mines Highly water-soluble, cationic luminescent labels By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications. Full Article
mines Display device substrate, display device substrate manufacturing method, display device, liquid crystal display device, liquid crystal display device manufacturing method and organic electroluminescent display device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides a display device substrate, a display device substrate manufacturing method, a display device, a liquid crystal display device, a liquid crystal display device manufacturing method and an organic electroluminescent display device that allow suppressing faults derived from occurrence of gas and/or bubbles in a pixel region. The present invention is a display device substrate that comprises: a photosensitive resin film; and a pixel electrode, in this order, from a side of an insulating substrate. The display device substrate has a gas-barrier insulating film, at a layer higher than the photosensitive resin film, for preventing advance of a gas generated from the photosensitive resin film, or has a gas-barrier insulating film, between the photosensitive resin film and the pixel electrode, for preventing advance of gas generated from the photosensitive resin film. Full Article
mines Organic electroluminescent device By www.freepatentsonline.com Published On :: Tue, 24 Mar 2015 08:00:00 EDT The invention provides an OLED device with improved light out-coupling, which can be manufactured easy and reliable at low costs, which comprises an electroluminescent layer stack (2, 3, 4) on top of a substrate (1), where the electroluminescent layer stack (2, 3, 4) comprises an organic light-emitting layer stack (3) with one or more organic layers sandwiched between a first electrode (2) facing towards the substrate (1) and a 10 second electrode (4), where the second electrode (4) comprises a layer stack of at least a transparent conductive protection layer (41) on top of the organic light-emitting layer stack (3), a transparent organic conductive buckling layer (42) on top of the protection layer (41) having a glass transition temperature lower than the lowest glass transition temperature of the organic layers within the organic light-emitting layer stack (3) and a stress inducing layer 15 (43) on top of the buckling layer (42) to introduce stress to the buckling layer (42). The invention further relates to a method to manufacture such OLED devices with heating the electroluminescent layer (2, 3, 4) stack to a temperature, which is above the glass transition temperature of the buckling layer (42) and below the lowest glass transition temperature of the organic layers within the organic light-emitting layer stack (3) for a time period sufficient 20 to obtain buckles (B) within the buckling layer (42). Full Article
mines Organic luminescence display device having getter pattern and method of manufacturing the same By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT Provided is a method of manufacturing an organic luminescence display device, the method including: bringing a getter powder into direct contact with a first surface of an encapsulation substrate; irradiating a laser to a second surface of the encapsulation substrate correspondingly to a getter pattern area to melt the second surface of the encapsulation substrate; and bonding the getter powder to the molten second surface of the encapsulation substrate to form a getter pattern corresponding to the getter pattern area. Since the getter powder is directly bonded to the encapsulation substrate by laser irradiation, a fine getter pattern may be formed. Full Article
mines ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Manufacturing method for organic electroluminescent panel and organic electroluminescent panel manufactured using the same By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A simple manufacturing method for an organic electroluminescent panel in which organic electroluminescent elements are arranged and sealed by a sealing adhesive. The electroluminescent panel has excellent sealing properties and excellent durability as a result of the organic electroluminescent elements being adhered to one another by a heat-curable adhesive. The manufacturing method is for an organic electroluminescent panel in which at least a first electrode, an organic functional layer containing a light-emitting layer, an organic electroluminescent element having a second electrode, and a sealing substrate are bonded together on a substrate by the heat-curable adhesive. The method includes forming a heat-curable adhesive layer on the sealing substrate, subjecting the heat-curable adhesive layer formed on the sealing substrate to pre-heating treatment, bonding the pre-heated heat-curable adhesive layer to the organic electroluminescent element, and subjecting the heat-curable adhesive layer to heat curing, in the given order. Full Article
