Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

Former NFL star Brett Favre said Wednesday he would repay the state of Mississippi $1.1 million after a state auditor discovered the Mississippi Department of Human Services paid the ex-quarterback for speaking engagements that never happened.

Former NFL star Brett Favre said Wednesday he would repay the state of Mississippi $1.1 million after a state auditor discovered the Mississippi Department of Human Services paid the ex-quarterback for speaking engagements that never happened.

Former NFL star Brett Favre said Wednesday he would repay the state of Mississippi $1.1 million after a state auditor discovered the Mississippi Department of Human Services paid the ex-quarterback for speaking engagements that never happened.

Former NFL star Brett Favre said Wednesday he would repay the state of Mississippi $1.1 million after a state auditor discovered the Mississippi Department of Human Services paid the ex-quarterback for speaking engagements that never happened.

The BMV's pattern of poor performance hardly inspires confidence in its ability to adequately monitor itself.

If you’re a big business and you abused the Small Business Association’s new Paycheck Protection Program, you’re getting very close to the deadline for you to pay the government back. If you don’t, that means the government is going to be coming after you — and you can definitely be ready for an audit. That’s…

The post Big Businesses That Abused Paycheck Protection Program Should Get Ready for an Audit appeared first on The Western Journal.

Prótese auditiva ancorada em osso não emite um som como o aparelho convencional. Seu diferencial é vibrar o osso da cabeça.

The post SUS vai oferecer aparelho de última geração para tipo de perda auditiva até então sem tratamento appeared first on Saúde Próspera.

A West Virginia official turns up the heat on financial disclosure for the state’s beleaguered schools, and ruffles feathers in the process.

The Maryland State Department of Education "inappropriately stored" personal information of 1.4 million students and more than 230,000 teachers, leaving them vulnerable to potential bad actors, according to an audit published earlier this month.

New Jersey used an incorrect method to calculate Medicaid reimbursements for services provided to students with disabilities, according to a federal audit, but the state disputes that claim.

School authorities in Utah have failed to report educator misconduct, possibly allowing teachers to offend again by moving to other schools, according to a new audit.

"The objective of the audit was to assess whether the award of funding under the RJIP program was informed by appropriate departmental advice and that processes complied with the grants administration framework."--Page 8.

"The objective of this audit was to examine the extent to which Australian Government entities have implemented the Digital Continuity 2020 policy, and how effectively the National Archives of Australia is monitoring, assisting, and encouraging entities to meet the specified targets of the policy."--Pages 7-8.

An audit of the early-childhood education offerings in Minnesota finds complexity and fragmentation as well as a lack of data about program effectiveness.

Régis Trapeau
Mar 28, 2018; 38:3252-3264
BehavioralSystemsCognitive

Sensory systems integrate multiple stimulus features to generate coherent percepts. Spectral surround suppression, the phenomenon by which sound-evoked responses of auditory neurons are suppressed by stimuli outside their receptive field, is an example of this integration taking place in the auditory system. While this form of global integration is commonly observed in auditory cortical neurons, and potentially used by the nervous system to separate signals from noise, the mechanisms that underlie this suppression of activity are not well understood. We evaluated the contributions to spectral surround suppression of the two most common inhibitory cell types in the cortex, parvalbumin-expressing (PV+) and somatostatin-expressing (SOM⁺) interneurons, in mice of both sexes. We found that inactivating SOM⁺ cells, but not PV+ cells, significantly reduces sustained spectral surround suppression in excitatory cells, indicating a dominant causal role for SOM⁺ cells in the integration of information across multiple frequencies. The similarity of these results to those from other sensory cortices provides evidence of common mechanisms across the cerebral cortex for generating global percepts from separate features.

SIGNIFICANCE STATEMENT To generate coherent percepts, sensory systems integrate simultaneously occurring features of a stimulus, yet the mechanisms by which this integration occurs are not fully understood. Our results show that neurochemically distinct neuronal subtypes in the primary auditory cortex have different contributions to the integration of different frequency components of an acoustic stimulus. Together with findings from other sensory cortices, our results provide evidence of a common mechanism for cortical computations used for global integration of stimulus features.

Statistical regularities in natural sounds facilitate the perceptual segregation of auditory sources, or streams. Repetition is one cue that drives stream segregation in humans, but the neural basis of this perceptual phenomenon remains unknown. We demonstrated a similar perceptual ability in animals by training ferrets of both sexes to detect a stream of repeating noise samples (foreground) embedded in a stream of random samples (background). During passive listening, we recorded neural activity in primary auditory cortex (A1) and secondary auditory cortex (posterior ectosylvian gyrus, PEG). We used two context-dependent encoding models to test for evidence of streaming of the repeating stimulus. The first was based on average evoked activity per noise sample and the second on the spectro-temporal receptive field. Both approaches tested whether differences in neural responses to repeating versus random stimuli were better modeled by scaling the response to both streams equally (global gain) or by separately scaling the response to the foreground versus background stream (stream-specific gain). Consistent with previous observations of adaptation, we found an overall reduction in global gain when the stimulus began to repeat. However, when we measured stream-specific changes in gain, responses to the foreground were enhanced relative to the background. This enhancement was stronger in PEG than A1. In A1, enhancement was strongest in units with low sparseness (i.e., broad sensory tuning) and with tuning selective for the repeated sample. Enhancement of responses to the foreground relative to the background provides evidence for stream segregation that emerges in A1 and is refined in PEG.

