A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R1, R2, Ar3, and α3). Further, a substituent which makes the band gap (Bg) and the T1 level of a compound in which a bond of the substituent is substituted with hydrogen wide and high is used as each of the substituents in General Formula (G1) (R1, R2, Ar3, and α3).

A liquid crystalline polyester composition containing at least 100 parts by weight of liquid crystalline polyester (A) and 10 to 100 parts by weight of talc (B). The talc (B) has a ratio (a1/a2) of oil absorption (a1) ml/100 g to specific surface area (a2) m2/g in a range of 14.0 to 26.0 (ml·g)/(100 g·m2) and has a number-average particle diameter of 10 to 30 μm.

Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans.

A method of controlling a pump for a hybrid transmission includes commanding a first line pressure of the transmission and deriving a first torque value—an open-loop torque value—from the first line pressure command, and commanding the pump to operate at the first torque value. The method monitors actual speed of the pump and derives a second torque value—a closed-loop torque value—therefrom. A third torque value is derived from the first and second torque values, and the pump commanded to operate at the third torque value. A first speed value may be derived from the first line pressure command, and the second torque value derived from the difference between the monitored and the first speed values. Deriving the third torque value may include a substantially-linear combination of the first and second torque values.

A transmission assembly in a vehicle includes a transmission configured to receive a transmission fluid. A controller operatively connected to the transmission and configured to store a first look-up table defining respective warm-up calibration factors (Fw) for a respective first set of ambient temperatures. The controller has a processor and tangible, non-transitory memory on which is recorded instructions for executing a method for determining a current temperature (TTF) of the transmission fluid. The vehicle is keyed off and then keyed on after a key-off time duration (te), the controller being deactivated when the vehicle is keyed off and activated when the vehicle is keyed on. The controller is configured to determine the current temperature of the transmission fluid (TTF) based at least partially on the first look-up table and a key-on temperature (TTFkey-on) of the transmission fluid.

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

An apparatus for rotating disc is provided, the apparatus according to an exemplary embodiment is characterized in that an anti-slip torque that is applied to the upper face of the disc by using the clamp unit and the elastic member is stronger than a rotation torque that is generated by the turn table to inhibit slipping of the optical disc from the turn table.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

A harvesting system includes a self-propelled harvesting machine and a drivable collecting container equipped with a drive unit, which can be positioned relative to the harvesting machine and moved in parallel therewith. Crop is fed directly or indirectly to the collecting container during harvesting operation from the harvesting machine using a feed pipe equipped with an outlet chute. The collecting container is equipped with a device for loading it with crop in a uniform manner. The collecting container is moved in a constant position relative to the harvesting machine by way of a control device while the crop is being conveyed. The collecting container is preferably a filling device, by way of which uniform distribution of the crop in the collecting container (8) can be attained.

The invention concerns a harvested crop residue chopper and distribution arrangement for a combine (10) with a straw chopper (60) with a rotor (74) that can be brought into rotation about a horizontal axis (98) with chopper blades (76) fastened thereto that define an outer envelope (96), and with at least one impeller blower (82) arranged downstream of the straw chopper (60) with impeller blades (84) that can rotate about an axis of rotation (88) that extends vertically, in which the impeller blades (84) are provided with outer edges (94) that conform to the envelope (96) of the chopper knives (76) and follow it very closely and are not in contact with it.

A granular material stirring apparatus for breaking up clumps of a granular material in an interior of a storage bin comprises a base assembly for resting on a floor of the bin, an agitation rotor rotatably mounted on the base assembly, and a rotation device connected to the rotatable agitation rotor to cause the agitation rotor to rotate with respect to the base assembly. The agitation rotor may include a central member rotatable about a substantially horizontal axis and a plurality of stirrer members extending substantially radially outwardly from the central member to rotate about the substantially horizontal axis.

