Location: Main Media Collection - Video record 42355 DVD

612 - The fall of Nineveh

Assyrians Beyond the Fall of Nineveh

Perspective: Guest-Editorial: The fabrication of Iraqi history and the “untold story of native Iraqis”

It all comes down to a thrilling vehicular showdown with a ruthless villain at an arctic base. With a clock ticking and the threat of a weapon of mass destruction looming, our hero races an absurdly modified classic car on a frozen lake, contending with assault rifle-wielding snowmobilers and enemy vehicles firing rockets…

Fresh off the latest meeting about incorporation, and I want to say: thank you to the moderators and Jessamyn who keep the site going and thank you to the volunteers past and present putting in work to build new possibilities for the site, including making it easier for more people to volunteer and contribute in different ways.

I'm also truly proud of the decision made early on by the volunteers to do things together, even if that meant slowing down. I'm the kind of person who sees a problem and goes into fix-it mode as fast as possible. Practicing on a hugely meaningful project like Metafilter to listen and consider all of our viewpoints and work through to a communal path was hard. It was sometimes frustratingly slow! But by the second half of our timeline, I can see now that we get important things done faster and faster and how strong the foundation we've built is (heh, bad pun) because we've got trust and a collaborative thoughtful process.

I'd also like to recognise the people who took a deep breath before writing a reply in a high-termperature thread, the people who edited down the snark in their comments or thought - I'll change to the thread about kitten videos instead. It is hard to be civil and think about other people when they're text on a screen - and it's harder when so much media encourages profit by provoking yelling.

Metafilter is an internet third space that isn't trying to profit actively from yelling. And sometimes we gotta yell in some threads - but most of the time we talk, and I so so appreciate having a third space where people can talk without an algorithm aimed at our lizard brains.

If you're visiting MetaFilter for the first time in a while because whoa, US election, just a friendly reminder that MetaFilter depends on member support in order to keep running. Additionally, MetaFilter is moving to a community-run model, so you might want to check out the latest update about that.

But because this is a weblog, a few additional links about communities below the fold.

Online communities come with real-world consequences for individuals and societies (Communications Psychology; the bibliography is fun)

How to find your community (Vox)

How to find healthy online communities (Mental Health America)

(Nostalgia trip) Online communities (Pew Research, 2001)

And more nostalgia - the classic 1995 Ghosts in the Machine

Korey Pereira: Johnnie, thanks for taking the time to talk to me and the designingsound.org readers about the sound of Director Yorgos Lanthimos’ latest film, The Favourite. This is the third of Yorgos’ films you have worked on; how did that relationship begin? Johnnie Burn: Hi Korey! Thanks so much for your time. I’ve got […]

Very special guest John Moltz returns to the show to talk about Center Stage, Stage Manager, and all the other stages.

The luggage ad started in the zoo and ended in the permanent collection at the New York Museum of Modern Art. But do you remember which brand was behind it?

Colorado Democrats will continue to dominate state government, possessing the most power Democrats have held in our state since FDR was president.

Steph Curry and Kevin Durant both didn't include Nikola Jokic among their candidates for the next face of the NBA after their generation. But Jokic, even after winning a championship heightened his exposure, is happy to just be the class clown anyway.

I thought he told you that he won't stop.

Seems that the apple didn't fall too far from the tree.

An AI forest exploration…

The post The Fantasy Forest appeared first on Stuck in Customs.

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https://www.play-asia.com/lords-of-the-fallen/13/70g6lb

Paperback, Hardcover, Kindle, Audiobook – July 9, 2013

Hardcover, Kindle, Audiobook – March 3, 2020

Historically, both law and facts are on the gun owners’ side of the “gun control” debate, and the Other Side had relied largely on emotion.  I respectfully submit that emotion is something our side should play to, as well. I made that point recently at the 2024 Gun Rights Policy Conference in San Diego last […]

The following article, It’s Election Day, But the Fat Lady Isn’t Singing Yet, was first published on The Black Sphere.

Photo Credit: Michigan Advance Shards of 2022 In the 2022 Midterm Election, the political soothsayers were predicting a huge ‘red wave’ was going to sweep over America akin to the 1994 Gingrich Revolution and the 2010 Tea Party Revolt.  However, writing in a previous article, we made a different prediction that went against the conventional …

Continue reading It’s Election Day, But the Fat Lady Isn’t Singing Yet ...

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

S-Acylation, a reversible post-translational lipid modification of proteins, controls the properties and function of various proteins, including ion channels. Large conductance Ca2+-activated potassium (BK) channels are S-acylated at two sites that impart distinct functional effects. Whereas the enzymes that attach lipid groups are known, the enzymes mediating lipid removal (i.e. deacylation) are largely unknown. Here, McClafferty et al. identify two enzymes, ABHD17a and ABHD17c, that excise BK channel lipid groups with remarkable precision. These findings lend insights into mechanisms that orchestrate the (de)acylation that fine-tunes ion channel function in physiology and disease.

