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A Bayesian nonparametric approach to log-concave density estimation

Ester Mariucci, Kolyan Ray, Botond Szabó.

Source: Bernoulli, Volume 26, Number 2, 1070--1097.

Abstract:
The estimation of a log-concave density on $mathbb{R}$ is a canonical problem in the area of shape-constrained nonparametric inference. We present a Bayesian nonparametric approach to this problem based on an exponentiated Dirichlet process mixture prior and show that the posterior distribution converges to the log-concave truth at the (near-) minimax rate in Hellinger distance. Our proof proceeds by establishing a general contraction result based on the log-concave maximum likelihood estimator that prevents the need for further metric entropy calculations. We further present computationally more feasible approximations and both an empirical and hierarchical Bayes approach. All priors are illustrated numerically via simulations.




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SPDEs with fractional noise in space: Continuity in law with respect to the Hurst index

Luca M. Giordano, Maria Jolis, Lluís Quer-Sardanyons.

Source: Bernoulli, Volume 26, Number 1, 352--386.

Abstract:
In this article, we consider the quasi-linear stochastic wave and heat equations on the real line and with an additive Gaussian noise which is white in time and behaves in space like a fractional Brownian motion with Hurst index $Hin (0,1)$. The drift term is assumed to be globally Lipschitz. We prove that the solution of each of the above equations is continuous in terms of the index $H$, with respect to the convergence in law in the space of continuous functions.




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Cliques in rank-1 random graphs: The role of inhomogeneity

Kay Bogerd, Rui M. Castro, Remco van der Hofstad.

Source: Bernoulli, Volume 26, Number 1, 253--285.

Abstract:
We study the asymptotic behavior of the clique number in rank-1 inhomogeneous random graphs, where edge probabilities between vertices are roughly proportional to the product of their vertex weights. We show that the clique number is concentrated on at most two consecutive integers, for which we provide an expression. Interestingly, the order of the clique number is primarily determined by the overall edge density, with the inhomogeneity only affecting multiplicative constants or adding at most a $log log (n)$ multiplicative factor. For sparse enough graphs the clique number is always bounded and the effect of inhomogeneity completely vanishes.




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English given names : popularity, spelling variants, diminutives and abbreviations / by Carol Baxter.

Names, Personal -- England.




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High on the hill : the people of St Philip & St James Church, Old Noarlunga / City of Onkaparinga.

St. Philip and St. James Church (Noarlunga, S.A.)




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High on the hill : the people of St Philip & St James Church, Old Noarlunga%cCity of Onkaparinga.

St. Philip and St. James Church (Noarlunga, S.A.)




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Discover Protestant nonconformity in England and Wales / Paul Blake.

Dissenters, Religious -- Great Britain.




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Welsh given names : popularity, spelling variants, diminutives and abbreviations / by Carol Baxter.

Names, Personal -- Welsh.




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Scottish given names : popularity, spelling variants, diminutives and abbreviations / by Carol Baxter.

Names, Personal -- Scottish.




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Letter from J. H Bannatyne to Other Windsor Berry Esq. relating to the Myall Creek Massacre, 17 December 1838




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Item 07: A Journal of ye [the] Proceedings of his Majesty's Sloop Swallow, Captain Phillip [Philip] Carteret Commander, Commencing ye [the] 23 of July 1766 and ended [4 July 1767]




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Item 08: A Logg [Log] Book of the proceedings on Board His Majesty's Ship Swallow, Captain Philip Carteret Commander Commencing from the 20th August 1766 and Ending [21st May 1768]




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Item 13: Swallow 1767, A journal of the proceedings on Board His Majesty's Sloop Swallow, commencing the 1st of March 1767 and Ended the 7th of July 1767




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Chaffetz: I don't understand why Adam Schiff continues to have a security clearance

Fox News contributor Jason Chaffetz and Andy McCarthy react to House Intelligence transcripts on Russia probe.





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Determinantal Point Process Mixtures Via Spectral Density Approach

Ilaria Bianchini, Alessandra Guglielmi, Fernando A. Quintana.

Source: Bayesian Analysis, Volume 15, Number 1, 187--214.

Abstract:
We consider mixture models where location parameters are a priori encouraged to be well separated. We explore a class of determinantal point process (DPP) mixture models, which provide the desired notion of separation or repulsion. Instead of using the rather restrictive case where analytical results are partially available, we adopt a spectral representation from which approximations to the DPP density functions can be readily computed. For the sake of concreteness the presentation focuses on a power exponential spectral density, but the proposed approach is in fact quite general. We later extend our model to incorporate covariate information in the likelihood and also in the assignment to mixture components, yielding a trade-off between repulsiveness of locations in the mixtures and attraction among subjects with similar covariates. We develop full Bayesian inference, and explore model properties and posterior behavior using several simulation scenarios and data illustrations. Supplementary materials for this article are available online (Bianchini et al., 2019).




