A selection of news photographs taken around the world this week.

A selection of news photographs taken around the world this week.

A selection of news photographs taken around the world this week.

A selection of news photographs taken around the world this week.

A selection of news photographs taken around the world this week.

Saskatchewan’s unemployment rose to 11.3 per cent in April, according to new numbers released by Statistics Canada.

"The Twilight Zone" delved into how human behavior changes in times of crisis.

Money needs to get spent fast. Money needs to get spent well. To some extent, those objectives are in tension.

Even the biggest sites on the internet can have problems with their SEO and Google.

Please visit Search Engine Land for the full article.

Want to know what the most well-loved recipes for the month of April were? You know the ones: the recipes our Simply sous chefs (that’s you!) have been cooking, sharing, and talking about nonstop. Read on to see what made the cut!

Continue reading "The Most Popular Recipes in April" »

Netcare St Augustine's and Netcare Kingsway hospitals have been given the green light to reopen.

Mountain Gorillas in Uganda and Rwanda

Celebrity Deaths in April 2020 Here’s a look at some of the famous faces we lost in the month of April. Ellis Marsalis Jr. Ellis Marsalis, 1934 – 2020 He went out the way he lived: embracing reality pic.twitter.com/sPyYUuBoIG — Wynton Marsalis (@wyntonmarsalis) April 2, 2020 New Orleans jazz legend Ellis Marsalis Jr., 85, died on…

The post Famous Faces Who Passed Away in April 2020 appeared first on The Western Journal.

Replaying Traffic to Test Proprietary Systems — using Wiresham to replay traffic to test blackbox proprietary systems. Outlaw Innovations — This paper will explore how the often illegal activities of hackers (in the original usage of the term to refer to individuals who modify computer hardware and software) may produce valuable innovations. It will explore […]

Imperial College’s COVID19 Model — in github, in R, MIT-licensed. This repository has code for replication purposes. The bleeding edge code and advancements are done in a private repository. Readings on Time — I bumped on this idea while reading Alan Kay’s writing about making the difference between mutable and immutable data “moot” in the […]

The Zero Trust Learning Curve (Palo Alto Networks) — don’t learn with the Crown Jewels. The trouble with starting with the most sensitive protect surfaces is that they’re often too fragile and many people don’t know how they work. Starting there with Zero Trust frequently results in failures. Too often, when this happens, organizations blame […]

Rufus — Create bootable USB drives the easy way. Improving Audio Quality in Duo with WaveNetEQ — Google filling in missing packets in voice calls using deep learning. CRN++ — language for programming deterministic (mass-action) chemical kinetics to perform computation. Crafting Crafting Interpreters — story behind the writing of the Crafting Interpreters book.

locust — open source load testing tool: define user behaviour with Python code, and swarm your system with millions of simultaneous users. (via @nzigel) Background Matting — a method for creating a matte – the per-pixel foreground color and alpha – of a person by taking photos or videos in an everyday setting with a […]

System Design for Advanced Beginners — a friendly explanation of the what and why of systems, with acknowledgement of the real world like There are many tools out there, each with different strengths and weaknesses, and many ways to build a technology company. The real, honest reasons that we will make many of our technological […]

The Fuzzy Edges of Character Encoding — the history, politics, and computational basics of text-based character encoding and digital representations of text, from Morse Code to ASCII to Unicode (and emoji), as well as alternative text encoding schemes. (via Everest Pipkin) AutoHotkey — an automation scripting language for Windows. The Electronic Nose and its Applications: […]

FairMOT — one-shot multi-object tracking that remarkably outperforms the state-of-the-arts on the MOT challenge datasets at 30 FPS. pipedream — IFTTT for coders. Compiler Explorer — an interactive tool that lets you type code in one window and see the results of its compilation in another window. Using the site should be pretty self-explanatory: by […]

Introduction to COBOL — a 1999 web site (!) with slides from a University of Limerick course. IBM will offer free (presumably more modern) training. zoombot — a highly advanced AI to handle Zoom calls. storybook.js — open source toolkit and sandbox to build UI components in isolation so you can develop hard-to-reach states and […]

Since early in March, technology news has been all Coronavirus, all the time. That’s a trend we expect to continue through April and probably beyond. So let’s start with Coronavirus news, and hope that we have something different for next month. Coronavirus The Coronavirus pandemic is forcing reconsideration of how private data is used.  Maciej […]

The Science of Happiness — free enrolment in Berkeley’s MOOC to teach positive psychology. Learn science-based principles and practices for a happy, meaningful life. The New Business of AI (A16Z) — many AI companies have: Lower gross margins due to heavy cloud infrastructure usage and ongoing human support; Scaling challenges due to the thorny problem […]

Coding vs Programming (John Gruber) — I’d noticed this linguistic change too. See also Engineering vs Programming vs Computer Science. Coding is shorter so it’s probably gaining in popularity because shorter is easier to say and thus more convenient. micrograd (Andre Karpathy) — A tiny Autograd engine (with a bite! :D). Implements backpropagation (reverse-mode autodiff) […]

