Platform.sh removes a major pain point for developers: having to invest time in managing servers, virtual machines, or containers. Instead, Platform.sh enables developers to focus 100% of their time on their code. Since the beginning, Platform.sh has provided instant cloning capability, so dev teams can work on perfect copies of their production sites in the cloud for every Git branch. Now, in partnership with Lando, we’re extending that capability to the desktop.

This article with drawings is in these links https://www.academia.edu/40876793/Synchronizing_moving_GPS_clocks Word, PDF https://pengkuanonphysics.blogspot.com/2019/11/synchronizing-moving-gps-clocks.html PDF 1. Light pulse synchronization Can we synchronize clocks of a moving frame? Let us see Figure 1 where we have stationary frame F1 and moving frame F’2. The 2 clocks in the frame F1 are synchronized with the master clock through a...

It's not your imagination -- you and your baby really are on the same wavelength. A team of Princeton researchers has now measured baby and adult brain activity moving in sync as they play and interact together.

Did you know you can subscribe to YouTube channels and playlist in Inoreader? Simply paste the URL of the channel…

Some people have the misguided belief that synchronized swimming is just an easy sport performed in beautiful swim team suits. That it’s merely dancing in the water that you can tune in to watch during the Olympic Games. But that is far from true; there is much more to the sport.  Synchro is a dominant […]

Edinburgi : Apud Balfour et Smellie, 1782.

We consider the standard model of distributed optimization of a sum of functions $F(mathbf z) = sum_{i=1}^n f_i(mathbf z)$, where node $i$ in a network holds the function $f_i(mathbf z)$. We allow for a harsh network model characterized by asynchronous updates, message delays, unpredictable message losses, and directed communication among nodes. In this setting, we analyze a modification of the Gradient-Push method for distributed optimization, assuming that (i) node $i$ is capable of generating gradients of its function $f_i(mathbf z)$ corrupted by zero-mean bounded-support additive noise at each step, (ii) $F(mathbf z)$ is strongly convex, and (iii) each $f_i(mathbf z)$ has Lipschitz gradients. We show that our proposed method asymptotically performs as well as the best bounds on centralized gradient descent that takes steps in the direction of the sum of the noisy gradients of all the functions $f_1(mathbf z), ldots, f_n(mathbf z)$ at each step.

Female dolphins, it seems, aren’t immune to the allure of a harmonizing boy band

Set of American Flamingos at Rio Lagartos Biosphere Reserve in Mexico, march in a synchronized formation whilst trying to find some food

No global real estate market despite higher price synchronisation and growing role of international investors, central banks find (Press release, 18 February 2020)

Adult patients with neurocardiogenic syncope have shown high rates of depression. Patients with more severe depressive symptoms have higher rates of syncope recurrence. Psychiatric interventions improve quality of life and decrease syncope recurrence rates.

Children with neurocargiogenic syncope presented a 2.6-fold higher rate of clinically significant depressive symptoms compared to healthy controls. No recurrent syncope was noted during follow-up which along with improvement in family functioning predicted depressive symptoms improvement. (Read the full article)

Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization among infants. Most estimates of RSV hospitalization rates are imprecise, having been calculated by using retrospective discharge diagnosis data and stratified age groups no narrower than 6 to 12 months.

Prospective, population-based surveillance data for infants hospitalized with laboratory-confirmed RSV infection were combined with birth certificate information to yield more precise age-specific hospitalization rates. These data should help determine priorities for the use of existing and future RSV prophylaxis strategies. (Read the full article)

Down syndrome is an independent risk factor for severe respiratory syncytial virus infection and subsequent hospitalization.

This observational study suggests that immunoprophylaxis may reduce respiratory syncytial virus-related hospitalization by 3.6-fold (95% confidence interval, 1.5–8.7) in children with Down syndrome overall. (Read the full article)

Respiratory syncytial virus (RSV) infection is a common cause of pediatric hospitalizations. Mortality rates associated with RSV hospitalizations are based on estimates from studies conducted decades ago. Accurate understanding of mortality is required for identifying high-risk infants and children.