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Probability Based Independence Sampler for Bayesian Quantitative Learning in Graphical Log-Linear Marginal Models

Ioannis Ntzoufras, Claudia Tarantola, Monia Lupparelli.

Source: Bayesian Analysis, Volume 14, Number 3, 797--823.

Abstract:
We introduce a novel Bayesian approach for quantitative learning for graphical log-linear marginal models. These models belong to curved exponential families that are difficult to handle from a Bayesian perspective. The likelihood cannot be analytically expressed as a function of the marginal log-linear interactions, but only in terms of cell counts or probabilities. Posterior distributions cannot be directly obtained, and Markov Chain Monte Carlo (MCMC) methods are needed. Finally, a well-defined model requires parameter values that lead to compatible marginal probabilities. Hence, any MCMC should account for this important restriction. We construct a fully automatic and efficient MCMC strategy for quantitative learning for such models that handles these problems. While the prior is expressed in terms of the marginal log-linear interactions, we build an MCMC algorithm that employs a proposal on the probability parameter space. The corresponding proposal on the marginal log-linear interactions is obtained via parameter transformation. We exploit a conditional conjugate setup to build an efficient proposal on probability parameters. The proposed methodology is illustrated by a simulation study and a real dataset.




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Control of Type I Error Rates in Bayesian Sequential Designs

Haolun Shi, Guosheng Yin.

Source: Bayesian Analysis, Volume 14, Number 2, 399--425.

Abstract:
Bayesian approaches to phase II clinical trial designs are usually based on the posterior distribution of the parameter of interest and calibration of certain threshold for decision making. If the posterior probability is computed and assessed in a sequential manner, the design may involve the problem of multiplicity, which, however, is often a neglected aspect in Bayesian trial designs. To effectively maintain the overall type I error rate, we propose solutions to the problem of multiplicity for Bayesian sequential designs and, in particular, the determination of the cutoff boundaries for the posterior probabilities. We present both theoretical and numerical methods for finding the optimal posterior probability boundaries with $alpha$ -spending functions that mimic those of the frequentist group sequential designs. The theoretical approach is based on the asymptotic properties of the posterior probability, which establishes a connection between the Bayesian trial design and the frequentist group sequential method. The numerical approach uses a sandwich-type searching algorithm, which immensely reduces the computational burden. We apply least-square fitting to find the $alpha$ -spending function closest to the target. We discuss the application of our method to single-arm and double-arm cases with binary and normal endpoints, respectively, and provide a real trial example for each case.




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Model-Based Approach to the Joint Analysis of Single-Cell Data on Chromatin Accessibility and Gene Expression

Zhixiang Lin, Mahdi Zamanighomi, Timothy Daley, Shining Ma, Wing Hung Wong.

Source: Statistical Science, Volume 35, Number 1, 2--13.

Abstract:
Unsupervised methods, including clustering methods, are essential to the analysis of single-cell genomic data. Model-based clustering methods are under-explored in the area of single-cell genomics, and have the advantage of quantifying the uncertainty of the clustering result. Here we develop a model-based approach for the integrative analysis of single-cell chromatin accessibility and gene expression data. We show that combining these two types of data, we can achieve a better separation of the underlying cell types. An efficient Markov chain Monte Carlo algorithm is also developed.




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Larry Brown’s Work on Admissibility

Iain M. Johnstone.

Source: Statistical Science, Volume 34, Number 4, 657--668.

Abstract:
Many papers in the early part of Brown’s career focused on the admissibility or otherwise of estimators of a vector parameter. He established that inadmissibility of invariant estimators in three and higher dimensions is a general phenomenon, and found deep and beautiful connections between admissibility and other areas of mathematics. This review touches on several of his major contributions, with a focus on his celebrated 1971 paper connecting admissibility, recurrence and elliptic partial differential equations.




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Producing Official County-Level Agricultural Estimates in the United States: Needs and Challenges

Nathan B. Cruze, Andreea L. Erciulescu, Balgobin Nandram, Wendy J. Barboza, Linda J. Young.

Source: Statistical Science, Volume 34, Number 2, 301--316.

