epa Ex-NFL star Brett Favre to repay $1.1 million for no-show speeches: auditor By www.nydailynews.com Published On :: Thu, 07 May 2020 20:52:13 +0000 Former NFL star Brett Favre said Wednesday he would repay the state of Mississippi $1.1 million after a state auditor discovered the Mississippi Department of Human Services paid the ex-quarterback for speaking engagements that never happened. Full Article
epa LAUSD packs 400,000 meals, prepares for months of 'grab-and-go.' Recipients express relief By www.latimes.com Published On :: Wed, 18 Mar 2020 18:10:51 -0400 One man wore plastic gloves and a face mask as he pulled up in a pickup to receive school-packed meals for his children. Full Article
epa Cal State Fullerton preparing to go online this fall. Will others follow? By www.latimes.com Published On :: Tue, 21 Apr 2020 13:42:24 -0400 Cal State Fullerton says that amid coronavirus uncertainty it will prepare to start the fall semester with online instruction. Will other campuses follow suit? Full Article
epa Op-Ed: Seven ways the AIDS epidemic prepared me for COVID-19 By www.latimes.com Published On :: Thu, 30 Apr 2020 06:00:55 -0400 The way the gay community responded to the AIDS crisis of the 1980s and 1990s has lessons for us all in the coronavirus pandemic. Full Article
epa One year on, how is London prepared to prevent another Notre Dame? By www.london-fire.gov.uk Published On :: Tue, 14 Apr 2020 18:58:10 +0100 London fire Brigade is warning managers of London’s closed historic venues not to be complacent about fire safety during the coronavirus outbreak Full Article
epa Tomie dePaola, beloved children's author and illustrator of 'Strega Nona,' dies at 85 By www.latimes.com Published On :: Tue, 31 Mar 2020 14:51:09 -0400 DePaola wrote or illustrated more than 270 children's books, sold nearly 25 million copies and had his books translated into more than 20 languages. Full Article
epa Letters to the Editor: Trump didn't prepare for the coronavirus, and neither did you By www.latimes.com Published On :: Sat, 18 Apr 2020 06:00:35 -0400 People who blame the president for failing to prepare the country ignore an important fact: We didn't want to believe America was vulnerable to COVID-19. Full Article
epa Coronavirus: Airlines preparing for future with fewer passengers and higher fares By www.independent.co.uk Published On :: 2020-04-14T15:32:00Z Tickets could cost 50% more because of 'de-densification' Full Article
epa 'We've been abandoned by our own embassy': Britons denied repatriation from Peru to London amid coronavirus chaos By www.independent.co.uk Published On :: 2020-04-17T13:48:00Z The 11 UK citizens left in Peru say they are 'terrified' they won't be put on a flight before the country officially shuts its borders on 22 April Full Article
epa World's biggest mass migration begins as China prepares to mark New Year By www.independent.co.uk Published On :: 2020-01-17T13:46:00Z Three billion trips to be made during Spring Harvest Full Article
epa Justice Department spots signs of fraud in applications for small business coronavirus bailout By www.independent.co.uk Published On :: 2020-05-01T20:37:18Z 'Whenever there's a trillion dollars out on the street that quickly, the fraudsters are going to come out of the woodwork' Full Article
epa Tesla loses $408 million as technology chief J.B. Straubel departs By www.latimes.com Published On :: Wed, 24 Jul 2019 17:25:08 -0400 Tesla's $408-million second-quarter loss raises the question: How will Tesla ever make money? Full Article
epa Martin Lewis says simple tips could prevent motorists from 'shelling out' for car repairs By feedproxy.google.com Published On :: Thu, 07 May 2020 07:06:00 +0100 MARTIN LEWIS has urged motorists to maintain their car in a good condition to prevent drivers from "shelling out" for repairs once the coronavirus lockdown is lifted. Full Article
epa Princess Diana’s row with John Major over royal departure exposed By feedproxy.google.com Published On :: Sat, 09 May 2020 15:46:00 +0100 PRINCESS DIANA's separation from Prince Charles was a messy affair - and it turns out even then-Prime Minister John Major waded into the row. Full Article
epa Pirates of the Caribbean 6 ‘is SEPARATE’ to potential female spin-off: TWO movies possible By feedproxy.google.com Published On :: Thu, 07 May 2020 09:54:00 +0100 PIRATES OF THE CARIBBEAN 6 is separate to a possible female-led spin-off, according to a Disney insider. We could be looking at two movies with Johnny Depp's Jack Sparrow returning. Full Article
epa Indianapolis police officers arrested in separate incidents unrelated to this week's shooting By rssfeeds.indystar.com Published On :: Fri, 08 May 2020 22:24:43 +0000 Two Indianapolis police officers have been arrested in separate and unrelated incidents. Full Article
epa Fishers announces coronavirus recovery plan, would become 3rd city with health department By rssfeeds.indystar.com Published On :: Thu, 23 Apr 2020 18:28:02 +0000 Fishers Mayor Scott Fadness announced Thursday that the city will seek to establish its own health department. Full Article
epa How fifth, eighth graders are preparing to leave elementary, middle school away from peers By rssfeeds.indystar.com Published On :: Tue, 21 Apr 2020 09:00:10 +0000 With schools closed, fifth and eighth grade students navigate the transition from elementary to middle school or middle to high school on their own. Full Article