Mortality associated with RSV is uncommon in the 21st century, with annual deaths far lower than previous estimates. The majority of deaths occurred in infants with complex chronic conditions or in those with life-threatening conditions in addition to RSV infection. (Read the full article)

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

The IMpact-RSV Study Group
Sep 1, 1998; 102:531-537
ARTICLES

Hi, I am in the middle of a design and had no problem going back and forth between schematics and layout. Now I am getting the error message below. I am using Cadence 17.2.

ERROR: Layout database has probably been reverted to an earlier version than that, which was used in the latest flow or the schematic database was synchronized with another board.

The basecopy file generated by the last back-to-front flow not found.

ERROR: Layout database has probably been reverted to an earlier version than that, which was used in the latest flow or the schematic database was synchronized with another board.

The basecopy file generated by the last back-to-front flow not found.

Error: CMFBC-1: The schematic and the layout constraints were not synchronized as the changes done since the last sync up could not be reconciled. Syncing the current version of the schematic or layout databases with a previous version would result in this issue. The  constraint difference report is displayed.

Continuing with "changes-only" processing may result in incorrect constraint updates.

Thanks for your input

Claudia

This is a whitepaper that discusses using DCSync to pull password hashes from a domain controller.

Druva inSync Windows Client version 6.5.2 suffers from a local privilege escalation vulnerability.

WASHINGTON (AP) — President Donald Trump says he didn’t know the Justice Department was planning to drop its case against his former national security adviser, Michael Flynn. But it didn't really matter. The extraordinary action underscored the extent to which Trump and Attorney General William Barr have been in sync in their views on the federal Trump-Russia investigation — with or without communicating about it. Barr himself has openly challenged the decisions of predecessors and his own prosecutors. He's launched internal probes to investigate the investigators. Trump is emphatically welcoming the Flynn action. He has relentlessly railed against the special counsel's...

Among evangelical Christians, the word syncretism usually conjures thoughts of third-world missionaries who blend their religion with the indigenous pagan practices they encounter. A visitor to my home church related a conversation he’d had with a Roman Catholic missionary while touring South America. The priest wore his syncretistic practices as a badge of honor, boasting of how he intentionally incorporated native religious observances into his worship services. He was critical of Protestant missionaries who refused to likewise accommodate the paganism of the people they ministered to.

Most of us are familiar with politicians who obfuscate simple questions with complex political answers. Who can forget Bill Clinton’s “It depends upon what the meaning of the word ‘is’ is”? Unfortunately, obfuscation exists in the realm of theology as well. God may not be “a God of confusion” (1 Corinthians 14:33), but there are scores of biblical scholars, theologians, and pastors who insert plenty of it into the first few chapters of Genesis.

It is no coincidence that the rise of feminism in the twentieth century paralleled an unprecedented push for female clergy in Western churches. With the shifting views and priorities of the culture, the timeless biblical truths of male headship and church leadership were suddenly under attack.

The language of therapy has a stranglehold on our culture. Children don’t lie anymore, they tell stories. Serial adulterers have been re-branded as sex addicts. Drunkenness is now an alcohol disorder—in fact, addiction itself is treated like a disease. Even the gross perversion of pedophilia is listed as a psychiatric disorder in the ever-expanding Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

Ecumenism is nothing new. Satan always works to mingle the truth with error, and the evangelistic co-belligerence of evangelicals and Catholics is just one example. But for some reason, this unlikely doctrinal mashup has been growing in popularity for the past two decades.

Does an unregenerate man bear a spark of the divine that draws him to a relationship with God, or is he utterly lost in the total depravity of his sin nature? While that might seem like an obscure theological question, don’t dismiss it as merely fodder for academic debates. It’s an immensely practical question—with implications for the church and for your own life. And it’s at the heart of the consumer-driven movement in the church, commonly known as seeker sensitivity.

In October 1978, 334 evangelical leaders gathered in the city of Chicago to formulate what is now known as the Chicago Statement on Biblical Inerrancy. One of the younger attendees at that gathering was John MacArthur, who was just shy of a decade into his pastorate at Grace Community Church.

BANGALORE, INDIA –  HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced the launch of limited edition JBL® Raaga Synchros S500AR headphones, autographed by academy award winner...

