The experimental theater company revisits Shakespeare using a 1964 filmed performance of Richard Burton. Here's how to stream it for free.

Butler hasn't had much practice time with the 76ers, but he's already acclimating to their preferred way of playing and closing out wins.

Discover what it is like to fly Air Tahiti Nui Boeing Dreamliner in Poerava Business Class. I discuss and review the aircraft, layout, seats, food, drink, service and facilities on board. Find out of this airline and business class is a thumbs up or thumbs down from me.

Note: I received a discount off the full fare price of my Air Tahiti Business class flight from Paris to Papeete Tahiti. The airline had no input of the content or opinions expressed in my video.

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Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

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Basecamp’s newest product HEY has lived on Kubernetes since development first began. While our applications are majestic monoliths, a product like HEY has numerous supporting services that run along-side the main app like our mail pipeline (Postfix and friends), Resque (and Resque Scheduler), and nginx, making Kubernetes a great orchestration option for us. As you… keep reading

Invitation Only Research Event

Event participants

Ambassador Andrés Rozental, Senior Adviser, Chatham House; Founding President, Mexican Council on Foreign Relations
Dr Elena Lazarou, Associate Fellow, US and the Americas Programme, Chatham House
Chair: Dr Christopher Sabatini, Senior Research Fellow for Latin America, US and the Americas Programme, Chatham House

Acute myeloid leukemia (AML) is a clonal disorder arising from hematopoietic myeloid progenitors. Aberrantly activated tyrosine kinases (TK) are involved in leukemogenesis and are associated with poor treatment outcome. Kinase inhibitor (KI) treatment has shown promise in improving patient outcome in AML. However, inhibitor selection for patients is suboptimal.

In a preclinical effort to address KI selection, we analyzed a panel of 16 AML cell lines using phosphotyrosine (pY) enrichment-based, label-free phosphoproteomics. The Integrative Inferred Kinase Activity (INKA) algorithm was used to identify hyperphosphorylated, active kinases as candidates for KI treatment, and efficacy of selected KIs was tested.

Heterogeneous signaling was observed with between 241 and 2764 phosphopeptides detected per cell line. Of 4853 identified phosphopeptides with 4229 phosphosites, 4459 phosphopeptides (4430 pY) were linked to 3605 class I sites (3525 pY). INKA analysis in single cell lines successfully pinpointed driver kinases (PDGFRA, JAK2, KIT and FLT3) corresponding with activating mutations present in these cell lines. Furthermore, potential receptor tyrosine kinase (RTK) drivers, undetected by standard molecular analyses, were identified in four cell lines (FGFR1 in KG-1 and KG-1a, PDGFRA in Kasumi-3, and FLT3 in MM6). These cell lines proved highly sensitive to specific KIs. Six AML cell lines without a clear RTK driver showed evidence of MAPK1/3 activation, indicative of the presence of activating upstream RAS mutations. Importantly, FLT3 phosphorylation was demonstrated in two clinical AML samples with a FLT3 internal tandem duplication (ITD) mutation.

Our data show the potential of pY-phosphoproteomics and INKA analysis to provide insight in AML TK signaling and identify hyperactive kinases as potential targets for treatment in AML cell lines. These results warrant future investigation of clinical samples to further our understanding of TK phosphorylation in relation to clinical response in the individual patient.

Acute myeloid leukemia (AML) is a clonal disorder arising from hematopoietic myeloid progenitors. Aberrantly activated tyrosine kinases (TK) are involved in leukemogenesis and are associated with poor treatment outcome. Kinase inhibitor (KI) treatment has shown promise in improving patient outcome in AML. However, inhibitor selection for patients is suboptimal.

In a preclinical effort to address KI selection, we analyzed a panel of 16 AML cell lines using phosphotyrosine (pY) enrichment-based, label-free phosphoproteomics. The Integrative Inferred Kinase Activity (INKA) algorithm was used to identify hyperphosphorylated, active kinases as candidates for KI treatment, and efficacy of selected KIs was tested.

Heterogeneous signaling was observed with between 241 and 2764 phosphopeptides detected per cell line. Of 4853 identified phosphopeptides with 4229 phosphosites, 4459 phosphopeptides (4430 pY) were linked to 3605 class I sites (3525 pY). INKA analysis in single cell lines successfully pinpointed driver kinases (PDGFRA, JAK2, KIT and FLT3) corresponding with activating mutations present in these cell lines. Furthermore, potential receptor tyrosine kinase (RTK) drivers, undetected by standard molecular analyses, were identified in four cell lines (FGFR1 in KG-1 and KG-1a, PDGFRA in Kasumi-3, and FLT3 in MM6). These cell lines proved highly sensitive to specific KIs. Six AML cell lines without a clear RTK driver showed evidence of MAPK1/3 activation, indicative of the presence of activating upstream RAS mutations. Importantly, FLT3 phosphorylation was demonstrated in two clinical AML samples with a FLT3 internal tandem duplication (ITD) mutation.

Our data show the potential of pY-phosphoproteomics and INKA analysis to provide insight in AML TK signaling and identify hyperactive kinases as potential targets for treatment in AML cell lines. These results warrant future investigation of clinical samples to further our understanding of TK phosphorylation in relation to clinical response in the individual patient.

