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CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model

By www.haematologica.org
Published On :: 2020-05-01T00:05:42-07:00


Full Article

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EZH2 mutations and impact on clinical outcome: an analysis in 1,604 patients with newly diagnosed acute myeloid leukemia

By www.haematologica.org
Published On :: 2020-05-01T00:05:42-07:00


Full Article

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Supervised consumption services for acute care hospital patients [Practice]

By www.cmaj.ca
Published On :: 2020-05-03T21:05:14-07:00


Full Article

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Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model [Pharmacology]

By aac.asm.org
Published On :: 2020-04-21T08:01:10-07:00

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (P = 0.018) versus that of the controls (P = 0.99) and histopathological damage (P = 0.013). A three-compartment model best described the data (bias, 0.129 mg/liter; imprecision, 0.729 mg2/liter2; R2, 0.652,). Area under the concentration-time curve at 24 h (AUC24) values were similar (P = 0.87). The thrice-daily dosing scheme resulted in the most PB-associated AKI in a rat model.


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Characterization of blaCTX-M-27/F1:A2:B20 Plasmids Harbored by Escherichia coli Sequence Type 131 Sublineage C1/H30R Isolates Spreading among Elderly Japanese in Nonacute-Care Settings [Mechanisms of Resistance]

By aac.asm.org
Published On :: 2020-04-21T08:01:09-07:00

We characterized 29 blaCTX-M-27-harboring plasmids of Escherichia coli sequence type 131 (ST131) sublineage C1/H30R isolates from healthy individuals and long-term-care facility (LTCF) residents. Most (27/29) plasmids were of the FIA, FIB, and FII multireplicon type with the same plasmid multilocus sequence typing (pMLST). Several plasmids (7/23) from LTCF residents harbored only blaCTX-M-27 as the resistance gene; however, their fundamental structures were very similar to those of previously isolated blaCTX-M-27/F1:A2:B20 plasmids, suggesting their prevalence as a newly arising public health concern.


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Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model [Pharmacology]

By aac.asm.org
Published On :: 2020-04-21T08:01:09-07:00

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.


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Is Histologic Thrombus Composition in Acute Stroke Linked to Stroke Etiology or to Interventional Parameters? [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

Detailed insight into the composition of thrombi retrieved from patients with ischemic stroke by mechanical thrombectomy might improve pathophysiologic understanding and therapy. Thus, this study searched for links between histologic thrombus composition and stroke subtypes and mechanical thrombectomy results.

MATERIALS AND METHODS:

Thrombi from 85 patients who had undergone mechanical thrombectomy for acute ischemic stroke between December 2016 and March 2018 were studied retrospectively. Thrombi were examined histologically. Preinterventional imaging features, stroke subtypes, and interventional parameters were re-analyzed. Statistical analysis was performed with the Kruskal-Wallis test, Mann-Whitney U test, or Spearman correlation as appropriate.

 RESULTS:

Cardioembolic thrombi had a higher percentage of macrophages and a tendency toward more platelets than thrombi of large-artery atherosclerotic stenosis (P = .021 and .003) or the embolic stroke of undetermined source (P = .037 and .099) subtype. Thrombi prone to fragmentation required the combined use of contact aspiration and stent retrieval (P = .021) and were associated with an increased number of retrieving maneuvers (P = .001), longer procedural times (P = .001), and a higher lymphocyte content (P = .035).

 CONCLUSIONS:

We interpreted the higher macrophage and platelet content in cardioembolic thrombi compared with large-artery atherosclerotic stenosis or embolic stroke of undetermined source thrombi as an indication that the latter type might be derived from an atherosclerotic plaque rather than from an undetermined cardiac source. The extent of thrombus fragmentation was associated with a more challenging mechanical thrombectomy and a higher lymphocyte content of the thrombi. Thus, thrombus fragmentation not only might be caused by the recanalization procedure but also might be a feature of a lymphocyte-rich, difficult-to-retrieve subgroup of thrombi.


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Glasgow Coma Scale on Presentation Predicts Outcome in Endovascular Treatment for Acute Posterior Large-Vessel Occlusion [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).


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White Matter Disease and Outcomes of Mechanical Thrombectomy for Acute Ischemic Stroke [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

The increased severity of white matter disease is associated with worse outcomes and an increased rate of intracerebral hemorrhage in patients with ischemic stroke undergoing thrombolytic treatment. However, whether white matter disease is associated with outcomes in patients undergoing endovascular treatment remains unclear.