Bottlenose dolphins in Shark Bay, Australia, form alliances and coordinate the timing of their clicking noises to attract females and deter other males

Respiratory syncytial virus (RSV) is an enveloped RNA virus which is responsible for approximately 80% of lower respiratory tract infections in children. Current lines of evidence have supported the functional involvement of long noncoding RNA (lncRNA) in many viral infectious diseases. However, the overall biological effect and clinical role of lncRNAs in RSV infection remain unclear. In this study, lncRNAs related to respiratory virus infection were obtained from the lncRNA database, and we collected 144 clinical sputum specimens to identify lncRNAs related to RSV infection. Quantitative PCR (qPCR) detection indicated that the expression of lncRNA negative regulator of antiviral response (NRAV) in RSV-positive patients was significantly lower than that in uninfected patients, but lncRNA psoriasis-associated non-protein coding RNA induced by stress (PRINS), nuclear paraspeckle assembly transcript 1 (NEAT1), and Nettoie Salmonella pas Theiler’s (NeST) showed no difference in vivo and in vitro. Meanwhile, overexpression of NRAV promoted RSV proliferation in A549 and BEAS-2B cells, and vice versa, indicating that the downregulation of NRAV was part of the host antiviral defense. RNA fluorescent in situ hybridization (FISH) confirmed that NRAV was mainly located in the cytoplasm. Through RNA sequencing, we found that Rab5c, which is a vesicle transporting protein, showed the same change trend as NRAV. Subsequent investigation revealed that NRAV was able to favor RSV production indirectly by sponging microRNA miR-509-3p so as to release Rab5c and facilitate vesicle transportation. The study provides a new insight into virus-host interaction through noncoding RNA, which may contribute to exploring potential antivirus targets for respiratory virus.

IMPORTANCE The mechanism of interaction between RSV and host noncoding RNAs is not fully understood. In this study, we found that the expression of long noncoding RNA (lncRNA) negative regulator of antiviral response (NRAV) was reduced in RSV-infected patients, and overexpression of NRAV facilitated RSV production in vitro, suggesting that the reduction of NRAV in RSV infection was part of the host antiviral response. We also found that NRAV competed with vesicle protein Rab5c for microRNA miR509-3p in cytoplasm to promote RSV vesicle transport and accelerate RSV proliferation, thereby improving our understanding of the pathogenic mechanism of RSV infection.

The entry/fusion complex (EFC) consists of 11 conserved proteins embedded in the membrane envelope of mature poxvirus particles. Poxviruses also encode proteins that localize in cell membranes and negatively regulate superinfection and syncytium formation. The vaccinia virus (VACV) A56/K2 fusion regulatory complex associates with the G9/A16 EFC subcomplex, but functional support for the importance of this interaction was lacking. Here, we describe serially passaging VACV in nonpermissive cells expressing A56/K2 as an unbiased approach to isolate and analyze escape mutants. Viruses forming large plaques in A56/K2 cells increased in successive rounds of infection, indicating the occurrence and enrichment of adaptive mutations. Sequencing of genomes of passaged and cloned viruses revealed mutations near the N terminus of the G9 open reading frame but none in A16 or other genes. The most frequent mutation was His to Tyr at amino acid 44; additional escape mutants had a His-to-Arg mutation at amino acid 44 or a duplication of amino acids 26 to 39. An adaptive Tyr-to-Cys substitution at amino acid 42 was discovered using error-prone PCR to generate additional mutations. Myristoylation of G9 was unaffected by the near-N-terminal mutations. The roles of the G9 mutations in enhancing plaque size were validated by homologous recombination. The mutants exhibited enhanced entry and spread in A56/K2 cells and induced syncytia at neutral pH in HeLa cells despite the expression of A56/K2. The data suggest that the mutations perturb the interaction of G9 with A56/K2, although some association was still detected in detergent-treated infected cell lysates.