mines Organic luminescent display device and method of manufacturing at organic luminescent display device By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An organic EL display device of the invention includes: a first substrate; a second substrate disposed above the first substrate and having a display area and a non-display area; and a light-emitting layer disposed between the display area and the first substrate, wherein a first alignment mark having the light-emitting layer is disposed between the non-display area and the first substrate, and a second alignment mark is disposed on the second substrate at a position corresponding to the first alignment mark. Full Article
mines Manufacturing method for organic electroluminescent panel and organic electroluminescent panel manufactured using the same By www.freepatentsonline.com Published On :: Tue, 16 Jun 2015 08:00:00 EDT A simple manufacturing method for an organic electroluminescent panel in which organic electroluminescent elements are arranged and sealed by a sealing adhesive. The electroluminescent panel has excellent sealing properties and excellent durability as a result of the organic electroluminescent elements being adhered to one another by a heat-curable adhesive. The manufacturing method is for an organic electroluminescent panel in which at least a first electrode, an organic functional layer containing a light-emitting layer, an organic electroluminescent element having a second electrode, and a sealing substrate are bonded together on a substrate by the heat-curable adhesive. The method includes forming a heat-curable adhesive layer on the sealing substrate, subjecting the heat-curable adhesive layer formed on the sealing substrate to pre-heating treatment, bonding the pre-heated heat-curable adhesive layer to the organic electroluminescent element, and subjecting the heat-curable adhesive layer to heat curing, in the given order. Full Article
mines Materials for organic electroluminescent devices By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention describes novel indenofluorene derivatives which can preferably be employed as matrix materials for phosphorescent dopants or as electron-transport materials, in particular for use in the emission and/or charge-transport layer of electroluminescent devices. The invention furthermore relates to polymers which comprise these compounds as structural units and to a process for the preparation of the compounds according to the invention and to electronic devices which comprise same. Full Article
mines Organic electroluminescence display device and method for manufacturing the same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The organic electroluminescence display device has a laminated portion on a base substrate. The device may have a cavernous portion formed by exploding a part of the laminated portion in a screening processing. A protective layer is formed to cover a whole surface of a wall defining the cavernous portion. Therefore, substances contained in the air are prevented from contacting to an organic electroluminescence layer at least partially defining the cavernous portion. Therefore, even if moisture is contained in the air, it is possible to prevent moisture from being absorbed by the organic electroluminescence layer. Moreover, since moisture is not absorbed by the organic electroluminescence layer, it is possible to reduce irregular spot on the device. In addition, it is possible to reduce a short circuit at an open defective portion. Full Article
mines Motor-driven unit for clearing mines from and securing a hazardous route By www.freepatentsonline.com Published On :: Tue, 25 Mar 2014 08:00:00 EDT The present disclosure relates to a motor-driven unit for clearing mines from and securing a hazardous route. According to the present method, system and device, a marker apparatus for a secured route is a liquid material for marking on the ground, and comprising dispensing members for providing one axial marking and two side markings on either side of said axial marking, respectively, for said route. Full Article
mines Marking having electroluminescent lighting effect, method for the production thereof By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An electroluminescent arrangement is described. This electroluminescent arrangement comprises the following functional layers: (a) rear electrode as layer A;(b) dielectric layer as layer B;(c) electroluminescent layer as layer C; and(d) cover electrode as layer D. Full Article
