o 30 low-key acquisitions who could pay off big By mlb.mlb.com Published On :: Tue, 12 Feb 2019 13:57:13 EDT Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with. Full Article
o Orioles considering using 'opener' strategy By mlb.mlb.com Published On :: Tue, 12 Feb 2019 15:24:38 EDT Since the Rays debuted "the opener" last May, no fewer than eight teams have helped transform the concept from a fad into a mini-movement. Consider the Orioles a candidate to dive in next. Full Article
o Hyde comes prepared to first Spring Training By mlb.mlb.com Published On :: Tue, 12 Feb 2019 16:36:22 EDT For Brandon Hyde, the days and weeks leading up to Tuesday were filled with phone calls to friends, to former colleagues, to mentors he's made across more than two decades in the game. A constant theme emerged from the ensuing chats: What, exactly, should Hyde expect from his first Spring Training as a big league manager? Full Article
o Spring Training launches new era for Orioles By mlb.mlb.com Published On :: Tue, 12 Feb 2019 09:07:02 EDT As pitchers and catchers reported Tuesday to Ed Smith Stadium, it marked the end to an offseason of overhaul in Baltimore, and the dawn of a new era. The focus will shift even further, from the front office to the field, when the club's first full squad workouts commence on Monday. Full Article
o 9 comeback candidates to root for this season By mlb.mlb.com Published On :: Wed, 13 Feb 2019 21:00:00 EDT A year ago, Danny Farquhar was not going to be in the middle of a spring storyline. That's going to change this spring as he tries to win a spot in the Yankees' bullpen Full Article
o Around the horn: Will Sisco be the starting C? By mlb.mlb.com Published On :: Wed, 13 Feb 2019 16:29:40 EDT As we inch closer and closer to Opening Day, we'll continue to take a position-by-position look at the Orioles roster options and remaining questions. Now that pitchers and catchers have officially reported to Spring Training, now feels like a good time to take a look behind the plate, where the Orioles have a ton of options but no clear answer. Full Article
o Visa issues delay Sucre's arrival to O's camp By mlb.mlb.com Published On :: Wed, 13 Feb 2019 15:14:25 EDT It may take the Orioles a little longer than expected to sift through their crowded catching situation. A club source confirmed that catcher Jesus Sucre is held up by visa issues in his native Venezuela and will report to camp late. Full Article
o Prospects who should vie for a roster spot By mlb.mlb.com Published On :: Thu, 14 Feb 2019 19:36:11 EDT The 30 prospects below all are getting very long looks this spring with an eye toward breaking camp with the parent club. Even if they start the year in the Minors, they all should get the chance to contribute at some point in the very near future. Full Article
o Givens a lock to take mound in late innings By mlb.mlb.com Published On :: Thu, 14 Feb 2019 16:39:33 EDT With more than a dozen pitchers seemingly in the mix for bullpen jobs this spring, it'll take weeks of assessment before candidates for certain roles begin to emerge. Even the club's few veteran holdovers will have to wait. That includes Mychal Givens, who finished 2018 as the Orioles' closer and arrived at camp the overwhelming favorite to reclaim that job. Full Article
o Now healthy, Karns looks to revive career By mlb.mlb.com Published On :: Thu, 14 Feb 2019 14:14:42 EDT Everyone hopes for health this early in spring. But few more than Nate Karns, who has trudged a longer road back than any player in Orioles camp. Full Article
o Wave him bye bye: O's voice Angel retires By mlb.mlb.com Published On :: Fri, 15 Feb 2019 13:51:18 EDT Wave him bye bye. A legendary voice of Orioles baseball is calling it a career. Joe Angel, beloved play-by-plan man and voice of the Orioles' radio broadcasts for nearly two decades, announced his retirement this week. The decision caps a 41-year career in the booth for Angel, 71, a fixture for 19 seasons across two stints in Baltimore. Full Article
o Davis embracing data, new approach to improve By mlb.mlb.com Published On :: Fri, 15 Feb 2019 17:07:20 EDT Looking to preempt questions about his work ethic in a nightmare 2018 season, Chris Davis reported to Spring Training in Florida more than a week before Orioles position players were required to. That's when his efforts to rebound hit their first minor snag. Full Article
o O's ink veteran Escobar, extend spring invite By mlb.mlb.com Published On :: Sat, 16 Feb 2019 17:04:22 EDT The Orioles' cloudy infield picture gained some clarity Saturday when the team signed veteran shortstop Alcides Escobar to a Minor League contract with an invitation to Spring Training. Full Article
o Top prospect Diaz looks to break camp with O's By mlb.mlb.com Published On :: Sat, 16 Feb 2019 15:49:39 EDT A lot has to go right for Yusniel Diaz to crack the Orioles' Opening Day roster. But the Orioles' No.1 prospect per MLB Pipeline isn't letting that impede his plans to compete for a spot anyway. Full Article
o Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
o Wilkerson is Orioles' man of many gloves By mlb.mlb.com Published On :: Sun, 17 Feb 2019 17:02:36 EDT Steve Wilkerson enters Orioles camp competing for a super-utility role after a brief big league cameo last year. He isn't traveling light, as Wilkerson has 10 gloves on display. Full Article
o O's pitchers welcoming high-tech revolution By mlb.mlb.com Published On :: Sun, 17 Feb 2019 13:49:26 EDT Like so many pitchers in Major League camps, Orioles hurlers have extra sets of eyes on them this spring. The Edgertronic cameras, perched on tripods, are set about a stride's length beyond the backfield bullpen mounds at the club's Ed Smith Stadium complex, as conspicuous as the coaches standing cross-armed behind them. Full Article
o Orioles' Top 30 Prospects list By m.mlb.com Published On :: Tue, 19 Feb 2019 14:46:05 EDT Who do the Orioles have in the pipeline? Get scouting reports, video, stats, projected ETAs and more for Baltimore's Top 30 Prospects on MLBPipeline.com's Prospect Watch. Full Article
o The Orioles' Spring Training battle to watch By mlb.mlb.com Published On :: Mon, 18 Feb 2019 18:20:16 EDT The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs. Full Article
o Here are the Orioles' 2019 Top 30 Prospects By mlb.mlb.com Published On :: Mon, 18 Feb 2019 11:56:36 EDT The Orioles began a long-overdue rebuild in July, when the club dealt many of its more-valued big assets in exchange for prospects. Full Article
o O's Harvey feeling good after BP session By mlb.mlb.com Published On :: Mon, 18 Feb 2019 17:25:04 EDT Orioles right-hander Hunter Harvey had hopped off a backfield mound at the club's Spring Training complex and exhaled. He was one of 14 pitchers scheduled to face hitters as part of the club's first full-squad workout on Monday, and now that he had, Harvey was asked to recall when was the last time he threw competitive pitches. Full Article
o Here are 12 Orioles to watch in spring camp By mlb.mlb.com Published On :: Mon, 18 Feb 2019 12:50:26 EDT In holding their first full-squad workout on Monday, the Orioles ushered in the first official phase of a spring set to surprise. Fresh faces flood Ed Smith Stadium. Questions litter the roster. Battles abound at nearly every position. Full Article
o Mountcastle tries 1B as O's preach versatility By mlb.mlb.com Published On :: Tue, 19 Feb 2019 14:55:25 EDT Taking reps behind Chris Davis at first base, Orioles prospect Ryan Mountcastle became the most high-profile participant yet in the club's grand spring experiment. Full Article
o Pitch clocks nothing new to younger players By mlb.mlb.com Published On :: Tue, 19 Feb 2019 18:02:13 EDT Pitch clocks are set to make their Spring Training debuts this week, and it will be in games featuring hordes of players for whom playing on a timer is nothing new. Full Article
o Orioles to honor Frank Robinson on uniforms By mlb.mlb.com Published On :: Wed, 20 Feb 2019 08:53:26 EDT The Orioles will honor late icon Frank Robinson during Grapefruit League play and will continue to do so throughout the season, with a patch on the sleeves of their uniforms. The patch features Robinson's No. 20 in orange against a black background. Full Article
o Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 The ability to switch fuels for oxidation in response to changes in macronutrient composition of diet (metabolic flexibility) may be informative of individuals’ susceptibility to weight gain. Seventy-nine healthy, weight-stable participants underwent 24-h assessments of energy expenditure and respiratory quotient (RQ) in a whole-room calorimeter during energy balance (EBL) (50% carbohydrate, 30% fat) and then during 24-h fasting and three 200% overfeeding diets in a crossover design. Metabolic flexibility was defined as the change in 24-h RQ from EBL during fasting and standard overfeeding (STOF) (50% carbohydrate, 30% fat), high-fat overfeeding (HFOF) (60% fat, 20% carbohydrate), and high-carbohydrate overfeeding (HCOF) (75% carbohydrate, 5% fat) diets. Free-living weight change was assessed after 6 and 12 months. Compared with EBL, RQ decreased on average by 9% during fasting and by 4% during HFOF but increased by 4% during STOF and by 8% during HCOF. A smaller decrease in RQ, reflecting a smaller increase in lipid oxidation rate, during HFOF but not during the other diets predicted greater weight gain at both 6 and 12 months. An impaired metabolic flexibility to acute HFOF can identify individuals prone to weight gain, indicating that an individual’s capacity to oxidize dietary fat is a metabolic determinant of weight change. Full Article
o Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 The whitening and loss of brown adipose tissue (BAT) during obesity and aging promote metabolic disorders and related diseases. The imbalance of Ca2+ homeostasis accounts for the dysfunction and clearance of mitochondria during BAT whitening. Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear. In this study, we determined that the inhibitory effects of capsaicin on HFD-induced obesity and BAT whitening were dependent on the participation of SIRT3, a critical mitochondrial deacetylase. SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD. Mechanistically, SIRT3 inhibits mitochondrial calcium uniporter (MCU)-mediated mitochondrial calcium overload by reducing the H3K27ac level on the MCU promoter in an AMPK-dependent manner. In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin. Capsaicin intervention also inhibited aging-induced BAT whitening through this mechanism. In conclusion, this study emphasizes a critical role of the AMPK/SIRT3 pathway in the maintenance of BAT morphology and function and suggests that intervention in this pathway may be an effective target for preventing obesity- or age-related metabolic diseases. Full Article
o Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:25-08:00 Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell–specific reduction of HMG-CoA reductase (Hmgcrm–/m–), which is the rate-limiting enzyme in cholesterol biosynthesis, protects against atherosclerosis by inhibiting macrophage migration in mice. We hypothesized that ATMs are harder to accumulate in Hmgcrm–/m– mice than in control Hmgcrfl/fl mice in the setting of obesity. To test this hypothesis, we fed Hmgcrm–/m– and Hmgcrfl/fl mice a high-fat diet (HFD) for 24 weeks and compared plasma glucose metabolism as well as insulin signaling and histology between the two groups. Myeloid cell–specific reduction of Hmgcr improved glucose tolerance and insulin sensitivity without altering body weight in the HFD-induced obese mice. The improvement was due to a decrease in the number of ATMs. The ATMs were reduced by decreased recruitment of macrophages as a result of their impaired chemotactic activity. These changes were associated with decreased expression of proinflammatory cytokines in adipose tissues. Myeloid cell–specific reduction of Hmgcr also attenuated hepatic steatosis. In conclusion, reducing myeloid HMGCR may be a promising strategy to improve insulin resistance and hepatic steatosis in obesity. Full Article
o Brantley's bat has Astros buzzing ahead of '19 By mlb.mlb.com Published On :: Sat, 9 Feb 2019 14:41:06 EDT The signing of veteran outfielder Michael Brantley by the Astros came a week after the Winter Meetings and only a few days before Christmas, meaning it didn't exactly garner much attention on national, or even local, news cycles. For the Astros, Brantley was exactly the player they needed at exactly the right price -- two years and $32 million -- and the kind of addition that should fire up the fanbase. Full Article
o 30 low-key acquisitions who could pay off big By mlb.mlb.com Published On :: Tue, 12 Feb 2019 13:57:13 EDT Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with. Full Article
o Uniform patch to mark 150 years of pro baseball By mlb.mlb.com Published On :: Tue, 12 Feb 2019 10:09:05 EDT All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team. Full Article
o Predicting the Astros' Opening Day roster By mlb.mlb.com Published On :: Mon, 11 Feb 2019 11:14:54 EDT There won't be many roster battles when the Astros open camp later this week, and they won't be decided until the final days of the team's stay in West Palm Beach, Fla. Houston has an open competition for its fifth starter spot heading into Spring Training, and the club also has to sort out a crowded outfield and the final spots in the bullpen. Full Article
o Especially for Altuve, Marwin's presence missed By mlb.mlb.com Published On :: Wed, 13 Feb 2019 15:48:35 EDT The reality is setting in for Astros star second baseman Jose Altuve, who's shared a clubhouse with close friend Marwin Gonzalez for the previous seven springs. They became confidants on and off the field, which is what makes this spring so strange. Full Article
o Astros open camp with bar 'set incredibly high' By mlb.mlb.com Published On :: Wed, 13 Feb 2019 12:14:03 EDT With this many stars and this much talent, you can't help but have visions of playing baseball deep into October. And considering it was only a year ago the Astros were talking about defending their World Series title, their window to win another one remains wide open. Full Article
o Cole wins arbitration case vs. Astros By mlb.mlb.com Published On :: Wed, 13 Feb 2019 14:49:54 EDT All-Star right-hander Gerrit Cole won his arbitration case against the Astros on Wednesday, meaning he will make $13.5 million this season. The team offerred $11.425 million, a difference of $2,075,000. Full Article
