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Pakistan among countries with most corona cases in Asia Pacific

Islamabad : Iran, China, India, Pakistan, Indonesia and the Philippines have the most cases of COVID-19 and related deaths in the Asia Pacific region.The COVID-19 situation of Asia Pacific was highlighted in the Second COVID-19 Situation Report Asia Pacific released by United Nations Population...




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Psycho-social support helpline dealing with 50 cases daily, says LG secretary

The newly launched ‘1093 helpline service’ of the Sindh Local Government Department has been providing counselling service to around 50 people on a daily basis who are suffering from various psychological issues due to the ongoing coronavirus crisis in the country, said Sindh Local...




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Lebanon confirms 13 new COVID-19 cases, total at 809

Lebanon confirms 13 new COVID-19 cases, total at 809




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Lebanon local infections jump to 16 new cases; 2 expats

Lebanon registered 18 new coronavirus infections Saturday, bringing the total number of cases in the country up to 809.




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Provinces announce easing lockdown even as Pakistan witnesses record rise in coronavirus cases

The governments of Punjab, Sindh, Khyber Pakhtunkhwa and Balochistan on Friday announced the partial easing of lockdown measures imposed to curb the spread of the coronavirus, even as the number of infections in the country registered a record daily increase.

On Thursday, Prime Minister Imran Khan had announced the lifting of the countrywide lockdown in phases from Saturday by reopening all construction-related industries and shopping centres for five days a week from Fajr (early morning) till 5pm and outpatient departments (OPDs) in hospitals.

The premier, who had announced the decision after a meeting of the National Coordination Committee (NCC) attended by the chief ministers of the four provinces, had acknowledged that the lockdown was being eased "at a time when our curve is going up" but maintained that "it is not edging up as we were expecting.”

The trend continued on Friday, with the country recording 1,807 cases of Covid-19 from the three provinces of Punjab, Sindh and KP alone, and the national tally nearing 27,000. It is the highest daily increase in the number of infections since Pakistan confirmed its first case on February 26.

Also read: Pakistan's Covid-19 death toll doubles in last 10 days

Khyber Pakhtunkhwa

A notification issued by the KP relief department said businesses associated with the construction industry will be exempt from closure subject to them following the standard operating procedures (SOPs) already issued for industrial units and sale points.

Businesses of steel and PVC pipes, electric appliances, manufacturers of steel and aluminium equipment, ceramic and paint industries, sanitary, paints, steel and aluminium works, and hardware stores will be allowed to open four days a week, not later than 4:00pm. They will remain closed on Fridays, Saturdays and Sundays.

KP relief department notification.

All factories which are not included in the negative lists of factories will also be allowed to resume operations.

According to the notification, all shops will be allowed to remain open for four days a week and not later than 4:00pm, subject to their implementation of the government's SOPs.

Meanwhile, Adviser to the Khyber Pakhtunkhwa chief minister on information, Ajmal Wazir, told a press conference in Peshawar that educational institutions in the province will reopen as per the federal government's instructions and the province will not take an independent decision in this regard.

He added that discussions were being held on inter-district and intra-district transport with transporters and the decision will be shared with the public whenever it is taken.

Punjab

Punjab Information Minister Fayyazul Hassan Chohan said that the provincial government will submit a recommendation to the Centre for not lifting the lockdown in the province's major cities.

Speaking to reporters in Lahore, he said: "We have seen that there is a hype about coronavirus in some big cities. Therefore, we are submitting this recommendation to the federal government and if it is approved, then the lockdown and standard operating procedures will remain in big cities like Lahore, Rawalpindi, Multan and Gujranwala."

Examine: The lockdown dilemma

He added that higher secondary board examinations in Punjab will be cancelled and students will be promoted based on last year's grades. Schools will reopen on July 15.

As per the federal government's decision, OPDs in the province will open from May 9, Chohan said.

He added that the SOPs for congregational and Taraweeh prayers in mosques as announced by President Arif Alvi will remain in place.

The first session of the Punjab Assembly since the pandemic began was also to be held today.

Sindh

Sindh Chief Minister Murad Ali Shah told a press conference in Karachi that under "phase two" of the easing of the restrictions, businesses linked to construction industries will be allowed to open while observing the preventive guidelines. Selective OPDs will also be allowed to resume services.

Industries will no longer be required to submit an application to resume operations; however, they will have to submit an undertaking and forward the details of their employees to the government.

Shops will be allowed to open after sehri (dawn) and will be required to close at 5pm. They will remain closed on Saturdays and Sundays which will be "safe days with 100 per cent lockdown", the chief minister said.

