At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

Cựu tổng thống Obama đột nhiên mạnh mẽ chỉ trích người kế nhiệm Donald Trump về cách xử lý cuộc khủng hoảng virus corona.

Trying Instagram on Android.. feels a bit slow maybe because my phone doesn’t have ICS (Taken with Instagram at St Peter’s College)

The government locked down South Africa without knowing exactly how the virus works. And while there is evidence it helped to "flatten the curve", its time to reopen more of the economy, writes Thabi Leoka.

Dozens of protesters descended on the legislature Saturday afternoon, calling for a quicker reopening of the Alberta economy.

A Canadian department store chain is calling it quits after more than a century in business.

A department store that served Vancouver's Gastown and Downtown Eastside neighbourhoods for decades is closing, along with four other Army and Navy locations, because of the COVID-19 pandemic.

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

I should have begun from Monday, but she was really sick on Monday. Today, she looks so bright. She’s beginning to forget things. I wish I could stay longer to help her. She eats when I sit with her. I’m glad when she eats. I learnt her middle name...

Briefing and discussion of the release of the latest paper by MPI's Labor Markets Initiative: The Impact of Immigrants in Recession and Economic Expansion.

Briefing and discussion of the release of the latest paper by MPI's Labor Markets Initiative. Speakers are report author Giovanni Peri, UC Davis Professor of Economics; Ross Eisenbrey, Vice President, Economic Policy Institute; and Demetrios G. Papademetriou, MPI President.

In a report by MPI's Labor Markets Initiative, noted economist and Georgetown University Public Policy Institute Professor Harry J. Holzer examines the economic reasoning and research on these questions and looks at the policy options that shape the impact of less-skilled immigration on the economy. The discussion is on what policy reform would best serve native-born American workers, consumers, and employers, as well as the overall U.S. economy.

He catches the fish, breathes on them, then throws them back. These infected fish will infect all bodies of water with Covid-19. He goes saltwater and fresh water fishing 

I am a dog sitter for my sister, she pays me around $100 a week. I also do extra chores around the house such as cleaning as an exchange for not paying rent. The money she pays me is usually transferred through zelle or paid cash. Im not sure if I would be considered an independent contractor or an employee. Also does she have to report to the irs my income and what forms would she have to use? Ive always received w2s from employers, so I’m Clueless to what I should do this tax season.  Thank you in advance!  Sorry I forgot to mention that my income for this last year was approximately $5000

I’ve liked him for a year and I told him, but he told me to date someone else. I started to forget about him, but then he told me that he liked me too. We’re dating now but I don’t think that I feel the same was as when I first started liking him. What should I do?

I just got sent an electronic message from one of the employers stating that I am unsuitable for the role based on my police record. I'm under the impression some people are still choosing to impersonate me on several job search engines by giving each employer the idea I'm an ex-con with work skills that came out of prison. Is there a chance they can see my old name?

is she thicc af? I made this in the Sims 4 lol 

The Army is requesting bids for a $25 million contract for wearable sensors to detect early symptoms of COVID-19.

The singer-composer, who has collaborated with quite a few international names in music, has his plans firmly in place.

Personal Agenda with Ricky Kej: “Best thing about lockdown? My dog is really happy!”  Hindustan Times

Composer Vayu''s new song ''Mummy'' an ode to mothers  Outlook India

The family owned Army & Navy department store chain is closing after more than a century in business.

A Turkish man gives his life to the Lord after seeing a performance by the Taco Outreach Team.

Zoila Garrido is building relationships with immigrants by teaching them Spanish. Some of them never had the chance to go to school before.

Since 2005, Rachel Chua (22) has been involved in TeenStreet Malaysia and she attended OCZ for the 2nd time this year. Her passion is contagious.

In an effort to respond to the growing need, OM partner organisation AIDSLink International conducts Channels of Hope training in Malaysia and Myanmar.

An act of compassion opens the door for a Zambian worker to share the Gospel with Somalis.

A call has gone out for help to identify thousands of mystery Scottish scenes, finds Sandra Dick.

Wise words

An Iranian refugee surprises a long-term worker by stating his desire to become a Christian.

A woman confesses a need for her heart to be healed following a terrible experience.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

Pat Cummins also said he owes Brendon McCullum and the KKR staff "a few dinners" for showing confidence in him during the IPL auction.

The app will generate real-time location-based alerts helping all employees and consumer base in being aware of the relevant localised corona safety information.

Warren Buffett on Saturday took a dive into the 231-year history of the United States of America to predict the future of the country’s economy struggling to stay on its feet amid the struggle against coronavirus and lockdown: “Nothing can basically stop America.”

Digital technologies have the potential to create $1 trillion economic value, says EY

Advertising Standards Council of India (ASCI) recently announced a set of guidelines that will help celebrities to perform due diligence on a product or brand they wish to endorse.