epa Secret to landing top-30 target Zeke Nnaji could lie in Indiana's music department By rssfeeds.indystar.com Published On :: Mon, 30 Jul 2018 00:32:41 +0000 Zeke Nnaji, a four-star, top-30 power forward from just outside Minneapolis, is arguably as good a pianist as he is a basketball player. Full Article
epa IU soccer coach believes culture will continue through separation By rssfeeds.indystar.com Published On :: Wed, 15 Apr 2020 16:30:55 +0000 Todd Yeagley is confident his players will carry out workouts and improve despite not being able to practice together. Full Article
epa NFL Draft 2020: IU lineman Simon Stepaniak picked by Green Bay Packers By rssfeeds.indystar.com Published On :: Sat, 25 Apr 2020 21:42:09 +0000 Simon Stepaniak started 31 games for the Indiana Hoosiers, mostly at guard; that's the second year in a row an IU guard was picked. Full Article
epa Green Bay Packers give IU football's Simon Stepaniak chance to chase NFL dream By rssfeeds.indystar.com Published On :: Mon, 27 Apr 2020 14:20:22 +0000 The Packers selected the Hoosiers' offensive lineman in the sixth round. Full Article
epa Indianapolis police officers arrested in separate incidents unrelated to this week's shooting By rssfeeds.indystar.com Published On :: Fri, 08 May 2020 22:24:43 +0000 Two Indianapolis police officers have been arrested in separate and unrelated incidents. Full Article
epa We need to prepare for the mental health impact of coronavirus on kids By www.latimes.com Published On :: Thu, 7 May 2020 11:00:29 -0400 More children are likely to experience toxic stress during the pandemic, which could lead to devastating impacts in the future. Full Article
epa California's tourism-dependent towns cautiously prepare new marketing for reopening By www.latimes.com Published On :: Sat, 9 May 2020 10:00:36 -0400 Tourist spots prepare to welcome visitors once coronavirus restrictions are lifted Full Article
epa Mount Everest: Nepal's government shuts off mountain amid virus outbreak By www.bbc.co.uk Published On :: Fri, 13 Mar 2020 02:23:40 GMT The highest mountain in the world will be closed to climbers until at least 30 April. Full Article
epa ‘Hey, Google! Let me talk to my departed father.’ By www.washingtonpost.com Published On :: Thu, 29 Aug 2019 20:29:25 +0000 If all goes according to plan, future generations will be able to interact with departed relatives using mobile devices or virtual assistants such as Amazon’s Alexa, asking the deceased questions, eliciting stories and drawing upon a lifetime’s worth of advice long after their physical body is gone. Full Article
epa Fordham University business students have a new tool to prepare them for boardrooms: Virtual reality By www.washingtonpost.com Published On :: Tue, 12 Nov 2019 17:42:02 +0000 Fordham University business students are using virtual reality to prepare them for boardrooms. Full Article
epa How would we repair the damage in a post-Trump America? By www.washingtonpost.com Published On :: Fri, 05 Jul 2019 16:00:22 +0000 Two new books critical of the president -- one from the left, one from the right -- imagine a path beyond our current divisions. Full Article
epa For many immigrants, family separation happens long before the border By www.washingtonpost.com Published On :: Fri, 30 Aug 2019 14:00:45 +0000 Review of 'A Good Provider Is One Who Leaves: One Family and Migration in the 21st Century' by Jason DeParle Full Article
epa Tomie dePaola: We will miss him — but what a legacy! By feedproxy.google.com Published On :: Mon, 06 Apr 2020 13:54:21 EDT The world lost an incredible talent with the death of Tomie dePaola. Full Article
epa Tomie dePaola: We will miss him — but what a legacy! By feedproxy.google.com Published On :: Mon, 06 Apr 2020 13:45 EDT The world lost an incredible talent with the death of Tomie dePaola. Full Article
epa REALTORS® Respond to EPA's Proposed WOTUS Revision By feedproxy.google.com Published On :: Wed, 12 Dec 2018 21:48:24 +0000 REALTORS® Respond to EPA's Proposed WOTUS Revision Shannon McGahn, NAR's Vice President of Government Affairs, issued the following statement after the EPA yesterday unveiled a proposal to change... By: Wesley Shaw Full Article
epa News24.com | Covid-19 wrap | China slams US after Trump virus 'attack' claim, India repatriation to begin and Poland, Syria postpone elections due to pandemic By www.news24.com Published On :: Thu, 07 May 2020 14:57:56 +0200 Here are the latest developments in the coronavirus crisis. Full Article
epa Channel24.co.za | Minister Nathi Mthethwa provides an update on the Department of Sports, Arts and Culture's Corona relief fund By www.channel24.co.za Published On :: Sat, 09 May 2020 13:47:23 +0200 On 4 May, 2020 Minister Nathi Mthethwa hosted a briefing, updating the public on the Department of Sports, Arts and Cultures Corona relief funds, and the received applications. Full Article
epa News24.com | Using printing presses for the SARB to repay Eskom loans By www.news24.com Published On :: Wed, 18 Mar 2020 09:31:27 +0200 So it is difficult to imagine who would want to stop the SARB if it would help reduce load shedding and contain further job losses.A similar argument arises in providing social houses to replace our dangerous rusty corrugated iron suburbs. Full Article
