From a scattering of fans to stadiums at near-capacity, women's cricket has come a long way in the last decade since Australia won its first women's T20 World Cup.

Australia is Women's T20 World Cup champion again after thumping India by 85 runs in front of a whopping 86,174 people at the MCG.

From small crowds and no coverage to filling the biggest stadium in Australia — the speed of the change in women's cricket defies belief, writes Geoff Lemon.

India's women fell short of a maiden T20 World Cup title at the MCG, but a women's IPL competition could help lift them to the next level, writes Brittany Carter.

Australian batsman David Warner has scored his first Twenty20 international century as Australia piled on 233 runs against Sri Lanka at the Adelaide Oval.

【動画】 宝塚OG有志による「すみれの花咲く頃」の歌唱動画第２弾が公開されました! 参加ＯＧ、６６名の氏名は以下 愛華みれ、朝霞舞、白馬麗、真琴つばさ、稔幸、香誦たつき 紫吹淳、五嶋りさ、えまおゆう、葛城七穂、麻希ゆい、麻乃佳世 加茂うらら、汐風幸、...

1. Suresh Raina, Irfan Pathan want BCCI to allow Indian players to participate in foreign T20 leagues  Times of India
2. "Such A rHAIR Picture": CSK Troll Shikhar Dhawan For His Throwback Photo With Suresh Raina  NDTV Tamil
3. Wish BCCI plans with ICC: Suresh Raina, Irfan Pathan want Indian players to participate in foreign T20...  Hindustan Times
4. Indian selectors made me an oldie at 30, didn't communicate with me: Irfan Pathan  CricTracker
5. MSK Prasad didn't speak to me at all: Suresh Raina responds to former chief selector's claims  CricTracker
6. View Full coverage on Google News

After England's 2-1 T20 series win in South Africa, pick your team for the opening T20 World Cup game in October.

Arsene Wenger says Liverpool will be regarded as 2019/20 Premier League winners even if the season is abandoned because of the coronavirus.

Rafael Nadal insists all players, including Novak Djokovic, will need to take a coronavirus vaccine should one become available.

Andy Robertson admits he would "love" the chance to play for Scottish giants Celtic one day.

The Vuelta a Espana organisers have confirmed that a race already rescheduled and shortened would also now cut its foray into neighbouring Portugal from the 2020 itinerary.

Former England opener Alex Hales is confident he has matured as a player and believes he is ready to make a return to international cricket.

It isn’t surprising that former Springbok tighthead Richard Bands is remembered mainly for one bullocking run for the Springboks in Dunedin in 2003.

India top-order batsman Rohit Sharma is hopeful their tour to Australia at the end of 2020 is allowed to proceed.

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the cornonavirus quarantine.

Salomon Rondon says he was on his way to joining Manchester United in January only for Dalian Professional to block the move.

Danny Jordaan says it would be massively complicated to ensure the safety of supporters should the PSL return while Covid-19 is still prevalent in South Africa.

Police in Haiti are investigating allegations that the president of the national football federation raped teenage girls.

Australia's Super Rugby competition is planning for an early July return, a spokesman has said.

Six-time world champion Lewis Hamilton has said he feels "fresher than ever" following an unexpected break from Formula One.

The South African Football Association has confirmed the appointment of advocate Tebogo Motlanthe as new acting CEO.

Philadelphia Phillies star Bryce Harper believes Major League Baseball should relax its "dumb" rule preventing top players from competing in the Olympics.

AC Milan have revealed that none of their first-team footballers or staff were positive for coronavirus.

The genial young administrator with a burgeoning reputation chuckles when it's pointed out to him that he can't seem to shake off 'working' for some of South Africa's biggest businessmen.

Including a shoulder-brush with a livid Steve Waugh, Rob Houwing remembers witnessing SA's heroic finish to an otherwise stormy 2001/02 Australian tour.

