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arc 12th annual Norman Bethune Symposium showcases breadth of ongoing research By www.blood.ca Published On :: Tue, 02 Jul 2024 13:46:31 +0000 12th annual Norman Bethune Symposium showcases breadth of ongoing research Transfusion Blood Tuesday, June 25, 2024 Guest Author Our partnership with the Centre for Blood Research (CBR) at the University of British Columbia (UBC) is helping to train the next generation of researchers in transfusion science. This blog post highlights just some of the achievements in education, training or knowledge mobilization accomplished by CBR trainees. This is an abbreviated repost that originally appeared on the Centre for Blood Research blog in June 2024. It was written by trainees Joyce Teodoro (PhD student in the lab of Canadian Blood Services’ adjunct scientist Dr. Hongshen Ma) and Kiran Toor (Masters student at CBR in the lab of Dr. Brown), with edits provided by Kaitlyn Chuong (communications and programs coordinator at CBR). On April 18th, 2024, the Centre for Blood Research (CBR) held their 12th annual Norman Bethune Symposium, a renowned research event that gathers scientists, clinicians, healthcare professionals, and trainees to discuss advancements in the field of blood research. The symposium was held at UBC Robson Square, on the traditional territory of the Musqueam, Squamish and Tsleil-Waututh people. The full day event consisted of expert talks on thalassemia, thrombocytopenia, sickle cell disease, and other bleeding disorders. Research trainees delivered impressive presentations on innovative topics including engineering cells for cancer immunotherapy and computational approaches to inhibit Klebsiella pneumoniae. The event showcased nearly 30 trainee research posters, demonstrating the breadth of ongoing research. CBR Director, Dr. Ed Conway, began with the opening remarks, followed by the presentation by Dr. Christian Kastrup, Professor at the Medical College of Wisconsin and Senior Investigator at Versiti Blood Research Institute. Dr. Kastrup’s presentation focused on his work on genetically modifying transfusable donor platelets using mRNA-lipid nanoparticles. Following this, there were a series of presentations on the topic of bleeding disorders. It was a research-filled day that honored the contributions of Drs. Don Brooks and Dana Devine. Blood research & reflections The symposium was an amazing opportunity to learn about the exciting advances in blood research. It also served as a great platform for speakers to share their personal experiences with blood disorders, as well as for scientists to discuss their professional path in blood sciences. Attendees were fortunate to hear Ritika Rakshit share her personal journey with thalassemia, a genetic blood disorder characterized by the body’s inability to produce enough hemoglobin. She detailed her experience from being diagnosed to her treatment plans including being on extramedullary hematopoiesis (EMH) and switching to luspatercept. She offered insights into her hesitancy to switch medications and highlighted the invaluable support of her clinical team. Ritika continues to be an advocate for thalassemia in her role on the patient advocacy board. It was an eye-opening opportunity to be able to hear from a patient reflect on their own journey and understand their perspective on living with a blood disorder. Dr. Geraldine Walsh, a development scientist with Canadian Blood Services, also gave an insightful talk describing her career path in blood sciences. Drawing from her experiences, she shared several pieces of advice on navigating a career in science. She highlighted the importance of finding work that we are passionate about, building strong relationships, and learning from those around us. Dr. Walsh concluded her talk by encouraging attendees, especially research trainees, to explore various career opportunities, including those that may deviate from the conventional scientific career trajectory. Celebrating Drs. Don Brooks and Dana Devine One of the highlights of the symposium was the talk by Dr. Cedric Carter, which celebrated Drs. Don Brooks and Dana Devine’s achievements and contributions. Drs. Don Brooks and Dana Devine are two of the founding members of the Centre for Blood Research (CBR). In addition to their significant and impactful contributions to the field of transfusion science and medicine, they have been instrumental in promoting research and developing initiatives through various leadership roles. Dr. Brooks has served as Associate Vice-President, Research at UBC and Founding Director of UBC’s Support Programs to Advance Research Capacity (SPARC). He has also served as a member of the Board of Directors for TRIUMF, Provincial Health Services Authority, and BC Emergency Health Services. Dr. Devine has held numerous leadership positions, which include her role as chief scientist at Canadian Blood Services, director of the CBR, president of the Association for the Advancement of Blood and Biotherapies (AABB), and editor-in-chief of Vox Sanguinis, a transfusion medicine journal. Their dedication and commitment to scientific discovery through research and development serve as inspiration for future generations of scientists. Inaugural Don Brooks and Dana Devine Transfusion Science Innovation Address In honour of Drs. Don Brooks and Dana Devine’s scientific contributions to advancing transfusion science and medicine, the inaugural Don Brooks and Dana Devine Transfusion Science Innovation Address was presented by Dr. Stephen Withers. Dr. Withers, in collaboration with Dr. Jay Kizhakkedathu’s lab, worked on identifying efficient enzymes for cleaving terminal sugar structures on the surface of red blood cells (RBCs), which are responsible for determining blood types. By removing these terminal sugar structures, A and B type RBCs can be converted to the universal donor blood type O, which can increase blood supply for transfusion applications. By screening the human gut microbiome for enzymes that can cleave these terminal sugar structures, they identified a pair of enzymes (FpGalNAc deacetylase and FpGalactosaminidase) that can convert type A to type O blood. Posters & awards This year, there were 29 posters presented by various graduate trainees, postdoctoral fellows, clinical fellows and research associates! These included members within the CBR, but we also had the pleasure of having presenters come from out of town. Multiple trainees from the University of Alberta, University of Toronto & Queen’s University were able to attend the symposium with the support of the CBR Travel Award. The Best Poster Presentation went to Dr. Georgina Butler from the Overall Lab for their poster on “SARS-CoV-2 main protease 3CLpro (nsp5), regulates the formation of tunnelling nanotubes by coordinating cytoskeleton reorganization.” Our final speaker was Dr. Ed Pryzdial with an exciting talk on Dengue virus-induced thrombocytopenia. Afterwards, a reception was held and attendees got to network and socialize with each other to celebrate the end of another incredible symposium! A huge thank you to everyone who attended, to our speakers and all presenters! The Centre for Blood Research would like to thank their event sponsors, without whom the 12th Annual Norman Bethune Symposium would not have been possible: the Naiman-Vickars Endowment Fund, Canadian Blood Services, Novo Nordisk, GRIFOLS, CSL Behring, ALEXION, Sobi and Pfizer. Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts 20th anniversary celebration at the Centre for Blood Research (CBR): commemorating two decades of historical milestones and outstanding achievements Tuesday, August 22, 2023 John Perrier The Centre for Blood Research (CBR) at the University of British Columbia celebrated its 20-year anniversary on July 7th by inviting CBR alumni to join current members in learning about the beginnings of the centre. Read about the celebration and the history of the centre in this blog reposted from CBR. Transfusion Blood Read full story, 20th anniversary celebration at the Centre for Blood Research (CBR): commemorating two decades of historical milestones and outstanding achievements Norman Bethune Symposium 2022 – trainee reports Thursday, June 02, 2022 Canadian Blood Services trainees The 11th annual Centre for Blood Research Norman Bethune Symposium was held on April 6, 2022. With a focus on recent research advances in bleeding and thrombosis, the symposium engages scientists and clinicians at all levels of training. Transfusion Blood Read full story, Norman Bethune Symposium 2022 – trainee reports Canadian Blood Services announces new Dana Devine Award Wednesday, January 24, 2024 Dr. Travis Sztainert Read about the new Canadian Blood Services Dana Devine Award program. This blog post, written by the Centre for Blood Research (CBR) includes reflections from individuals who worked with Dr. Devine. Stem Cells Transfusion Blood Read full story, Canadian Blood Services announces new Dana Devine Award Full Article
arc Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training By www.blood.ca Published On :: Tue, 30 Jul 2024 15:32:29 +0000 Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training Plasma Stem Cells Transfusion Blood Tuesday, July 30, 2024 Kaitlyn Chuong This blog was originally prepared by CBR communications and programs coordinator Kaitlyn Chuong and former Canadian Blood Services knowledge broker Dr. Travis Sztainert, with edits provided by Abby Wolfe. After more than 20 years, the Centre for Blood Research (CBR) and Canadian Blood Services are proud to share that they have renewed their collaboration agreement which supports education, training and knowledge mobilization for the next generation of trainees and researchers in blood science and transfusion at CBR. The collaboration agreement which is administered by Innovation and Portfolio Management at Canadian Blood Services has recently been extended for three more years to 2027. This agreement formalizes the next iteration of this long-standing partnership and is the result of continued commitment from both organizations to improve blood research. This partnership emerged in response to recommendations made following Canada’s public inquiry into the contaminated blood crisis of the 1980s and 1990s. Thus, to address a recognized gap in transfusion science knowledge, in 2002, a group of visionary blood researchers at the University of British Columbia (UBC) established Canada’s first interdisciplinary blood research centre — an entirely unique and valuable resource for established and emerging blood scientists. With its creation, the CBR brought together a wide range of multi-talented investigators to develop highly specialized labs to study blood and transfusion science. Since its inception, the CBR has grown to include more than 35 basic science, applied science, social science and clinical investigators in 12 departments, representing 6 faculties at UBC, with a focus on advancing knowledge of transfusion science and medicine in the lab and in the clinic. "We are delighted to extend our partnership with the Centre for Blood Research through 2027. This renewal highlights our shared commitment to advancing education, training, and research in transfusion science. Together, we aim to drive innovation and improve transfusion practices, ensuring a safer and more effective future for the Canadian blood system." Dr. Chantale Pambrun Senior Medical Director, Innovation & Portfolio Management “The long-term relationship of Canadian Blood Services and the CBR has been nothing less than fantastic! By combining resources and sharing knowledge, education and research outputs, this unique partnership has resulted in more rapid and meaningful advances that are recognized locally, nationally and internationally. The entire transfusion medicine community has benefitted and will continue to do so.” Dr. Ed Conway Director of the Centre for Blood Research The partnership of Canadian Blood Services was integral to creating the Centre for Blood Research, providing essential start-up funding and continuing to support infrastructure for the centre and its training and education programs. Several Canadian Blood Services scientists are active members within the Centre for Blood Research including senior scientist Dr. Ed Pryzdial and adjunct scientists Dr. Ed Conway, Dr. Hongshen Ma and Dr. Jay Kizhakkedathu. Learn more about some of the research these scientists and members of their labs undertake in our previous R.E.D. blogs and videos: Pryzdial lab: Investigating envelope viruses (blood.ca) Ma lab: A novel microfluidic device to aid in the search for red blood cell "super-storers" Graduate trainees: Recipients of the Canadian Blood Services Graduate Fellowship Program The CBR is grateful for Canadian Blood Services’ continuous support, without which its many educational, training and research programs would not be possible. This includes, for example, CBR’s Graduate Award Program and Summer Studentship Program, as well as the CBR's weekly seminar series and the annual Earl W. Davie and Norman Bethune symposia. Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts 12th annual Norman Bethune Symposium showcases breadth of ongoing research Tuesday, June 25, 2024 Guest Author The Centre for Blood Research (CBR) Norman Bethune Symposium gathers scientists, clinicians, healthcare professionals, and trainees to discuss advancements in the field of blood research. The 12th Annual event, held in April 2024, consisted of expert talks on thalassemia, thrombocytopenia, sickle cell disease, and other bleeding disorders, demonstrating the breadth of ongoing research. Transfusion Blood Read full story, 12th annual Norman Bethune Symposium showcases breadth of ongoing research One month left to enter the 2024 Lay Science Writing Competition! Tuesday, May 14, 2024 Abby Wolfe The 2024 Canadian Blood Services’ Lay Science Writing Competition is open for submissions from research trainees in Canadian Blood Services’ research network until Friday, June 14, 2024. The theme this year is: “Connecting science with society”. Additional competition details available in this post! Transplantation Organs and Tissues Plasma Stem Cells Transfusion Blood Read full story, One month left to enter the 2024 Lay Science Writing Competition! Earl W. Davie Symposium 2023: Seventeen years of connecting through science sharing Wednesday, February 21, 2024 Dr. Travis Sztainert In this blog post, read about the 2023 Earl W. Davie Symposium held at the Centre for Blood Research (CBR) - a research event that brings together scientists, medical doctors, healthcare professionals, and trainees in the field of blood research and beyond. Transfusion Blood Read full story, Earl W. Davie Symposium 2023: Seventeen years of connecting through science sharing Full Article
arc Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils By www.blood.ca Published On :: Thu, 29 Aug 2024 14:37:37 +0000 Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils Plasma Transfusion Blood Thursday, August 29, 2024 Abby Wolfe Dr. Donald R. Branch’s work as a discovery scientist at Canadian Blood Services focuses on immunotherapy, seeking to further enhance understanding of the cellular and molecular mechanisms involved in autoimmune diseases. Based in Toronto, Dr. Branch’s laboratory develops models of rheumatoid arthritis, Alzheimer’s disease, immune thrombocytopenia (ITP) and multiple sclerosis in mice. These models are particularly useful in examining how cells affected by these conditions respond to current therapeutic agents like intravenous immunoglobulin – a blood product made from human plasma commonly known as IVIg – and investigating potential alternative therapeutics. Over the years, Dr. Branch’s lab research findings have included the discovery of a special reagent that makes identification of antibodies easier by “zapping" autoantibodies, answers around unexpected side effects of IVIg therapy, and insights around recipients’ responses to bone marrow transplantation. It has also earned him numerous awards and accolades, including four from AABB, the Association for the Advancement of Blood & Biotherapies. Dr. Don Branch, Canadian Blood Services senior scientist New knowledge about neutrophils Recently, contributions from Dr. Branch’s lab helped a U.K.-based team of researchers discover new information about how neutrophil function and activity is regulated. Neutrophils are a type of white blood cell that are part of the body’s normal immune response. A person’s neutrophil levels may be affected by infections as well as chronic or acute illnesses. Patients who have very low neutrophil counts and/or persistent infections may receive a boost to their neutrophil levels via granulocyte transfusion therapy. However, in some diseases, overactivation of neutrophils can also create an inflammatory environment and harm healthy tissue. The research has been published in the high-impact scientific journal, Nature. This publication has filled a gap in knowledge about the mechanisms involved in maintaining balance between neutrophils’ infection-fighting power and inflammation-causing potential. As Dr. Branch describes: “This research by Dr. Brown and team shows that the myeloid inhibitory C-type lectin enzyme, which is known as MICL, controls neutrophil activity in rheumatoid arthritis. It is likely that MICL also regulates neutrophil activity in general. This suggests that if therapeutics can be designed to target MICL, they may be useful in controlling inflammation and infection. It is a fundamental finding that will change our understanding of the biology of neutrophils.” Discovery research, like the study to which Don and Ruqayyah contributed, is essential to improving patient care in the long run. New biomedical insights are essential to crafting new drugs and new therapeutic approaches in a rational way. Dr. William (Bill) Sheffield, Canadian Blood Services senior scientist and associate director of research Discovery research expertise leads to new collaboration The special mouse model that Dr. Branch’s lab uses is known as K/BxN. In this model, two mouse populations are selectively bred to produce offspring whose genetic material carry an antibody that destroys bone cartilage. An arthritis-causing serum containing this destructive antibody can then be obtained from the mice for use as a reagent in research. This process is termed “serum-transfer arthritis” and has been used by many investigators in the study of treatments that may alleviate the condition. Knowledge of Dr. Branch’s lab’s expertise in this area prompted a connection to the team of researchers at the Universities of Exeter and Aberdeen in the U.K. for this study. Says Dr. Branch, “In 2021, I supported a successful application to Canadian Blood Services’ Blood Efficiency Accelerator Program (BEAP) by Dr. Maria Fernandes, a researcher from Héma-Québec who works with neutrophils. Through this collaboration, Dr. Fernandes was aware that I work on rheumatoid arthritis with K/BxN mice, and she also knew that Dr. Gordon Brown in the U.K. was looking to collaborate with a researcher in this area for some planned neutrophil research. My lab, which included postdoctoral fellow Dr. Ruqayyah Almizraq at the time, contributed to Dr. Brown’s research by providing the sera from our K/BxN mice. With this sera, Dr. Brown and his collaborators were able to induce rheumatoid arthritis and show that it could be resolved by removing the inhibition of a specific enzyme.” Science that is never boring The Branch lab is currently using these same mouse models to investigate whether a recombinant protein called IgG1 Fc hexamer could be an effective replacement for IVIg in the treatment of autoimmune conditions like rheumatoid arthritis and ITP. While early results are promising, continued work is needed. In fact, back in 2018, Dr. Branch was asked in a previous R.E.D. blog post to describe what he found to be the most exciting part of science. Reflecting on the same question now, he reiterates that his response still rings true after 50 years in the field: The most exciting part of science is that when you do good science, you get more questions than you get answers, which means it is never boring. There is no end to imagination; new ideas, theories, experiments and discoveries occur often and provide a level of excitement to which many other professions cannot attest. Dr. Donald (Don) Branch, Canadian Blood Services senior scientist Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts Senior scientist wins prestigious award for discovering a ‘gold standard’ reagent used in transfusion medicine