It’s Time to Learn (Scott Berkun) — a strong response to Marc Andreessen’s It’s Time to Build. It feels like we are in a disrupted time when anything is possible, and folks are wondering where the levers are to pull. pygraphistry — a library to extract, transform, and visually explore big graphs. Desert Island Devops […]

Posthog — open source product analytics. Into the Mainframe (Recurse) — the interviews with two mainframe programmers are a great reminder of how much things have changed. And how they haven’t. For instance, later in my career I kept a weighted punching clown in my office. As programmers, we liked our users, but we also […]

Moloch — Large scale, open source, indexed packet capture and search. 3Dify Instagram Photos — open source toolset for adding a 3d effect to photos on Instagram’s web site. It uses 3d-photo-inpainting running in Colab (free GPU) and Cloud pubsub/storage for communication. A glimpse of the future: we could augment all our apps with deep […]

The Suddenly Remote Playbook — I just want to note that if you have to look after kids when you’re supposed to be working, you’re not working from home. Not everyone’s getting a glorious introduction to the delights of working from home. taichi — a programming language designed for high-performance computer graphics. It is deeply […]

Teleforking a Process onto a Different Computer — a working proof of concept (I just don’t replicate tricky things so that I could keep it simple, meaning it’s just a fun tech demo you probably shouldn’t use for anything real) of a telefork() function call that spawns a process on another machine and returns the […]

Learning a Language — this list of questions facing anyone taking a new language for a test run just burns with truth. (Also: encouraging to see how many of these questions are answered by the Cookbook format) OpenVAS — Open Vulnerability Assessment Scanner, aka “what a cheap external security assessment vendor will run and then […]

podpaperscissors — From the classic “prisoner’s dilemma” to more obscure coördination games, Pod Paper Scissors takes game theory out of the dry textbook and into the real world. … Each episode will feature different kinds of games and situations. Experts in a variety of fields will casually converse with the hosts about how the particular […]

To Microservices and Back Again: Why Segment Went Back to a Monolith — microservices came with increased operational overhead and problems around code reuse. … If microservices are implemented incorrectly or used as a band-aid without addressing some of the root flaws in your system, you’ll be unable to do new product development because you’re […]

Tasmota — Alternative firmware for ESP8266 with easy configuration using webUI, OTA updates, automation using timers or rules, expandability and entirely local control over MQTT, HTTP, Serial or KNX. Selfie 2 Waifu — deep learning constructs an anime character from your photo. Paper for the underlying technique. (via @tkasasagi) The Handbook of Cyber Wargames: Wargaming […]

Popcorn Linux — exploring how to improve the programmability of emerging heterogeneous hardware, in particular, those with Instruction Set Architecture (ISA)-diverse cores, from node-scale (e.g., Xeon/Xeon-Phi, ARM/x86, CPU/GPU/FPGAs) to rack-scale (e.g., Scale-out processors, Firebox, The Machine), in both native and virtualized settings. Additionally, the project is exploring how to automatically compile/synthesize/execute code on ISA-heterogeneous hardware. […]

Leaving Amazon (Tim Bray) — May 1st was my last day as a VP and Distinguished Engineer at Amazon Web Services, after five years and five months of rewarding fun. I quit in dismay at Amazon firing whistleblowers who were making noise about warehouse employees frightened of Covid-19. Observability is a Many-Splendoured Thing (Charity Majors) […]

Raman Spectroscopy — Low Cost, High Performances, 100% Open Source Raman Spectrometer. […] We currently offer the spectrometer in a Starter Edition version designed for teaching Raman spectroscopy and we will soon release a Performance Edition version which achieves a tested 12 cm-1 resolution at low costs. Great to see this getting into the hands […]

Super Bootable 64 — Super Mario 64 shipped before the SDK was finalised, and it had to be compiled with optimisations turned off. This meant the binary was easily reversed to source code, and now the unportable has been ported. This site probably won’t last long, because DMCA, but it’s technically a sweet feat. (via […]

Mathematics for Machine Learning — We wrote a book on Mathematics for Machine Learning that motivates people to learn mathematical concepts. The book is not intended to cover advanced machine learning techniques because there are already plenty of books doing this. Instead, we aim to provide the necessary mathematical skills to read those other books. […]

1 July 2007 , Number 2

Iran has energy that China needs and Beijing provides a counter balance to western pressures on Tehran. The benefits are clear, but so are the risks for a rising power in the labyrinthine politics of the Middle East.

K. D. Cherednichenko, Yu. Yu. Ershova, A. V. Kiselev and S. N. Naboko
Trans. Moscow Math. Soc. 80 (2020), 251-294.
Abstract, references and article information

Cathy Lloyd
Apr 1, 2005; 18:121-127
Feature Articles

Cathy Lloyd
Apr 1, 2005; 18:121-127
Feature Articles

1 July 2007 , Number 2

Iran has energy that China needs and Beijing provides a counter balance to western pressures on Tehran. The benefits are clear, but so are the risks for a rising power in the labyrinthine politics of the Middle East.

Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22 producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically, we addressed the hypothesis that early in the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant changes in the gut microbiome. Clustering iHMP study participants on the basis of longitudinal IL-17/IL-22 profiles identified discrete groups. Individuals distinguished by low levels of IL-17/IL-22 were linked to established markers of metabolic disease, including insulin sensitivity. These individuals also displayed gut microbiome dysbiosis, characterized by decreased diversity, and IL-17/IL-22-related declines in the phylum Firmicutes, class Clostridia, and order Clostridiales. This ancillary analysis of the iHMP data therefore supports a link between the gut microbiome, IL-17/IL-22 and the onset of metabolic diseases. This raises the possibility for novel, microbiome-related therapeutic targets that may effectively alleviate metabolic diseases in humans as they do in animal models.

In type 2 diabetes, β-cells endure various forms of cellular stress, including oxidative stress and endoplasmic reticulum stress, secondary to increased demand for insulin production and extracellular perturbations, including hyperglycemia. Chronic exposure to stress causes impaired insulin secretion, apoptosis, and loss of cell identity, and a combination of these processes leads to β-cell failure and severe hyperglycemia. Therefore, a better understanding of the molecular mechanisms underlying stress responses in β-cells promises to reveal new therapeutic opportunities for type 2 diabetes. In this perspective, we discuss posttranscriptional control of gene expression as a critical, but underappreciated, layer of regulation with broad importance during stress responses. Specifically, regulation of mRNA translation occurs pervasively during stress to activate gene expression programs; however, the convenience of RNA sequencing has caused translational regulation to be overlooked compared with transcriptional controls. We highlight the role of RNA binding proteins in shaping selective translational regulation during stress and the mechanisms underlying this level of regulation. A growing body of evidence indicates that RNA binding proteins control an array of processes in β-cells, including the synthesis and secretion of insulin. Therefore, systematic evaluations of translational regulation and the upstream factors shaping this level of regulation are critical areas of investigation to expand our understanding of β-cell failure in type 2 diabetes.

Bio-engineered models of the human brain infected with herpes simplex virus-1 develop many of the same characteristics found in Alzheimer's disease, according to a new analysis published by Science Advances.

OBJECTIVE

HbA_1c levels are increasingly measured in screening for diabetes; we investigated whether HbA_1c may simultaneously improve cardiovascular disease (CVD) risk assessment, using QRISK3, American College of Cardiology/American Heart Association (ACC/AHA), and Systematic COronary Risk Evaluation (SCORE) scoring systems.

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Our weekly round-up of the best psychology coverage from elsewhere on the web

Our weekly round-up of the best psychology coverage from elsewhere on the web

The Chinese Communist Party (CCP) is building links between China’s civilian universities, military and security agencies. Those efforts, carried out under a policy of leveraging the civilian sector to maximise military power (known as ‘military–civil fusion’), have accelerated in the past decade. Research for the China Defence Universities Tracker has determined that greater numbers of Chinese universities are engaged in defence research, training defence scientists, collaborating with the military and cooperating with defence industry conglomerates and are involved in classified research.1 At least 15 civilian universities have been implicated in cyberattacks, illegal exports or espionage. China’s defence industry conglomerates are supervising agencies of nine universities and have sent thousands of their employees to train abroad.

WHEN Malian quartet Songhoy Blues performed at last year's Celtic Connections, audiences were treated to a form of music appealingly dubbed “desert blues”. A user-friendly term, it sounds like it could have been dreamed up by a marketing agency and applied equally well to a perfume, a brand of jeans or a chain of upmarket Tex-Mex restaurants.

"Reshaping rural schools in the Northwest Region: Lessons from federal School Improvement Grant implementation" was written by Caitlin Scott and Nora Ostler at the Regional Education Laboratory At Education Northwest, and prepared for the Institute of Education Sciences.

Governor Jack Markell, Delaware State Housing Authority, and their partners are pleased to announce the launch of a free housing locator website providing information about rental housing across the First State.

Governor Markell and the Delaware State Housing Authority announced the launch of a free housing locator website providing information about rental housing across the First State.

After being on the run for nearly a year, the National Investigation Agency on Saturday arrested Ranjit Singh, a "notorious narco-terrorist", from Sirsa as he was acting as a conduit of Pakistan-based...

With the country remaining under a lockdown due to coronavirus, the supply chain of essential goods has been disrupted, but, the same has also presented the government with an opportunity to identify and plug those gaps.

South Australia Minister for Trade, Tourism and Investment, David Ridgway, recently hosted a roundtable in Guangzhou to promote the state’s newly launched Landing Pad program.

Hackers used Aria-body, an intrusive new tool, to attack computers in Thailand, Indonesia, the Philippines, Vietnam, Myanmar and Brunei, report says.

By James H. Spencer, Sumeet Saksena, and Jefferson Fox HONOLULU (1 April 2020)—The current COVID-19 pandemic, which started in Wuhan, China, underscores what the public health community has warned about for more than two decades—the risk of viral diseases capable of spreading from animal to human hosts. The first outbreaks of “bird flu” (highly pathogenic avian influenza―HPAI, subtype H5N1) raised similar concerns 20 years ago―concerns that have persisted with the outbreak of SARS in 2002–2004 and COVID-19 today. New outbreaks of avian influenza are also still occurring in poultry and humans, primarily in Asia but also in other parts of the world.

This is a summary only. Click the title for the full article, or visit www.EastWestCenter.org/Research-Wire for more.

A terminal in the U.S. is now linked to the Tijuana International Airport via a cross-border bridge. Julie Noce reports.

Dr Harpreet Bajaj summarizes the known and unknown links between diabetes and COVID-19, focusing on three clinical questions.