IMPORTANCE The entry of enveloped viruses is achieved by the fusion of viral and cellular membranes, a critical step in infection that determines host range and provides targets for vaccines and therapeutics. Poxviruses encode an exceptionally large number of proteins comprising the entry/fusion complex (EFC), which enables infection of diverse cells. Vaccinia virus (VACV), the prototype member of the poxvirus family, also encodes the fusion regulatory proteins A56 and K2, which are displayed on the plasma membrane and may be beneficial by preventing reinfection and cell-cell fusion. Previous studies showed that A56/K2 interacts with the G9/A16 EFC subcomplex in detergent-treated cell extracts. Functional evidence for the importance of this interaction was obtained by serially passaging wild-type VACV in cells that are nonpermissive because of A56/K2 expression. VACV mutants with amino acid substitutions or duplications near the N terminus of G9 were enriched because of their ability to overcome the block to entry imposed by A56/K2.

Neutralizing antibodies specific for respiratory syncytial virus (RSV) represent a major protective mechanism against RSV infection, as demonstrated by the efficacy of the immune-prophylactic monoclonal antibody palivizumab in preventing RSV-associated lower respiratory tract infections in premature infants. Accordingly, the RSV neutralization assay has become a key functional method to assess the neutralizing activity of serum antibodies in preclinical animal models, epidemiology studies, and clinical trials. In this study, we qualified a 24-h, fluorescent focus-based microneutralization (RSVA FFA-MN) method that requires no medium exchange or pre- or postinfection processing to detect green fluorescent protein-expressing RSV strain A2 (RSVA-GFP)-infected cells, using a high-content imaging system for automated image acquisition and focus enumeration. The RSVA FFA-MN method was shown to be sensitive, with a limit of detection (LOD) and limit of quantitation (LOQ) of 1:10, or 3.32 log₂; linear over a range of 4.27 to 9.65 log₂ 50% inhibitory concentration (IC₅₀); and precise, with intra- and interassay coefficients of variation of <21%. This precision allowed the choice of a statistically justified 3-fold-rise seroresponse cutoff criterion. The repeatability and robustness of this method were demonstrated by including a pooled human serum sample in every assay as a positive control (PC). Over 3 years of testing between two laboratories, this PC generated data falling within 2.5 standard deviations of the mean 98.7% of the time (n = 1,720). This high-throughput and reliable RSV microneutralization assay has proven useful for testing sera from preclinical vaccine candidate evaluation studies, epidemiology studies, and both pediatric and adult vaccine clinical trials.

Singer Lance Bass turned 41 on 4 May.

Two teens send a powerful message about the effects of plastic pollution.

The world economy has picked up momentum, as expanding investment, employment and trade support synchronised growth across most countries, according to the OECD’s latest Interim Economic Outlook.

Caroline Flack's manager Nathan Smith has shared a heartbreaking video of the late TV star on Instagram, five days after she passed away. 

Lorraine Kelly, 60, couldn't resist asking Sasha Velour, 32, for a friendly lip sync battle when the American drag queen appeared on her show this morning, with some branding the moment 'cringe'.

Alongside the video, Nicole wrote: 'Definitely didn't learn this choreography over the Christmas break from my 9yr old niece's TikTok.'

Selena Gomez is passing quarantine time with a bit of goofing around. The singer/actress, 27, certainly looked like she was having fun while sharing a silly TikTok of herself on Wednesday.

They kept fans on the edge of their seats over whether or not they would reform for Sunday night's MTV awards - which only served to heighten anticipation further

'N Sync fans prepare to be disappointed - there will be no repeat of Sunday's performance.

With funds at an all-time low on The Block, this year's contestants were forced to participate in a 'lip sync battle' for $10,000 on Wednesday's episode.

The Super Bowl is officially hours away. And Lady Gaga, 33, made a grand entrance at the AT&T Super Saturday Night Concert ahead of her headlining performance before the big game.

The TV talent show judge, 67, previously claimed he had ended his decade-long war of words with the singer, 36, after several explosive on-air rows while they both were on the panel for the ITV show.

She was accused on Twitter for lip syncing during a performance on American Idol earlier this year in May. And now Mariah Carey has been blasted for the same offense at the BET Awards.

Ever wonder why Justin Timberlake’s face always pops up on social media at the end of every April? There’s a good reason for it. Here's all you need to know about the 'It's Gonna Be May' meme.

For many, the recent rise in the equity market was bewildering as almost all indicators of the domestic economy had been showing signs of acute distress due to COVID-19.