mines Method to use a photoluminescent adjuvant in agricultural applications By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT The invention provides a nontoxic photoluminescent adjuvant delivered to targeted crops, plants and seeds to assist spray operations in low light or dark light operations. These crops and plants include: not for human consumption crops, turf grass, ornamental flowers, seeds, shrubs and bushes. Spray operations are delivered to the foliar, crown and soil parts and seeds of a crop or plant. Full Article
mines Method to use a photoluminescent adjuvant in agricultural applications By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention provides a non-toxic photoluminescent adjuvant delivered to targeted crops, plants and seeds to assist spray operations in low light or dark light operations. These crops and plants include: not for human consumption crops, turf grass, ornamental flowers, seeds, shrubs and bushes. Spray operations are delivered to the foliar, crown and soil parts and seeds of a crop or plant. Full Article
mines Use of a reaction product of carboxylic acids with aliphatic polyamines for improving or boosting the separation of water from fuel oils By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Use of a reaction product of saturated or unsaturated aliphatic mono- or polycarboxylic acids with aliphatic polyamines for improving or boosting the separation of water from fuel oils which comprise additives with detergent action. A Fuel additive concentrate comprising the said reaction product, certain additives with detergent action and optionally dehazers, cetane number improvers and solvents or diluents. Full Article
mines MONOFUNCTIONAL AMINES AS ADHESION PRIMERS FOR CONDUCTIVE POLYMERS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention relates to a process for producing an electrolytic capacitor, the process comprising process steps i) ii): i) providing a capacitor body (1) that comprises an electrode body (2) of an electrode material,a dielectric (3) which at least partially covers the surface of this electrode material, anda solid electrolyte (4) at least comprising an electrically conductive material which at least partially covers the dielectric surface; ii) applying a primer solution e) to the capacitor body (1), followed by an application of a solution or dispersion a) comprising a conjugated polymer b) and a solvent or dispersant d), followed by an at least partial removal of the solvent or dispersant d) for the formation of the polymeric outer layer (5) that is formed onto the capacitor body (1); wherein the primer solution e) comprises at least one monofunctional amine and at least one carboxylic acid. Full Article
mines ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC PHOTOELECTRIC APPARATUS By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides a nitrogen-containing heterocyclic compound having a general formula (I) and an organic photoelectric apparatus thereof. The general formula (I) is wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, and A10 are independently selected from a hydrogen atom, at least one compound having the general formula (II) and at least one compound having a general formula (III), wherein Y1, Y2, and Y3 are independently selected from C and N; and R3 and R4 are independently selected from C6-30 aromatic group and C2-30 heterocyclic aromatic group, wherein X is selected from oxyl group, sulfenyl group, substituted or non-substituted imino group, substituted or non-substituted methylene group, and substituted or non-substituted silicylene group, and R5, R6, R7, R8, R9, R10, R11, and R12 are independently selected from hydrogen, deuterium, C1-30 alkyl group, C6-30 aromatic group, and C2-30 heterocyclic aromatic group. Full Article
mines ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC PHOTOELECTRIC APPARATUS THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides a nitrogen-containing heterocyclic compound having general formula (I) and an organic photoelectric apparatus thereof. where A1, A2, A3, A4, A5, A6, A7, and A8 are independently selected from a hydrogen atom, at least one compound having the general formula (II) and at least one compound having the general formula (III), where Y1, Y2, and Y3 are independently selected from C and N; R3 and R4 are independently selected from C6-30 aromatic group and C2-30 heterocyclic aromatic group, wherein X is selected from any one of oxyl group (—O—), sulfhydryl group (—S—), substituted or non-substituted imino group, substituted or non-substituted methylene group, and substituted or non-substituted silicylene group; R5, R6, R7, R8, R9, R10, R11, and R12 are independently selected from hydrogen, deuterium, C1-30 alkyl group, C6-30 aromatic group, or C2-30 heterocyclic aromatic group. Full Article