The businesses permitted to resume from Monday include shops in rural areas and neighbourhood shops situated in residential localities, excluding large market places.

Shah said marriage halls, shopping malls, hotels and restaurants in the province will remain closed and there will be no congregations or sports events either.

"These guidelines will remain applicable until May 31. This is what the federal government has outlined and we are ready to comply with these directives," he said.

The chief minister appealed to citizens to stay at home as much as possible. "If you are allowed to leave your homes, according to the directives issued by the government, then make sure to follow standard operating procedures. Wear a mask," he said.

Referring to the increase in Covid-19 infections, he added: "I am seeing the rise in cases, but for national integrity and uniform policy we are going along."

In a statement released by the CM House later in the day, Shah denied media reports stating that the lockdown will end on Monday, saying: "We are entering the second phase of the lockdown with some extra restrictions, particularly at hotspots."

He maintained that air, train and public transport will continue to remain suspended.

Balochistan

In Balochistan, a meeting chaired by Chief Minister Jam Kamal Khan approved the move to turn the lockdown imposed in the province into a 'smart lockdown', under which restrictions are enforced in virus hotspots only, according to Balochistan government spokesperson Liaquat Shahwani.

He announced that markets will be allowed to open from 3am till 5 in the evening.

Shopkeepers and traders will be bound to implement SOPs for precautionary measures while legal action will be taken against the violators, Shahwani said in a tweet.




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IHC reserves judgement in Hamdullah citizenship case

ISLAMABAD: The Islamabad High Court (IHC) on Friday reserved its judgement on a petition filed against the National Database and Registration Authority’s (Nadra) notification of revoking the citizenship of Jamiat Ulema-i-Islam-Fazl (JUI-F) leader Hafiz Hamdullah.

Nadra in its written reply referred to intelligence reports claiming that Mr Hamdullah is not a Pakistani national.

On Oct 11 last year, Mr Hamdullah lost his citizenship when Nadra declared him an ‘alien’.

Subsequently, the Pakistan Electronic Media Regulatory Authority (Pemra) banned his appearance on TV channels.

As per the Oct 26 Pemra directive, Nadra had in a letter dated Oct 11 conveyed that “Hafiz Hamdullah Saboor is ‘confirmed alien’ as he is not a citizen of Pakistan”.

It further said Nadra had “cancelled and digitally impounded” the CNIC [computerised national identity card] issued to Mr Hamdullah.

“Since it is established that the said person is an ‘alien’, all the TV channels (news and current affairs) are directed to refrain from inviting and projecting Mr Hafiz Hamdullah Saboor in their programmes/talk shows, news, etc,” the authority said in its letter.

In October, JUI-F leader lost his citizenship when Nadra declared him an ‘alien’

Nadra took the stance before the IHC that the intelligence agencies claimed that Mr Hamdullah’s credentials were also fake and subsequently his computerised national identity card had been cancelled.

Mr Hamdullah, who was a senator from Balochistan between March 2012 and March 2018, frequently makes appearances in evening talk shows on different news channels.

The directive banning his TV appearances came at a time when the JUI-F’s Azadi March was about to start.

Advocate Kamran Murtaza, who filed a petition on behalf of Mr Hamdullah, informed the court that the petitioner was born in the province of Balochistan and that his father, children and other family members also held CNICs. One of Mr Hamdullah’s children is serving in the armed forces of the country as a commissioned officer.

According to the petition, Mr Hamdullah has also remained member of the Balochistan Assembly and “Nadra is not vested with jurisdiction to adjudicate upon the citizenship of citizen which otherwise has to be dealt with the Pakistan Citizenship Act, 1951. It shows that Nadra’s order was issued without any lawful authority,” the petition said.

IHC Chief Justice Athar Minallah, after hearing the arguments of petitioner’s counsel and other respondents, reserved the judgement.

Published in Dawn, May 9th, 2020




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Record Covid-19 cases reported in a single day

ISLAMABAD: The country witnessed a record rise in Covid-19 cases on Friday, a day before lifting of the nationwide lockdown in phases announced by Prime Minister Imran Khan.

Although the decision to lift the lockdown from Saturday was taken in consultation with all the provinces, Punjab and Sindh on Friday expressed their desire to extend the lockdown restrictions for some more time.

With the addition of 2,000 new cases during the last 24 hours, the total number of infections in the country on Friday stood at 26,954.

