The programmed supply reduction could potentially bring a supply shock and large price implications.

The post Bitcoin Halving Could Be Different This Time Around appeared first on OpenMarkets.

The Royal Canadian Mint's newest offering features Manitoba's most famous UFO encounter, which happened in 1967 when Stefan Michalak went looking for precious metals near Falcon Lake.

The softball camp in Hungary was not originally planned. But there in the 38-degree (100° F) heat, prayers and decisions opened lives to the Lord.

Puerto Barrios, Guatemala :: Logos Hope is welcomed by the mayor, who believes the ship brings what the city needs.

Jill Gascoine, actress and novelist

A team of Delaware volunteer firefighters who have been battling a blaze in Utah for the past week are now headed to a new assignment in the Payette National Forest near McCall, Idaho. According to Delaware state forester Michael Valenti of Dover, who is traveling with the team, Delaware's crew will be traveling over 500 miles from Utah to Idaho on August 20, and then begin its first operational period on August 21.

China’s central bank has started testing its official Bitcoin-like digital currency DCEP, and the bank is now planning to roll out the virtual money payment system soon.

Craig Wright Says He Is Bitcoin Payment System's Creator. Watch his interview

Bitcoin will “halve” for the third time next week, slowing down the discovery of new bitcoins and preventing disruptions from new miners. Read more...

The Court in AA v Persons Unknown [2019] EWHC 3556 (Comm) (17 January 2020) ordered injunctive relief against unknown persons accused of extorting ransom payments in the form of Bitcoin worth $950,000 from an insurance company, following a cyber-att...

Digital currency has been arousing a lot of interest for some time. In public administration circles - at least officially – so far, it has not been discussed very much. A few days ago though, the situation has changed. The National Bank of Po...

Pennies and cents clog up wallets and pockets. Cold, hard mathematics proves it's time to ditch the shrapnel in favour of a new denomination

Key Points

Flemming Dahlke, Magnus Lucassen, Ulf Bickmeyer, Sylke Wohlrab, Velmurugu Puvanendran, Atle Mortensen, Melissa Chierici, Hans-Otto Pörtner, and Daniela Storch

The vulnerability of fish embryos and larvae to environmental factors is often attributed to a lack of adult-like organ systems (gills) and thus insufficient homeostatic capacity. However, experimental data supporting this hypothesis are scarce. Here, by using Atlantic cod (Gadus morhua) as a model, the relationship between embryo vulnerability (to projected ocean acidification and warming) and homeostatic capacity was explored through parallel analyses of stage-specific mortality and in vitro activity and expression of major ion pumps (ATP-Synthase, Na⁺/K⁺-ATPase, H⁺-ATPase) and co-transporters (NBC1, NKCC1). Immunolocalization of these transporters was used to study ionocyte morphology in newly-hatched larvae. Treatment-related embryo mortality until hatch (+20% due to acidification and warming) occurred primarily during an early period (gastrulation) characterized by extremely low ion transport capacities. Thereafter, embryo mortality decreased in parallel with an exponential increase in activity and expression of all investigated ion transporters. Significant changes in transporter activity and expression in response to acidification (+15% activity) and warming (-30% expression) indicate some potential for short-term acclimatization, although likely associated with energetic trade-offs. Interestingly, whole-larvae enzyme capacities (supported by abundant epidermal ionocytes) reached levels similar to those previously measured in gill tissue of adult cod, suggesting that early-life stages without functional gills are better equipped in terms of ion homeostasis than previously thought. This study implies that the gastrulation period represents a critical transition from inherited (maternal) defenses to active homeostatic regulation, which facilitates enhanced resilience of later stages to environmental factors.

Burkholderia sp. strain SG-MS1 and Pseudomonas sp. strain SG-MS2 have previously been found to mineralize (+)-pinoresinol through a common catabolic pathway. Here, we used comparative genomics, proteomics, protein semipurification, and heterologous expression to identify a flavoprotein from the vanillyl alcohol oxidase/p-cresol methyl hydroxylase (VAO/PCMH) enzyme family in SG-MS2 that carries out the initial hydroxylation of (+)-pinoresinol at the benzylic carbon. The cognate gene is translationally coupled with a downstream cytochrome gene, and the cytochrome is required for activity. The flavoprotein has a unique combination of cofactor binding and cytochrome requirements for the VAO/PCMH family. The heterologously expressed enzyme has a K_m of 1.17 μM for (+)-pinoresinol. The enzyme is overexpressed in strain SG-MS2 upon exposure to (+)-pinoresinol, along with 45 other proteins, 22 of which were found to be encoded by genes in an approximately 35.1-kb cluster also containing the flavoprotein and cytochrome genes. Homologs of 18 of these 22 genes, plus the flavoprotein and cytochrome genes, were also found in a 38.7-kb cluster in SG-MS1. The amino acid identities of four of the other proteins within the SG-MS2 cluster suggest they catalyze conversion of hydroxylated pinoresinol to protocatechuate and 2-methoxyhydroquinone. Nine other proteins upregulated in SG-MS2 on exposure to (+)-pinoresinol appear to be homologs of proteins known to comprise the protocatechuate and 2-methoxyhydroquinone catabolic pathways, but only three of the cognate genes lie within the cluster containing the flavoprotein and cytochrome genes.

