s An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1 [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Arrestin-1 is the arrestin family member responsible for inactivation of the G protein–coupled receptor rhodopsin in photoreceptors. Arrestin-1 is also well-known to interact with additional protein partners and to affect other signaling cascades beyond phototransduction. In this study, we investigated one of these alternative arrestin-1 binding partners, the glycolysis enzyme enolase-1, to map the molecular contact sites between these two proteins and investigate how the binding of arrestin-1 affects the catalytic activity of enolase-1. Using fluorescence quench protection of strategically placed fluorophores on the arrestin-1 surface, we observed that arrestin-1 primarily engages enolase-1 along a surface that is opposite of the side of arrestin-1 that binds photoactivated rhodopsin. Using this information, we developed a molecular model of the arrestin-1–enolase-1 complex, which was validated by targeted substitutions of charge-pair interactions. Finally, we identified the likely source of arrestin's modulation of enolase-1 catalysis, showing that selective substitution of two amino acids in arrestin-1 can completely remove its effect on enolase-1 activity while still remaining bound to enolase-1. These findings open up opportunities for examining the functional effects of arrestin-1 on enolase-1 activity in photoreceptors and their surrounding cells. Full Article
s Amino Acid Metabolism, {beta}-Cell Function, and Diabetes By diabetes.diabetesjournals.org Published On :: 2006-12-01 Philip NewsholmeDec 1, 2006; 55:S39-S47Section II: The Muscle and Liver Connections Full Article
s Amylin Agonists: A Novel Approach in the Treatment of Diabetes By diabetes.diabetesjournals.org Published On :: 2004-12-01 Ole SchmitzDec 1, 2004; 53:S233-S238Section V: The Incretin Pathway Full Article
s Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study By diabetes.diabetesjournals.org Published On :: 2020-05-01 Barbara H. BraffettMay 1, 2020; 69:1000-1010Complications Full Article
s The Biology of Mitochondrial Uncoupling Proteins By diabetes.diabetesjournals.org Published On :: 2004-02-01 Sophie RoussetFeb 1, 2004; 53:S130-S135Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes Full Article
s The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2017-09-01 Andrew S. KimballSep 1, 2017; 66:2459-2471Immunology and Transplantation Full Article
s A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets By diabetes.diabetesjournals.org Published On :: 2020-05-01 David J. HodsonMay 1, 2020; 69:864-866Commentaries Full Article
s Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients By diabetes.diabetesjournals.org Published On :: 2005-11-01 Mandeep BajajNov 1, 2005; 54:3148-3153Metabolism Full Article
s AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer By diabetes.diabetesjournals.org Published On :: 2013-07-01 D. Grahame HardieJul 1, 2013; 62:2164-2172Perspectives in Diabetes Full Article
s The High-Fat Diet-Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-12-01 Maria Sörhede WinzellDec 1, 2004; 53:S215-S219Section V: The Incretin Pathway Full Article
s Muscle Weakness: A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy By diabetes.diabetesjournals.org Published On :: 2006-03-01 Christer S. AndreassenMar 1, 2006; 55:806-812Complications Full Article
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s Sugar, Uric Acid, and the Etiology of Diabetes and Obesity By diabetes.diabetesjournals.org Published On :: 2013-10-01 Richard J. JohnsonOct 1, 2013; 62:3307-3315Perspectives in Diabetes Full Article
s Nicotine and Insulin Resistance: When the Smoke Clears By diabetes.diabetesjournals.org Published On :: 2012-12-01 Mandeep BajajDec 1, 2012; 61:3078-3080Commentary Full Article
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s Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans By diabetes.diabetesjournals.org Published On :: 2007-04-01 Luigi FontanaApr 1, 2007; 56:1010-1013Metabolism Full Article
s Systeme International (SI) Units Table By diabetes.diabetesjournals.org Published On :: 1992-10-01 Oct 1, 1992; 41:1368-1369System[egrave] International (SI) Units Table Full Article
s The Incretin Approach for Diabetes Treatment: Modulation of Islet Hormone Release by GLP-1 Agonism By diabetes.diabetesjournals.org Published On :: 2004-12-01 Jens Juul HolstDec 1, 2004; 53:S197-S204Section V: The Incretin Pathway Full Article
s Insulin Regulates Brain Function, but How Does It Get There? By diabetes.diabetesjournals.org Published On :: 2014-12-01 Sarah M. GrayDec 1, 2014; 63:3992-3997Perspectives in Diabetes Full Article
s Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors By diabetes.diabetesjournals.org Published On :: 2020-04-01 Mariam AlatrachApr 1, 2020; 69:681-688Pathophysiology Full Article
s A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of {beta}-Cell Glucolipotoxicity By diabetes.diabetesjournals.org Published On :: 2020-05-01 Jennifer VogelMay 1, 2020; 69:1032-1041Pharmacology and Therapeutics Full Article
