Background:

Incentive payments for chronic diseases in British Columbia were intended to support primary care physicians in providing more comprehensive care, but research shows that not all physicians bill incentives and not all eligible patients have them billed on their behalf. We investigated patient and physician characteristics associated with billing incentives for chronic diseases in BC.

Maintenance of the proteome, ensuring the proper locations, proper conformations, appropriate concentrations, etc., is essential to preserve the health of an organism in the face of environmental insults, infectious diseases, and the challenges associated with aging. Maintaining the proteome is even more difficult in the background of inherited mutations that render a given protein and others handled by the same proteostasis machinery misfolding prone and/or aggregation prone. Maintenance of the proteome or maintaining proteostasis requires the orchestration of protein synthesis, folding, trafficking, and degradation by way of highly conserved, interacting, and competitive proteostasis pathways. Each subcellular compartment has a unique proteostasis network compromising common and specialized proteostasis maintenance pathways. Stress-responsive signaling pathways detect the misfolding and/or aggregation of proteins in specific subcellular compartments using stress sensors and respond by generating an active transcription factor. Subsequent transcriptional programs up-regulate proteostasis network capacity (i.e., ability to fold and degrade proteins in that compartment). Stress-responsive signaling pathways can also be linked by way of signaling cascades to nontranscriptional means to reestablish proteostasis (e.g., by translational attenuation). Proteostasis is also strongly influenced by the inherent kinetics and thermodynamics of the folding, misfolding, and aggregation of individual proteins, and these sequence-based attributes in combination with proteostasis network capacity together influence proteostasis. In this review, we will focus on the growing body of evidence that proteostasis deficits leading to human pathology can be reversed by pharmacologic adaptation of proteostasis network capacity through stress-responsive signaling pathway activation. The power of this approach will be exemplified by focusing on the ATF6 arm of the unfolded protein response stress responsive-signaling pathway that regulates proteostasis network capacity of the secretory pathway.

The remains of three slaves found in Mexico contain the earliest signs of the hepatitis B virus and yaws bacteria in the Americas, suggesting transatlantic slavery introduced these diseases

Herd immunity means that after a certain percentage of a population is immune to a disease, the whole population is. This is usually achieved through vaccination but some are not convinced.

Science has a reputation for moving slowly. The very process of publishing solid scientific data—let alone developing vaccines and therapies—requires a long timeline. But outbreaks of infectious diseases spread quickly, demanding a much quicker pace. Scientific endeavors to better understand SARS-COV-2, the virus that causes COVID-19, have progressed rapidly. Within weeks of the virus emerging…

Reflecting research-driven changes in clinical practice, a revised set of evidence-based recommendations for the medical and surgical treatment of left-sided colonic diverticulitis has been published in Diseases of the Colon & Rectum (DC&R), the official journal of the American Society of Colon and Rectal Surgeons (ASCRS). The journal is published by Wolters Kluwer.

Bats are extremely social, have turbo-charged metabolisms, and elite immune systems. All of these combined creates the perfect storm for harboring and transmitting diseases.

“John, I’m very aware of your family’s journey, Twelve years ago I was one of the producers considering bidding on your life rights.”

The Gene-Z app works with Apple and Android and can detect plant diseases in 10-30 minutes.

A new plug-in diagnostic tool could mean better healthcare around the world.

Help Kids Defeat the Mouth Monsters

Masimo CEO Joe Kiani discussed how the medical device maker's telehealth systems can be useful in the fight against coronavirus.

A hotter planet could change the relationship among infectious agents, their hosts and the human body’s defense mechanisms

-- Read more on ScientificAmerican.com

The remains of three slaves found in Mexico contain the earliest signs of the hepatitis B virus and yaws bacteria in the Americas, suggesting transatlantic slavery introduced these diseases

Skin vaccination generates protective CD8 T-cells that are recruited to the genital tissues. Study conducted by King's College London scientists has revealed

Statins, the most commonly used cholesterol-lowering agents, were found to be significantly underutilized to treat lipid abnormalities in patients who

New technology uses optical imaging to help surgeons map out tumors in the body and help them learn how certain diseases affect activity in the brain.

University of Freiburg scientists have used gene scissors to edit genetic material in order to better diagnose diseases such as cancer. The results are

New study has found a recently developed system for switching on the activity of genes that could improve treatments for a broad range of neurological diseases.

Age-related macular degeneration and diabetic retinopathy could be treated by targeting a vital step in the process that leads to leaky vessels and harmful

New study has discovered different types of white fat cells, even within a single site, may play different roles in disease. The findings of the study

The molecular mechanisms that trigger metabolic imbalance between the two distinct but linked processes have been discovered by scientists. The new finding

New study devised a way to encapsulate therapeutic cells that can be implanted in patients, which could secrete drugs as-needed in the patient. This novel

Deep learning-based artificial intelligence (AI) algorithm has been developed by Korean researchers. The AI can accurately classify cutaneous skin disorders,

Telemedicine, home-monitoring devices, regular medical appointments, positive reinforcement from carers and health professionals could keep supported

Though overall medical care is improving, efforts to prevent and better manage chronic diseases such as diabetes and asthma would improve results and lower costs, according to the OECD’s latest edition of Health at a Glance.

Dementia is increasing in prevalence, and to date has no cure or treatment. One element in improving this situation is using and sharing data more widely to increase the power of research. Further, moving beyond established medical data into big data offers the potential to tap into routinely collected data from both within and outside the health system.

Rising levels of obesity and diabetes around the world could halt a trend of decreasing mortality rates for cardiovascular diseases, such as strokes and heart attacks, and even cause rates to start rising again, particularly among younger people, according to a new OECD report.

Too many lives are still lost in OECD countries because healthcare quality is improving too slowly to cope with ageing populations and the growing number of people with one or more chronic diseases, according to a new OECD report.

Better public health and prevention policies as well as more effective health care could save hundreds of thousands of lives and billions of euros each year in Europe, according to a new joint OECD/European Commission report.

In a conversation with BW Businessworld Chairman and Editor-in-Chief Annurag Batra and Abhinav Trivedi and Kavi Bhandari of BW Businessworld, Chhachhi emphasises the unavoidable connection between the mind and the body. Excerpts of a BW Wellbeing Dialogue:

The insect, known by the scientific name Aedes aegypti as well as the common name 'yellow fever mosquito', currently only thrives in the world's hottest regions.

The insect, known by the scientific name Aedes aegypti as well as the common name 'yellow fever mosquito', currently only thrives in the world's hottest regions.

Medical and agricultural research institutes ink MoU for cooperation in the area of zoonoses, anti-microbial resistance, nutrition and pesticide residues

Popular social networking sites like Facebook and Twitter have been blamed for the rise in cases of sexually transmitted diseases. STD like Syphilis is on the rise as members opt for unprotected sex with the partners they meet over the Internet.Official

Cham : Springer, c2019.

[S.l.] : SPRINGER NATURE, 2019.

Cham : Springer, 2020.

Cham : Springer, c2019.

Vienna : Springer, 2019.

Cham, Switzerland : Springer, [2019]