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Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging and cataract formation. One mechanism that has been implicated in this cross-linking is glycation through formation of advanced glycation end products (AGEs). Here, we found an age-associated increase in stiffness in human lenses that was directly correlated with levels of protein–cross-linking AGEs. α-Crystallin in the lens binds to other proteins and prevents their denaturation and aggregation through its chaperone-like activity. Using a FRET-based assay, we examined the stability of the αA-crystallin–γD-crystallin complex for up to 12 days and observed that this complex is stable in PBS and upon incubation with human lens–epithelial cell lysate or lens homogenate. Addition of 2 mm ATP to the lysate or homogenate did not decrease the stability of the complex. We also generated complexes of human αA-crystallin or αB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress. Upon glycation under physiological conditions, the chaperone–client complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures. LC-MS/MS analyses revealed that the levels of cross-linking AGEs were significantly higher in the glycated chaperone–client complexes than in glycated but uncomplexed protein mixtures. Mouse lenses subjected to thermal stress followed by glycation lost resilience more extensively than lenses subjected to thermal stress or glycation alone, and this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels. These results uncover a protein cross-linking mechanism in the lens and suggest that AGE-mediated cross-linking of α-crystallin–client complexes could contribute to lens aging and presbyopia.

"This document is an adaptation by the Law Society of South Australia of the document entitled 'Indigenous Protocols for Lawyers in the Northern Territory' second edition 2015. The Law Society of South Australia acknowledges the primacy of the Northern Territory document and states that the adaptations that it has made to that document are an attempt to modify the original text to make it more suitable to South Australian conditions" -- page 3.

Rockville, Maryland : National Institute on Drug Abuse, 1986.

Rockville, Maryland : National Institute on Drug Abuse, 1980.

In Canada, financial advisors and dealers by provincial securities commissions, and those self-regulatory organizations charged with direct regulation over investment dealers and mutual fund dealers, respectively to collect and maintain Know Your Client (KYC) information, such as their age or risk tolerance, for investor accounts. With this information, investors, under their advisor's guidance, make decisions on their investments which are presumed to be beneficial to their investment goals. Our unique dataset is provided by a financial investment dealer with over 50,000 accounts for over 23,000 clients. We use a modified behavioural finance recency, frequency, monetary model for engineering features that quantify investor behaviours, and machine learning clustering algorithms to find groups of investors that behave similarly. We show that the KYC information collected does not explain client behaviours, whereas trade and transaction frequency and volume are most informative. We believe the results shown herein encourage financial regulators and advisors to use more advanced metrics to better understand and predict investor behaviours.

We review and compare four of the most popular universal VPN software clients used by businesses. These solutions have the ability to work as VPN solutions on their own or integrate with any VPN servers or services you might already be using.

With the merger we had set out to create a new agency breed — a creative, data and technology agency that can offer genuine end-to-end solutions to our clients.

H K Digital Online comprises of some leading names in real estate, automotive, healthcare, cosmetics, engineering industries and so on. The company has been offering industry specifications to the clients.

This Metasploit module exploits a stack-based buffer overflow in the Win32AddConnection function of the VideoLAN VLC media player. Versions 0.9.9 throught 1.0.1 are reportedly affected. This vulnerability is only present in Win32 builds of VLC. This payload was found to work with the windows/exec and windows/meterpreter/reverse_tcp payloads. However, the windows/meterpreter/reverse_ord_tcp was found not to work.

Juniper VPN client with remote desktop lets an attacking spawn Internet Explorer prior to authentication.

Druva inSync Windows Client version 6.5.2 suffers from a local privilege escalation vulnerability.

NSClient++ version 0.5.2.35 suffers from an authenticated remote code execution vulnerability.

SmartClient version 120 suffers from information disclosure, local file inclusion, remote file upload, and XML external entity injection vulnerabilities.

Cisco AnyConnect Secure Mobility Client for Windows version 4.8.01090 suffer from a privilege escalation vulnerability due to insecure handling of path names.

Why is getting it right important? Each year statutory undertakers are engaged in hundreds of thousands of street works activities across the country to keep our key utilities and infrastructure running. They must all comply with the New Roads and S...

Coronavirus restrictions are causing significant ongoing disruption and difficulties for employers, pension trustees, administrators and providers. To assist our clients during these unprecedented times, we are introducing a weekly pensions clinic. ...

Communications need to be clear and timely Constantly review and maintain your customer communications content and strategy.  There is a regulatory expectation that firms will ensure consumers are adequately protected during severe disruption.&...

ABSTRACTIntroduction:Multimonth dispensing (MMD) of antiretroviral therapy (ART) is a differentiated model of care that can help overcome health system challenges and reduce the burden of HIV care on clients. Although 3-month dispensing has been the standard of care, interest has increased in extending refill intervals to 6 months. We explored client and provider experiences with MMD in Malawi as part of a cluster randomized trial evaluating 3- versus 6-month ART dispensing.Methods:Semi-structured in-depth interviews were conducted with 17 ART providers and 62 stable, adult clients with HIV on ART. Clients and providers were evenly divided by arm and were eligible for an interview if they had been participating in the study for 1 year (clients) or 6 months (providers). Questions focused on perceived challenges and benefits of the 3- or 6-month amount of ART dispensing. Interviews were transcribed, and data were coded and analyzed using constant comparison.Results:Both clients and providers reported that the larger medication supply had benefits. Clients reported decreased costs due to less frequent travel to the clinic and increased time for income-generating activities. Clients in the 6-month dispensing arm reported a greater sense of personal freedom and normalcy. Providers felt that the 6-month dispensing interval reduced their workload. They also expressed concerned about clients' challenges with ART storage at home, but clients reported no storage problems. Although providers mentioned the potential risk of clients sharing the larger medication supply with family or friends, clients emphasized the value of ART and reported only rare, short-term sharing, mostly with their spouses. Providers mentioned clients' lack of motivation to seek care for illnesses that might occur between refill appointments.Conclusions:The 6-month ART dispensing arm was particularly beneficial to clients for decreased costs, increased time for income generation, and a greater sense of normalcy. Providers' concerns about storage, sharing, and return visits to the facility did not emerge in client interviews. Further data are needed on the feasibility of implementing a large-scale program with 6-month dispensing.