epa How Offices Are Preparing for Workers' Return By feedproxy.google.com Published On :: Thu, 07 May 2020 00:00:00 -0500 From smartphone-operated elevators to contactless coffee machines, businesses are trying to eliminate major touchpoints to help deter coronavirus spread in the workplace. Full Article
epa AT#205 - Travel to Nepal and Everest By asia.amateurtraveler.com Published On :: Sat, 31 Oct 2009 14:00:00 +0000 The Amateur Traveler talks to Jon Miller of the Rest of Everest podcast about his journeys in Nepal. Jon originally went to Nepal as part of a film he was shooting on an Everest expedition, but as Jon tells it you come for the mountain but fall in love with the people and the culture. Jon describes Kathmandu with is various temples or stupas like Swayambhunath (the monkey temple) and Boudhanath with crowds of people performing a kora around them. He tells us places to get a good meal in Thamel (the tourist district) and suggests a day trip to the well preserved city of Bhaktapur. After Katmandu Jon tells us about trekking and also hiking up to Everest basecamp where the altitude can be very challenging (and Jon lives up at 6000 feet at home in Colorado). Full Article
epa AT#492 - Trekking the Annapurna Circuit in Nepal By asia.amateurtraveler.com Published On :: Sat, 28 Nov 2015 15:30:00 +0000 Hear about Trekking the Annapurna Circuit in Nepal as the Amateur Traveler talks to the Su Family from sufamilyadventures.com about tackling this well known route. Full Article
epa The unreasonable importance of data preparation By feedproxy.google.com Published On :: Tue, 24 Mar 2020 10:00:00 +0000 In a world focused on buzzword-driven models and algorithms, you’d be forgiven for forgetting about the unreasonable importance of data preparation and quality: your models are only as good as the data you feed them. This is the garbage in, garbage out principle: flawed data going in leads to flawed results, algorithms, and business decisions. […] Full Article AI & ML Deep Dive
epa Video: Stars' Oscar preparations By www.bbc.co.uk Published On :: 2008-02-22T12:30:00 Part of the Going for gold promo for the BBC UK Homepage Full Article
epa Breaking: Justice Department Dropping Michael Flynn Criminal Case By 100percentfedup.com Published On :: Thu, 07 May 2020 18:47:49 +0000 The following article, Breaking: Justice Department Dropping Michael Flynn Criminal Case, was first published on 100PercentFedUp.com. Michael Flynn has finally been exonerated. The Associated Press is reporting exclusively that the Justice Department said it is dropping the criminal case against President Trump’s first national security adviser, Michael Flynn. In court documents being filed Thursday, the Justice Department said it is dropping the case “after a considered review of all the facts […] Continue reading: Breaking: Justice Department Dropping Michael Flynn Criminal Case ... Full Article Breaking Crime Featured Politics
epa VIDEO: Man seen kicking gas pump to avoid prepayment By winnipeg.ctvnews.ca Published On :: Fri, 8 May 2020 13:37:00 -0600 Brandon police officers are searching for a man who was caught on camera attempting to pump gas in his car – without prepaying. Full Article
epa The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3 [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC. Full Article
epa Zinc promotes liquid-liquid phase separation of tau protein [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau can undergo liquid–liquid phase separation (LLPS), forming highly dynamic liquid droplets. Here, using recombinantly expressed proteins, turbidimetry, fluorescence microscopy imaging, and fluorescence recovery after photobleaching (FRAP) assays, we show that the divalent transition metal zinc strongly promotes this process, shifting the equilibrium phase boundary to lower protein or crowding agent concentrations. We observed no tau LLPS-promoting effect for any other divalent transition metal ions tested, including Mn2+, Fe2+, Co2+, Ni2+, and Cu2+. We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting effect and provide insights into the mechanism of this process. Zinc concentration is highly elevated in AD brains, and this metal ion is believed to be an important player in the pathogenesis of this disease. Thus, the present findings bring a new dimension to understanding the relationship between zinc homeostasis and the pathogenic process in AD and related neurodegenerative disorders. Full Article