MATERIALS AND METHODS:

In this prespecified exploratory analysis of our prospective multi-institutional study that enrolled consecutive adult patients with anterior circulation ischemic stroke undergoing endovascular treatment from November 2017 to September 2018, we compared the following outcomes between patients with none-to-minimal (van Swieten score, 0–2) and moderate-to-severe (van Swieten score, 3–4) white matter disease using logistic regression: 90-day mRS 3–6, death, intracerebral hemorrhage, successful recanalization, and early neurologic recovery.

 RESULTS:

Of the 485 patients enrolled in the Blood Pressure after Endovascular Stroke Therapy (BEST) study, 389 had white matter disease graded (50% women; median age, 68 years; range, 58–79 years). A van Swieten score of 3–4 (n = 74/389, 19%) was associated with a higher rate of 90-day mRS of 3–6 (45% versus 18%; adjusted OR, 2.73; 95% CI, 1.34–5.93; P = .008). Although the death rate was higher in patients with van Swieten scores of 3–4 (26% versus 15%), the adjusted likelihood was not significantly different (adjusted OR, 1.14; 95% CI, 0.56–2.26; P = .710). Ordered regression revealed a shift toward worse mRS scores with increasing van Swieten scores (adjusted common OR, 3.04; 95% CI, 1.93–4.84; P < .001). No associations between white matter disease severity and intracerebral hemorrhage, successful recanalization, and early neurologic recovery were observed.

 CONCLUSIONS:

Moderate-to-severe white matter disease is associated with worse outcomes in patients undergoing endovascular treatment without a significant increase in hemorrhagic complications. Studies comparing patients with and without endovascular treatment are necessary to determine whether the benefit of endovascular treatment is attenuated with greater white matter disease.


Full Article

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Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

The use of invasive cerebral angiography with CTA for active treatment of patients with suspected ischemic strokes has been increasing recently. This study aimed to identify the incidence of postcontrast acute kidney injury using baseline renal function when CTA and cerebral angiography were performed sequentially.

MATERIALS AND METHODS:

This retrospective observational study evaluated adults (18 years of age or older) with ischemic stroke who underwent CTA and cerebral angiography sequentially between 2010 and 2018. The incidence of postcontrast acute kidney injury was determined using the baseline estimated glomerular filtration rate. The value of the baseline estimated glomerular filtration rate at which the occurrence of postcontrast acute kidney injury increased was also determined.

 RESULTS:

Postcontrast acute kidney injury occurred in 57/601 (9.5%) patients. Those with a baseline estimated glomerular filtration rate of <30 mL/min/1.73 m2 showed a higher incidence of acute kidney injury. Age, chronic kidney disease, medication (nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, β blockers, statins, and insulin) use following contrast media exposure, and serum albumin affected the incidence of postcontrast acute kidney injury. The incidence of postcontrast acute kidney injury increased when the baseline estimated glomerular filtration rate was <43 mL/min/1.73 m2.

 CONCLUSIONS:

Patients with low baseline renal function had the highest incidence of postcontrast acute kidney injury after CTA and cerebral angiography, but no fatal adverse effects were documented. Thus, patients suspected of having a stroke should be actively managed with respect to neurovascular function.


Full Article

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MRI Vessel Wall Imaging after Intra-Arterial Treatment for Acute Ischemic Stroke [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

Vessel wall imaging is increasingly performed in the diagnostic work-up of patients with ischemic stroke. The aim of this study was to compare vessel wall enhancement after intra-arterial thrombosuction with that in patients not treated with thrombosuction.

MATERIALS AND METHODS:

From 2009 to 2017, forty-nine patients with an ischemic stroke underwent 7T MR imaging within 3 months after symptom onset as part of a prospective intracranial vessel wall imaging study. Fourteen of these patients underwent intra-arterial treatment using thrombosuction (intra-arterial treatment group). In the intra-arterial treatment group, vessel walls were evaluated for major vessel wall changes. All patients underwent pre- and postcontrast vessel wall imaging to assess enhancing foci of the vessel wall using coregistered subtraction images. A Wilcoxon signed rank test was performed to test for differences.