Invitation Only Research Event

Event participants

Ambassador Andrés Rozental, Senior Adviser, Chatham House; Founding President, Mexican Council on Foreign Relations
Dr Elena Lazarou, Associate Fellow, US and the Americas Programme, Chatham House
Chair: Dr Christopher Sabatini, Senior Research Fellow for Latin America, US and the Americas Programme, Chatham House

FOUR MORE applicants are vying to provide mobile payment services in various formats, including one applicant seeking to use phone credit as a cash equivalent, but successful applicants will fall under a new framework the regulator calls its “...

John B. Buse
Jul 1, 2002; 20:
Feature Articles

Interior Health officials are asking people who went to the Save-On-Foods pharmacy in Columbia Place Shopping Centre in Kamloops, March 10, 13 and 14 along with March 16 to 21 to self-isolate following a positive case of COVID-19 at the store.

A man in Kamloops, B.C., has died and two others are in hospital with life-threatening injuries after a stabbing at a party at an apartment complex Saturday night. 

The B.C. Wildfire Service and the Adams Lake Fire Department are responding to a wildfire burning east of Kamloops in B.C.'s southern Interior.

Most of the animals at the B.C. Wildlife Park in Kamloops are unfazed by the absence of paying visitors since it closed in March over COVID-19 concerns. But Blue the turkey appears "bummed," staff say.

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210.”

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210.”

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210.

Monday 13 January: Royals’ family meeting

This week, our resident cartoonist turned his pen on the Coronavirus outbreak, Bernie Sanders rising popularity in the United States and the battle for an SNP seat at Holyrood.

This week, our resident cartoonist turned his pen on the Coronavirus outbreak, bullying claims surrounding the home secretary and Scotland making in to the world list of top beaches.

Framed prints of Steven Camley's cartoons are available by calling 0141 302 6210

Earlier, the Business Correspondent Federation of India (BCFI) had said that while the BCs were offering services of cash withdrawal, very few are depositing money in the wake of the current lockdown.

The U.S. House of Representatives has passed bipartisan hydroelectric power regulatory improvement provisions as part of the North American Energy Security and Infrastructure Act of 2015, potentially helping to expedite the project approval process.

As part of the UK Governments’ ongoing programme to implement the European Union’s Fifth Money Laundering Directive (5MLD) in UK law, the FCA will begin supervising Anti Money Laundering and Countering Financing of Terrorism (AML/CFT) co...

As additional EU rules come into force requiring UK credit and financial institutions with branches and subsidiaries in third countries to identify local law conflicts with group-wide AML policies and procedures, Zia Ullah and Ruth Paley of Evershed...

As the European Banking Authority publishes a wide-ranging workplan for 2020, Zia Ullah and Ruth Paley explain the EBA’s role and its forthcoming programme, and take a look at the substance of the developments planned for the next twelve month...

Cross-border fund marketing arrangements into the UK are poised to be significantly amended when the current post-Brexit ‘transition or implementation period’ (“TIP”) comes to an end on 31 December 2020.  Retail funds&rs...

Microchip Smart Storage Adapters Now Interoperate Seamlessly with MegaRAC® SP-X Management Firmware from AMI for At-Scale Secure Storage Management

At HARMAN, our Connected Car division designs, engineers and innovates every day to provide connected solutions for our most valued partners, and our compute model integration with Mercedes-Benz is no exception. Earlier this year, the luxury vehicle ...

Objective

To use the variations in neurology consultations requested by emergency department (ED) physicians to identify opportunities to implement multidisciplinary interventions in an effort to reduce ED overcrowding.

Background:

The recent expansion of treatment options in acute myeloid leukemia (AML) has necessitated a greater understanding of patient preferences for treatment benefits, about which little is known.

Trong khi nhiều dự án BĐS bị ảnh hưởng bởi đại dịch covid-19 thì dự án hỗn hợp văn phòng dịch vụ và nhà ở Dreamland Bonanza (23 phố Duy Tân, Cầu Giấy, Hà Nội) do Công ty Cổ phần Đầu tư bất động sản Vinaland làm chủ đầu tư, đã đảm bảo các điều kiện thi công an toàn, về đích đúng tiến độ và bàn giao cho khách hàng vào ngày 11/5/2020.

StreamLink Software began as nonprofit executives saw a need for solutions to common management issues. When it became clear there was gap in quality, affordable products, StreamLink Software was formed to develop them.

"This is a direct result of what we heard from tribal leaders at the department's listening session. Tribal leaders have made it clear that a single application would significantly improve their ability to apply and receive critical federal funding, which so many of their communities depend on," said Associate Attorney General Perrelli.

Following a public comment period, the Department of Justice and the Federal Trade Commission (FTC) have made changes to reduce the filing burden and streamline the form parties must file when seeking antitrust clearance of proposed mergers and acquisitions under the Hart-Scott-Rodino (HSR) Act and the Premerger Notification Rules.

The Department of Justice’s Antitrust Division today announced a new streamlined procedure that will lower the costs and expedite the review process for parties seeking to modify or terminate old antitrust settlements and litigated judgments.