A feed system for a biomass collection device uses a conveyor for dropping a flow comprising a mixture of denser or heavier biomass to be collected such as cobs, and less dense or lighter biomass residue such as leaf trash, through a space, and rotary feed apparatus below for receiving the flow, operable for propelling the received flow into a collection device, in combination with a fan configured and operable for directing a flow of air along a second path intersecting the first path in a manner to divert at least a substantial portion of the less dense or lighter biomass residue away from the feed apparatus, while allowing substantially all of the denser or heavier biomass to continue along the first path to the feed apparatus for feeding into the collection device. Distribution apparatus along the second path can then be used to spread the diverted biomass.

A biomass feed system includes a device to propel an airborne flow of the biomass along a trajectory within a collection device. At least one air flow port is disposed and operable in cooperation with at least one fan for discharging a flow of air for creating a blanket of pressurized air within the interior cavity beneath the trajectory for supporting and extending a distance of travel of the biomass within the collection device. The collection device can include an air flow outlet adjacent to a terminal end of the trajectory, to and through which the pressurized air will flow, in a manner for lifting and carrying at least some of the airborne biomass farther into the interior cavity. And, vanes or other elements can be provided to used to achieve better sideward distribution.

A conveying apparatus has a conveying path to supply a plurality of products for consumption having soft parts and intended for processing to a processing device. A conveying intermediate space has conveying surfaces that face one another and receive the products for consumption between them while applying pressure thereto. A first conveying surface comprises a flexible surface-deformable conveying cover and a row arrangement of pressure elements that are arranged next to one another in a row extending transverse to the conveying direction, each having a pressure-applying transverse profile extending transverse to the conveying direction, and are held to be displaceable in the height dimension direction of the conveying intermediate space against a restoring force such that each pressure element co-operates with the surface-deformable conveying cover during the passage of the products for consumption through the conveying path in order to form a variable conveyor cross-section.

Apparatuses and methods of use are provided that include a battery cell comprising a flexible resistive thermal device. The resistive thermal device includes a flexible conductive circuit that is positioned on or adjacent to the surface of the battery cell. Resistance measured in the conductive circuit is correlated with a temperature of the battery cell thereby allowing control of a cooling system and/or the charging/discharging rates of the battery cell to be adjusted in response to temperature. Flexibility of the resistive thermal device also accommodates dimensional changes in the battery cell.

An energy storage composite particle is provided, which includes a carbon film, a conductive carbon component, an energy storage grain, and a conductive carbon fiber. The carbon film surrounds a space. The conductive carbon component and the energy storage grain are disposed in the space. The conductive carbon fiber is electrically connected to the conductive carbon component, the energy storage grain, and the carbon film, and the conductive carbon fiber extends from the inside of the space to the outside of the space. The energy storage composite particle has a high gravimetric capacity, a high coulomb efficiency, and a long cycle life. Furthermore, a battery negative electrode material and a battery using the energy storage composite particle are also provided.

A composite material tape and a lithium secondary battery using the same are provided. The composite material tape includes an organic base and at least one inorganic element dispersed within the organic base. The composite material tapes of the present invention exhibit improved Insulative and heat-resistant characteristics.

In a method for operating a high-temperature fuel cell, which in normal mode of generating electrical power is supplied with liquid fuel, preferably diesel oil, and is preceded on the anode side by a reformer for liquid fuel, where at least part of the hot anode exhaust gas is recirculated into the anode circuit via a recirculation line. Upstream of a compressor preceding the reformer the liquid fuel is sprayed or injected into the hot anode exhaust gas, the quantity of air needed for reforming the liquid fuel being added to the mixture of anode exhaust gas and fuel. On change-over from normal operational mode to standby mode without power generation, the supply of liquid fuel and air is stopped and the gas mixture present in the anode circuit be permanently circulated. A defined amount of air being introduced into the anode circuit in order to remove deposits and contaminations in the high-temperature fuel cell following standby operation.