epa Biosecurity: Preparing for the Aftermath of Global Health Crises By feedproxy.google.com Published On :: Thu, 09 Jan 2020 14:16:59 +0000 9 January 2020 Professor David R Harper CBE Senior Consulting Fellow, Global Health Programme @DavidRossHarper Benjamin Wakefield Research Associate, Global Health Programme @BCWakefield LinkedIn The Ebola outbreak in the Democratic Republic of the Congo is a reminder that the security of samples taken during global health emergencies is a vital part of safeguarding biosecurity. 2020-01-09-DRC.jpg A nurse prepares a vaccine against Ebola in Goma in August 2019. Photo: Getty Images. The world’s second-largest Ebola outbreak is ongoing in the Democratic Republic of the Congo (DRC) and experts from around the world have been parachuted in to support the country’s operation to stamp out the outbreak. The signs are encouraging, but we need to remain cautious.In such emergencies, little thought is usually given to what happens to the body-fluid samples taken during the course of the outbreak after the crisis is over. What gets left behind has considerable implications for global biosecurity.Having unsecured samples poses the obvious risk of accidental exposures to people who might come into contact with them, but what of the risk of malicious use? Bioterrorists would have ready access to materials that have the characteristics essential to their purpose: the potential to cause disease that is transmissible from person to person, the capacity to result in high fatality rates and, importantly, the ability to cause panic and social disruption at the very mention of them.Comparisons can be drawn with the significant international impact of the anthrax attacks in the US in 2001. Not only was there a direct effect in the US with five deaths and a further 17 people infected, but there was a paralysis of public health systems in other countries involved in the testing of countless samples from the so-called ‘white-powder incidents’ that followed.Many laboratory tests were done purely on a precautionary basis to eliminate any possibility of a risk, no matter how remote. However, the UK was also hit when a hoaxer sent envelopes of white powder labelled as anthrax to 15 MPs.The threat of the pathogen alone resulted in widespread fear, the deployment of officers trained in response to chemical, biological, radiological and nuclear incidents and the evacuation of a hospital emergency department.We learned from the 2014–16 West Africa Ebola outbreaks that during the emergency, the future biosecurity implications of the many thousands of samples taken from people were given very little consideration. It is impossible to be sure where they all are and whether they have been secured.It is widely recognized that the systems needed at the time for tracking and monitoring resources, including those necessary for samples, were weak or absent, and this has to be addressed urgently along with other capacity-building initiatives.In Sierra Leone, for example, the remaining biosecurity risk is only being addressed after the fact. To help achieve this, the government of Canada is in the process of providing a secure biobank in the Sierra Leonean capital of Freetown. The aim is to provide the proper means of storage for these hazardous samples and to allow them to remain in-country, with Sierra Leonean ownership.However, it is already more three years since the emergency was declared over by the then director-general of the World Health Organization (WHO), Margaret Chan, and the biobank and its associated laboratory are yet to be fully operational.There are many understandable reasons for this delay, including the critical issue of how best to ensure the sustainability of any new facility. But what is clear is that these solutions take time to implement and must be planned for in advance.The difficulties of responding to an outbreak in a conflict zone have been well documented, and the frequent violence in DRC has undoubtedly caused delays in controlling the outbreak. According to figures from WHO, during 2019 approximately 390 attacks on health facilities in DRC killed 11 and injured 83 healthcare workers and patients.Not only does the conflict inhibit the response, but it could also increase the risk posed by unsecured samples. There are two main potential concerns.First is the risk of accidental release during an attack on a health facility, under which circumstances sample containers may be compromised or destroyed. Second is that the samples may be stolen for malicious use or to sell them to a third-party for malicious use. It is very important in all outbreaks to ensure the necessary measures are in place to secure samples; in conflict-affected areas, this is particularly challenging.The sooner the samples in the DRC are secured, the sooner this risk to global biosecurity is reduced. And preparations for the next emergency must be made without further delay.The following steps need to be taken:Affected countries must ‘own’ the problem, with clear national government commitment to take the required actions.Funding partners must coordinate their actions and work closely with the countries to find the best solutions.If samples are to be kept in-country, secure biobanks must be established to contain them.Sustainable infrastructure must be built for samples to be kept secure into the future.An international agreement should be reached on the best approach to take to prepare for the aftermath of global health emergencies. Full Article