April 13, 2020 – The Food and Drug Administration (FDA) is responding to the challenges of COVID-19 in new ways that streamline product review and policy approaches, while also ensuring that entities promoting unapproved products that claim to be effective against the virus do not go unchecked. Last week, the FDA and the Federal Trade […]

Mexican President Andrés Manuel López Obrador, known as AMLO, has now been in office for about one year. It’s a good time to review his policies, and in particular his approach to the energy sector. The previous administration of President Enrique Peña Nieto undertook significant energy sector reforms, which AMLO generally opposed at the time…

Like many other populist leaders around the world, including Donald Trump, Jair Bolsanaro in Brazil, and Imran Khan in Pakistan, Mexican President Andrés Manuel López Obrador (commonly known as AMLO) has mostly taken a dangerously dismissive and outright irresponsible attitude toward the coronavirus. Late into March, he failed to adopt any necessary preparation for the…

Mexican President Andrés Manuel López Obrador (AMLO) assumed office in December 2018, promising to bring a fourth revolution to Mexico and to reduce Mexico’s inequality, corruption, and violent crime. Yet a year into his administration, homicides and violent criminality in Mexico have not diminished. While the new government has undertaken new security initiatives and adopted…

Like many other populist leaders around the world, including Donald Trump, Jair Bolsanaro in Brazil, and Imran Khan in Pakistan, Mexican President Andrés Manuel López Obrador (commonly known as AMLO) has mostly taken a dangerously dismissive and outright irresponsible attitude toward the coronavirus. Late into March, he failed to adopt any necessary preparation for the…

The device is so thin it could be woven into fabric without changing the feel of it.

These high-end kits make converting a van into a home-on-wheels an easier proposition.

Alleppy Prawns Curry in Spicy Rosemary Warqi Taco

It's hard to miss London Taxi standing tall at a corner of Kamala Mills. The facade of the three-level gastropub, which opens this Saturday, might seem like it’s bovine inspired but a close look reveals a map of London, the city that serves as an inspiration for this pub, with the river Thames running through it.

The 6,000-sq ft property is helmed by ad filmmakers Vivek DasChaudhary, Sanjay Shetty and Ricky Singh Bedi, with Dhaval Udeshi as the managing partner. The first things we notice when we enter are the custom-made, taxi-shaped tiles. The bar features cab grills lining the front. Colourful pipes run across the ceiling, to form a map of the London Underground. The table tops are printed with artwork inspired by Abbey Road.

Sherlock in a Pickle

The London inspiration continues on the menu, albeit in a less obvious manner. It has a wild mix of cuisines (think Prawn Thai Broth, Moroccan Fish Tikka and Madras Curry Scotch Egg). Chef Nagraj Bhat says the menu speaks of London’s cosmopolitan nature, and stories from his time spent there. The south Indian dishes are an ode to his mother’s cooking. Everything is made in-house, including the sausages, sauces and breads. Ami Shroff, who has created the bar menu, informs that the infused liquor and shrubs are made in-house too.

Bhat picks some of his favourites for us to try. The first is Truffle-scented Dark Chocolate Caramelised Cauliflower Veloute ('260).

A soup is not something we would normally have at a pub, but the dark chocolate flavour, heightened by the bitter-sweetness of the caramelised onion, makes it a must-try. From the salad spread, we are served Cajun-spiced Prawn and Kale Chips Salad ('385). Grilled pieces of spicy pineapple add a punch to the dish, with drops of mango jalapeño coulis offering a sweet-and-spice combination.

By now, Shroff is ready with her cocktails, the first concoction being The Trip ('725). A pleasant woody flavour of turmeric envelopes our palate, thanks to the gin infused with the healthy ingredient. Saffron honey water and fresh orange add to the unique flavour.

It is followed by Sherlock In A Pickle ('675). The savoury cocktail features Earl Grey-infused vodka mixed with wine-beetroot reduction, sweet lime juice and pickled gherkins — inspired by the culinary favourites of the fictional sleuth. Beer lovers can opt for Picadilly Circus ('450), made with lager, espresso and cocoa-infused whisky with bitters. There is a section dedicated to gin and tonic and martinis for the Londoner in you. Only paper or metal straws are offered, to reduce plastic usage, a move that we wholly approve of.

Our food picks also include Alleppy Prawns Curry in Spicy Rosemary Warqi Taco ('580), Truffle Scented Welsh Rarebite Doughnut ('365), which makes for a great bar bite, and Theecha Tepenade Flatbread ('575) made with beer-fermented flatbread. For dessert, try their Banana Rum and Toffee Parfait ('465).

With intriguing decor, a crowd-pleasing menu and unique cocktails (which are heavy on the pocket), London Taxi is revving up as the newest entrance in the restaurant race at Kamala Mills.

Opens on September 9, 6 pm to 1 am At Kamala Mills, Trade World, Lower Parel.
Call 24951000

In, rapid enhancement of telecommunication industry, it is quite drastic job to deliver right solutions. CSPs aren’t finding the perfect telecom service providers, and so it has become one of...