These are trying times, not least because corporate life needs to go on, which for millions of businesses means delivering compute resources…

Geoffrey Rush's barrister tells an appeal hearing his client has been "slurred" by The Daily Telegraph's lawyer, who yesterday accused the actor of "delivering lines" when describing the impact the newspaper's articles had on his life.

From “Animal Flow” to “Move Like an Avenger” and kids Muay Thai, the city’s many shuttered fitness clubs and studios are offering creative online options to keep you moving.

AbbVie may be working through COVID-19, but it's pressing ahead with its Allergan merger, too—and taking stock of products hit by pandemic lockdowns. That puts Allergan’s aesthetics business top of mind, but AbbVie CEO Rick Gonzalez figures customers are ready and able to return quickly for treatment.

Steven Michael Rubinstein, of Boca Raton, Fla., has been charged, via criminal complaint, with filing a false income tax return. Rubinstein made his initial appearance this morning before Magistrate Judge Barry S. Seltzer in Ft. Lauderdale, Fla. The defendant was temporarily detained, pending a bond hearing scheduled for Tuesday, April 7, 2009, at 10:00 a.m. before Magistrate Judge Seltzer.

Robert Moran, of Lighthouse Point, Fla., pleaded guilty today to a criminal information charging him with filing a false income tax return. Moran appeared today before Judge James I. Cohn in Ft. Lauderdale and accepted responsibility for concealing more than $3 million in assets in a secret bank account at UBS in Switzerland.

Following a four-day trial and less than an hour of deliberations, a federal jury today convicted tax return preparer, Marcel J. Toto-Ngosso, of Silver Spring, Md., of 17 counts of preparing false tax returns in connection with a scheme to generate fraudulent tax refunds for client-taxpayers.

UBS client, Steven Michael Rubinstein of Boca Raton, Fla., pleaded guilty today to filing a false tax return for tax year 2004. On April 1, 2009, Rubinstein was charged with filing a false tax return that intentionally failed to disclose the existence of a Swiss bank account maintained by UBS of which he was the beneficial owner and failed to report any income earned on that account.

Jeffrey P. Chernick, of Stanfordville, N.Y., pleaded guilty today to charges of filing a false tax return. Chernick, who owns a corporation which represents toy manufacturers in China and Hong Kong, appeared today before Judge James I. Cohn in Ft. Lauderdale, Fla., and accepted responsibility for concealing more than $8 million in Swiss bank accounts.

Edward H. Okun, the former owner of The 1031 Tax Group LLP (1031TG), was sentenced today to 100 years in prison for his leading role in a scheme to defraud and obtain approximately $126 million in client funds held by 1031TG.

Two former employees of Edward H. Okun, who was sentenced to 100 years in prison on Aug. 4, 2009, after a three-week jury trial, were sentenced today before U.S. District Judge Robert E. Payne for their roles in a scheme to defraud and obtain approximately $126 million in client funds held by The 1031 Tax Group LLP (1031TG).

A Saddle River, N.J., man pleaded guilty today to failure to file a Report of Foreign Bank or Financial Accounts (F-BAR. Juergen Homann appeared today before Judge Stanley R. Chesler in Newark, N.J., and accepted responsibility for concealing more than $5 million in Swiss bank accounts.

According to court documents and statements made in court, Cittadini, a retired sales manager for Boeing, failed to report income from bank accounts under his control at UBS AG in Switzerland on his individual income tax returns from 2001 through 2003.

Marcel J. Toto-Ngosso of Silver Spring, Md., was sentenced to 70 months in prison today for preparing and filing false tax returns in connection with a scheme to generate fraudulent tax refunds for his clients.

John A. Campbell, a resident of Portage, Mich., was sentenced to 60 months in prison today by the Honorable Janet T. Neff of the U.S. District Court in the Western District of Michigan for conspiring to defraud the United States.

The department has filed papers seeking a federal court order authorizing the Internal Revenue Service (IRS) to serve a “John Doe summons” on Ralph Janvey, the court-appointed receiver of the Stanford Group Company (SGC) and related entities.

Jack Barouh of Golden Beach, Fla., pleaded guilty today to filing a false tax return.

Harry Abrahamsen, a resident of Oradell, N.J., pleaded guilty today to failure to file a Report of Foreign Bank or Financial Accounts.

Paul Zabczuk, a resident of The Woodlands, Texas, pleaded guilty to filing a false tax return in Ft. Lauderdale, Fla.

Jack Barouh of Golden Beach, Fla., was sentenced today to 10 months in prison by U.S. District Court Judge Adalberto Jordan in Miami.

A Milltown, N.J., man pleaded guilty today to a federal charge of willfully subscribing to a false tax return, admitting he concealed over $2 million in a Swiss bank account.

The Justice Department announced today that a federal grand jury in Alexandria, Va., returned an indictment charging Felix M. Mathis, an attorney practicing in Zurich, Switzerland, with conspiring to defraud the United States and structuring the importation of currency into this country.