Former Proteas head coach Ray Jennings is adamant Aiden Markram should be chosen as Faf du Plessis' replacement as captain of the Test team.

Sundowns coach Pitso Mosimane says the premature return of football, even behind closed doors, poses a number of potential problems.

NZ Rugby CEO Mark Robinson says there is still no clarity on the prospects for Test rugby in 2020, but said they will explore every avenue.

Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability is dynamically regulated by endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes DAT surface expression by accelerating DAT internalization. Previous cell line studies demonstrated that PKC-stimulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT. However, it is unknown whether Rit2 is required for PKC-stimulated DAT endocytosis in DAergic terminals or whether there are region- and/or sex-dependent differences in PKC-stimulated DAT trafficking. Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT endocytosis are unknown. Here, we directly examined these important questions. Ex vivo studies revealed that PKC activation acutely decreased DAT surface expression selectively in ventral, but not dorsal, striatum. AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum. Further, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum. FRET and surface pulldown studies in cell lines revealed that PKC activation drives DAT-Rit2 surface dissociation and that the DAT N terminus is required for both PKC-mediated DAT-Rit2 dissociation and DAT internalization. Finally, we found that Rit2 and Ack1 independently converge on DAT to facilitate PKC-stimulated DAT endocytosis. Together, our data provide greater insight into mechanisms that mediate PKC-regulated DAT internalization and reveal unexpected region-specific differences in PKC-stimulated DAT trafficking in bona fide DAergic terminals.

Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability is dynamically regulated by endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes DAT surface expression by accelerating DAT internalization. Previous cell line studies demonstrated that PKC-stimulated DAT endocytosis requires both Ack1 inactivation, which releases a DAT-specific endocytic brake, and the neuronal GTPase, Rit2, which binds DAT. However, it is unknown whether Rit2 is required for PKC-stimulated DAT endocytosis in DAergic terminals or whether there are region- and/or sex-dependent differences in PKC-stimulated DAT trafficking. Moreover, the mechanisms by which Rit2 controls PKC-stimulated DAT endocytosis are unknown. Here, we directly examined these important questions. Ex vivo studies revealed that PKC activation acutely decreased DAT surface expression selectively in ventral, but not dorsal, striatum. AAV-mediated, conditional Rit2 knockdown in DAergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from female ventral, but not dorsal, striatum. Further, Rit2 was required for PKC-stimulated DAT internalization in both male and female ventral striatum. FRET and surface pulldown studies in cell lines revealed that PKC activation drives DAT-Rit2 surface dissociation and that the DAT N terminus is required for both PKC-mediated DAT-Rit2 dissociation and DAT internalization. Finally, we found that Rit2 and Ack1 independently converge on DAT to facilitate PKC-stimulated DAT endocytosis. Together, our data provide greater insight into mechanisms that mediate PKC-regulated DAT internalization and reveal unexpected region-specific differences in PKC-stimulated DAT trafficking in bona fide DAergic terminals.

Sodium–glucose cotransport 2 inhibitors (SGLT2i) lower plasma glucose but stimulate endogenous glucose production (EGP). The current study examined the effect of dapagliflozin on EGP while clamping plasma glucose, insulin, and glucagon concentrations at their fasting level. Thirty-eight patients with type 2 diabetes received an 8-h measurement of EGP ([3-³H]-glucose) on three occasions. After a 3-h tracer equilibration, subjects received 1) dapagliflozin 10 mg (n = 26) or placebo (n = 12); 2) repeat EGP measurement with the plasma glucose concentration clamped at the fasting level; and 3) repeat EGP measurement with inhibition of insulin and glucagon secretion with somatostatin infusion and replacement of basal plasma insulin and glucagon concentrations. In study 1, the change in EGP (baseline to last hour of EGP measurement) in subjects receiving dapagliflozin was 22% greater (+0.66 ± 0.11 mg/kg/min, P < 0.05) than in subjects receiving placebo, and it was associated with a significant increase in plasma glucagon and a decrease in the plasma insulin concentration compared with placebo. Under glucose clamp conditions (study 2), the change in plasma insulin and glucagon concentrations was comparable in subjects receiving dapagliflozin and placebo, yet the difference in EGP between dapagliflozin and placebo persisted (+0.71 ± 0.13 mg/kg/min, P < 0.01). Under pancreatic clamp conditions (study 3), dapagliflozin produced an initial large decrease in EGP (8% below placebo), followed by a progressive increase in EGP that was 10.6% greater than placebo during the last hour. Collectively, these results indicate that 1) the changes in plasma insulin and glucagon concentration after SGLT2i administration are secondary to the decrease in plasma glucose concentration, and 2) the dapagliflozin-induced increase in EGP cannot be explained by the increase in plasma glucagon or decrease in plasma insulin or glucose concentrations.

Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including T2DM and non-alcoholic fatty liver disease. However, whether BCAAs disrupt the homeostasis of hepatic glucose and lipid metabolism remains unknown. In this study, we observed that BCAAs supplementation significantly reduced high-fat (HF) diet-induced hepatic lipid accumulation while increasing the plasma lipid levels and promoting muscular and renal lipid accumulation. Further studies demonstrated that BCAAs supplementation significantly increased hepatic gluconeogenesis and suppressed hepatic lipogenesis in HF diet-induced obese (DIO) mice. These phenotypes resulted from severe attenuation of Akt2 signaling via mTORC1- and mTORC2-dependent pathways. BCAAs/branched-chain α-keto acids (BCKAs) chronically suppressed Akt2 activation through mTORC1 and mTORC2 signaling and promoted Akt2 ubiquitin-proteasome-dependent degradation through the mTORC2 pathway. Moreover, the E3 ligase Mul1 played an essential role in BCAAs/BCKAs-mTORC2-induced Akt2 ubiquitin-dependent degradation. We also demonstrated that BCAAs inhibited hepatic lipogenesis by blocking Akt2/SREBP1/INSIG2a signaling and increased hepatic glycogenesis by regulating Akt2/Foxo1 signaling. Collectively, these data demonstrate that in DIO mice, BCAAs supplementation resulted in serious hepatic metabolic disorder and severe liver insulin resistance: insulin failed to not only suppress gluconeogenesis but also activate lipogenesis. Intervening BCAA metabolism is a potential therapeutic target for severe insulin-resistant disease.

David J. Hodson
May 1, 2020; 69:864-866
Commentaries

Mariam Alatrach
Apr 1, 2020; 69:681-688
Pathophysiology

Robert R. Henry
Mar 1, 2015; 38:412-419
Evolving Tactics With Inhibition of Sodium-Glucose Cotransporters

Samy Suissa
Jan 1, 2018; 41:6-10
Perspectives in Care

Paola Fioretto
Aug 1, 2016; 39:S165-S171
III. SGLT2 Therapy

Amazon is offering up to 30 percent off Acer laptops, desktops, and monitors. Plus, you can save $930 on the 65-inch Vizio P-Series Quantum X 4K TV.

BCCI treasurer Arun Dhumal has expressed his concerns over the possibility of hosting the T20 World Cup in October as per scheduled.

Alex Carey chose Shikhar Dhawan over Rohit Sharma to open along with Australian cricketer David Warner.

Poonam Yadav (4/19) snapped four wickets, two in successive deliveries of the 12th over to break the backbone of Australia's chase.

In the final over, Heyley Jensen (11) and Kerr cracked a four each but Shikha held her nerves in the end to complete the win.

Radha Yadav was initially a pace bowler who loved to bowl fast, says her coach Praful Naik who asked her to shorten her run-up and switch from pace to leg-spin.

The 16-year-old Verma takes over from New Zealand's Suzie Bates, who had been the top batter since October 2018 after wresting the spot from West Indies captain Stafanie Taylor.