epa Why an Inclusive Circular Economy is Needed to Prepare for Future Global Crises By feedproxy.google.com Published On :: Wed, 15 Apr 2020 13:23:01 +0000 15 April 2020 Patrick Schröder Senior Research Fellow, Energy, Environment and Resources Programme @patricks_CH Google Scholar The risks associated with existing production and consumption systems have been harshly exposed amid the current global health crisis but an inclusive circular economy could ensure both short-term and long-term resilience for future challenges. 2020-04-15-Waste-Collection-Peru.jpg Lima city employees picking up garbage during lockdown measures in Peru amid the COVID-19 crisis. Photo: Getty Images. The world is currently witnessing how vulnerable existing production and consumption systems are, with the current global health crisis harshly exposing the magnitude of the risks associated with the global economy in its current form, grounded, as it is, in a linear system that uses a ‘take–make–throw away’ approach.These ‘linear risks’ associated with the existing global supply chain system are extremely high for national economies overly dependent on natural resource extraction and exports of commodities like minerals and metals. Equally vulnerable are countries with large manufacturing sectors of ready-made garments and non-repairable consumer goods for western markets. Furthermore, workers and communities working in these sectors are vulnerable to these changes as a result of disruptive technologies and reduced demand.In a recently published Chatham House research paper, ‘Promoting a Just Transition to an Inclusive Circular Economy’, we highlight why a circular economy approach presents the world with a solution to old and new global risks – from marine plastic pollution to climate change and resource scarcity.Taking the long viewSo far, action to transition to a circular economy has been slow compared to the current crisis which has mobilized rapid global action. For proponents of transitioning to a circular economy, this requires taking the long view. The pandemic has shown us that global emergencies can fast-forward processes that otherwise might take years, even decades, to play out or reverse achievements which have taken years to accomplish.In this vein, there are three striking points of convergence between the COVID-19 pandemic and the need to transition to an inclusive circular economy.Firstly, the current crisis is a stark reminder that the circular economy is not only necessary to ensure long-term resource security but also short-term supplies of important materials. In many cities across the US, the UK and Europe, councils have suspended recycling to focus on essential waste collection services. The UK Recycling Association, for example, has warned about carboard shortages due to disrupted recycling operations with possible shortages for food and medicine packaging on the horizon.Similarly, in China, most recycling sites were shut during the country’s lockdown presenting implications for global recycling markets with additional concerns that there will be a fibre shortage across Europe and possibly around the world.Furthermore, worldwide COVID-19 lockdowns are resulting in a resurgence in the use of single-use packaging creating a new wave of plastic waste especially from food deliveries – already seen in China – with illegal waste fly-tipping dramatically increasing in the UK since the lockdown.In this vein, concerns over the current global health crisis is reversing previous positive trends where many cities had established recycling schemes and companies and consumers had switched to reusable alternatives.Secondly, the need to improve the working conditions of the people working in the informal circular economy, such as waste pickers and recyclers, is imperative. Many waste materials and recyclables that are being handled and collected may be contaminated as a result of being mixed with medical waste.Now, more than ever, key workers in waste management, collection and recycling require personal protective equipment and social protection to ensure their safety as well as the continuation of essential waste collection so as not to increase the potential for new risks associated with additional infectious diseases.In India, almost 450 million workers including construction workers, street vendors and landless agricultural labourers, work in the informal sector. In the current climate, the poorest who are unable to work pose a great risk to the Indian economy which could find itself having to shut down.Moreover, many informal workers live in make-shift settlements areas such as Asia’s largest slum, Dharavi in Mumbai, where health authorities are now facing serious challenges to contain the spread of the disease. Lack of access to handwashing and sanitation facilities, however, further increase these risks but circular, decentralized solutions could make important contributions to sustainable sanitation, health and improved community resilience.Thirdly, it is anticipated that in the long term several global supply chains will be radically changed as a result of transformed demand patterns and the increase in circular practices such as urban mining for the recovery and recycling of metals or the reuse and recycling of textile fibres and localized additive manufacturing (e.g. 3D printing).Many of these supply chains and trade flows have now been already severely disrupted due to the COVID-19 pandemic. For example, the global garment industry has been particularly hard-hit due to the closure of outlets amid falling demand for apparel.It is important to note, workers