The organic anion transporters (OATs) and organic anion–transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically important drugs and, thereby, drug exposure in the target organs or cells. Various mechanisms (e.g. genetic, environmental, and disease-related factors, drug-drug interactions, and food-drug interactions) can lead to variations in the expression and activity of the anion drug-transporting proteins of OATs and OATPs, possibly impacting the therapeutic outcomes. Previous investigations mainly focused on the regulation at the transcriptional level and drug-drug interactions as competing substrates or inhibitors. Recently, evidence has accumulated that cellular trafficking, post-translational modification, and degradation mechanisms serve as another important layer for the mechanisms underlying the variations in the OATs and OATPs. This review will provide a brief overview of the major OATs and OATPs implicated in drug therapy and summarize recent progress in our understanding of the post-translational modifications, in particular ubiquitination and degradation pathways of the individual OATs and OATPs implicated in drug therapy.

Advanced technologies in the face of war 24 October 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 5 October 2022 Online

How is NATO strengthening its technological edge?

Russia’s invasion of Ukraine has brought with it a heavy focus on technology and weaponry, particularly as casualties mount and large numbers of equipment are lost on both sides. The conflict has highlighted how states and their militaries seek technological superiority and how access to advanced capabilities can help shape the course of the war.

Aiming to sharpen the Alliance’s technological edge, NATO is working to support the development of emerging and potentially disruptive technologies such as artificial intelligence (AI), autonomous systems, biotechnologies and quantum technologies that are seen as presenting both risks and opportunities for the Alliance.

As part of this work, NATO’s newly formed Defence Innovation Accelerator for the North Atlantic (DIANA), hosted by both the UK and Estonia, brings together academia, industry and government to support the development of critical technologies to deter and defend against existing and future threats.

Key questions to be considered by the panel include:

• How will the technologies that form the focus of DIANA’s efforts strengthen the Alliance and prepare it to better deal with threats to peace and security across the region?

• How will these technologies be applied and used in war?

• To what extent can a war be won by technology?

• Is Ukraine, and other future conflict zones, in danger of becoming a testing ground for emerging technologies?

• What has the war in Ukraine taught NATO about modern warfare and how should the Alliance respond to this?

• After the commotion of AUKUS, how will the Alliance manage the sharing of technologies and IP among member states?

As with all members events, questions from the audience drive the conversation.

Read the transcript. 

Does your name suit your face? A study finds it is a kind of self-fulfilling prophecy.

Schools may have to continue closures in the fall if the coronavirus resurges, state schools chiefs in Maryland and Washington said. The warnings came the same week thata key federal official predicted schools would be able to reopen for the 2020-21 school year.

Mr Chairman,

I wish to convey, through you, to the Committee on Fisheries, the considered views of the FAO Secretariat on the item on the proposed Fisheries University.  

So far, the [...]

Addressing the plenary meeting in the closing session of the 159^th Session of the Council, the Director-General expressed his appreciation to delegates for their commitment and hard work to [...]

The FAO Conference meets every two years to determine the policies of the Organization, approve the budget, and make recommendations to its Members. 

If you would like to dig deeper into [...]

Did you know FAO Library collections date back to the start of the 15th century? From historical texts on growing rice in China, to commercial guides on producing wine in [...]

FAO is pleased to announce the release of a new and upgraded version of theGlobal Record of Fishing Vessels, Refrigerated Transport Vessels and Supply Vessels (Global Record), [...]

A statement by FAO Director-General QU Dongyu

Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems.

Check out the 2023 edition of the FAO publications catalogue! From the State of the World collection and other major reports to freshly penned technical studies, the catalogue features a selection of FAO’s best [...]

Nearly 300,000 people gather every Memorial Day to witness the legendary Indianapolis 500, one of the greatest spectacles in U.S. racing

In 1619, George Yeardley, the newly appointed governor of Jamestown, made history: He convened 22 elected members of a burgeoning commonwealth, creating the first democratic assembly in America.

Artist Abbot Thayer illustrated the prevalence of camouflage in the animal world and advocated using it as a military tactic

The wild canines have the same muscles used by domestic dogs to create the wide-eyed, pleading look that captures humans' hearts

The Gestapo seized the Impressionist painting from storage after its owners fled from their home in Vienna. Now, the piece has been returned to their granddaughters

Scientists in France solved the evolutionary mystery of this prehistoric monster, which resembles both the centipedes and millipedes of today

In the 1960s, a vaccine for chlamydia made patients more susceptible to chlamydia. Now scientists know why

Nassau, Bahamas :: The Esposito family from Argentina enjoys serving God together on board Logos Hope, bringing professional skills and supporting each other.

A Malawian missionary brings change to his village and food to his family through farming techniques taught by OM Malawi.

Going house to house to share the Good News, a team discovers a believing family who had been isolated and out of Christian fellowship for eight years.

Young men from African nations find their identity and destiny through hiking in Namibia with the Wilderness Therapy Programme.

As a young organisation, OM challenged the status quo of world missions and has since evolved into a global movement seeking to share the gospel with the least reached.

When they come back to us in the fall, our students’ need for connection, belonging, and real-world experience will be fierce, and we need to adjust our approach based on their needs, writes teacher Ariel Sacks.