 RESULTS:

In the intra-arterial treatment group, 11 of 14 patients (79%) showed vessel wall enhancement compared with 17 of 35 patients without intra-arterial treatment (49%). In the intra-arterial treatment group, more enhancing foci were detected on the ipsilateral side (n = 18.5) compared with the contralateral side (n = 3, P = .005). Enhancement was more often concentric on the ipsilateral side (n = 8) compared with contralateral side (n = 0, P = .01). No differences were found in the group without intra-arterial treatment between the number and configuration of ipsilateral and contralateral enhancing foci.

 CONCLUSIONS:

Patients with intra-arterial treatment by means of thrombosuction showed more (concentric) enhancing foci of the vessel wall ipsilateral compared with contralateral to the treated artery than the patients without intra-arterial treatment, suggesting reactive changes of the vessel wall. This finding should be taken into account when assessing vessel wall MR images in patients with stroke.


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CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice [INTERVENTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error.

MATERIALS AND METHODS:

Five hundred twenty consecutive patients with a clinical diagnosis of acute ischemic stroke (49.4% men; mean age, 72 years) who underwent CTA to evaluate large-vessel occlusion of the proximal anterior circulation were included. CTA scans were retrospectively reviewed by a consensus panel of 2 neuroradiologists. Logistic regression analysis was performed to investigate the association between several variables and missed large-vessel occlusion at the initial CTA interpretation.

 RESULTS:

The prevalence of large-vessel occlusion was 16% (84/520 patients); 20% (17/84) of large-vessel occlusions were missed at the initial CTA evaluation. In multivariate analysis, non-neuroradiologists were more likely to miss large-vessel occlusion compared with neuroradiologists (OR = 5.62; 95% CI, 1.06–29.85; P = .04), and occlusions of the M2 segment were more likely to be missed compared with occlusions of the distal internal carotid artery and/or M1 segment (OR = 5.69; 95% CI, 1.44–22.57; P = .01). There were no calcified emboli in initially correctly identified large-vessel occlusions. However, calcified emboli were present in 4 of 17 (24%) initially missed or misinterpreted large-vessel occlusions.

 CONCLUSIONS:

Several factors may have an association with missing a large-vessel occlusion on CTA, including the CTA interpreter (non-neuroradiologists versus neuroradiologists), large-vessel occlusion location (M2 segment versus the distal internal carotid artery and/or M1 segment), and large-vessel occlusion caused by calcified emboli. Awareness of these factors may improve the accuracy in interpreting CTA and eventually improve stroke outcome.


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RPGCast – Episode 516: “Listening to Link Drown Is the Cutest Thing”

By feedproxy.google.com
Published On :: Sat, 05 Oct 2019 21:05:18 +0000

While Chris destroys Anna Marie's right joycon (press R to pay respects), the rest of the cast discusses their now playing, the news of the week, and there are still far too many games releasing every week. Please save us.


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Dua Lipa reveals orange hair in cute quarantine snap with boyfriend Anwar Hadid

By www.standard.co.uk
Published On :: 2020-04-27T09:58:20Z

The Hotter than Hell singer has revealed her new 'do in a sweet Instagram post


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Frank Lampard reveals Chelsea are ready to execute various transfer plans depending on coronavirus impact

By www.standard.co.uk
Published On :: 2020-04-13T08:32:02Z

Frank Lampard has revealed Chelsea are ready to execute various different transfer plans depending on the impact of the coronavirus pandemic.


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REACH2 Highlights Efficacy of JAK1/2 Inhibitor vs Standard Care for Acute GVHD

By www.medpagetoday.org
Published On :: Fri, 08 May 2020 12:30:00 +0000

(MedPage Today) -- Study Authors: Robert Zeiser, Nikolas von Bubnoff, et al.; Nelson Chao Target Audience and Goal Statement: Oncologists, hematologists The goal of this study was to determine the benefit/risk profile of the Janus kinase (JAK...


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Technology, cute and horrific, in Samanta Schweblin's latest modern nightmare

By www.latimes.com
Published On :: Tue, 5 May 2020 15:33:03 -0400

"Little Eyes" puts the Argentinian surrealist alongside writers — Shirley Jackson, Toni Morrison — whose horrors expose the rotten parts of ourselves.