at the bottom of these garment supply chains are among the most vulnerable and most affected by the crisis as global fashion brands, for example, have been cancelling orders – in the order of $6 billion in the case of Bangladesh alone. Only after intense negotiations are some brands assuming financial responsibility in the form of compensation wage funds to help suppliers in Myanmar, Cambodia and Bangladesh to pay workers during the ongoing crisis.In addition, the current pandemic is damaging demand for raw materials thereby affecting mining countries. Demand for Africa’s commodities in China, for example, has declined significantly, with the impact on African economies expected to be serious, with 15 per cent of the world’s copper and 20 per cent of the world’s zinc mines currently going offline. A further threat is expected to come from falling commodity prices as a result of the curtailment of manufacturing activity in China particularly for crude oil, copper, iron ore and other industrial commodities which, in these cases, will have direct impacts on the Australian and Canadian mining sectors.This is all being compounded by an associated decline in consumer demand worldwide. For example, many South African mining companies – leading producers of metals and minerals – have started closing their mining operations following the government’s announcement of a lockdown in order to prevent the transmission of the virus among miners who often work in confined spaces and in close proximity with one another. As workers are laid off due to COVID-19, there are indications that the mining industry will see fast-tracking towards automated mining operations. All of these linear risks that have been exposed through the COVID-19 pandemic reinforce the need for a just transition to a circular economy. But while the reduction in the consumption of resources is necessary to achieve sustainability, the social impacts on low- and middle- income countries and their workers requires international support mechanisms.In addition, the current situation also highlights the need to find a new approach to globalized retail chains and a balance between local and global trade based on international cooperation across global value chains rather than implementation of trade protectionist measures.In this vein, all of the recovery plans from the global COVID-19 pandemic need to be aligned with the principles of an inclusive circular economy in order to ensure both short-term and long-term resilience and preparedness for future challenges and disruptions. Full Article
epa Legal Provision for Crisis Preparedness: Foresight not Hindsight By feedproxy.google.com Published On :: Tue, 21 Apr 2020 17:03:31 +0000 21 April 2020 Dr Patricia Lewis Research Director, Conflict, Science & Transformation; Director, International Security Programme @PatriciaMary COVID-19 is proving to be a grave threat to humanity. But this is not a one-off, there will be future crises, and we can be better prepared to mitigate them. 2020-04-21-Nurse-COVID-Test Examining a patient while testing for COVID-19 at the Velocity Urgent Care in Woodbridge, Virginia. Photo by Chip Somodevilla/Getty Images. A controversial debate during COVID-19 is the state of readiness within governments and health systems for a pandemic, with lines of the debate drawn on the issues of testing provision, personal protective equipment (PPE), and the speed of decision-making.President Macron in a speech to the nation admitted French medical workers did not have enough PPE and that mistakes had been made: ‘Were we prepared for this crisis? We have to say that no, we weren’t, but we have to admit our errors … and we will learn from this’.In reality few governments were fully prepared. In years to come, all will ask: ‘how could we have been better prepared, what did we do wrong, and what can we learn?’. But after every crisis, governments ask these same questions.Most countries have put in place national risk assessments and established processes and systems to monitor and stress-test crisis-preparedness. So why have some countries been seemingly better prepared?Comparing different approachesSome have had more time and been able to watch the spread of the disease and learn from those countries that had it first. Others have taken their own routes, and there will be much to learn from comparing these different approaches in the longer run.Governments in Asia have been strongly influenced by the experience of the SARS epidemic in 2002-3 and - South Korea in particular - the MERS-CoV outbreak in 2015 which was the largest outside the Middle East. Several carried out preparatory work in terms of risk assessment, preparedness measures and resilience planning for a wide range of threats.Case Study of Preparedness: South KoreaBy 2007, South Korea had established the Division of Public Health Crisis Response in Korea Centers for Disease Control and Prevention (KCDC) and, in 2016, the KCDC Center for Public Health Emergency Preparedness and Response had established a round-the-clock Emergency Operations Center with rapid response teams.KCDC is responsible for the distribution of antiviral stockpiles to 16 cities and provinces that are required by law to hold and manage antiviral