A carbon supported catalyst composition for solid polymer electrolyte fuel cells is disclosed that shows a high mass activity and favorable stability and durability. The catalyst composition comprises an intermetallic phase or alloy comprising Pt and a metal selected from the group consisting of Nb, Ta, V and Mo, and comprises an oxide of the metal. The carbon supported catalyst composition can be prepared at relatively low temperature either by first depositing and heating an oxide precursor of the metal on a suitable carbon to make a hybrid support, and then depositing and heating a Pt precursor on the hybrid support, or by depositing both an oxide precursor of the metal and a Pt precursor on a suitable carbon support, and directly heating to a final temperature.

The invention concerns a form for non impact printers, characterized in that it consists of four sections including an upper section and a lower section, and in that each section is separated from the next section by parallel fold lines or perforations. The upper section has the same surface area as the total surfaces of the two subsequent sections, over which the upper section is folded before printing, in such a manner that after printing the upper section can be folded further over the lower section and that an image can be transferred to the lower section by means of mechanical or chemical self-copying techniques by exerting a pressure on the upper section.

A business form with laser compatible punch-out card and the methods of making the combination. The card is permanently adhered to a perforated backer sheet, the periphery of which extends beyond the card and is coated with adhesive for application to the bottom surface of a form containing a hole such that the card is disposed within the hole. The card and attached portion of the backer sheet can then be removed from the card-in-form combination by breaking the perforations. The card is die cut from card stock laminated to the backer layer and is prepared for application to the form by stripping a waste matrix of card material from the laminate through the use of patterned release material.

Disclosed are sets of ink components, and ink compositions, useful for printing markings, on security documents, that are relatively resistant to counterfeiting. Also disclosed are the security documents formed, a method of printing and a method of authenticating the printed material. The markings, formed of the ink compositions have a spectral response that deviates from a predicted spectral response when linearly additively combining spectral responses of components of the ink composition, so that it becomes difficult to reverse-engineer the ink composition from the markings. Use of plural different markings, with each marking being a microdot, increases difficulty in counterfeiting. By forming a template of spectral responses of the original pattern, spectral responses of a pattern on an unknown document can be compared to the spectral responses on the template for determining whether the unknown document is authentic. Formation of the markings is facilitated using an inkjet printer.

An apparatus for recording foot, hoof and paw impressions is disclosed. An impression member is atop a foundation member, both of which are concealed by a removable protective cover. The impression member records the shape of a foot, hoof or paw which steps upon the apparatus, while the cover resists water and camouflages the apparatus.

A printer, as an image forming apparatus, reverses the front and back sides of tab sheets that became no longer necessary and discharges when a reverse discharge is specified.

The invention provides the user a first insertion page position setting part that allows a user to designate insertion page positions that respectively indicate pages at which first tab sheets are to be inserted, and a second insertion page position setting part that allows the user to designate insertion page positions that respectively indicate pages at which second tab sheets are to be inserted, when a request for initiating the setting concerning the tab sheets is received. Further, the tab positions in the second tab sheets, which correspond to the insertion page positions designated in said second insertion page position setting part, are set up in accordance with the tab positions in the first tab sheets, which correspond to the insertion page positions designated in said first insertion page position setting part.

A method for controlling within a printer driver the insertion of tab sheets into a print job. According to one embodiment, sheets of multiple levels are insertable. The printer driver provides at least input fields for entry and display of parameters for the definition of at least one tab sheet, and an interactive area for visualizing the hierarchical structure and the order of the at least one defined tab sheet corresponding to the level of the tab sheet in the print job. Depending on changes of a tab sheet defined by entered parameters, the visualization of the hierarchical structure and the order of the at least one defined tab sheet in the print job is updated in the interactive area.

An impression system is provided for capturing an anatomical impression of an animal. The impression system comprises a foam that substantially retains an impression after application of pressure and subsequent removal of pressure and a case having a recessed area for receiving the foam and a case for retaining the foam therein. The system further comprises a cover having a viewing pane attachable to the case for providing viewing of the foam when closed.