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NICE publishes rapid COVID-19 guideline for acute kidney injury

By www.pharmatimes.com
Published On :: Wed, 06 May 2020 12:21:13 +0100

The guideline is designed to help healthcare professionals who are not kidney specialists to prevent, detect and manage AKI in hospitalised patients with suspected or confirmed COVID-19


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Justice Department Recognizes Efforts to Rescue Children from Abuse and Prosecute Predators

By www.justice.gov
Published On :: Wed, 23 May 2012 14:14:23 EDT

Deputy Attorney General James M. Cole paid tribute to four individuals today during the National Missing Children’s Day ceremony at the Justice Department’s Great Hall.


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  • OPA Press Releases
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Cost-effectiveness of <i>CYP2C19-</i>guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data

By feeds.nature.com
Published On :: 2020-02-11


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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission

By feeds.nature.com
Published On :: 2020-05-06


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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome

By feeds.nature.com
Published On :: 2020-05-06


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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR

By feeds.nature.com
Published On :: 2020-05-09


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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

By feeds.nature.com
Published On :: 2020-05-06


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Incidence of acute spinal cord injury in South Korea does not reflect a sizable number of traumatic spinal cord injuries

By feeds.nature.com
Published On :: 2020-04-30


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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system

By feeds.nature.com
Published On :: 2020-04-30


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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

By feeds.nature.com
Published On :: 2020-05-07


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Scientists had a Twitter battle for the cutest creature, and everybody wins

By www.treehugger.com
Published On :: Fri, 04 Sep 2015 15:23:10 -0400

There are a number of reasons why this is an excellent idea.


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10 Cute Crafty Nautical Gifts on Etsy

By www.treehugger.com
Published On :: Thu, 12 Jul 2012 05:09:32 -0400

From knots and yachts to anchors and orcas, maritime motifs have escaped the marina to be embraced by seafarers and landlubbers alike.


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Cute animal photos boost your mental focus

By www.treehugger.com
Published On :: Wed, 10 Oct 2018 11:17:18 -0400

Need help paying attention? Cue up the cute baby animals.


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Cute new snail named after Greta Thunberg

By www.treehugger.com
Published On :: Thu, 20 Feb 2020 11:31:30 -0500

The Swedish activist is 'delighted' that the new-to-science species will bear her name.


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Two cute videos teach kids about climate change and smog

By www.treehugger.com
Published On :: Fri, 01 Jun 2018 11:14:00 -0400

Explaining climate science to kids is challenging, which is why clever animated videos can help.


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Sneak peak: Britain's cute new baby!

By www.treehugger.com
Published On :: Mon, 13 May 2019 08:00:00 -0400

Move over royal baby, there's an infant two-toed sloth in town.


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World's cutest baby turtle is part of an amazing story

By www.treehugger.com
Published On :: Wed, 21 Jun 2017 13:39:10 -0400

Asian giant softshell turtles were once thought to be extinct in the Mekong River; this little trooper is one of 150 hatchlings bringing them back.


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cute

Hello Kitty organic farm is obviously super cute

By www.treehugger.com
Published On :: Tue, 13 Jan 2015 15:20:34 -0500

The cute-yet-cool Japanese cartoon promotes sustainable food at the Hello Kitty Go Green Organic Farm in Hong Kong.


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Cute Animal Bulletin Boards Deliver a Serious Reminder About Mass Extinction

By www.treehugger.com
Published On :: Wed, 12 May 2010 06:13:14 -0400

Nobody likes being beaten about the head with the eco-stick. As many of us have experienced, railing against friends and family about the state of the planet rarely produces favourable results, or in fact any result at all. That's why TreeHugger is a


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cute

Honeybees make a cute 'whoop' when they're surprised

By www.treehugger.com
Published On :: Wed, 18 Apr 2018 07:00:00 -0400

Listen to the Betty Boops of the insect world as they "boop oop a doop" in the hive.


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Photo: Cutest mountain goat babies ever, we kid you not

By www.treehugger.com
Published On :: Mon, 24 Jul 2017 16:08:17 -0400

Our absolutely adorable photo of the day comes from Mount Evans, Colorado.


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Cute, Low Impact Wool Felt Christmas Tree Ornaments by Planar

By www.treehugger.com
Published On :: Thu, 16 Dec 2010 10:00:32 -0500

I have to admit I'm a bit the green grinch of the family: I really can't stand all the mindless consumption over the holidays, and I'm always pushing the buy nothing concept. I don't even have a Christmas tree.