Prime Minister Khan, after chairing a meeting of the National Coordination Committee (NCC) on Thursday, announced the lifting of the lockdown by opening several industries, businesses and markets from Saturday (today).

Punjab, Sindh express wish to extend lockdown restrictions; Umar dismisses Murad’s claim about unilateral decisions by Centre; PM reviews economic situation

On Friday, Sindh Chief Minister Syed Murad Ali Shah and Punjab Information Minister Fayyazul Hassan Chohan said they wanted to extend the lockdown but agreed to the Centre’s call at the NCC meeting that the restrictions should be lifted from Saturday.

“It was our desire that the lockdown should be extended, but we agreed to whatever decided at the NCC meeting on Thursday,” CM Shah said at a press briefing.

The PTI-led Punjab government took a step forward and recommended that major cities of the province should remain under lockdown as there was an increasing trend of the viral disease there. “We want continuation of lockdown in eight to 10 cities, including Lahore, Rawalpindi, Multan and Gujranwala,” Mr Chohan said at a press conference.

In a related development, the federal government expressed its surprise and dismay over Sindh chief minister’s remarks that Islamabad was imposing its decision regarding ending the lockdown. Federal Minister for Planning and Development Asad Umar, who also heads the National Command and Operation Centre, in a television programme categorically on Friday evening, said that all decisions were made with the approval of the provincial governments. He even said that some of the federal government’s proposals on which there were objections, or difference of opinion, were not included as the government wanted to have complete consensus on the matter.

Prime Minister Khan has urged people to follow the standard operating procedures (SOPs) evolved by the government when the lockdown is lifted, otherwise there will be trajectory of Covid-19 and then the government will have no option but to enforce another lockdown.

The prime minister presided over a meeting on Friday to review the economic situation and its future outlook in the wake of the Covid-19 pandemic. The finance ministry briefed the meeting on the overall situation and the performance of various macroeconomic indicators during the last nine months of the current financial year, as well as the impact of coronavirus on the economy, an official press release said.

The meeting reviewed the progress and impact of the Rs1.25 trillion economic stimulus package announced by the government to provide relief to the poor and vulnerable segments of society and support various sectors of the economy affected by the pandemic.

The prime minister appreciated the efforts made by the finance ministry to ensure financial discipline and provision of relief during the Coved-19 situation. He emphasised that greater attention should be paid to supporting small and medium enterprises and the agriculture sector, enabling them to create greater job opportunities for people. “The process of reforming public sector organisations should be expedited to plug leakages of the economy,” he added.

The prime minister said the process of provision of subsidies should also be reviewed to make these interventions more effective and target-oriented. “Out of the box solutions are needed to meet the present day economic challenges,” he emphasised.

Reviewing the future economic outlook, Mr Khan said all-out efforts should be made to provide maximum possible relief to the people. He emphasised that priorities and targets for the next Public Sector Development Programme (PSDP) should be clearly defined with a focus on completion of projects rather than mere initiation. He stressed the need for maximum utilisation of the public-private partnership model and involving international development partners to enhance and broaden the PSDP scope.

Meanwhile, Special Assistant to the PM on Health Dr Zafar Mirza said the government had signed a memorandum of understanding with the International Organisation of Migration, which helps connect countries with expatriates.

At a press conference, he said the government wanted to develop a networking system with overseas Pakistani doctors in order to learn from their experiences and expertise even after the coronavirus crisis is over.

Published in Dawn, May 9th, 2020




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Justice Department dropping Flynn’s Trump-Russia case

The Justice Department on Thursday said it is dropping the criminal case against President Donald Trump's first national security adviser, Michael Flynn, abandoning a prosecution that became a rallying cry for the president and his supporters in attacking the FBI's Trump-Russia investigation.




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Saudi Arabia coronavirus cases exceed 35,000

The number of coronavirus cases in Saudi Arabia exceeded 35,000 on Friday as the kingdom struggles to get to grips with rising numbers of new infections.




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Iran reports more than 1,500 new virus cases

Iran warned Saturday that coronavirus infections were rising in the southwest despite falls in other regions, as it announced more than 1,500 new confirmed cases.




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Effective Approaches to Poverty Reduction: Selected Cases from the Asian Development Bank

This report presents nine case studies on poverty reduction projects financed by ADB in Mongolia, Nepal, the People’s Republic of China, the Philippines, Sri Lanka, Uzbekistan, and Viet Nam.




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Advancing the K-12 Reform from the Ground: A Case Study in the Philippines

This paper describes the implementation of the Certificate in Educational Studies in Leadership (CESL) in the Philippines as a professional development initiative delivered in a customized blended learning mode.




