targeting [ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00339 Full Article
targeting [ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00395 Full Article
targeting [ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00574 Full Article
targeting [ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00192 Full Article
targeting [ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00022 Full Article
targeting A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization By feeds.rsc.org Published On :: Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02943B, CommunicationLe Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung KimWe report a novel fluorescent molecular conjugate V-M1 enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, well within the near-infrared therapeutic window. Tumor...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting [ASAP] Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins By dx.doi.org Published On :: Tue, 08 Oct 2019 04:00:00 GMT ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00305 Full Article
targeting Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3229-3233DOI: 10.1039/D0OB00265H, CommunicationYing Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing CaiAn anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3288-3296DOI: 10.1039/C9OB02682G, PaperMatthew B. Minus, Haopei Wang, Jaime O. Munoz, Alexandra M. Stevens, Alicia E. Mangubat-Medina, Michael J. Krueger, Wei Liu, Moses M. Kasembeli, Julian C. Cooper, Mikhail I. Kolosov, David J. Tweardy, Michele S. Redell, Zachary T. BallRecurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis By feeds.rsc.org Published On :: Nanoscale Horiz., 2020, Advance ArticleDOI: 10.1039/D0NH00148A, CommunicationFang Ding, Lingpu Zhang, Hao Chen, Haiqin Song, Shiguo Chen, Haihua XiaoCombination of cisplatin prodrug nanoparticles and Dp44mT results in enhanced anticancer and anti-metastatic efficiencies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Influence of nanomedicine mechanical properties on tumor targeting delivery By feeds.rsc.org Published On :: Chem. Soc. Rev., 2020, 49,2273-2290DOI: 10.1039/C9CS00575G, Tutorial ReviewZheng Li, Chen Xiao, Tuying Yong, Zifu Li, Lu Gan, Xiangliang YangThis tutorial review summarizes the influence of nanomedicine mechanical properties on drug delivery efficiency, antitumor efficacy and safety.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Gold(I,III) complexes designed for selective targeting and inhibition of zinc finger proteins Raphael Enoque Ferraz de Paiva By library.mit.edu Published On :: Sun, 25 Nov 2018 07:23:59 EST Online Resource Full Article
targeting Nitin Desai: On inflation targeting By www.business-standard.com Published On :: Wed, 24 Aug 2016 21:50:00 +0530 It is just one element of the new architecture of macroeconomic policy. Much more is required to shore up the economy Full Article Premium
targeting [ASAP] Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity By feedproxy.google.com Published On :: Thu, 09 Apr 2020 04:00:00 GMT BiomacromoleculesDOI: 10.1021/acs.biomac.0c00379 Full Article
targeting [ASAP] Bottlebrush Glycopolymers from 2-Oxazolines and Acrylamides for Targeting Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin and Mannose-Binding Lectin By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT BiomacromoleculesDOI: 10.1021/acs.biomac.0c00246 Full Article
targeting [ASAP] Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders By feedproxy.google.com Published On :: Thu, 16 Apr 2020 04:00:00 GMT ACS Chemical BiologyDOI: 10.1021/acschembio.0c00140 Full Article
targeting [ASAP] Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.0c00079 Full Article
targeting [ASAP] Supramolecular ß-Sheet Forming Peptide Conjugated with Near-Infrared Chromophore for Selective Targeting, Imaging, and Dysfunction of Mitochondria By feedproxy.google.com Published On :: Fri, 10 Apr 2020 04:00:00 GMT Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.0c00153 Full Article
targeting [ASAP] The Protein Corona Does Not Influence Receptor-Mediated Targeting of Virus-like Particles By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.0c00240 Full Article
targeting Targeting biofilms in translational research, device development, and industrial sectors / Dustin L. Williams, editor By library.mit.edu Published On :: Sun, 22 Dec 2019 06:23:55 EST Online Resource Full Article
targeting Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance By pubs.rsc.org Published On :: Inorg. Chem. Front., 2020, 7,1864-1871DOI: 10.1039/D0QI00224K, Research ArticleCheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Jiangping Liu, Liangnian Ji, Hui ChaoA dinuclear complex [(ppy)Ir(tpy)PtCl]2+ (Ir–Pt) can exhibit strong antitumor activity towards cisplatin-resistant cancer cells and induce cell necrosis via mtDNA damage and mitochondrial dysfunction.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Effectiveness of the current temporary skilled visa system in targeting genuine skills shortages / The Senate, Legal and Constitutional Affairs References Committee By prospero.murdoch.edu.au Published On :: Australia. Parliament. Senate. Legal and Constitutional Affairs References Committee Full Article