Kanboard — free and open source Trello-like Kanban boards. Remote Work Playbook — really useful advice on the actual mechanics of working remotely, not just which tools to use but how to use them. E.g., As an individual contributor, is there something you just did that you think a colleague would have to do at […]

Nebula —open source distributed, scalable, lightning-fast graph database. COBOL Programming Course — from the Open Mainframe Project. Serverless Handbook — a resource teaching frontend engineers everything they need to know to dive into backend. Novel Annealing Processor Is the Best Ever at Solving Combinatorial Optimization Problems (IEEE Spectrum) — Dubbed STATICA (Stochastic Cellular Automata Annealer […]

CastleDB — a structured static database […]. CastleDB looks like any spreadsheet editor, except that each sheet has a data model. […] stores both its data model and the data contained in the rows into an easily readable JSON file. […] allows efficient collaboration on data editing. Mainframes Are Having a Moment (IEEE Spectrum) — […]

It’s Time to Learn (Scott Berkun) — a strong response to Marc Andreessen’s It’s Time to Build. It feels like we are in a disrupted time when anything is possible, and folks are wondering where the levers are to pull. pygraphistry — a library to extract, transform, and visually explore big graphs. Desert Island Devops […]

Posthog — open source product analytics. Into the Mainframe (Recurse) — the interviews with two mainframe programmers are a great reminder of how much things have changed. And how they haven’t. For instance, later in my career I kept a weighted punching clown in my office. As programmers, we liked our users, but we also […]

Moloch — Large scale, open source, indexed packet capture and search. 3Dify Instagram Photos — open source toolset for adding a 3d effect to photos on Instagram’s web site. It uses 3d-photo-inpainting running in Colab (free GPU) and Cloud pubsub/storage for communication. A glimpse of the future: we could augment all our apps with deep […]

The Suddenly Remote Playbook — I just want to note that if you have to look after kids when you’re supposed to be working, you’re not working from home. Not everyone’s getting a glorious introduction to the delights of working from home. taichi — a programming language designed for high-performance computer graphics. It is deeply […]

Teleforking a Process onto a Different Computer — a working proof of concept (I just don’t replicate tricky things so that I could keep it simple, meaning it’s just a fun tech demo you probably shouldn’t use for anything real) of a telefork() function call that spawns a process on another machine and returns the […]

Learning a Language — this list of questions facing anyone taking a new language for a test run just burns with truth. (Also: encouraging to see how many of these questions are answered by the Cookbook format) OpenVAS — Open Vulnerability Assessment Scanner, aka “what a cheap external security assessment vendor will run and then […]

podpaperscissors — From the classic “prisoner’s dilemma” to more obscure coördination games, Pod Paper Scissors takes game theory out of the dry textbook and into the real world. … Each episode will feature different kinds of games and situations. Experts in a variety of fields will casually converse with the hosts about how the particular […]

To Microservices and Back Again: Why Segment Went Back to a Monolith — microservices came with increased operational overhead and problems around code reuse. … If microservices are implemented incorrectly or used as a band-aid without addressing some of the root flaws in your system, you’ll be unable to do new product development because you’re […]

Is it just me, or did this month majorly speed up? March 2020, the month that coronavirus ramped up enormously, was the longest month of my life. I know it was for many of you, too. By comparison, April seemed to go by in 10 days. This month the hardest decision of my life — …

AK Monthly Recap: April 2020 Read More »

The post AK Monthly Recap: April 2020 appeared first on Adventurous Kate.

Manitoba’s unemployment rate nearly doubled between March and April, according to the monthly report from Statistics Canada released Friday morning.

The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate ligands or receptors and is a key step in niche or host colonization and pathogenicity. Streptococcus gordonii is a primary colonizer of the human oral cavity and an opportunistic pathogen, as well as a leading cause of infective endocarditis in humans. The fibrillar adhesin CshA is an important determinant of S. gordonii adherence, forming peritrichous fibrils on its surface that bind host cells and other microorganisms. CshA possesses a distinctive multidomain architecture comprising an N-terminal target-binding region fused to 17 repeat domains (RDs) that are each ∼100 amino acids long. Here, using structural and biophysical methods, we demonstrate that the intact CshA repeat region (CshA_RD1–17, domains 1–17) forms an extended polymeric monomer in solution. We recombinantly produced a subset of CshA RDs and found that they differ in stability and unfolding behavior. The NMR structure of CshA_RD13 revealed a hitherto unreported all β-fold, flanked by disordered interdomain linkers. These findings, in tandem with complementary hydrodynamic studies of CshA_RD1–17, indicate that this polypeptide possesses a highly unusual dynamic transitory structure characterized by alternating regions of order and disorder. This architecture provides flexibility for the adhesive tip of the CshA fibril to maintain bacterial attachment that withstands shear forces within the human host. It may also help mitigate deleterious folding events between neighboring RDs that share significant structural identity without compromising mechanical stability.

Junmei Zhang
Feb 1, 2009; 8:215-225
Research

4 March 2020 , Volume 96, Number 2

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews