Tyrone expect Justin McMahon to be fit to play in the Ulster championship opener against Armagh on June 10.

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Princeton chemists used MacMillan's µMap, a molecular mapping technology, to watch tiny changes in a DNA-protein complex called chromatin — essentially, an architecture that allows for the compaction of DNA — in the presence of genetic mutations associated with cancer.

In honor of his parents, Chemistry Nobel Laureate David MacMillan has founded The May and Billy MacMillan Foundation to provide educational opportunities for financially disadvantaged students in Scotland.

velocityconf: What Is the Risk That Amazon Will Go Down (Again)? http://t.co/DgnfQynjcM Thank you @bergstrom_johan for the awesome #velocityconf post.

Jeffrey C. Silva
Jan 1, 2006; 5:144-156
Research

Elizabeth Wilmshurst CMG appointed Honorary Queen’s Counsel News release jon.wallace 14 January 2022

Founder of the International Law Programme at Chatham House recognized for her major contribution to the law of England and Wales.

Elizabeth Wilmshurst CMG, distinguished fellow of Chatham House’s International Law Programme, has been awarded the title of Honorary Queen’s Counsel (QC Honoris Causa), recognizing her major contribution to the law of England and Wales, outside practice in the courts. The Lord Chancellor will preside over an appointment ceremony at Westminster Hall on 21 March 2022.

Elizabeth founded the International Law Programme at Chatham House and is an academic expert member of Doughty Street Chambers. She was a legal adviser in the United Kingdom diplomatic service between 1974 and 2003. Between 1994 and 1997 she was the Legal Adviser to the United Kingdom mission to the United Nations in New York. She also took part in the negotiations for the establishment of the International Criminal Court.

Throughout her career, Elizabeth has worked to strengthen the role of international law in reducing global tensions, addressing cross-border challenges and promoting individual liberty, including through influential publications at the Institute such as The Chatham House Principles of International Law on the Use of Force in Self-Defence. 

Robin Niblett CMG, Director and Chief Executive of Chatham House said:

‘We are delighted by this award which recognizes Elizabeth’s outstanding contribution to the field of international law, both in government and – on a continuing basis – through the International Law Programme at Chatham House.’

Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor and that its expression can be significantly induced under H2O2 stress. CmtR can physically interact with the negative regulator Zur and de-represses the expression of the esx-3 operon, which leads to Zn2+ accumulation and promotion of reactive oxygen species detoxication in mycobacterial cells. Zn2+ can also act as an effector molecule of the CmtR regulator, using which the latter can de-repress its own expression for further inducing bacterial antioxidant adaptation. Consistently, CmtR can induce the expression of EsxH, a component of esx-3 operon involved in Zn2+ transportation that has been reported earlier, and inhibit phagosome maturation in macrophages. Lastly, CmtR significantly contributes to bacterial survival in macrophages and in the lungs of infected mice. Our findings reveal the existence of an antioxidant regulatory pathway in mycobacteria and provide novel information on stress-triggered gene regulation and its association with host–pathogen interaction.

Soun-Hi Kwon
Trans. Amer. Math. Soc. 377 (), 6021-6022.
Abstract, references and article information

Luiz Ricardo Abreu Melo
Proc. Amer. Math. Soc. 152 (), 5373-5380.
Abstract, references and article information

Visual Abstract

Weixian Deng
Dec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411
Research

Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass spectrometry. By decreasing the number of co-eluting precursor peptide ions, fractionation effectively reduces the complexity of the sample leading to higher sample coverage and reduced bias towards high abundance precursors that are preferentially identified in data-dependent acquisition strategies. To achieve this goal, we report a bead-based off-line peptide fractionation method termed CIF or Carboxylate modified magnetic bead-based isopropanol gradient peptide fractionation. CIF is an extension of the SP3 (single-pot solid-phase-enhanced sample preparation) strategy and provides an effective but complementary approach to other commonly used fractionation methods including strong cation exchange (SCX) and reversed phase (RP)-based chromatography. We demonstrate that CIF is an effective offline separation strategy capable of increasing the depth of peptide analyte coverage both when used alone or as a second dimension of peptide fractionation in conjunction with high pH RP. These features make it ideally suited for a wide range of proteomic applications including the affinity purification of low abundance bait proteins.

CALGARY, Alberta, Nov. 5, 2024 — Computer Modelling Group Ltd. (CMG) has announced it is collaborating with NVIDIA to further develop and optimize CMG subsurface simulation solutions for increased speed, […]

The post CMG Targets Faster Simulation Solutions with NVIDIA for Enhanced Reservoir Modeling appeared first on HPCwire.

It’s a significant milestone – but what does the GFCM actually do? What has it achieved so far?

Since its creation, the GFCM has evolved into an efficient [...]

RCMP are investigating after officers discovered human remains in an abandoned, burned vehicle in Greenhill, N.S.

Hay River RCMP say they believe two weekend incidents, including one in which a person was shot, are linked to drugs and organized crime.

Eight years ago, a woman filed a complaint about two RCMP constables in Moncton. She accused them of having "an improper and racist attitude" and of discriminating against her and her husband during an investigation into a stolen truck and trailer. 

A museum in Fort McMurray is helping visitors gain a deeper understanding of Canada’s role in previous wars. The Wood Buffalo Military Museum Centre is offering a chance to get up close to military artifacts. Young visitors say seeing the remnants of conflict gives them a new understanding of Remembrance Day's meaning.

A man from Calgary has been charged in the death of a worker after a 24-year-old woman sustained fatal injuries when a pickup truck crashed into a pizza restaurant in Fort McMurray. 

A missing 26-year-old Sagkeeng First Nation man has been found dead in the community of Fort Alexander, about 100 kilometres northeast of Winnipeg, Powerview RCMP say. Christian Letander's body was found Monday near the Winnipeg River.

Over the weekend, RCMP says officers searched for answers in the death of the toddler, knocking door-to-door on Saturday in Ashern and the surrounding communities of Gypsumville as they canvassed for information that may shed light on the timeline surrounding the child's death.

RCMP say a 23-year-old woman was found dead in a residence in central Manitoba on Tuesday. 

Drivers are being warned to use caution on Saskatchewan's highways after five separate collisions involving moose were reported to RCMP in a 30-minute window on Friday evening.

Five people are in hospital after a five-vehicle crash on on Highway 1 just east of Kensington Avenue on Tuesday morning, police say. 

CME Group, the world's leading derivatives marketplace, today announced its new CBL Australian Carbon Credit Unit (ACCU) futures have launched and are available for trading. A total of five...

Record revenue of $1.6 billion Record quarterly ADV of 28.3 million contracts - the second consecutive quarter of volume, open interest growth across every asset class CHICAGO, Oct. 23, 2024...

CME Group, the world's leading derivatives marketplace, today announced its new Spodumene CIF China (Fastmarkets) futures have launched and are available for trading. A total of 29 contracts...

CME Group, the world's leading derivatives marketplace, today announced it has received approval from the National Futures Association (NFA) to establish a futures commission merchant (FCM). "We...

Record October ADV for interest rate, energy, metals and agricultural products Record October ADV across U.S. Treasury and SOFR complexes All-time record monthly ADV in U.S. Treasury options and...

CME Group, the world's leading derivatives marketplace, today declared a fourth-quarter dividend of $1.15 per share. The dividend is payable December 27, 2024, to shareholders of record as of...

Indiana University took first place, with the rest of the top five from outside the United States Record participation from nearly 570 teams across 24 countries CHICAGO, Nov. 7, 2024 /PRNewswire/...

Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO,

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