Tuesday, March 28, 2023 Aldis Brennan Dr. Donald Branch, Canadian Blood Services senior scientist, has received the Dale A. Smith Memorial Award for his discovery of the ZZAP reagent. This award, from the Association for the Advancement of Blood & Biotherapies (AABB), recognizes the application of technology to the practice of transfusion medicine or biotherapies. Transfusion Blood Read full story, Senior scientist wins prestigious award for discovering a ‘gold standard’ reagent used in transfusion medicine Interactive lab tour helps undergraduate students learn from Canadian Blood Services senior scientist and team Thursday, March 16, 2023 Beth Binnington, Senior Research Assistant Students from the Undergraduate Pathology Alliance at Western University posed insightful questions to researchers during an interactive visit to the research laboratory of Dr. Donald Branch, Canadian Blood Services senior scientist in February 2023. Plasma Transfusion Blood Read full story, Interactive lab tour helps undergraduate students learn from Canadian Blood Services senior scientist and team Meet the researcher: Dr. Donald Branch Wednesday, February 28, 2018 Dr. Kendra Hodgkinson For this instalment of “Meet the researcher”, we met with Dr. Donald Branch, a scientist at Canadian Blood Services who studies infectious diseases and immunology. How long have you been with Canadian Blood Services? I started with the Canadian Red Cross at the Edmonton Blood Centre in December 1985... Plasma Transfusion Blood Read full story, Meet the researcher: Dr. Donald Branch Full Article
arc Celebrating young researchers: A look back at CBR Research Day 2024 By www.blood.ca Published On :: Tue, 10 Sep 2024 17:00:09 +0000 Celebrating young researchers: A look back at CBR Research Day 2024 Plasma Stem Cells Transfusion Blood Tuesday, September 10, 2024 Trainees Our partnership with the Centre for Blood Research (CBR) at the University of British Columbia (UBC) is helping to train the next generation of researchers in transfusion science. This blog post highlights just some of the achievements in education, training or knowledge mobilization accomplished by CBR trainees. This is a repost of a blog written by CBR summer students Jackie Hagstrom, Mohammed Al-Seragi and Nastaran Davilu. It was edited by CBR Communications and Programs Coordinator Kaitlyn Chuong, and originally appeared on the CBR blog in September 2024. Each year, CBR’s Research Day provides an opportunity for CBR Summer Studentship Program participants to share their research projects with their peers and other labs while practicing presentation skills through short talks and poster presentations. A look back at CBR Research Day 2024 On August 15th, the CBR community gathered in-person and online to celebrate the hard work and research of this year’s summer students. The day kicked off with welcoming remarks, followed by oral presentations from students, where we heard from peers working on diverse projects. Each student had just 3 minutes to present their summer research projects, with the promise of a rubber chicken noise signaling if they exceeded their time limit. It was inspiring to learn what these four months looked like for this year’s summer students. The collection of three-minute flash talks was a striking window into the immense breadth of research behind the twenty-one-membered cohort. Everything from cancer glycoimmunology to stem cell differentiation, blood disease pathology and the like were subjects of the two-hour triage of presentations. More impressive than the research itself was how effectively everybody was able to collapse many weeks of work into a mere three minutes — something many students said they struggled with! The day provided both a platform to showcase our work and an opportunity to engage in meaningful conversations within the CBR community. Nastaran Davilu, CBR Summer Student 2024 This year’s Neil Mackenzie Mentorship Award was presented to Dr. Michael Sutherland who spoke on what excellent mentorship means to him, as he reflected on his 20+ years of working under Dr. Ed Pryzdial. He emphasized the value of giving students actionable advice when challenges arise, the importance of empathy, comradery and being understanding and even showcased his knowledge of “brat summer”, a term he learned from his students. A particularly memorable moment was Dr. Sutherland humorously mentioning being told he has no “rizz,” and shared his experience of checking if the term was offensive, only to have Reddit users call his question “cringe.” This lighthearted moment, featuring other classic Gen-Z phrases, added humor to the day and highlighted the inclusive and fun spirit of the CBR community. CBR summer students pose for a group photo with keynote speaker, Dr. Brianne Kent. To top it off, Dr. Brianne Kent, this year’s keynote speaker, delivered a highly insightful address on the intersection of learning, sleep, and circadian rhythms with dementia and what that means for our aging and vulnerable populations. Dr. Kent began by discussing novel biomarkers that could help predict the onset age of Alzheimer’s disease (AD), which may provide patients a better chance at benefiting from treatment. One such biomarker is disturbed sleep, with research suggesting that targeting sleep disturbances could prevent up to 15% of AD cases. She explored various topics, including the potential of the antidepressant Trazodone to slow cognitive decline. Overall, this research points to slow wave sleep as a key area of therapeutic intervention and suggests that cognitive tasks assessing pattern separation are particularly sensitive to sleep disruptions and sleep aids. Maybe a bit more upending was Dr. Kent’s realization that students don’t sleep nearly as much as she thought, something that many students can attest to. Attendees visit the poster presentations during Research Day. Following the keynote address, the event transitioned to the poster session in the UBC Life Sciences Centre West Atrium. The CBR community circulated and engaged in in-depth discussions with students eager to delve deeper into their research. Ending the day off with poster presentations was an amazing representation of the collaborative atmosphere that permeated the event. It was clear that this year’s Research Day was more than just a platform for sharing results; it was a space for building connections, exchanging ideas, and sparking new collaborations.” Sajida Chowdhury, CBR Summer Student 2024 Poster judges provided valuable feedback, helping to explore future research directions, critiquing methodologies, and making connections to other related work happening at the CBR. With refreshments in hand, students also took the opportunity to explore their peers' posters, gaining insight into where their research paths might lead after the CBR Summer Studentship Program. The evening ended with a BBQ dinner shared