s Mechanisms of {beta}-Cell Death in Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2005-12-01 Marc Y. DonathDec 1, 2005; 54:S108-S113Section III: Inflammation and beta-Cell Death Full Article
s Type 2 Diabetes: Demystifying the Global Epidemic By diabetes.diabetesjournals.org Published On :: 2017-06-01 Ranjit UnnikrishnanJun 1, 2017; 66:1432-1442Perspectives in Diabetes Full Article
s Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice By diabetes.diabetesjournals.org Published On :: 2008-06-01 Patrice D. CaniJun 1, 2008; 57:1470-1481Metabolism Full Article
s Environmental Triggers and Determinants of Type 1 Diabetes By diabetes.diabetesjournals.org Published On :: 2005-12-01 Mikael KnipDec 1, 2005; 54:S125-S136Section IV: Polygenic Disease and Environment Full Article
s Insulin Resistance and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2012-04-01 Roy TaylorApr 1, 2012; 61:778-779Commentary Full Article
s Predictors of Postpartum Diabetes in Women With Gestational Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2006-03-01 Kristian LöbnerMar 1, 2006; 55:792-797Pathophysiology Full Article
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s The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism By diabetes.diabetesjournals.org Published On :: 2019-06-01 Juli BaiJun 1, 2019; 68:1099-1108Perspectives in Diabetes Full Article
s Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes By diabetes.diabetesjournals.org Published On :: 2002-02-01 Errol B. MarlissFeb 1, 2002; 51:S271-S283Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men Full Article
s A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium By diabetes.diabetesjournals.org Published On :: 2011-04-01 Aldi T. KrajaApr 1, 2011; 60:1329-1339Genetics Full Article
s Vitamin D Receptor Overexpression in {beta}-Cells Ameliorates Diabetes in Mice By diabetes.diabetesjournals.org Published On :: 2020-05-01 Meritxell MorróMay 1, 2020; 69:927-939Islet Studies Full Article
s Is Sugar Addictive? By diabetes.diabetesjournals.org Published On :: 2016-07-01 George A. BrayJul 1, 2016; 65:1797-1799Commentaries Full Article
s The Rise of Childhood Type 1 Diabetes in the 20th Century By diabetes.diabetesjournals.org Published On :: 2002-12-01 Edwin A.M. GaleDec 1, 2002; 51:3353-3361Perspectives in Diabetes Full Article
s ACE2 and Diabetes: ACE of ACEs? By diabetes.diabetesjournals.org Published On :: 2010-12-01 Daniel BatlleDec 1, 2010; 59:2994-2996Commentaries Full Article
s Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-09-01 Mary C. GannonSep 1, 2004; 53:2375-2382Pathophysiology Full Article
s Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
s Metabolic Endotoxemia Initiates Obesity and Insulin Resistance By diabetes.diabetesjournals.org Published On :: 2007-07-01 Patrice D. CaniJul 1, 2007; 56:1761-1772Obesity Studies Full Article
s One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation By diabetes.diabetesjournals.org Published On :: 2016-10-01 Marlou L. DirksOct 1, 2016; 65:2862-2875Metabolism Full Article
s Protecting the Heart in Obesity: Role of ACE2 and Its Partners By diabetes.diabetesjournals.org Published On :: 2016-01-01 Rhian M. TouyzJan 1, 2016; 65:19-21Commentaries Full Article
s Autoantibodies in Diabetes By diabetes.diabetesjournals.org Published On :: 2005-12-01 Catherine PihokerDec 1, 2005; 54:S52-S61Section II: Type 1-Related Forms of Diabetes Full Article
s Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study By diabetes.diabetesjournals.org Published On :: 2003-07-01 Bruce B. DuncanJul 1, 2003; 52:1799-1805Pathophysiology Full Article
s Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes By diabetes.diabetesjournals.org Published On :: 2004-12-01 Gordon C. WeirDec 1, 2004; 53:S16-S21Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes Full Article
s From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2009-04-01 Ralph A. DeFronzoApr 1, 2009; 58:773-795Banting Lecture Full Article
s Diabetes in China: Epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication By diabetes.diabetesjournals.org Published On :: 2018-01-01 Cheng HuJan 1, 2018; 67:3-11Perspectives in Diabetes Full Article
s The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion By diabetes.diabetesjournals.org Published On :: 2002-12-01 Patrick E. MacDonaldDec 1, 2002; 51:S434-S442Section 5: Beta-Cell Stimulus-Secretion Coupling: Hormonal and Pharmacological Modulators Full Article
s The Pathobiology of Diabetic Complications: A Unifying Mechanism By diabetes.diabetesjournals.org Published On :: 2005-06-01 Michael BrownleeJun 1, 2005; 54:1615-1625Banting Lecture 2004 Full Article
s Latent Autoimmune Diabetes in Adults: Definition, Prevalence, {beta}-Cell Function, and Treatment By diabetes.diabetesjournals.org Published On :: 2005-12-01 Gunnar StenströmDec 1, 2005; 54:S68-S72Section II: Type 1-Related Forms of Diabetes Full Article
s Poverty and Obesity in the U.S. By diabetes.diabetesjournals.org Published On :: 2011-11-01 James A. LevineNov 1, 2011; 60:2667-2668Editorials Full Article
s A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels By diabetes.diabetesjournals.org Published On :: 2002-10-01 Elisabeth F.C. van RossumOct 1, 2002; 51:3128-3134Genetics Full Article
