The continuing flow calls into question previous Coalition claims that people were crossing the border from Northern Ireland because of fears of the former British Government’s Rwanda policy.

The post International Protection applicants to exceed a record of 20,000 this year was curated by information for practice.

In her final appearance, Laura Knoy is on the other side of The Exchange mic, as Peter Biello interviews her about her 25 years as host. We discuss the show's origins, moments that have stood out over the years, and hear her observations on how New Hampshire has changed.

Academy Award-winning filmmaker Martin Scorsese is embarking on a spiritual journey through the lives of revered saints, from Joan of Arc to John the Baptist, with his latest docudrama series, “The Saints,” premiering next month.

Grammy Award-winning artist Lauren Daigle has written and recorded a powerful end-title track for the new film “Bonhoeffer: Pastor. Spy. Assassin” declaring obedience to God’s calling, even in the face of death. 

In 2023, central banks around the world purchased significant amounts of gold. China's activity in this area was particularly noticeable as the nation's gold reserves increased by 225 tons over the year. An article published on Chinese Internet platform Baijiahao says that Russia actively participated in the gold rush to increase its precious metals reserves. As a result, Russia's gold reserves reached a record 2.36 thousand tons. Russia is thus ranked fifth following the USA, Germany, Italy and France.

As AI regulations in the US have evolved to be more supportive of commercial use, retailers and malls are increasingly adopting technologies that were once the domain of law enforcement and federal agencies. This shift is driven by the need for enhanced security and operational efficiency, with many turning to advanced video analytics and facial intelligence.

CIRRO Fulfillment, the e-commerce fulfilment service provider, has been honoured with the Best New Member Award by the UK Warehousing Association (UKWA).

Building on the theme, ‘Make the impossible, possible’, Manhattan Associates has opened its annual EMEA Exchange event to an audience of more than 300 customers and press, with keynotes that introduced the European market to Manhattan Active Supply Chain Planning and Generative AI solutions; Manhattan Active Maven and Manhattan Assist.

According to dietician Elena Solomatina, overeating can have fatal consequences. Internal organs often suffer, as the swollen stomach presses on the diaphragm, which can even lead to death during sleep. Existing medical conditions can also worsen, causing belching, gastritis, and inflamed gallbladder. "If a person sleeps with a full stomach, it can lead to snoring and even to stopping breathing during sleep. If there are already cardiovascular diseases, it can lead to heart failure, angina, and even a heart attack or stroke... If there is nausea, vomiting with greenish content, weakness - an ambulance must be called," Solomatina was quoted as saying by URA.RU. To reduce the risk of aggravating old illnesses and let the food lump pass, it is necessary to take a walk in the fresh air. Afterwards, it is recommended to prepare a caffeine-containing beverage that can act as a mild laxative.

American University's School of Communication (SOC) announced today that seasoned student journalist Gabe Castro-Root was selected to join an expedition to Antarctica where he will be reporting on the expedition.

So-called "XYZ states" defy the standard picture of particle behavior and have given rise to several attempts to understand their nature. But researchers with the Center for Theoretical and Computational Physics (Theory Center) at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility say there is a simpler way to explain the abundance of exotic charmonium particles using lattice quantum chromodynamics.

[Domestic] :
Testimonies from surviving crew members who were aboard the fishing boat that sank in waters off Jeju Island on Friday suggest that the excessive amount of fish caught may have caused the ship to go down. According to the Jeju branch of the Korea Coast Guard on Saturday, all of the rescued crew members ...

[more...]

BGS to help deliver International Centre of Excellence on Sustainable Resource Management  British Geological Survey

The seventh blind test of crystal structure prediction (CSP) methods substantially increased the level of complexity of the target compounds relative to the previous tests organized by the Cambridge Crystallographic Data Centre. In this work, the performance of density-functional methods is assessed using numerical atomic orbitals and the exchange-hole dipole moment dispersion correction (XDM) for the energy-ranking phase of the seventh blind test. Overall, excellent performance was seen for the two rigid molecules (XXVII, XXVIII) and for the organic salt (XXXIII). However, for the agrochemical (XXXI) and pharmaceutical (XXXII) targets, the experimental polymorphs were ranked fairly high in energy amongst the provided candidate structures and inclusion of thermal free-energy corrections from the lattice vibrations was found to be essential for compound XXXI. Based on these results, it is proposed that the importance of vibrational free-energy corrections increases with the number of rotatable bonds.

The third complementary-determining regions of the heavy-chain (CDR3H) variable regions (VH) of some cattle antibodies are highly extended, consisting of 48 or more residues. These `ultralong' CDR3Hs form β-ribbon stalks that protrude from the surface of the antibody with a disulfide cross-linked knob region at their apex that dominates antigen interactions over the other CDR loops. The structure of the Fab fragment of a naturally paired bovine ultralong antibody (D08), identified by single B-cell sequencing, has been determined to 1.6 Å resolution. By swapping the D08 native light chain with that of an unrelated antigen-unknown ultralong antibody, it is shown that interactions between the CDR3s of the variable domains potentially affect the fine positioning of the ultralong CDR3H; however, comparison with other crystallo­graphic structures shows that crystalline packing is also a major contributor. It is concluded that, on balance, the exact positioning of ultralong CDR3H loops is most likely to be due to the constraints of crystal packing.

This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for recognition by receptors on T lymphocytes (T cell receptors, TCR) and natural killer (NK) cells. The past few decades have accumulated a vast knowledge base of the structures of MHC molecules and the complexes of MHC/TCR with specificity for many different peptides. In recent years, the structures of MHC-I molecules complexed with chaperones that assist in peptide loading have been revealed by X-ray crystallography and cryogenic electron microscopy. These structures have been further studied using mutagenesis, molecular dynamics and NMR approaches. This review summarizes the current structures and dynamic principles that govern peptide exchange as these relate to the process of antigen presentation.

Source: Streetwise Reports 11/07/2024

Drilling and field operations at Golden Cariboo Resources Ltd.'s (GCC:CSE; GCCFF:OTC; A0RLEP:WKN; 3TZ:FSE) past-producing Quesnelle project in British Columbia's Cariboo Gold District continue to find the yellow metal throughout the project, from visible gold in drill cores to mineralization in outcrop samples.

President and Chief Executive Officer Frank Callaghan told Streetwise Reports that despite the high level of experience on his team, several geologists had never seen visible gold before, and their first views of it were "priceless."

"It was on the outside of this piece of core," Callaghan said. "And then the core had split … and there was more gold on the inside of it, as well."

Callaghan said he's drilled "hundreds and hundreds" of holes, but he "can count on my hands how many times I've seen it (visible gold)."

He said the company is seeing the gold in "every drill hole," so they keep moving forward chasing the deposit and working at the site 24 hours a day.

And according to Callaghan, the structure of the mineralization is "thickening up" as they drill. The technical team has also recognized multiple types of quartz veins that can contain gold, a common feature in large gold deposits of similar nature.

Last month, the company announced it was even forced to stop drilling in a vein zone at the property due to proximity to Osisko Development Corp.'s nearby mineral claims. Drill hole QGQ24-17 was terminated at a depth of 477.32 meters, and the "only thing that stopped us from drilling further was the claim boundary with Osisko," Callaghan said at the time.

On Tuesday, the company announced rock sample results from its 2024 field campaign, which found up to 8.47 grams per tonne gold (g/t Au) in one outcrop in the Halo zone and 1.13 g/t Au in another outcrop near the Pioneer showing.

"Although there is a lot of glacial cover on this project, our geologists still managed to find new gold-bearing outcrops in areas of great significance," Callaghan said in a release announcing the results. "We have now expanded the surface footprint of gold mineralization at the Halo zone to the northeast and increased the strike length of our gold trend. We're in a very large gold system that is being demonstrated by multiple, varied work programs."

Drilling 'Nonstop' and 'Underbudget'

Golden Cariboo, a Canadian explorer-developer, is targeting a potential multimillion-ounce gold resource at the 3,814-hectare Quesnelle project, where gold, silver, lead and zinc were produced historically, according to its Investor Presentation.

The company's neighbors in the mining district include Osisko's Cariboo Gold Project, Spanish Mountain Gold Ltd. (SPA:TSX.V) (Spanish Mountain deposit), Omineca Mining and Metals Ltd. (OMM:TSX.V; OMMSF:OTCMKTS) (Wingdam mine) and Taseko Mines Ltd. (TKO:TSX; TGB:NYSE.MKT) (Gibraltar mine).

Callaghan began rediscovering the Cariboo Camp in the mid-1990s as Barkerville Gold Mines Ltd. He and his then team discovered a gold deposit at Bonanza Ledge and advanced the project to production. He also assembled and developed the Cariboo Gold Project. Ultimately, Osisko Royalties acquired Barkerville and the assets in 2015 for US$338M. Osisko is about to restart mining operations in the camp.