SIGNIFICANCE STATEMENT To interact with the world successfully, the brain must parse behaviorally important information from a complex sensory environment. Complex mixtures of sounds often arrive at the ears simultaneously or in close succession, yet they are effortlessly segregated into distinct perceptual sources. This process breaks down in hearing-impaired individuals and speech recognition devices. By identifying the underlying neural mechanisms that facilitate perceptual segregation, we can develop strategies for ameliorating hearing loss and improving speech recognition technology in the presence of background noise. Here, we present evidence to support a hierarchical process, present in primary auditory cortex and refined in secondary auditory cortex, in which sound repetition facilitates segregation.

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">FCC Launches New Round of Audits of Radio Station EEO Performance http://bit.ly/anoP3q</span></span>

Application deadline: 17 May 2020 | Banking Settlements Centre | Location: Basel, Switzerland

The grassroots programme of the Bosnia and Herzegovina Football Federation has been given special recognition during an ceremony hosted by the Bosnian Olympic Committee.

Adding second-stage automated auditory brainstem response (ABR) testing for infants who failed the initial OAE test in a two-stage neonatal hearing screening has been shown to reduce false referrals to the hearing clinic.

Infants with hearing loss may be missed by a 2-stage hearing screening because they pass the automated ABR test. In our study, a significant number of infants with hearing loss >45 decibel hearing level passed screening with automated ABR. (Read the full article)

The Scottish Parliament will next week (Tuesday 10 March) be invited to nominate Stephen Boyle to Her Majesty the Queen for appointment as the new Auditor General for Scotland.

The National Financial Reporting Authority (NFRA) has floated draft procedures for submission of audit logs to the regulator by audit companies and chartered accountants (CAs).

RBI introduces Information System(IS) Audit for Urban Cooperative Banks (UCBs)

Banks to have a robust system of internal audit of all outsourced activities

Nsauditor version 3.2.0.0 denial of service proof of concept exploit.

SpotAuditor version 5.3.4 Name denial of service proof of concept exploit.

Lynis is an auditing tool for Unix (specialists). It scans the system and available software to detect security issues. Beside security related information it will also scan for general system information, installed packages and configuration mistakes. This software aims in assisting automated auditing, software patch management, vulnerability and malware scanning of Unix based systems.

Open-AudIT version 3.3.0 suffers from a cross site scripting vulnerability.

Open-AudIT Professional version 3.3.1 suffers from a remote code execution vulnerability.

Open-AudIT version 3.2.2 suffers from OS command injection, arbitrary file upload, and remote SQL injection vulnerabilities.

hwk is an easy-to-use wireless authentication and de-authentication tool. Furthermore, it also supports probe response fuzzing, beacon injection flooding, antenna alignment and various injection testing modes. Information gathering is selected by default and shows the incoming traffic indicating the packet types.

DA-WIN, a wireless IDS, provides an organization a continuous wireless scanning capability that is light touch and simple. It utilizes compact and discreet sensors that can easily be deployed reducing the total cost of protection and simplifying the effort required for absolute, categoric regulatory compliance. This archive includes a dd image to be used on a Raspberry Pi and a user manual.

DA-WIN, a wireless IDS, provides an organization a continuous wireless scanning capability that is light touch and simple. It utilizes compact and discreet sensors that can easily be deployed reducing the total cost of protection and simplifying the effort required for absolute, categoric regulatory compliance. This archive includes a dd image to be used on a Raspberry Pi and a user manual.

A recent report by the Energy Futures Initiative (EFI), established by former Energy Secretary Ernest Moniz, and the National Association of State Energy Officials confirms that the energy sector as a whole grew 2 percent last year, which is .3 percent more than the national job growth percentage of 1.7 percent.

  On 18 December 2019, the Government published the final report of the independent review undertaken by Sir Donald Brydon into the quality and effectiveness of audit (Report). The Report contains recommendations ...

U.S. brokers should not be forced to sign an agreement that could make them liable for breaches of a massive new industry trading database that they have no control over, a leading financial industry...

Show has been praised for its representation of consensual sex

Invista will pay a $1.7 million civil penalty and spend up to an estimated $500 million to correct self-reported environmental violations discovered at facilities in seven states. The company disclosed more than 680 violations of water, air, hazardous waste, emergency planning and preparedness, and pesticide regulations to EPA after auditing 12 facilities it acquired from DuPont in 2004.

The president and the auditor of a Costa Rican company selling reinsurance bonds to life settlement companies were arrested and charged, along with the company itself, in a seven-count indictment unsealed today for their alleged role in a $670 million fraud scheme involving victims throughout the United States and abroad.

The Department of Justice today released the executive summary of the report by an independent auditor of the Gulf Coast Claims Facility (GCCF), the facility set up to process claims in the wake of the April 20, 2010, Deepwater Horizon oil spill.

The former director of accounting and the former outside auditor of Arizona-based residential mortgage loan originator American Mortgage Specialists Inc. pleaded guilty in Arizona to conspiracy to defraud BNC National Bank and obstruction of justice, respectively.