mines PYRIMIDINE DERIVATIVE AND AN ORGANIC ELECTROLUMINESCENT DEVICE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT According to the present invention, there are provided a pyrimidine derivative represented by a general formula (1) indicated below, and an organic electroluminescent device comprising a pair of electrodes, and at least one organic layer sandwiched therebetween, wherein the pyrimidine derivative is used as a constituent material for the at least one organic layer. The pyrimidine derivative of the present invention is a material for a high efficiency, high durability organic electroluminescent device, is excellent in electron injection/transport performance, has hole blocking capability, and excels in characteristics. Full Article
mines Organic Electroluminescent Materials and Devices By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Host materials with pentafluorophenyl substitution are described. These compounds are designed for, and used for hosting aza substituted dopants that may be susceptible to intramolecular deprotonation. In addition, the fluorinated substitution aids with electron transport within the emissive layer. Full Article
mines ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC PHOTOELECTRIC APPARATUS THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides a nitrogen-containing heterocyclic compound having a general formula (I) and an organic photoelectric apparatus thereof. The compound of general formula (I) is: wherein A1, A2, A3, and A4 are independently selected from a hydrogen atom, a function group having a general formula (II); A1, A2, A3, and A4 include at least one function group having the general formula (II); R1 and R2 are independently selected from one of hydrogen, deuterium, C1-30 alkyl group, C6-30 aromatic group and C2-30 heterocyclic aromatic group; Y1 and Y2 are independently selected from substituted or non-substituted C and N,the general formula (II) being: wherein X is selected from one of oxyl group (—O—), sulfhydryl group (—S—), substituted or non-substituted imino group, substituted or non-substituted methylene group, and substituted or non-substituted silicylene group; and R3, R4, R5, R6, R7, R8, R9, and R10 are independently selected from one of hydrogen, deuterium, C1-30 alkyl group, C6-30 aromatic group, and C2-30 heterocyclic aromatic group. Full Article
mines ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC PHOTOELECTRIC APPARATUS THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present disclosure provides a nitrogen-containing heterocyclic compound having a general formula (I) and an organic photoelectric apparatus thereof. The general formula (I) is: wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, and A10 are independently selected from a hydrogen atom, a nitrile group and a function group having a general formula (II), and A1, A2, A3, A4, A5, A6, A7, A8, A9, and A10 include at least one nitrile group and at least one function group having the general formula (II),the general formula (II) being: wherein R1, R2, R3, R4, R5, R6, R7, and R8 are independently selected from hydrogen atoms, deuterium atoms, C6-30 aromatic group and C2-30 heterocyclic aromatic group. Full Article
mines Organic Electroluminescent Materials and Devices By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Compounds containing indolocathazole, and aromatic and/or heteroaromatic building blocks, are disclosed in this application. These compounds are useful for application in organic electroluminescent devices. Full Article
mines ELECTROLUMINESCENT DIODE HAVING DELAYED FLORESCENCE QUANTUM DOT By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention relates to a delayed fluorescence-quantum dot (QD) electroluminescent diode, the delayed fluorescence-quantum dot electroluminescent diode includes an anode, a cathode, and a light emitting layer located between the anode and the cathode, and the light emitting layer includes a QD and a delayed fluorescence material which supplies energy to the QD. Full Article
mines Militants increasing attacks on Burkina Faso mines By www.seattletimes.com Published On :: Sat, 09 May 2020 02:04:23 -0700 BOUDA, Burkina Faso (AP) — Jihadists burst into the gold mine where Moussa Tambura worked in Burkina Faso, forbidding everyone from smoking and drinking. It wasn’t long before the men returned and leveled the place to the ground. “They attacked the site, killed people and burned houses,” said Tambura, 29, clenching his fists. He was […] Full Article World