stockpiles.And, at the international level, there are frameworks for preparedness for pandemics. The International Health Regulations (IHR) - adopted at the 2005 World Health Assembly and binding on member states - require countries to report certain disease outbreaks and public health events to the World Health Organization (WHO) and ‘prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks, and which avoid unnecessary interference with international traffic and trade’.Under IHR, governments committed to a programme of building core capacities including coordination, surveillance, response and preparedness. The UN Sendai Framework for Disaster Risk highlights disaster preparedness for effective response as one of its main purposes and has already incorporated these measures into the Sustainable Development Goals (SDGs) and other Agenda 2030 initiatives. UN Secretary-General António Guterres has said COVID-19 ‘poses a significant threat to the maintenance of international peace and security’ and that ‘a signal of unity and resolve from the Council would count for a lot at this anxious time’.Case Study of Preparedness: United StatesThe National Institutes of Health (NIH) and the Center for Disease Control (CDC) established PERRC – the Preparedness for Emergency Response Research Centers - as a requirement of the 2006 Pandemic and All-Hazards Preparedness Act, which required research to ‘improve federal, state, local, and tribal public health preparedness and response systems’.The 2006 Act has since been supplanted by the 2019 Pandemic and All-Hazards Preparedness and Advancing Innovation Act. This created the post of Assistant Secretary for Preparedness and Response (ASPR) in the Department for Health and Human Services (HHS) and authorised the development and acquisitions of medical countermeasures and a quadrennial National Health Security Strategy.The 2019 Act also set in place a number of measures including the requirement for the US government to re-evaluate several important metrics of the Public Health Emergency Preparedness cooperative agreement and the Hospital Preparedness Program, and a requirement for a report on the states of preparedness and response in US healthcare facilities.This pandemic looks set to continue to be a grave threat to humanity. But there will also be future pandemics – whether another type of coronavirus or a new influenza virus – and our species will be threatened again, we just don’t know when.Other disasters too will befall us – we already see the impacts of climate change arriving on our doorsteps characterised by increased numbers and intensity of floods, hurricanes, fires, crop failure and other manifestations of a warming, increasingly turbulent atmosphere and we will continue to suffer major volcanic eruptions, earthquakes and tsunamis. All high impact, unknown probability events.Preparedness for an unknown future is expensive and requires a great deal of effort for events that may not happen within the preparers’ lifetimes. It is hard to imagine now, but people will forget this crisis, and revert to their imagined projections of the future where crises don’t occur, and progress follows progress. But history shows us otherwise.Preparations for future crises always fall prey to financial cuts and austerity measures in lean times unless there is a mechanism to prevent that. Cost-benefit analyses will understandably tend to prioritise the urgent over the long-term. So governments should put in place legislation – or strengthen existing legislation – now to ensure their countries are as prepared as possible for whatever crisis is coming.Such a legal requirement would require governments to report back to parliament every year on the state of their national preparations detailing such measures as:The exact levels of stocks of essential materials (including medical equipment)The ability of hospitals to cope with large influx of patientsHow many drills, exercises and simulations had been organised – and their findingsWhat was being done to implement lessons learned & improve preparednessIn addition, further actions should be taken:Parliamentary committees such as the UK Joint Committee on the National Security Strategy should scrutinise the government’s readiness for the potential threats outlined in the National Risk register for Civil Emergencies in-depth on an annual basis.Parliamentarians, including ministers, with responsibility for national security and resilience should participate in drills, table-top exercises and simulations to see for themselves the problems inherent with dealing with crises.All governments should have a minister (or equivalent) with the sole responsibility for national crisis preparedness and resilience. The Minister would be empowered to liaise internationally and coordinate local responses such as local resilience groups.There should be ring-fenced budget lines in annual budgets specifically for preparedness and resilience measures, annually reported on and assessed by parliaments as part of the due diligence process.And at the international level:The UN Security Council should establish a Crisis Preparedness Committee to bolster the ability of United Nations Member States to respond to international crisis such as