with friends, families, and lab members, a fitting end to a summer filled with connections and opportunities. CBR Research Day was a hit in many more ways than the findings we were able to share. It was a time of learning but one of celebration as well. I have high promises for the Research Days to come and hope to be around for them too! Mohammed Al-Seragi, CBR Summer Student 2024 Congratulations to all of the award winners at this year’s Research Day: Best Oral Presentation (voted by the students) – Madelyn Tisdale, Mizumoto Lab People’s Choice Award (voted by the audience) – Houria Afshar Moghaddam, Av-Gay Lab Best Poster Presentation (voted by the poster judges) – Simrat Binning, Cote Lab Dr. Ed Conway presents the Best Oral Presentation award to Madelyn Tisdale. Dr. Ed Conway presents the People’s Choice Award to Houria Afshar Moghaddam Dr. Ed Conway presents the Best Poster Presentation award to Simrat Binning. Many thanks to our sponsors, without whom the CBR Summer Studentship Program and CBR Research Day would not be possible: the Neil Mackenzie Memorial Fund, the Naiman-Vickars Endowment Fund, Canadian Blood Services, GSK, AstraZeneca, GRIFOLS, Beigene, Stago and Sobi. We’d also like to say thank you to the Life Sciences Institute for partnering with us on this year’s program. Lastly, we are grateful for all the support and kindness of Kaitlyn Chuong, the CBR Communications and Programs Coordinator. More about events at the Centre for Blood Research Missed the event? Watch the recording of CBR Research Day 2024, see photos from the event and review the program on the CBR website. Other upcoming CBR events: Registration is now open for the 18th Annual Earl W. Davie Symposium taking place November 13, 2024. The goal of the Earl W. Davie Symposium is to disseminate advances in the field of hemostasis-thrombosis, as applied to innate immunity, infectious diseases, inflammation and cancer. The registration deadline for oral presentations is October 8th with travel awards available for trainees to attend and present at the symposium. Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training Tuesday, July 30, 2024 Kaitlyn Chuong Canadian Blood Services’ partnership with the Centre for Blood Research (CBR) at the University of British Columbia (UBC) has been renewed to 2027 to continue training the next generation of researchers in transfusion science. Plasma Stem Cells Transfusion Blood Read full story, Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training CBR Research Day 2023: Celebrating our summer students! Tuesday, November 28, 2023 Abby Wolfe Read about the annual Research Day event held at the Centre for Blood Research (CBR) in this blog post written by CBR summer student alumni. Transfusion Blood Read full story, CBR Research Day 2023: Celebrating our summer students! CBR Research Day 2022: A day to celebrate summer student research Tuesday, November 08, 2022 Trainees Want to learn about the latest research at the Centre for Blood Research (CBR)? If cutting-edge, interdisciplinary work in science and medicine interests you, then you’ll want to catch this event recap on CBR Research Day 2022! Plasma Transfusion Blood Read full story, CBR Research Day 2022: A day to celebrate summer student research Full Article
arc Canadian Blood Services research engineer applies network modelling techniques and mentorship skills to benefit Canada’s Lifeline By www.blood.ca Published On :: Tue, 22 Oct 2024 15:13:20 +0000 Canadian Blood Services research engineer applies network modelling techniques and mentorship skills to benefit Canada’s Lifeline Plasma Stem Cells Transfusion Blood Tuesday, October 22, 2024 Dr. Emily Freeman Dr. John Blake is a research engineer at Canadian Blood Services and a Professor in the Department of Industrial Engineering at Dalhousie University. Based in Halifax, Nova Scotia, Dr. Blake and his trainees use engineering principles and various computer-based optimization techniques to inform large scale decisions at Canadian Blood Services. Applying network modelling to biologics To some, it may be surprising to learn that there is such opportunity to integrate engineering into the health-care focused setting of Canadian Blood Services. However, as Dr. Blake explains, the same engineering principles that apply to the development and quality assurance of other products also apply to biologics such as blood, stem cells and organs. One of these classic engineering approaches currently applied to improving operations at Canadian Blood Services is network modelling. Network modelling is a computer-based method that creates a virtual representation of objects and their relation to each other. The resulting models are particularly useful for maintaining adaptability in the collection of blood donations, as well as the distribution and inventory management strategies that allow Canadian Blood Services to remain a safe and reliable provider of life-saving products. Dr. Blake making friends while walking the Camino de Santiago in Spain Contributing to efficiency and sustainability in Canada’s Lifeline For Dr. Blake’s team, modelling is not about the data acquired but rather how they can turn existing data into real life change. Part of this approach is ensuring that Canadian Blood Services is asking the right questions when it comes to allocating resources. For example, Dr. Blake has worked on models to assess how changing stem cell donor recruitment will affect the number of matches for Canadian patients. By modelling things such as recruitment approaches, Dr. Blake’s work assists Canadian Blood Services to consistently identify ways to improve Canada’s Lifeline. Recently, Dr. Blake has also been applying this method to optimize the number and location of mobile and permanent donor facilities across the nation. This redesign of the donation facility network will address the growing demand for donations by bringing Canadian Blood Services’ facilities closer to the donors. “I have waited my entire career for a problem of this type – it is truly a once in a lifetime opportunity.” Dr. John Blake, Canadian Blood Services Research Engineer Securing the future of Canada’s Lifeline To sustain a safe and effective blood system in Canada for years to come, network modelling and optimization is a never-ending process. This is one of the reasons that Dr. Blake is committed to securing the future of transfusion and transplantation systems by training and mentoring the next generation of engineers. In fact, seeing his former students join Canadian Blood Services and dedicate their talents to improving the future of Canada’s Lifeline is one of Dr. Blake’s proudest achievements. One of Dr. Blake’s former students, Matt Nelson, is now an industrial engineer at Canadian Blood Services. “In my role, I use systematic thinking to build and run complex models; collect and analyze the required data; produce useful