mines Two coal mines pull out hundreds of workers over mining equipment safety issue By www.abc.net.au Published On :: Wed, 28 Aug 2019 18:46:00 +1000 Mining company South32 removes hundreds of workers from its two Illawarra underground coal mines as it investigates an issue with an emergency breathing mask. Full Article ABC Illawarra illawarra Business Economics and Finance:All:All Business Economics and Finance:Industry:All Business Economics and Finance:Industry:Mining Government and Politics:All:All Health:safety:All Australia:NSW:Wollongong 2500
mines Mines Rovers Football Club's first indigenous guernsey By www.abc.net.au Published On :: Sat, 25 May 2019 09:16:00 +1000 Full Article ABC Goldfields goldfields Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Aboriginal Community and Society:Race Relations:All Sport:Australian Football League:All Australia:WA:Kalgoorlie 6430 Australia:WA:Kambalda 6442
mines Squalid homes demolished, residents relocated from Aboriginal reserves, in shadow of big-money mines By www.abc.net.au Published On :: Sat, 13 Jul 2019 12:52:00 +1000 People are living in squalor right next to the richest mines in the country, and no-one's prepared to take responsibility for maintenance. Full Article ABC Goldfields goldfields Community and Society:Indigenous (Aboriginal and Torres Strait Islander):All Community and Society:Poverty:All Australia:WA:Kalgoorlie 6430
mines What could Newmont Mining's $14b merger with Goldcorp mean for Australian gold mines? By www.abc.net.au Published On :: Wed, 24 Apr 2019 16:55:00 +1000 Two of the world's biggest gold mining companies have merged in a $14 billion deal. What does it mean for the Kalgoorlie Super Pit and other Aussie gold mines? Full Article ABC Great Southern alicesprings greatsouthern goldfields kimberley Business Economics and Finance:Industry:Gold Business Economics and Finance:Industry:Mining Business Economics and Finance:Markets:Stockmarket Rural:Mining:All Australia:NT:Yuendumu 0872 Australia:WA:Boddington 6390 Australia:WA:Kalgoorlie 6430 Australia:WA:Kununurra 6743 Canada:All:All United States:All:All
mines Australia's $19b gold industry on edge of 'production cliff' as mines run out of gold, analyst warns By www.abc.net.au Published On :: Tue, 30 Apr 2019 09:52:00 +1000 Australia was built on gold rushes a century ago, but there is a warning it could slip from second to fourth on a list of the world's biggest gold producing nations by 2024. Full Article ABC Great Southern alicesprings greatsouthern goldfields Business Economics and Finance:Industry:Gold Business Economics and Finance:Industry:Mining Rural:Mining:All Australia:NT:Alice Springs 0870 Australia:WA:Boddington 6390 Australia:WA:Kalgoorlie 6430 Australia:WA:Kambalda 6442 Australia:WA:Laverton 6440 Australia:WA:Leinster 6437
mines Victorian gold rush revival digs in as surging price, investment in deeper mines sees production double By www.abc.net.au Published On :: Mon, 01 Jul 2019 13:29:00 +1000 With production doubling in the past five years thanks to new extraction technology and investment, Victorian mines are digging deeper where most of its gold actually is. Full Article ABC Central Victoria ballarat centralvic westernvic Business Economics and Finance:Industry:Gold Community and Society:History:All Science and Technology:All:All Australia:VIC:Ballarat 3350 Australia:VIC:Bendigo 3550 Australia:VIC:Castlemaine 3450 Australia:VIC:Costerfield 3523 Australia:VIC:Fosterville 3557 Australia:VIC:Stawell 3380
mines Trains deliver water to drought-affected NSW coal mines to keep production going and save jobs By www.abc.net.au Published On :: Thu, 15 Aug 2019 19:36:00 +1000 As the drought continues, water is being carted by train for the first time in decades to keep production on track at a NSW coal mine and secure 140 full-time jobs. Full Article ABC Central West NSW newcastle westernplains centralwest Business Economics and Finance:Industry:Coal Business Economics and Finance:Industry:Mining Business Economics and Finance:Industry:Rail Transport Disasters and Accidents:Drought:All Environment:Water Supply:All Australia:NSW:Charbon 2848 Australia:NSW:Cobar 2835 Australia:NSW:Lithgow 2790
mines Map of mines By www.abc.net.au Published On :: Tue, 29 Oct 2019 06:27:00 +1100 Full Article ABC Central West NSW centralwest Business Economics and Finance:Industry:Gold Australia:NSW:Parkes 2870