Abstract:
In the United States, county-level estimates of crop yield, production, and acreage published by the United States Department of Agriculture’s National Agricultural Statistics Service (USDA NASS) play an important role in determining the value of payments allotted to farmers and ranchers enrolled in several federal programs. Given the importance of these official county-level crop estimates, NASS continually strives to improve its crops county estimates program in terms of accuracy, reliability and coverage. In 2015, NASS engaged a panel of experts convened under the auspices of the National Academies of Sciences, Engineering, and Medicine Committee on National Statistics (CNSTAT) for guidance on implementing models that may synthesize multiple sources of information into a single estimate, provide defensible measures of uncertainty, and potentially increase the number of publishable county estimates. The final report titled Improving Crop Estimates by Integrating Multiple Data Sources was released in 2017. This paper discusses several needs and requirements for NASS county-level crop estimates that were illuminated during the activities of the CNSTAT panel. A motivating example of planted acreage estimation in Illinois illustrates several challenges that NASS faces as it considers adopting any explicit model for official crops county estimates.




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Comment: Empirical Bayes, Compound Decisions and Exchangeability

Eitan Greenshtein, Ya’acov Ritov.

Source: Statistical Science, Volume 34, Number 2, 224--228.

Abstract:
We present some personal reflections on empirical Bayes/ compound decision (EB/CD) theory following Efron (2019). In particular, we consider the role of exchangeability in the EB/CD theory and how it can be achieved when there are covariates. We also discuss the interpretation of EB/CD confidence interval, the theoretical efficiency of the CD procedure, and the impact of sparsity assumptions.




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Angel over the city.

1990.




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The Joyful Reduction of Uncertainty: Music Perception as a Window to Predictive Neuronal Processing




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The 2019 Victoria’s Secret Fashion Show Is Canceled After Facing Backlash for Lack of Body Diversity

The reaction on social media has been fierce.




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Multisensory Integration and the Society for Neuroscience: Then and Now

Barry E. Stein
Jan 2, 2020; 40:3-11
Viewpoints




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Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Jasper Akerboom
Oct 3, 2012; 32:13819-13840
Cellular




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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

William W. Seeley
Feb 28, 2007; 27:2349-2356
BehavioralSystemsCognitive




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Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage

Benjamin E. Reese
Mar 2, 2005; 25:2167-2175
BehavioralSystemsCognitive




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Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry

Brian Zingg
Apr 15, 2020; 40:3250-3267
Systems/Circuits




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The Representation of Semantic Information Across Human Cerebral Cortex During Listening Versus Reading Is Invariant to Stimulus Modality

Fatma Deniz
Sep 25, 2019; 39:7722-7736
BehavioralSystemsCognitive




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Astrocytes Modulate Baroreflex Sensitivity at the Level of the Nucleus of the Solitary Tract

Svetlana Mastitskaya
Apr 8, 2020; 40:3052-3062
Systems/Circuits




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Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances

Sebastian Onasch
Apr 15, 2020; 40:3186-3202
Systems/Circuits




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Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear

Ben Warren
Apr 8, 2020; 40:3130-3140
Neurobiology of Disease




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Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and L-DOPA Administration

Benjamin Meyer
Jul 3, 2019; 39:5326-5335
Systems/Circuits




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Neighbourhood : designing a liveable community

Friedman, Avi, 1952- author.
9781550654981 (paperback)




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Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Jasper Akerboom
Oct 3, 2012; 32:13819-13840
Cellular




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Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse

Joshua A. Gordon
May 15, 1996; 16:3274-3286
Articles




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Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

Randy L. Buckner
Feb 11, 2009; 29:1860-1873
Neurobiology of Disease




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{alpha}-Band Electroencephalographic Activity over Occipital Cortex Indexes Visuospatial Attention Bias and Predicts Visual Target Detection

Gregor Thut
Sep 13, 2006; 26:9494-9502
BehavioralSystemsCognitive




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The neural circuit for touch sensitivity in Caenorhabditis elegans

M Chalfie
Apr 1, 1985; 5:956-964
Articles




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Linearity and Normalization in Simple Cells of the Macaque Primary Visual Cortex

Matteo Carandini
Nov 1, 1997; 17:8621-8644
Articles




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Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

Peter Klivenyi
Jan 1, 2000; 20:1-7
Cellular




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High-Level Neuronal Expression of A{beta}1-42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke
Jun 1, 2000; 20:4050-4058
Cellular




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Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

EL Bienenstock
Jan 1, 1982; 2:32-48
Articles




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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type

Guo-qiang Bi
Dec 15, 1998; 18:10464-10472
Articles




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The establishment of polarity by hippocampal neurons in culture

CG Dotti
Apr 1, 1988; 8:1454-1468
Articles




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The Variable Discharge of Cortical Neurons: Implications for Connectivity, Computation, and Information Coding

Michael N. Shadlen
May 15, 1998; 18:3870-3896
Articles




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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

William W. Seeley
Feb 28, 2007; 27:2349-2356
BehavioralSystemsCognitive




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Facility Attendant




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BIRTHDAY PARTY PACKAGE/ DROP-IN LEADERS