o Astros have unfinished business this season By mlb.mlb.com Published On :: Thu, 14 Feb 2019 16:40:00 EDT The Astros logo outside the Ballpark of the Palm Beaches really is something to see, all the way from Haverhill Rd. The closer you get the bigger it gets, the white "H" right there in front of the huge orange star. Underneath the "H" is the following message, white against orange: "2017 World Champions." It would have been a simple matter to put "2018" down there, too. There was room. Full Article
o Prospects who should vie for a roster spot By mlb.mlb.com Published On :: Thu, 14 Feb 2019 19:36:11 EDT The 30 prospects below all are getting very long looks this spring with an eye toward breaking camp with the parent club. Even if they start the year in the Minors, they all should get the chance to contribute at some point in the very near future. Full Article
o WATCH: Astros' rotation is ready By mlb.mlb.com Published On :: Sat, 16 Feb 2019 13:00:00 EDT Spring Training is underway. Players around the league are stepping back onto the baseball field as they get ready for the 2019 season. MLB.com's beat reporters have you covered with the action from every team's training camp. Keep track of the latest highlights of Spring Training right here. Full Article
o Astros can still win the offseason By mlb.mlb.com Published On :: Thu, 14 Feb 2019 23:00:00 EDT We're reluctant to finalize our list of offseason winners because, as you may have heard, there are some prominent unsigned free agents. Not just Bryce Harper and Manny Machado, either. Full Article
o How does Altuve rank on Top 100 Right Now? By mlb.mlb.com Published On :: Thu, 14 Feb 2019 23:00:00 EDT The 2019 MLB season feels so close now. Spring Training has begun. Players are taking the field. So it's time to rank the best of the best. Full Article
o Cole: Arb win a bigger victory for players to come By mlb.mlb.com Published On :: Thu, 14 Feb 2019 18:47:15 EDT By winning his arbitration case against the Astros, pitcher Gerrit Cole stands to make $2,075,000 more this season than if he'd lost. That's a significant victory for Cole, who will double his salary this year and make $13.5 million, and a significant victory for other players to come, the veteran pitcher said. Full Article
o Back in rotation, McHugh able to draw on relief By mlb.mlb.com Published On :: Thu, 14 Feb 2019 14:14:01 EDT With Dallas Keuchel and Charlie Morton leaving in free agency and Lance McCullers Jr. on the mend following Tommy John surgery, Collin McHugh is returning to his roots this year and is back in the Houston rotation. He said his experience as a reliever will only help him evolve as a starter. Full Article
o Whitley throws first bullpen session of spring By mlb.mlb.com Published On :: Fri, 15 Feb 2019 18:00:43 EDT All eyes were on right-hander Forrest Whitley, MLB Pipeline's top pitching prospect, when he threw in the bullpen for the first time Friday in Major League camp. Astros manager AJ Hinch, assistant general manager Brandon Taubman and director of player development Pete Putila were all watching intently as Whitley threw 21 pitches -- fastballs, changeups and cutters. Full Article
o Cole, Verlander push back on 'opener' concept By mlb.mlb.com Published On :: Fri, 15 Feb 2019 15:44:40 EDT Gerrit Cole and Justin Verlander are not fans of the "opener" and explained why it's not a long-term option. Full Article
o Healthy Correa looks to put 2018 behind him By mlb.mlb.com Published On :: Sat, 16 Feb 2019 14:11:18 EDT You can't help but learn a few things when you had the kind of year Astros star shortstop Carlos Correa experienced last season, when a nagging back injury derailed him in the second half and forced him to deal with the biggest adversity of his career. Full Article
o Bregman progressing from elbow surgery By mlb.mlb.com Published On :: Sat, 16 Feb 2019 16:25:12 EDT Astros third baseman Alex Bregman continues to progress from the arthroscopic elbow surgery he had a month to remove bone chips. Full Article
o Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
o JV, Cole, Rodgers face live hitters at camp By mlb.mlb.com Published On :: Sun, 17 Feb 2019 16:58:17 EDT The first live bullpen sessions of the spring typically draw a crowd, and that certainly was the case when Justin Verlander, Gerrit Cole and Brady Rodgers faced hitters for the first time Sunday afternoon on the back fields at Ballpark of the Palm Beaches. Full Article
o Winter ball: Snowy offseason ideal for Sneed By mlb.mlb.com Published On :: Sun, 17 Feb 2019 16:18:58 EDT The question would come shortly after Cy Sneed would write his name on the chalkboard. A young hand would rise into the air, and Sneed would brace himself for the chuckles that were sure to soon fill the classroom. "Are you a lumberjack?" Full Article
o Astros' Top 30 Prospects list By m.mlb.com Published On :: Fri, 17 Feb 2017 21:25:12 EDT Who do the Astros have in the pipeline? Get scouting reports, video, stats, projected ETAs and more for Houston's Top 30 Prospects on MLB Pipeline's Prospect Watch. Full Article