Subsequently, in 2019, Callaghan acquired the Quesnelle Gold Quartz project, where he aims to repeat his previous successes, given the property's geology is similar to that of the other two projects.

Previously, the company reported observing multiple instances of visible gold in several holes earlier this fall and summer.

"Visible gold in current drilling indicates potential for high-grade assays from mineralized targets," Couloir Capital Senior Mining Analyst Ron Wortel wrote in a recent research report.

Given that Golden Cariboo is continuing its exploration program at Quesnelle throughout 2024, near-term catalysts include drill and assay results demonstrating significant grades or widths and better-defined mineralization controls and trends, according to Wortel.

Callaghan told Streetwise Reports that drilling continues to be "nonstop" and underbudget."

External catalysts include market transactions in the junior mining space involving projects or companies in the Cariboo region. Reports by Osisko Development of project advancements or production results relative to adjacent land also could boost Golden Cariboo's stock price.

The Catalyst: Index Also Confirms Bull Run for Junior Stocks

Experts agreed gold is in a bull market and expect it to go higher. However, after hitting a record high of US$2,790.15 per ounce last week, spot gold was down more than 3% to a three-week low on Wednesday morning as investors moved to the U.S. dollar after Donald Trump's election as U.S. president on Tuesday, Reuters reported.

Market participants are also looking ahead to the Federal Reserve's interest rate decision on Thursday for further clues on the bank's easing cycle, Reuters said.

"A clear presidential victory when the market has been pricing in a contested result, removal of an element of risk, Trump-trades include the dollar's strengthening this morning and the combination of the two has brought gold lower," StoneX analyst Rhona O'Connell said, according to Reuters.

Gold's rise has "resulted in big returns for the investors who bought in earlier this year," Angelica Leicht reported for CBS News last month. "For example, the investors who purchased gold in March when it hit US$2,160 per ounce have seen their gold values increase by nearly 27% in the time since. That's a huge uptick in value in a matter of months, especially on an asset that's known more for long-term growth."

Recently polled London Bullion Market Association members indicated they believe the gold price could reach US$2,940/oz during 2025, reported Stockhead on Oct. 28.[OWNERSHIP_CHART-11131]

"Combined with expectations of lower global interest rates, this further enhances gold's attractiveness as an investment," the article noted.

As for gold equities, the S&P/TSX Venture Composite Index (SPCDNX) confirmed a bull run for junior, intermediate, and senior mining stocks when it closed above 1,000 recently, Stewart Thomson with 321Gold wrote. The index is a key indicator of the health of the general gold, silver, and mining stocks market.

Ownership and Share Structure

According to Golden Cariboo, management and insiders own 30% of Golden Cariboo Resources. President and CEO Frank Callaghan owns 16.45% or 6.93 million shares; Elaine Callaghan has 0.97% or 0.41 million shares; Director Andrew Rees has 0.79% or 0.33 million shares; and Director Laurence Smoliak has 0.3% or 0.13 million shares.

Retail investors hold the remaining. There are no institutional investors.

The company said it has 50.3 million shares outstanding, 24.83 million warrants, and 3.8 million options.

Its market cap is CA$9.63 million. Over the past 52 weeks, Golden Cariboo has traded between CA$0.08 and CA$0.36 per share.

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Important Disclosures:

1. Omineca Mining and Metals Ltd. is a billboard sponsor of Streetwise Reports and pays SWR a monthly sponsorship fee between US$4,000 and US$5,000.
2. Golden Cariboo Resources Ltd. has a consulting relationship with Street Smart an affiliate of Streetwise Reports. Street Smart Clients pay a monthly consulting fee between US$8,000 and US$20,000.
3. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Golden Cariboo Resources Ltd. and Omineca Mining and Metals Ltd.
4. Steve Sobek wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.
5. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

( Companies Mentioned: GCC:CSE; GCCFF:OTC; A0RLEP:WKN;3TZ:FSE, )

Most Americans and Canadians up to age 70 need no more than 600 international units (IUs) of vitamin D per day to maintain health, and those 71 and older may need as much as 800 IUs, says a new report from the Institute of Medicine.

The use of compounded bioidentical hormone therapies (cBHTs) — an increasingly popular approach to relieve symptoms of menopause and male hypogonadism — should be limited to the small number of patients who cannot benefit from an FDA-approved hormone therapy product, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Each year, more than 1.7 million adults in the United States develop sepsis, and 270,000 people die as a result. It’s a dangerous medical complication that occurs when an existing infection — such as pneumonia, a bladder infection, or a skin infection — triggers an extreme reaction throughout the body that can rapidly lead to tissue damage, organ failure, and even death.