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Holiday How-to : Cuter Candles

By www.mypapercrane.com
Published On :: Sat, 24 Nov 2012 18:08:18 +0000

Hi friends! November has been a blur of activities and get-togethers so I wanted to stop in today with a super easy “how-to”. These candles make great hostess gifts, or they are just a fun way to dress up some candles you have around the house for the holidays. Recently … Continue reading →


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Cute, Really

By questionablecontent.net
Published On :: Mon, 29 Jul 2019 22:59:57 -0300


I will be at gencon this weekend! Come find me at booth #1537 with a bunch of my great cartoonist friends!


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cute

Time To Take In The Weekly Dose Of Cute (#81)

By feedproxy.google.com
Published On :: Tue, 05 May 2020 09:00:00 PDT

Once a week, your cuteness prescription will always be automatically refilled for your viewing pleasure!

Nothing -- and we mean nothing brings on those warm mushy feeling like a huge dose of animal cuteness! We scoured the internet to bring you the cutest animal pictures of the week! Bringing you cuteness every week - stay tuned for next week's dose! If you missed last week's dose, and you need a cuteness overload, check out last week's here.


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Somebody Built The Cutest "Cheers" Bar For A Squirrel

By feedproxy.google.com
Published On :: Wed, 06 May 2020 06:00:00 PDT

When @JoshuaPotash shared this cute video on twitter, people couldn't handle the thought of a cute little squirrel going to a place where everybody knows its name.


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Model Hosts The Cutest Wedding Ceremony For Her Dog And His Bride

By feedproxy.google.com
Published On :: Thu, 07 May 2020 09:00:00 PDT

28-years-old model, Emily Ratajkowski, and her husband are the loving owners of Colombo, the cutest good boy.   

They have all spent their quarantine days with their close friends, Josh Ostrovsky, founder of the Fat Jewish meme account, his wife, Caitlin King, and their dog, Happy.

On Saturday, Emily decided to hosts a special wedding ceremony for Colombo and happy - 'quarantined together so why not marry our children".  
Ratajkowski shared plenty of behind-the-scenes footage on Instagram from the ceremony, including individual images of Colombo and Happy posing while wearing dog cones as the "the groom" and "the bride", respectively.

Congrats, Colombo and Happy! 


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Mega Cuteness: Tiny Crocheted Couches With Matching Little Granny Blankets

By feedproxy.google.com
Published On :: Thu, 07 May 2020 11:00:00 PDT

Our pets are our children, and they deserve to be spoiled as such.

That's why we had to share with you these tiny crochet cat couches created by the crafty people on the subreddit r/crochet.

Sure, you could go and just buy a cat bed without exerting much effort, but they're not as fun or cute as this too cute to handle cat couch.

So, if you're looking for a new crochet project to tackle, this has got to be it! 

The couches are shaped with thick foam and polyester filling to really give it that comfy sofa look.

There are a few craft stores online who are offering the crochet patterns if you like. 



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Dumbo Movie Review - Cute and appealing but not Burton's style

By www.mid-day.com
Published On :: 28 Mar 2019 12:44:36 GMT

Dumbo
U/A: Family, Fantasy
Cast: Colin Farrell, Michael Keaton, Danny DeVito
Director: Tim Burton
Rating: 

Disney's attempt to lend more darkness and quirks to this live-action remake of its 1941 animated classic about a baby elephant whose ears double as wings, Dumbo, pays off with loads of cuteness but the director Tim Burton's signature strangeness is missing. Burton's craft is more simplistic here - even though the film is a sort of circus fantasia with all the aspects of an imagination running wild.

The owner of a struggling circus, Max Medici(Danny De Vito) enlists a man(Colin Farrell) and his two children to care for a new born elephant that can fly. Of course, the contretemps are not merely about a flying elephant but also about those opportunistic times when diabolical people sought to make their fortunes off the sweat of lesser mortals.

Check out the trailer here:

With Michael Keaton and Danny DeVito on the same page here, one would have expected something more whimsical and intriguing but this production doesn't quite fit the bill. Burton's attempts to stuff up the visuals with a surrounding darkness doesn't set flight to the imagination. Ehren Kruger's screenplay is inconsistent and chaotic. Character development is uneven so even the leads don't come across as engaging. Burton's attempts to give vein to the freakish performer doesn't have much impact because the plotting is quite wayward. Even the presence of snake charmer Pramesh Singh (Roshan Seth) and the resident circus "mermaid," Miss Atlantis (Sharon Rooney), who strums a ukulele by the fireside and sings "Baby Mine," feels out of place in this extravaganza that lacks connect and soul!