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The Effects of Privatization and Corporate Governance of SOEs in Transition Economy: The Case of Kazakhstan

Privatization has different effects depending on the types of owners to whom it gives control in corporate governance.




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The Effects of Privatization and Corporate Governance of SOEs in Transition Economy: The Case of Kazakhstan

Privatization has different effects depending on the types of owners to whom it gives control in corporate governance.




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HARMAN Showcases Today’s Ultimate In-Vehicle Experiences at CES 2019

CES 2019 - LAS VEGAS, NV – January 7, 2019 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is showcasing at CES 2019 the vehicle’s role...




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HARMAN Showcases Life-Saving Potential of Vehicle-to-Pedestrian 5G Technology at CES 2020

CES 2020 – LAS VEGAS, Nev. – January 6, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies and solutions for automotive, consumer and enterprise markets, today unveiled a new ADAS use case, called...




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CES - HARMAN on the CASE for user centric audio experiences




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HARMAN Premium Audio Showcased in Next-Generation Vehicles at Los Angeles Auto Show

LOS ANGELES, CA – HARMAN (NYSE: HAR), the premier global audio and infotainment group, is making its mark at this year’s Los Angeles Auto Show with several leading automakers debuting vehicles that feature HARMAN branded audio systems. With brands like Harman Kardon, JBL, Infinity, Mark Levinson and Lexicon, HARMAN technology and solutions can be found on automaker stands throughout the show -- a reflection of the company’s strong, longstanding automotive OEM partnerships and industry-leading audio innovation.




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'Justice finally prevailed' in Michael Flynn case: WH

White House spokeswoman Kayleigh McEnany on Friday said it appears that the FBI 'manufactured' a crime in the case of President Trump's former national security adviser Michael Flynn, after the Department of Justice moved to drop the case on Thursday.




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'Justice finally prevailed' in Michael Flynn case: WH

White House spokeswoman Kayleigh McEnany on Friday said it appears that the FBI 'manufactured' a crime in the case of President Trump's former national security adviser Michael Flynn, after the Department of Justice moved to drop the case on Thursday.




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Anthropocene review – tough film makes case for human-created epoch

From Kenyan children picking through plastic waste to swathes of Germany laid waste for coal mining, a film shows why we are in a new, human-created epoch




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Nearly 90 coronavirus cases reported at Polyus unit in Siberia

Nearly 90 cases of the novel coronavirus have been recorded among employees of Polyus Krasnoyarsk, a unit of Russia's largest gold producer Polyus , the regional branch of Russia's consumer health watchdog said on Saturday.




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DOJ to drop case against Trump ex-advisor Flynn

The U.S. Justice Department on Thursday abruptly asked a judge to drop criminal charges against President Donald Trump's former national security adviser Michael Flynn following mounting pressure from Trump and his political allies on the right. This report produced by Jillian Kitchener.




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'Justice finally prevailed' in Michael Flynn case: WH

White House spokeswoman Kayleigh McEnany on Friday said it appears that the FBI 'manufactured' a crime in the case of President Trump's former national security adviser Michael Flynn, after the Department of Justice moved to drop the case on Thursday.




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The Met showcases Islamic art as a response to Trump's Muslim ban

The Metropolitan Museum of Art in New York leads Islamic art tours to improve understanding of its contributions to the world heritage. Fred Katayama reports.




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Australia sees huge decrease in flu cases due to coronavirus measures

Australia recorded just 229 flu cases this April, compared with 18,705 last April, probably due to lockdown measures to stop the spread of the coronavirus




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DOJ to drop case against Trump ex-advisor Flynn

The U.S. Justice Department on Thursday abruptly asked a judge to drop criminal charges against President Donald Trump's former national security adviser Michael Flynn following mounting pressure from Trump and his political allies on the right. This report produced by Jillian Kitchener.




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'Justice finally prevailed' in Michael Flynn case: WH

White House spokeswoman Kayleigh McEnany on Friday said it appears that the FBI 'manufactured' a crime in the case of President Trump's former national security adviser Michael Flynn, after the Department of Justice moved to drop the case on Thursday.