Mechanisms and methods for clamping force generation are described. In one embodiment, a clamping force generator system includes a permanent magnet bearing coupled to a traction ring and to a torque coupling. The traction ring can be provided with an electromagnetic bearing rotor and the torque coupling can be provided with an electromagnetic bearing stator. In some embodiments, a mechanical load cam, a permanent magnet bearing, and an electromagnetic bearing cooperate to generate a clamping force between the traction rings, the power rollers, and the idler. In other embodiments, a series of permanent magnet bearings and a mechanical bearing are configured to produce a clamping force. In one embodiment an electromagnetic bearing is coupled to a control system and produces an optimal clamping force that is associated with a torque transmitted in the transmission during operation. In some embodiments, a mechanical load cam produces a clamping force proportional to torque, while a permanent magnet bearing provides a minimum clamping force.

Inventive embodiments are directed to components, subassemblies, systems, and/or methods for infinitely variable transmissions (IVT). In one embodiment, a control system is adapted to facilitate a change in the ratio of an IVT. In another embodiment, a control system includes a carrier member configured to have a number of radially offset slots. Various inventive carrier members and carrier drivers can be used to facilitate shifting the ratio of an IVT. In some embodiments, the traction planet assemblies include planet axles configured to cooperate with the carrier members. In one embodiment, the carrier member is configured to rotate and apply a skew condition to each of the planet axles. In some embodiments, a carrier member is operably coupled to a carrier driver. In some embodiments, the carrier member is configured to couple to a source of rotational power. Among other things, shift control interfaces for an IVT are disclosed.

Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously and infinitely variable transmissions (IVT). In one embodiment, a variator is adapted to receive a control system that cooperates with a shift nut to actuate a ratio change in an IVT. In another embodiment, a neutral lock-out mechanism is adapted to cooperate with the variator to, among other things, disengage an output shaft from a variator. Various inventive mechanical couplings, such as an output engagement mechanism, are provided to facilitate a change in the ratio of an IVT for maintaining a powered zero operating condition. In one embodiment, the output engagement mechanism selectively couples an output member of the variator to a ratio adjuster of the variator. Embodiments of a ratio adjuster cooperate with other components of the IVT to support operation and/or functionality of the IVT. Among other things, user control interfaces for an IVT are disclosed.

A fluid pump includes a drive shaft driven by power from an engine, a rotor adapted to be provided at a housing and rotating unitarily with the drive shaft, a driving wheel which is provided separately from the drive shaft and to which the power from the engine is always transmitted when the engine is running, a driven wheel transmitting the power from the engine to the drive shaft upon being in contact with the driving wheel, and a displacement mechanism causing the driving wheel and the driven wheel to be out of contact from each other by moving at least one of the driving wheel and the driven wheel.

A magnetic storage medium is formed of magnetic nanoparticles that are encapsulated within nanotubes (e.g., carbon nanotubes).

A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign.

Provided herein is an apparatus, including a clamping means for clamping at least one disk onto a hub at a mounting point on the hub for the at least one disk, wherein the clamping means is configured to sit wholly above the at least one disk; a seat in an outer perimeter of the hub configured to receive the clamping means; and a locking means for locking the clamping means onto the hub.

A novel information storage device is disclosed and claimed. The information storage device includes a device housing with a generally rectangular bay to accommodate a disk drive. The generally rectangular bay includes a base portion and a plurality of side portions. The information storage device further includes a damping insert sheet disposed between the disk drive and the base portion. The damping insert sheet has a plurality of elastomeric cushions, for example with a cushion thickness in the range 0.5 mm to 10 mm, and a spanning sheet, for example having a sheet thickness in the range 0.02 mm to 0.35 mm. Each of the plurality of elastomeric cushions is attached to the spanning sheet. Each of the plurality of elastomeric cushions contacts and is compressed between the generally rectangular bay and the disk drive.