Also Read: Disney's 'Dumbo' will take you to new heights

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COVID-19: Radio Club staffer called to change swimming pool water, electrocuted

By www.mid-day.com
Published On :: 1 May 2020 01:49:59 GMT

A swimming pool maintenance employee working at the Bombay Presidency Radio Club (BPRC) in Colaba amid the Coronavirus lockdown died of electrocution on Thursday. Ramchandra Bhuneshwar's body was seen floating in the swimming pool by another staffer.

Deputy Commissioner of Police Sangramsinh Nishandar said an Accidental Death Report has been filed. "Prima facie, a 42-year-old man in charge of maintaining the swimming pool at Colaba's Radio Club died of electrocution. We have registered a case under Section 188 (disobedience to order duly promulgated by public servant) of the Indian Penal Code against Radio Club officials and the contractor for breaking lockdown norms," he said.

Senior police inspector of Colaba police Shivaji Phadtare said Bhuneshwar was taking water out of the pool with the help of an electric pump when he got electrocuted.
Sources said that Bhuneshwar, a contractual employee, was asked by his contractor Babu Khomrekar to clean the water of the swimming pool a week ago. "At the time of conducting the panchnama, Khomrekar was called by Colaba police. He told the police that Adi Mistry, a Managing Committee Member working as the Chairman of Swimming Pool and Gym at the Radio Club, told him to get Bhuneshwar to change the pool water," a source working at the Radio Club said.

Bhuneshwar is survived by wife, Vimal, two daughters and a six-year-old son. His relative, Siddhant Gaikwad, said, "Bhuneshwar was asked to continue maintenance work at Radio Club's swimming pool even during the lockdown. He lives in Murud Janjira. When no permanent staff is working at the club, why was he forced to continue his work?"

President of Radio Club, Harish Kumar Garg, said, "I am not aware how Bhuneshwar died and what was he doing at the Radio Club amid a lockdown as I am a 72-year-old man and I have been staying home."

Ramchandra Bhuneshwar

Sources said nearly a dozen Radio Club employees living at the premises spoke to the Colaba police during the panchanama. "Committee members forced these workers to leave the club amid the lockdown because they spoke to the police," source added.

Club members speak

Advocate Ravi Goenka, a member of the club, said, "We all are following the lockdown rules and sitting at home. And the rich and powerful people who are on the committee of tony clubs (i.e Radio Club) call staff to work in spite of the lockdown."

The Radio Club committee refused to answer calls. A club member said angrily, "Calling in staff to work is exploitation and violation of the lockdown."

Several members expressed surprise that the pool was filled with water and not drained as no one swims there amid the lockdown. Another member said, "We do not want this brushed away as an Accidental Death Report. A poor employee has lost his life, let us get to the bottom of this through a thorough investigation."

Catch up on all the latest Mumbai news, crime news, current affairs, and a complete guide from food to things to do and events across Mumbai. Also download the new mid-day Android and iOS apps to get latest updates.

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Watch video: Sunny Leone pranks hubby Daniel Weber; his reaction was cuter!

By www.mid-day.com
Published On :: 4 May 2020 07:08:19 GMT

Sunny Leone pulled a prank on her husband Daniel Weber by making him believe that she had accidentally chopped off her finger. Sunny took to Instagram to share the video of the same. In the video, she cries out for help, shouting out to her husband that she has chopped off her. Daniel comes in running and panics and runs around as he tries to figure out how he can help.

However, when Sunny draws his attention towards the phone, he understands that he was being recorded all the while, and this was just a prank.

 

Just before the prank, Sunny had shared another video talking about the funny scene:

 
 
 
View this post on Instagram

This ain’t no cooking video!!!! Haha @dirrty99 got pranked and served!!

A post shared by Sunny Leone (@sunnyleone) onMay 3, 2020 at 2:23am PDT

When Sunny asks Daniel how much he enjoyed the prank, he said: "Generally, I am a pretty serious person in life. That is just my personality. I actually don't even like pranks that much. I don't even like pranks on other people and I definitely don't like pranks on me. So, if you want me to rate your prank, I think it's a zero because I hated that it was done on me."

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