results; and explain these results to non-technical leaders on a regular basis,” Matt says. Recently, Matt contributed to the launch and expansion of pathogen-reduced platelets, a new product that was implemented across Canadian Blood Services production sites starting in 2022. The implementation of pathogen-reduced platelets has provided an additional layer of safety for recipients by reducing the risk of potential transfusion-transmitted pathogens without compromising the quality of the component. Matt credited Dr. Blake in helping him develop the necessary skills he now dedicates to safeguarding Canada’s Lifeline: “Dr. Blake was the professor who introduced me to the uses of simulation to understand complex non-linear systems. This type of system is very common in situations that have a lot of variability – like the blood system – and simulation allows for exploration of the response of the system to changes.” Matt Nelson, Canadian Blood Services Industrial Engineer Over the years, Dr. Blake’s ongoing modelling work and mentorship activities have also led to many recognitions and awards, but he is most proud of being recognized as Professor of the Year by Dalhousie Undergraduate students, and with awards for his contributions to the Canadian Operational Research Society. He has even the earned the distinction of being Dalhousie’s first engineer to be awarded grant funding from the tri-council agency, Social Sciences and Humanities Research Council (SSHRC). “I am proud to work on projects that have a measurable impact on people’s health and well-being,” Dr. Blake says. “I am forever grateful to Dr. Dana Devine for first giving me the opportunity to serve Canadians in this role at Canadian Blood Services.” Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts Revisiting cold-stored platelets: An effort to improve patient care and storage feasibility Tuesday, March 29, 2022 Marie-Soleil Smith This post was written by Marie-Soleil Smith, PhD Candidate in Dr. Hélène Côté’s Lab at the University of British Columbia, and edited by Dr. Geraldine Walsh, knowledge broker at Canadian Blood Services. It originally appeared on the Centre for Blood Research blog in March 2022. Blood Read full story, Revisiting cold-stored platelets: An effort to improve patient care and storage feasibility Meet the Researcher: Dr. John Blake Monday, January 22, 2018 Dr. Geraldine Walsh For the latest instalment of “Meet the researcher” we chatted with Dr. John Blake, Canadian Blood Services’ research engineer and also known as “the numbers guy”. Transfusion Blood Read full story, Meet the Researcher: Dr. John Blake Canadian Blood Services receives Omandt Solandt Award Wednesday, June 13, 2018 Jenny Ryan On June 5, Canadian Blood Services was honoured to accept the Canadian Operational Research Society's Omandt Solandt Award at a reception in Halifax, Nova Scotia. Michelle Rogerson, Director, Supply Chain (Atlantic), Canadian Blood Services, accepted the award on behalf of the organization. About... Transfusion Blood Read full story, Canadian Blood Services receives Omandt Solandt Award Full Article
arc Kratos’ DeMarco Bullish On What Trump, With Help From Musk, Means For Startups And Non-Traditional Defense Companies By www.defensedaily.com Published On :: Fri, 08 Nov 2024 21:17:28 +0000 A second Trump administration committed to cutting federal spending could mean very good things for non-traditional defense companies and startups because of a focus on affordability, Eric DeMarco, the president […] Full Article Business/Financial
arc Marcone Appoints Asterios Satrazemis to CEO of Marcone Group By www.achrnews.com Published On :: Sun, 03 Nov 2024 11:00:00 -0500 With a proven track record of driving transformational growth, Satrazemis spearheads Marcone’s next chapter of expansion and customer-centric innovation. Full Article
arc SolarCity Launches Smart Energy Home in Hawaii By www.achrnews.com Published On :: Mon, 21 Mar 2016 07:15:00 -0400 SolarCity is introducing a Smart Energy Home offering to new residential customers in Hawaii. It includes advanced technology: solar photovoltaic (PV), battery storage, smart electric water heaters, and the Nest Learning Thermostat, all coordinated by a home gateway. Full Article
arc FYI: News Briefs in HVAC - March 11, 2024 By www.achrnews.com Published On :: Mon, 11 Mar 2024 01:00:00 -0400 For your information news briefs from a wide variety of categories within the HVAC industry. Price increases, mergers and acquisitions, award winners, and more are highlighted here each week. Full Article
arc FYI: News Briefs in HVAC - March 25, 2024 By www.achrnews.com Published On :: Mon, 25 Mar 2024 01:00:00 -0400 For your information news briefs from a wide variety of categories within the HVAC industry. Price increases, mergers and acquisitions, award winners, and more are highlighted here each week. Full Article
arc New Refrigerant Research Center Funded By NSF By www.achrnews.com Published On :: Fri, 27 Sep 2024 07:00:00 -0400 The NSF is providing a grant to six universities, which will work together to create sustainable refrigerant technologies. Full Article
arc Sip a Smoothie While Researching Reach-Ins, Coolers, and Ice Makers By www.achrnews.com Published On :: Mon, 09 Jul 2018 07:33:00 -0400 Refrigeration contractors who have not yet attended the annual National Restaurant Association (NRA) show really need to put it on their bucket lists. For four days each year, McCormick Place convention center is filled to the rafters with vendors exhibiting everything from gluten-free pasta to pizza ovens to high-tech ice machines. Full Article
arc A Deep Dive Into Five Refrigeration Architectures By www.achrnews.com Published On :: Mon, 10 Feb 2020 04:22:00 -0500 As refrigerant regulations grow more stringent, manufacturers are beginning to offer new refrigeration architectures that utilize low-GWP refrigerants. Full Article
arc March 27, 2023 NEWSRoom: Heat Pumps Part of Musk’s Master Plan, AHRI Policy Leadership Award, Enter Top 30 Distributors of 2023 By www.achrnews.com Published On :: Mon, 27 Mar 2023 13:00:00 -0400 Catch up on the latest headlines in our NEWSRoom video series. Full Article
arc Episode 23: Architecture Pt. 1 By feedproxy.google.com Published On :: Fri, 14 Jul 2006 22:00:00 +0000 This is the first of a series of Episodes on Software Architecture. Alex, Michael and Markus talk about rather fundamental topics in this episode, we'll go into much more detail in subsequent episodes in that series. Topics in this episode include: What is architecture, how is it different from design what different kinds of architecture are there in addition to software architecture the role of the architect, do we have one or more? architecture in agile software development tasks of the architect architect vs. the technical project lead architecture and project politics architecture requirements, estimating, team assembling There aren't too many good references for this general architecture discussion. You might want to take a look at Software Architecture in Practice by Len Bass, or, if you speak German, at the book Software-Architektur by Vogel, Arnold, Chugtai, Ihler, Mehlig, Neumann, Voelter and Zdun. Full Article
