. Study finds viewers had slightly more negative perceptions of people with mental illness after seeing the movie.

A California teacher battling breast cancer made headlines recently when she was told state law required her to pay for the cost of a sub during her treatment. Where else are these kinds of sick leave policies in place? And why aren’t the unions doing more to fight them?

What goes on behind all the closed doors in politics? Most teachers never get a chance to find out, writes teacher-turned-politician John Waldron.

Hawaii's schools are prepared to respond to ballistic missile threats, education officials wrote in a letter to parents after Saturday's false alarm.

The NFL wants college football season to proceed as usual in 2020. It may proceed, but there's a good chance it will be very unusual. Via Sports Business Daily, commissioners of two of the Power Five conferences (Kevin Warren of the Big 10 and Greg Sankey of the SEC) have hinted in recent days at [more]

"It is timely that the higher education sector examines paths forward to address and indeed engage in the new environment in which it will work in the future. This fellowship explored two approaches to engage students more deeply in their education. The first approach is generally termed 'interdisciplinary studies' where students define their own program of study; the second approach focuses on topic structure where students are given a wide range of choice and in effect can build a topic that suits their interests."--Page iv.

English language -- Textbooks for foreign speakers.

Self-actualization (Psychology)

Feminism and art.

Vestibular apparatus -- Diseases.

American essays -- 21st century.

19th century

London : Rebman, 1901.

London : Bailliere, Tindall and Cox, 1884.

The nation's largest tax-credit scholarship program doesn't seem to have hurt the academics of students who remain in public schools, a new study shows.

When Idaho education leaders pitched social-emotional learning training for teachers, some state lawmakers compared the plan to dystopian behavior control. Some walked out of the meeting.

[Paris], [1807]

'The Comeback on Katella' was complete when Corey Perry scored the winning goal in double overtime to give the Ducks a 4-3 victory and 3-2 series lead.

Led by Hecht’s two goals and Briere’s three assists, the Sabres emerged with a 5-4 victory to claim what remains their most recent playoff series win.

The win was the first of four straight for the Flyers, culminating in a historic comeback over the Bruins.

Spanking new stadiums in Los Angeles and Las Vegas unveiled in prime time. Business as usual, and you really can't blame the NFL for that. “The release of the NFL schedule is something our fans eagerly anticipate every year, as they look forward with hope and optimism to the season ahead,” Commissioner Roger Goodell said.

2018

2017

Durham, [NC] : Duke University Press, 2010.