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Second Man Arrested in Tainted Letter Case, Officials Report

Title: Second Man Arrested in Tainted Letter Case, Officials Report
Category: Health News
Created: 4/27/2013 6:35:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM




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Vaccine Against Bird Flu Readied, Just in Case

Title: Vaccine Against Bird Flu Readied, Just in Case
Category: Health News
Created: 4/30/2014 2:36:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM




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Surge in Pollen May Spur Many Cases of Dry Eye

Title: Surge in Pollen May Spur Many Cases of Dry Eye
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM




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Teen Suicide Thoughts, Self-Harm Cases Double in a Decade

Title: Teen Suicide Thoughts, Self-Harm Cases Double in a Decade
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM




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More Cases of Tick-Borne Powassan Disease Expected in U.S. This Year

Title: More Cases of Tick-Borne Powassan Disease Expected in U.S. This Year
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM




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Measles Outbreak in Minnesota Grows to 34 Cases

Title: Measles Outbreak in Minnesota Grows to 34 Cases
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM




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Food Poisoning Cases Rise in U.S.

Title: Food Poisoning Cases Rise in U.S.
Category: Health News
Created: 4/26/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM




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E. Coli Outbreak Tied to Ground Beef Climbs to 177 Cases

Title: E. Coli Outbreak Tied to Ground Beef Climbs to 177 Cases
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM




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Measles Case Leads to Quarantine of Cruise Ship in St. Lucia

Title: Measles Case Leads to Quarantine of Cruise Ship in St. Lucia
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/2/2019 12:00:00 AM




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States Move Forward With Plans to Reopen as Coronavirus Case Count Passes 930,000

Title: States Move Forward With Plans to Reopen as Coronavirus Case Count Passes 930,000
Category: Health News
Created: 4/26/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM




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Trump Orders Meat Plants to Stay Open as U.S. Coronavirus Cases Pass 1 Million

Title: Trump Orders Meat Plants to Stay Open as U.S. Coronavirus Cases Pass 1 Million
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM




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Loss of Smell May Signal Milder Case of COVID-19: Study

Title: Loss of Smell May Signal Milder Case of COVID-19: Study
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM




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U.S. Jobless Rate at Nearly 15 Percent as Coronavirus Cases Top 1.2 Million

Title: U.S. Jobless Rate at Nearly 15 Percent as Coronavirus Cases Top 1.2 Million
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM




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Thousands of COVID-19 Cases Among Inmates and Staff at U.S. Prisons and Jails: CDC

Title: Thousands of COVID-19 Cases Among Inmates and Staff at U.S. Prisons and Jails: CDC
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM




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Trump Says Obamacare Must Go as U.S. Coronavirus Cases Climb Past 1.2 Million

Title: Trump Says Obamacare Must Go as U.S. Coronavirus Cases Climb Past 1.2 Million
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM




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Multisociety Roadmap for Restarting Elective Cardiac Cases

A new consensus document provides guidance on the safe reintroduction of cardiovascular procedures and testing derailed by the COVID-19 pandemic.




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U.S. Primary Care Docs Unprepared for Surge in Alzheimer's Cases

Title: U.S. Primary Care Docs Unprepared for Surge in Alzheimer's Cases
Category: Health News
Created: 3/11/2020 12:00:00 AM
Last Editorial Review: 3/11/2020 12:00:00 AM




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Trump Signs Massive Relief Package Into Law as U.S. Coronavirus Cases Reach 9,000

Title: Trump Signs Massive Relief Package Into Law as U.S. Coronavirus Cases Reach 9,000
Category: Health News
Created: 3/19/2020 12:00:00 AM
Last Editorial Review: 3/19/2020 12:00:00 AM




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Residents Perspectives on and Application of Dental Public Health Competencies Using Case-Based Methods

The aims of this study were to qualitatively assess dental public health (DPH) residents’ perspectives on teaching methods for DPH competencies and to develop and implement a case-based simulation to address those competencies, constructed on the basis of the qualitative assessment. Focus group discussions were conducted with 18 DPH residents enrolled in two university-based DPH programs. Topic areas discussed in the two focus groups were perceived value of DPH competencies, ways to acquire new DPH skills/abilities, and additional skills/abilities needed by DPH residents. The focus groups’ responses showed that the residents felt competent in the analytical thinking competencies such as research methodology and critiquing literature. They emphasized the importance of learning leadership skills and reported feeling somewhat uncertain about their mastery of the policy and advocacy and system evaluation competencies. Of the two distinct categories of DPH skills and competencies— analytical/critical thinking and practical competencies—these residents reported that a greater proportion of time needed to be devoted to integrating the practical competencies into their education. Based on the residents’ feedback, the authors developed a structured seminar series taking a case-based approach to simulate real-world DPH problems, using real and semi-hypothetical planning projects to meet the residents’ perceived needs and covering gaps between didactic learning and practice.