targeting Capacitive Sensing of Triglyceride Film Reactions: A Proof-of-Concept Demonstration for Sensing in Simulated Duodenal Contents with Gastrointestinal Targeting Capsule System By feeds.rsc.org Published On :: Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00133C, PaperGeorge Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza GhodssiIngestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue By feeds.rsc.org Published On :: Metallomics, 2020, 12,562-571DOI: 10.1039/C9MT00302A, PaperLanqiao Wang, Xu Shi, Shufang Zheng, Shiwen XuSe deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease By feeds.rsc.org Published On :: Metallomics, 2020, Accepted ManuscriptDOI: 10.1039/D0MT00069H, PaperMarie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth MintzCopper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Leadership decapitation: strategic targeting of terrorist organizations / Jenna Jordan By library.mit.edu Published On :: Sun, 22 Mar 2020 07:44:49 EDT Dewey Library - HV6431.J674 2019 Full Article
targeting Could targeting STING make a universal flu vaccine? By feedproxy.google.com Published On :: 21 Feb 2020 13:14:25 +0000 In animal tests, vaccine gives broad protection Full Article
targeting Light-controlled guide RNA hones CRISPR targeting By feedproxy.google.com Published On :: 05 May 2020 20:37:44 +0000 Technique modifies subsets of cells and frees gene editing proteins for potential further improvements Full Article
targeting Drug targeting [electronic resource] : strategies, principles, and applications / edited by G.E. Francis and Cristina Delgado By darius.uleth.ca Published On :: Totowa, N.J. : Humana Press, [2000] Full Article
targeting [ASAP] Targeting CNS Related Protist Pathogens: Calcium Ion Dependency in the Brain-Eating Amoebae By feedproxy.google.com Published On :: Mon, 16 Dec 2019 05:00:00 GMT ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00635 Full Article
targeting [ASAP] Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.0c00052 Full Article
targeting Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery By pubs.rsc.org Published On :: Biomater. Sci., 2020, 8,2274-2282DOI: 10.1039/C9BM02036E, PaperYue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong SunPEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry By pubs.rsc.org Published On :: Biomater. Sci., 2020, 8,2283-2288DOI: 10.1039/D0BM00088D, PaperGuihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan XieA highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy By pubs.rsc.org Published On :: Biomater. Sci., 2020, Advance ArticleDOI: 10.1039/D0BM00003E, PaperJia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui WangThe advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy By pubs.rsc.org Published On :: Biomater. Sci., 2020, Accepted ManuscriptDOI: 10.1039/D0BM00062K, PaperChaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin YangHerein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging By pubs.rsc.org Published On :: Biomater. Sci., 2020, 8,2590-2599DOI: 10.1039/D0BM00314J, PaperJulie Tzu-Wen Wang, Umberto Martino, Rehan Khan, Maasoomeh Bazzar, Paul Southern, Dönüş Tuncel, Khuloud T. Al-JamalSelf-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection By pubs.rsc.org Published On :: Biomater. Sci., 2020, 8,2682-2693DOI: 10.1039/D0BM00162G, PaperYuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing GuThe designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells By pubs.rsc.org Published On :: Biomater. Sci., 2020, Accepted ManuscriptDOI: 10.1039/D0BM00556H, PaperAna Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno SarmentoColorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway By pubs.rsc.org Published On :: Toxicol. Res., 2019, 8,875-884DOI: 10.1039/C9TX00100J, PaperXuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping XiongBevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
targeting Antibody targeting of non ionic surfactant vesicles to vascular inflammation By digital.lib.usf.edu Published On :: Sat, 15 Feb 2014 18:47:11 -0400 Full Article
targeting Synthesis of small molecule inhibitors targeting signal transduction pathways By digital.lib.usf.edu Published On :: Sat, 15 Feb 2014 19:04:25 -0400 Full Article
targeting An analysis of U.S. policies targeting the Iranian nuclear program By digital.lib.usf.edu Published On :: Sat, 15 Feb 2014 19:20:16 -0400 Full Article
targeting Targeting non-Arabized civilians in Darfur By digital.lib.usf.edu Published On :: Mon, 17 Feb 2014 14:08:21 -0400 Full Article
targeting Predicting bat colony survival under controls targeting multiple transmission routes of white-nose syndrome By digital.lib.usf.edu Published On :: Fri, 24 Mar 2017 10:57:56 -0400 Full Article
targeting Bat white-nose syndrome: a real-time TaqMan polymerase chain reaction test targeting the intergenic spacer region of Geomyces destructans By digital.lib.usf.edu Published On :: Mon, 06 Apr 2020 15:18:56 -0400 Full Article
targeting Targeting immune cells could relieve chronic pain By feedproxy.google.com Published On :: 16 Jul 2018 21:30:52 +0000 Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage Full Article
targeting Targeting immune cells could relieve chronic pain By feedproxy.google.com Published On :: 23 Jul 2018 05:00:16 +0000 Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage Full Article
targeting BJP attacks Pawar for targeting Fadnavis: ‘Shows NCP chief’s caste prejudices’ By indianexpress.com Published On :: Mon, 27 Jun 2016 19:26:53 +0000 Full Article India Politics
targeting Chinese hackers targeting India-China border dispute: Report By indianexpress.com Published On :: Fri, 21 Aug 2015 12:19:16 +0000 Full Article DO NOT USE Asia World
targeting Second stimulus: Govt plans targeting based on need, MSMEs to begin with By indianexpress.com Published On :: Thu, 30 Apr 2020 23:23:32 +0000 Full Article Business Economy