pandemics, within their borders and across regions. The Committee would function in a similar fashion as the Counter Terrorism Committee that was established following the 9/11 terrorist attacks in the United States.States should present reports on their level of preparedness to the UN Security Council. The Crisis Preparedness Committee could establish a group of experts who would conduct expert assessments of each member state’s risks and preparedness and facilitate technical assistance as required.Regional bodies such as the OSCE, ASEAN and ARF, the AU, the OAS, the PIF etc could also request national reports on crisis preparedness for discussion and cooperation at the regional level.COVID-19 has been referred to as the 9/11 of crisis preparedness and response. Just as that shocking terrorist attack shifted the world and created a series of measures to address terrorism, we now recognise our security frameworks need far more emphasis on being prepared and being resilient. Whatever has been done in the past, it is clear that was nowhere near enough and that has to change.Case Study of Preparedness: The UKThe National Risk Register was first published in 2008 as part of the undertakings laid out in the National Security Strategy (the UK also published the Biological Security Strategy in July 2018). Now entitled the National Risk Register for Civil Emergencies it has been updated regularly to analyse the risks of major emergencies that could affect the UK in the next five years and provide resilience advice and guidance.The latest edition - produced in 2017 when the UK had a Minister for Government Resilience and Efficiency - placed the risk of a pandemic influenza in the ‘highly likely and most severe’ category. It stood out from all the other identified risks, whereas an emerging disease (such as COVID-19) was identified as ‘highly likely but with moderate impact’.However, much preparatory work for an influenza pandemic is the same as for COVID-19, particularly in prepositioning large stocks of PPE, readiness within large hospitals, and the creation of new hospitals and facilities.One key issue is that the 2017 NHS Operating Framework for Managing the Response to Pandemic Influenza was dependent on pre-positioned ’just in case’ stockpiles of PPE. But as it became clear the PPE stocks were not adequate for the pandemic, it was reported that recommendations about the stockpile by NERVTAG (the New and Emerging Respiratory Virus Threats Advisory Group which advises the government on the threat posed by new and emerging respiratory viruses) had been subjected to an ‘economic assessment’ and decisions reversed on, for example, eye protection.The UK chief medical officer Dame Sally Davies, when speaking at the World Health Organization about Operation Cygnus – a 2016 three-day exercise on a flu pandemic in the UK – reportedly said the UK was not ready for a severe flu attack and ‘a lot of things need improving’.Aware of the significance of the situation, the UK Parliamentary Joint Committee on the National Security Strategy launched an inquiry in 2019 on ‘Biosecurity and human health: preparing for emerging infectious diseases and bioweapons’ which intended to coordinate a cross-government approach to biosecurity threats. But the inquiry had to postpone its oral hearings scheduled for late October 2019 and, because of the general election in December 2019, the committee was obliged to close the inquiry. Full Article
epa The Human Plasma Proteome: A Nonredundant List Developed by Combination of Four Separate Sources By feedproxy.google.com Published On :: 2004-04-01 N. Leigh AndersonApr 1, 2004; 3:311-326Research Full Article
epa Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair [Enzymology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Incorporation of ribonucleotides into DNA can severely diminish genome integrity. However, how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote replication stress and genomic instability and have been implicated in several diseases. We report here the impact of the ribonucleotide rATP and of its naturally occurring damaged analog 1,N6-ethenoadenosine (1,N6-ϵrA) on translesion synthesis (TLS), mediated by human DNA polymerase η (hpol η), and on RNase H2–mediated incision. Mass spectral analysis revealed that 1,N6-ϵrA in DNA generates extensive frameshifts during TLS, which can lead to genomic instability. Moreover, steady-state kinetic analysis of the TLS process indicated that deoxypurines (i.e. dATP and dGTP) are inserted predominantly opposite 1,N6-ϵrA. We also show that hpol η acts as a reverse transcriptase in the presence of damaged ribonucleotide 1,N6-ϵrA but has poor RNA primer extension activities. Steady-state kinetic analysis of reverse transcription and RNA primer extension showed that hpol η favors the addition of dATP and dGTP opposite 1,N6-ϵrA. We also found that RNase H2 recognizes 1,N6-ϵrA but has limited incision activity across from this lesion, which can lead to the persistence of this detrimental DNA adduct. We conclude that the damaged and unrepaired ribonucleotide 1,N6-ϵrA in DNA exhibits mutagenic potential and can also alter the reading frame in an mRNA transcript because 1,N6-ϵrA is incompletely incised by RNase H2. Full Article