The National Academy of Medicine (NAM) has selected 10 professionals for the inaugural class of the NAM Scholars in Diagnostic Excellence program.

The National Academy of Sciences has established a new Strategic Council for Research Excellence, Integrity, and Trust, which will convene stakeholders across the research enterprise to develop ways to promote high-quality research practices and to address challenges to research ethics and integrity.

The National Academy of Medicine has selected 11 professionals for the 2022 class of the NAM Scholars in Diagnostic Excellence program, which supports the scholars in a one-year, part-time experience to advance their diagnostic skills, reduce diagnostic errors that lead to patient harm, and accelerate their career development as national leaders in this field.

The 24 inaugural recipients of the Eric and Wendy Schmidt Awards for Excellence in Science Communication have been announced. Given by the National Academies in partnership with Schmidt Futures, the awards recognize science journalists and research scientists who have developed creative, original work about issues and advances in science, engineering, and medicine.

Higher education institutions and science, technology, engineering, mathematics, and medicine organizations should go beyond a focus on simply increasing the numeric participation of minoritized racial and ethnic groups. To increase diversity, equity, and inclusion in STEMM fields, organizations of all sizes must act to change their cultures and environments.

Submissions are now being accepted for the 2023 Eric and Wendy Schmidt Awards for Excellence in Science Communications, which honor top science communicators, journalists, and research scientists who have developed creative, original work to communicate issues and advances in science, engineering, and medicine for the general public.

Cisco’s new facility at Chennai will manufacture Network Convergence System (NCS) 540 Series of routers.

GCC leaders discuss how by breaking silos, fostering collaboration, and focusing on execution and innovation, GCCs will be instrumental in India’s journey toward becoming a global economic powerhouse.

Certain antibiotic resistance genes are easily transferred from one bacterial species to another, and can move between farm animals and the human gut. A team led by Chinese researchers has characterized this "mobile resistome," which they say is largely to blame for the spread of antibiotic resistance. They found that many antibiotic resistance genes that are shared between the human and animal gut microbiome are also present in multiple human pathogens. These findings are published September 9 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.

read more

Honeybees are hardwired to efficiently search the landscape enabling them to continue working for the greater good of their hives even when they are sick, according to new research co-authored by Queen Mary University of London (QMUL).

read more

The more plant personnel who participate in your facility’s food safety audit, the better. These educational experiences allow your staff to engage with the audit process and improve their food safety knowledge.

We recently were able to talk to Anthony Spinato, president of Spinato's Fine Foods, Tempe, AZ, about their new broccoli pizza crust and other frozen pizza aspects. 

Snack Food & Wholesale Bakery recently was able to talk to Marc Kuo, CEO and co-founder, Routific, about SMBs and non-traditional delivery methods during the COVID-19 pandemic.

To be held Feb. 1, Dansco’s online probiotics event will cover the latest developments and global digestive health market trends as well as clinical study data supporting the effect of probiotics on key measures of digestive health.

The Killer Brownie Co. discusses the benefits of its new sanitary constructed, single tray dual lane product turning conveyor required to rotate single lane brownie containers 90°.  

Attendees can vote on the awards during the packaging show, Sept. 11–13 in Las Vegas.

ABA recently released an infographic about the demand for soybean oil and vegetable oils. The demand has currently exceeded the supply, causing prices to rapidly increase.  

According to IBISWorld, tortilla production in the U.S. has grown 3 percent in the past five years thanks to the fact that tortillas, especially ones boosted with ingredients like spinach and whole wheat, are perceived to be healthier than bread during a time when consumers value nutrition.

Much like its predecessor, the FGP Primary Cleaner, the FGP with External Spring features FDA-approved, food grade materials including a stainless-steel tensioner and a solid pole.

The initial offering will include 6-oz. resealable bags for retail as well as 2-lbs. bags perfect for foodservice applications.

A new report from the Centers for Disease Control and Prevention (CDC) reveals that nearly half of children’s sodium intake comes from 10 foods, including bread and rolls.

Snacking healthier is getting easier nowadays with graze, a subscription box that also sells its products in stores. 

Insights into the top sandwich trends across the U.S. restaurant industry, including R&D inspirations for sandwich-specific breads, buns and rolls.

Georgia-based HRS Heat Exchangers has been awarded the American 3-A Sanitary Standards approval for two of its key heat exchanger models for food and beverage use.

Munk Pack, winner of the 2017 ‘Best Health School Snacks’ contest, discusses natural, healthy, vegan snacks.