arc Episode 25: Architecture Pt. 2 By feedproxy.google.com Published On :: Thu, 03 Aug 2006 22:00:00 +0000 In this Episode, Michael and Markus continue the discussion about the fundamentals of software architecture (we're doing it without Alex, because it is really hard to find a suitable time for all of us on the phone :-)). We talk about the various quality attributes (such as performance, scalability, maintainability and many more) and how they relate to each other. Full Article
arc Episode 27: Service Oriented Architecture Pt.1 By feedproxy.google.com Published On :: Wed, 23 Aug 2006 22:00:00 +0000 SOA (Service Oriented Architecture) appears to be just another hype - after all we have been building distributed systems for quite a while now. But the real value of SOA is non-technical. In this episode Eberhard and Markus discuss the advantages and disadvantages, what SOA actually is and how it compares to other approaches that have been tried out before. Full Article
arc Episode 30: Architecture Pt.3 By feedproxy.google.com Published On :: Fri, 22 Sep 2006 22:00:00 +0000 In this third Episode on software architecture, Michael and Markus talk about the basic tools that an architect uses when architecting systems. These tools include things like separation, abstraction, compression and sharing. We also relate these tools to the quality attributes we introduced in previous archtecture episodes. Full Article
arc Episode 32: Service Oriented Architecture, Pt.2a By feedproxy.google.com Published On :: Fri, 13 Oct 2006 13:20:46 +0000 In this, as well as in the next episode Eberhard and Markus continue their discussion about SOA (the episode got too long, so we had to split it into two ... SOA 2a and SOA 2b). In this episode, we talk about the various perspectives on SOA (CBD, EAI, BPM), about fundamental requirements towards an SOA, and we discuss the role of models in defining sustainable architectures. We also discuss how a programming model based on the described approach typically looks like. We then discuss a number of issues any large-scale SOA faces (and for which the SOA paradigm does not really provide an out-of-the-box solution: In this episode we discuss data type ownership and (weak) typing of data types. Full Article
arc Episode 33: Service Oriented Architecture, Pt.2b By feedproxy.google.com Published On :: Mon, 23 Oct 2006 13:19:03 +0000 This is the second snippet of the SOA 2 double-episode. Eberhard and Markus continue the discussion with the issue of service reuse and a couple of development process issues. We also look at the duality between infrastructure development and application development in the context of an SOA. We then discuss the great spaghetti misunderstanding :-). We conclude this episode with a look at how to integrate BPM into the conceptual SOA framework we've built up to now, and we'll also briefly skim over a number of technologies related to SOA. Note that this episode, as well as the last one, is based on a set of slides; these can be downloaded from here. This episode covers slides 39 through 74. Full Article
arc Episode 34: Enterprise Architecture By feedproxy.google.com Published On :: Thu, 02 Nov 2006 12:17:02 +0000 In this episode Markus and our Guest Andy Longshaw talk about enterprise architecture. More specifically, we talk about some of the patterns in Andy Longshaw's and Paul Dyson's book Architecting Enterprise Solutions: Patterns for High-Capability Internet-based Systems. These includes things like replication, load balancing, monitoring and application management. Full Article
arc Episode 41: Architecture Patterns (Architecture Pt. 4) By feedproxy.google.com Published On :: Wed, 27 Dec 2006 10:14:51 +0000 This is the fourth and final episode on the fundamentals of Software Architecture. We talk mainly about architectural styles and patterns, as introduced in the POSA 1 Book. We also discuss a little bit the process of actually using those patterns for architecting systems. Full Article
arc Episode 64: Luke Hohmann on Architecture and Business By feedproxy.google.com Published On :: Sat, 04 Aug 2007 22:00:00 +0000 In this episode we talk about the relationship between software architecture and the business. Based on his book, Beyond Software Architecture we discuss how things such as branding, licensing, updating or different deployment scenarios influence the technical architecture of a system. We also discuss issues such as portability that add a huge amount of complexity, although from a business perspective it often does not make much sense. In the second part of the interview we discuss how the technical team and the business team can improve the way they work together. We look at some of the games (such as Buy a Feature or Give them a Hot Tub) from his new book Innovation Games, which discusses how to use collaborative play to be more creative and innovative in product creation. Full Article
arc Episode 74: Enterprise Architecture II By feedproxy.google.com Published On :: Sat, 03 Nov 2007 11:35:09 +0000 Enterprise Architecture is already common practice in most Fortune 100 companies. As the topic is comparably young, knowledge about it is not so widespread in the Software Architects Community, who deals mostly with project architectures. In this episode Alex speaks with Wolfgang Keller who has practical experience as an enterprise architect and has written a book on the topic. He is a Partner with BusinessGlue Consulting. They are specializing in the relationship between EAM and SOA. This episode gives a rough overview what Enterprise Architecture actually is touches the standards in the field and also gives hints on the practical work of Enterprise Architects. Full Article
arc Episode 88: The Singularity Research OS with Galen Hunt By feedproxy.google.com Published On :: Sun, 02 Mar 2008 20:58:38 +0000 In this episode we talk to Galen Hunt about the Singularity research OS. Galen is the head of Microsoft's OS Research Group and, together with a team of about 30 other researches, has built Singularity. We started our discussion by covering the basics of Singularity: why it was designed, what the goals of the project are as well as some of the architectural foundations of Singularity: software isolated processes, contract-based channels and manifest-based programs. In this context we also looked at the role of the Spec# and Sing# programming languages and the role of static analysis tools to statically verify important properties of a singularity application. We then looked a little bit more closely at the role of the kernel and how it is different from kernels in traditional OSes. In a second part of the discussion we looked at some of the experiments the group did based on the OS. These include compile-time reflection, using hardware protection domains, heterogenerous multiprocessing as well as the typed assembly language We closed the conversation with a look at some of the performance characteristics of Singularity, compatibility with traditional operating systems and a brief look at how the findings from Singularity influence product development at Microsoft. Full Article