mines Parkes' abandoned gold mines continue to be unearthed by residents a century on By www.abc.net.au Published On :: Tue, 29 Oct 2019 06:27:00 +1100 Cave-ins, bottomless pits filled with car bodies and cyanide-laced sandhills are just some of the remnants left behind from Parkes' long gold-rush history. Full Article ABC Central West NSW centralwest Business Economics and Finance:Industry:Building and Construction Business Economics and Finance:Industry:Gold Community and Society:History:All Community and Society:Regional:All Education:Subjects:History Australia:NSW:Parkes 2870
mines NYC schoolteacher self-quarantined with coronavirus symptoms, as city examines virus response By www.nydailynews.com Published On :: Wed, 04 Mar 2020 21:54:42 +0000 The teacher recently traveled to Italy and came back to class before noticing the symptoms, according to a source familiar with the situation. Full Article
mines Grand jury examines evidence in 2019 overdose death of Angels pitcher Tyler Skaggs By www.latimes.com Published On :: Mon, 2 Mar 2020 22:48:42 -0500 A Texas grand jury has been hearing evidence that could form the basis for criminal charges related to the opioid overdose death of Angels pitcher Tyler Skaggs. Full Article
mines Readers React: Article examines Sterling charity ads, but reader questions remain By www.latimes.com Published On :: Mon, 5 May 2014 20:31:00 -0400 Print readers of the Los Angeles Times are no doubt familiar with Donald Sterling's advertisements. Full Article
mines Militants increasing attacks on Burkina Faso mines By www.ctvnews.ca Published On :: Sat, 9 May 2020 08:55:25 -0400 Jihadists linked to al-Qaida and the Islamic State organization have been overrunning gold mines, forcing the miners to sell them the gold exclusively, which is then smuggled and sold across the border in places like Benin, Ghana or Togo. Full Article
mines CBD News: The Collaborative Partnership on Sustainable Wildlife Management (CPW) today launched the Bushmeat Sourcebook, an online resource, on the occasion of the second World Wildlife Day. The sourcebook examines bushmeat's vital contribution to f By www.cbd.int Published On :: Tue, 03 Mar 2015 00:00:00 GMT Full Article
mines New study examines which galaxies are best for intelligent life By www.eurekalert.org Published On :: Fri, 01 May 2020 00:00:00 EDT (University of Arkansas) Giant elliptical galaxies are not as likely as disk-shaped galaxies, such as our own Milky Way, to be cradles of technological civilizations, according to a recent paper by a University of Arkansas astrophysicist. Full Article
mines Intraoperative 68Gallium-PSMA Cerenkov Luminescence Imaging for surgical margins in radical prostatectomy - a feasibility study By jnm.snmjournals.org Published On :: 2020-02-14T14:01:21-08:00 Objective: To assess the feasibility and accuracy of Cerenkov Luminescence Imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy (RPE). Methods: A single centre feasibility study included 10 patients with high-risk primary prostate cancer (PC). 68Ga-PSMA PET/CT scans were performed followed by RPE and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first two patients the prostate gland was incised and imaged with CLI to visualise the primary tumour. We compared the tumour margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumour to background ratio (TBR). Results: Tumour cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. 3 of 10 men had histopathological positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) out of 35 regions of interest (ROIs) proved to visualize a tumour signal according to standard histopathology. The median tumour radiance in these areas was 11301 photons/s/cm2/sr (range 3328 - 25428 photons/s/cm2/sr) and median TBR was 4.2 (range 2.1 – 11.6). False positive signals were seen mainly at the prostate base with PC cells overlaid by benign tissue. PSMA-immunohistochemistry (PSMA-IHC) revealed strong PSMA staining of benign gland tissue, which impacts measured activities. Conclusion: This feasibility showed that 68Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen’s surface to detect PC tissue at the resection margin. Further optimisation of the CLI protocol, or the use of lower-energetic imaging tracers such as 18F-PSMA, are required to reduce false positives. A larger study will be performed to assess diagnostic performance. Full Article