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Examining the Case for Dental Hygienists Teaching Predoctoral Dental Students: A Two-Part Study

Dental students in North American dental schools are exposed to faculty members with various professional backgrounds. These faculty members may include dentists, dental hygienists, and scientists without clinical dental credentials. The practice of dental hygienists’ educating predoctoral dental students has not been well documented. The aims of this two-part study were to investigate the parameters of didactic, preclinical, and clinical instruction of dental students by dental hygienist faculty members in North American dental schools and to explore dental students’ perceptions of this form of teaching. In part one, a survey was sent electronically to the clinical or academic affairs deans of all 76 American Dental Education Association (ADEA) member dental schools in 2017. Twenty-nine responded, for a 38.2% response rate. In 76% of the responding schools, dental hygienists were teaching dental students. Most respondents reported that, in their schools, the minimum degree required to teach didactically was a master’s, while a bachelor’s degree was required for preclinical and clinical courses. There was no significant association between dental hygienists’ instructing dental students and having a dental hygiene educational program at the institution. In part two of the study, a questionnaire was completed by 102 graduating dental students (85% response rate) at one U.S. university to evaluate the impact of dental hygienist educators. Among the respondents, 87% reported feeling that dental hygienists were very effective educators. There were no significant differences in responses between traditional and advanced standing international dental students. This study found that dental hygienists were educating dental students in many North American dental schools and were doing so in curricular content beyond periodontics and that their educational contributions at a sample school were valued by the dental students there.




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CASEIN KINASE2-Dependent Phosphorylation of PHOSPHATE2 Fine-tunes Phosphate Homeostasis in Rice

Plants have evolved complex physiological and biochemical mechanisms to adapt to a heterogeneous soil phosphorus environment. PHOSPHATE2 (PHO2) is a phosphate (Pi) starvation-signaling regulator involved in maintaining Pi homeostasis in plants. Arabidopsis (Arabidopsis thaliana) PHO2 targets PHOSPHATE TRANSPORTER1 (PHT1) and PHO1 for degradation, whereas rice (Oryza sativa) PHO2 is thought to mediate PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 degradation. However, it is unclear whether and how PHO2 is post-translationally regulated. Here, we show that in rice, the CASEIN KINASE2 (OsCK2) catalytic subunit OsCK2α3 interacts with OsPHO2 in vitro and in vivo in vascular tissues cells, and phosphorylates OsPHO2 at Ser-841. Phosphorylated OsPHO2 is degraded more rapidly than native OsPHO2 in cell-free degradation assays. OsPHO2 interacts with OsPHO1 and targets it for degradation through a multivesicular body-mediated pathway. PHO1 mutation partially rescued the pho2 mutant phenotype. Further genetic analysis showed that a nonphosphorylatable version of OsPHO2 rescued the Ospho2 phenotype of high Pi accumulation in leaves better than native OsPHO2. In addition to the previously established role of OsCK2 in negatively regulating endoplasmic reticulum exit of PHT1 phosphate transporters, this work uncovers a role for OsCK2α3 in modulating Pi homeostasis through regulating the phosphorylation status and abundance of OsPHO2 in rice.




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{alpha}-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases

Cystinuria is an autosomal recessive disorder characterized by excessive urinary excretion of cystine, resulting in recurrent cystine kidney stones, often presenting in childhood. Current treatment options for cystinuria include dietary and/or fluid measures and potassium citrate to reduce cystine excretion and/or increase solubility. Tiopronin and D-penicillamine are used in refractory cases to bind cystine in urine, albeit with serious side effects. A recent study revealed efficacy of nutritional supplement α-lipoic acid (ALA) treatment in preventing kidney stones in a mouse model of cystinuria. Here, we report 2 pediatric patients (6 and 15 years old) with cystinuria who received regular doses of ALA in addition to conventional therapy with potassium citrate. Both patients tolerated ALA without any adverse effects and had reduced frequency of symptomatic and asymptomatic kidney stones with disappearance of existing kidney stones in 1 patient after 2 months of ALA therapy. ALA treatment markedly improved laboratory markers of cystine solubility in urine with increased cystine capacity (–223 to –1 mg/L in patient 1 and +140 to +272 mg/L in patient 2) and decreased cystine supersaturation (1.7 to 0.88 in patient 1 and 0.64 to 0.48 in patient 2) without any changes in cystine excretion or urine pH. Our findings suggest that ALA improves solubility of cystine in urine and prevents stone formation in patients with cystinuria who do not respond to diet and citrate therapy.