arc Episode 93: Lessons Learned From Architecture Reviews with Rebecca Wirfs-Brock By feedproxy.google.com Published On :: Tue, 15 Apr 2008 12:38:12 +0000 In this episode, Markus talks to Rebecca Wirfs-Brock on what she has learned from architecture reviews. This is a very complement to the earlier episode on architecture evaluation. Full Article
arc Episode 104: Plugin Architectures By feedproxy.google.com Published On :: Sun, 20 Jul 2008 07:30:56 +0000 In this episode we talk with Klaus Marquardt about building systems out of plugins. After briefly introducing the concept of a plugin in contrast to modules and related software engineering concepts, we discuss different views on plugins and different ways of working with plugins for developing software. We are looking at plugins for embedded systems as well as large business systems, at how plugins change the working mode and team organization, and discuss the possibilities of why and when to use plugins for implementing software systems. Full Article
arc Episode 109: eBay’s Architecture Principles with Randy Shoup By feedproxy.google.com Published On :: Mon, 08 Sep 2008 06:57:11 +0000 In this episode we discuss with Randy Shoup, Distinguished Architect at eBay, about architectural pinciples and patterns used for building the highly scalable eBay infrastructure. The discussion is structured into four main ideas: partition everything, use asynchrony everywhere, automate everything, and design the system keeping in mind that everything fails at some point in a large distributed system. Full Article
arc Episode 115: Architecture Analysis By feedproxy.google.com Published On :: Tue, 28 Oct 2008 07:41:25 +0000 During Evolution of a software system, it becomes more and more difficult to understand the originally planned software architecture. Often an architectural degeneration happens because of various reasons during the development phases. In this session we will be looking how to avoid such architectural decay and degeneration and how continuous monitoring can improve the situation (and avoid architectural violations). In addition we will look at "refactoring in the large" and how refactoring can be simulated. A new family of "lint like tools for software architectures" is currently emerging in the marketplace I will show some examples and how they scale and support you in real world projects. Full Article
arc Episode 131: Adrenaline Junkies with DeMarco and Hruschka By feedproxy.google.com Published On :: Mon, 06 Apr 2009 09:43:54 +0000 This episode is an interview with Tom DeMarco and Peter Hruschka about the new book of the Altantic Systems Guild: Adrenaline Junkies and Template Zombies: Understanding Patterns of Project Behavior. This is a session recorded live at OOP 2009. SE Radio thanks Tom and Peter, SIGS Datacom and the programme chair, Frances Paulisch, for their great support! Full Article
arc Episode 132: Top 10 Architecture Mistakes with Eoin Woods By feedproxy.google.com Published On :: Thu, 16 Apr 2009 15:53:47 +0000 This is a discussion with Eoin Woods about his collection of top 10 software architecture mistakes. Looking at things that don't work is always a good way to learn what you should actually do. Full Article
arc Episode 142: Sustainable Architecture with Kevlin Henney and Klaus Marquardt By feedproxy.google.com Published On :: Mon, 10 Aug 2009 17:39:57 +0000 This is another episode recorded at OOP 2009, thanks to SIGS Datacom and programme chair Frances Paulisch for making this possible. Here is the abstract from the conference program: Many software systems have fragile architectures that are based on brittle assumptions or rigid architectures that reduce options and make change difficult. On the one hand, an architecture needs to be fit for the present day, suitable for immediate use, and on the other it needs to accommodate the future, absorbing reasonable uncertainty. However, an approach that is overly focused on today's needs and nothing more can create an inflexible architecture. An approach that becomes obsessed with possible future changes creates an overly complex architecture that is unfit for both today's and tomorrow's needs. Both approaches encourage an early descent into legacy for a system. The considerations presented in this talk reflect an approach that is more about thinking in the continuous present tense than just the present or the future tense. This includes principles from lean thinking, practices common in agile processes and techniques for loosely coupled design. Full Article
arc Episode 144: The Maxine Research Virtual Machine with Doug Simon By feedproxy.google.com Published On :: Mon, 07 Sep 2009 18:49:33 +0000 In this episode we talk with Doug Simon from Sun Microsystems Laboratories about the Maxine Research VM, a so-called meta-circular virtual machine. Maxine is a JVM that is written itself in Java, but aims at taking JVM development to the next level while using highly integrated Java IDEs as development environments and running and debugging the VM itself directly from the Inspector, an IDE-like tool specialized for the Maxine VM. During the episode we talk about the basic ideas behind Maxine, what exactly "meta-circular" means and what makes it interesting and promising to build a Java VM in Java. We talk about the relationship to Sun's current production JVM (HotSpot) and about ideas and directions for the future of Maxine. Full Article
arc Episode 148: Software Archaeology with Dave Thomas By feedproxy.google.com Published On :: Mon, 02 Nov 2009 06:33:57 +0000 Dave explains why reading source code is at least as important a skill as writing source code. He shares approaches for how to get to grips with unknown and undocumented source code even if it is non-trivial in size. He finishes with advice for how to get started reading code. Full Article
arc Episode 166: Living Architectures with John Wiegand By www.se-radio.net Published On :: Wed, 18 Aug 2010 19:37:29 +0000 This time we have John Wiegand on the mic for an episode on architectures and agile software development. We talk about the role of architectures in an agile world and why architectures change and need to change over time. We discuss the characteristics of those living architectures, using the Eclipse and the Jazz projects as examples, and the surrounding development methods for such environments. Full Article