mines Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:25-08:00 Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell–specific reduction of HMG-CoA reductase (Hmgcrm–/m–), which is the rate-limiting enzyme in cholesterol biosynthesis, protects against atherosclerosis by inhibiting macrophage migration in mice. We hypothesized that ATMs are harder to accumulate in Hmgcrm–/m– mice than in control Hmgcrfl/fl mice in the setting of obesity. To test this hypothesis, we fed Hmgcrm–/m– and Hmgcrfl/fl mice a high-fat diet (HFD) for 24 weeks and compared plasma glucose metabolism as well as insulin signaling and histology between the two groups. Myeloid cell–specific reduction of Hmgcr improved glucose tolerance and insulin sensitivity without altering body weight in the HFD-induced obese mice. The improvement was due to a decrease in the number of ATMs. The ATMs were reduced by decreased recruitment of macrophages as a result of their impaired chemotactic activity. These changes were associated with decreased expression of proinflammatory cytokines in adipose tissues. Myeloid cell–specific reduction of Hmgcr also attenuated hepatic steatosis. In conclusion, reducing myeloid HMGCR may be a promising strategy to improve insulin resistance and hepatic steatosis in obesity. Full Article
mines February JADA examines connection between healthy eating habits, untreated caries By www.ada.org Published On :: Mon, 27 Jan 2020 08:00:00 -0600 Greater compliance with dietary guidelines may reduce the chance of untreated caries in adults, according to a study published in the February issue of The Journal of the American Dental Association. Full Article
mines HPI poll examines impact of COVID-19 on dental practices By www.ada.org Published On :: Wed, 01 Apr 2020 12:27:00 -0500 The ADA Health Policy Institute launched an ongoing biweekly poll the week of March 23 that shows 76% of dentists surveyed had closed their offices to all but emergency patients during the COVID-19 pandemic. Another 19% indicated their offices are closed completely. Full Article
mines Genetic Susceptibility Determines {beta}-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76) By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort. RESEARCH DESIGN AND METHODS EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs. RESULTS Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity. CONCLUSIONS The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children. Full Article
mines Minister's performance assessment report Water plan (Mary Basin) 2006 / compiled by Water Policy and Water Services (South Region) - Department of Natural Resources, Mines and Energy. By www.catalog.slsa.sa.gov.au Published On :: This report provides an overview of the implementation of the Water plan (Mary Basin) 2006 and summarises the findings of the assessments undertaken for the last five years. The plan supports urban water supply and a variety of industries including significant agricultural production, a growing tourism industry and fisheries. Full Article
mines Dolphins, Surfers and Waves Sparkle in Bright Blue Bioluminescent Glow Off California Coast By www.smithsonianmag.com Published On :: Tue, 28 Apr 2020 16:31:43 +0000 A rare bloom of microscopic organisms capable of making their own blue light has transformed several of the state’s beaches Full Article
mines Weather Risk Management Club stays connected, examines pandemic impacts remotely By news.psu.edu Published On :: Wed, 06 May 2020 12:25 -0400 The Weather Risk Management Club has continued meeting via Zoom during the remote learning period, carrying on their work examining the impacts of severe weather events on the economy. Full Article
mines Study Examines Crab Impact on Salt Marsh Health By dnerr.blogs.delaware.gov Published On :: Fri, 20 Sep 2019 17:27:56 +0000 A study within the National Estuarine Research Reserve System to determine the destructiveness of crabs to salt marshes found that, while crabs can be a problem in some areas, a far greater threat facing marshes is sea level rise. Crabs play an important role in maintaining a balanced ecosystem in salt marshes, but too many […] The post Study Examines Crab Impact on Salt Marsh Health appeared first on DNERR Blog - State of Delaware. Full Article NERR Research St. Jones Reserve
mines New Book Examines Asia's Energy Issues and Their Global Impact By feedproxy.google.com Published On :: Thu, 07 Apr 2011 08:32:50 +0000 New Book Examines Asia's Energy Issues and Their Global Impact FOR IMMEDIATE RELEASE Media Contact: Derek Ferrar Media Relations Specialist East-West Center Phone: (808) 944-7204 Email: ferrard@EastWestCenter.org Full Article
mines Military now controls Myanmar’s scientifically important amber mines By www.newscientist.com Published On :: Fri, 30 Aug 2019 14:29:51 +0000 Hundreds of scientifically priceless fossils are extracted in horrendous conditions in Myanmar’s amber mines and smuggled over the border for sale in China Full Article