IMPORTANCE (+)-Pinoresinol is an important plant defense compound, a major food lignan for humans and some other animals, and the model compound used to study degradation of the β-β' linkages in lignin. We report a gene cluster, in one strain each of Pseudomonas and Burkholderia, that is involved in the oxidative catabolism of (+)-pinoresinol. The flavoprotein component of the α-hydroxylase which heads the pathway belongs to the 4-phenol oxidizing (4PO) subgroup of the vanillyl alcohol oxidase/p-cresol methyl hydroxylase (VAO/PCMH) enzyme family but constitutes a novel combination of cofactor and electron acceptor properties for the family. It is translationally coupled with a cytochrome gene whose product is also required for activity. The work casts new light on the biology of (+)-pinoresinol and its transformation to other bioactive molecules. Potential applications of the findings include new options for deconstructing lignin into useful chemicals and the generation of new phytoestrogenic enterolactones from lignans.

Spencer's ideas laid the groundwork for social Darwinism, but scholars say there was much more to the Victorian Age thinker than that

Bitcoin is about to undergo a scheduled technical adjustment as the number of new coins awarded the computer wizards who "mine" the cryptocurrency will be cut in half, but forecasting which way its price will move afterward is more complicated now.

Royal Mint to mark landmark anniversary of end of Second World War in Europe

In anticipation for a technical event that may be a new catalyst, Bitcoin has rallied to more than US$9,000 from around US$6,000 just a month ago

Pioneering TV star passed away after a long battle with Alzheimer's

Gascoine was best known for her role as DI Maggie Forbes in the groundbreaking ITV police drama

Pokemon GO (Free) from Niantic has been improving with letting people play the game in one place or at home. …

Continue reading "PokeCoin System Changes Are Coming to ‘Pokemon GO’ as Niantic Begins Testing in Australia"

The Justice Department announced today the unsealing of a criminal information earlier today, charging four defendants with conspiracy to commit wire fraud involving a nation-wide reverse mortgage scam that defrauded elderly borrowers, financial institutions and the Department of Housing and Urban Development (HUD).

In honor of these brave public servants – and in order to preserve, perpetuate, and promote the Marshals Service’s singular history – it my privilege today to unveil three commemorative coins. These coins were commissioned by an act of Congress. And they will be struck by the U.S. Mint.

Read the latest developments from the cryptocurrency space, breaking news and analysis on Bitcoin and blockchain on RTTNews. Know more about altcoins, mining, ICOs, warnings and regulation. Find out how to acquire and trade digital currencies.

The company focuses on providing alternatives to single-use plastics.

The post HK’s plant-based packaging startup Ecoinno bags $6m from Alibaba funds appeared first on DealStreetAsia.

It creates as much CO2 as a million transatlantic flights. Why isn't this a bigger deal?

Bitcoin mining uses so much power that it may well turn into an environmental disaster.

It's a moveable feast of cheaper, cooler, greener electricity for building blockchains.

The digital currency is in its death throes.

The Bitcoin is the Hummer of speculative vehicles; let's hope it doesn't make it to its Bar Mitzvah.

We live in his world of conspicuous waste.

Instead of flaring off gas, they are burning it to run computers that mine bitcoins. Is this any better?

Merging energy-intensive Bitcoin mining with aquaculture, this project is experimenting with how technology might be used to develop better food systems.

Sabra Launches New Ad Campaign.

Sabra Launches New Ad Campaign.

EAMF 2016 Highlights

CNBC's Mary Thompson reports on bitcoin's biggest transaction thus far: a luxury villa in Bali.

A rally in bitcoin led the cryptocurrency market higher ahead of a major technical event for the digital coin and as industry participants report an increased interest from institutional investors.

Key catalysts for bitcoin, with CNBC's Seema Mody and the Futures Now traders, Jim Iuorio and Scott Nations, both at the CME.

Exchange-traded bitcoin options launched Monday on the Chicago Mercantile Exchange, and they will likely provide a great tool for cryptocurrency speculators.

Cryptocurrency isn't a fad. That's according to experts at the TD Ameritrade LINC conference in Orlando, Florida. If investors want to dip a toe into bitcoin, they should aim for this allocation. They should just make sure they know the risks first.

Canopy Growth surges as Constellation ups its stake in the company. And a look at bitcoin's big week. With CNBC's Melissa Lee and the Fast Money traders, Tim Seymour, Guy Adami, Brian Kelly and Steve Grasso.

FM trader Brian Kelly on legendary investor Paul Tudor Jones buying bitcoin. With CNBC's Melissa Lee and the Fast Money traders, Guy Adami, Tim Seymour, Karen Finerman and Dan Nathan.

Bitcoin hits $10,000 ahead of Monday's 'halving' event. With CNBC's Melissa Lee and the Fast Money traders, Guy Adami, Tim Seymour, Brian Kelly and Jeff Mills.