Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.

A soy protein product having a protein content of at least 60 wt % (N×6.25) d.b., preferably an isolate having a protein content of at least about 90 wt % (N×6.25) d.b., is formed from the supernatant from the precipitation of a soy protein micellar mass. A calcium salt or other divalent salt is added to the supernatant, before concentration, after initial concentration or after final concentration, to provide a conductivity of about 2 to about 30 mS. Precipitate is removed from the resulting solution and the pH of the clear soy protein solution is optionally adjusted to about 1.5 to about 4.4. The optionally pH-adjusted clear solution is concentrated to a concentration of about 50 to about 400 g/L and the clear concentrated protein solution is optionally diafiltered prior to drying. The soy protein product is soluble in acidic media and produces transparent, heat stable solutions at low pH values and, therefore, may be used for protein fortification of soft drinks and sports drinks.

A wireless small motor driver, in which power consumption is decreased by adjusting a gear ratio, the efficiency of an operation is increased due to a high torque, and the safety of a worker at night is ensured using an illumination lamp. The wireless small motor driver includes a driver case inside of which a motor is provided. A driver bit has a predetermined length in a bilateral direction, the driver bit being replaceable, with one or both ends thereof conforming to the shape of a bolt, and has a fixing projection. A socket is coupled to an end portion of the driver case, the driver bit being fastened to the socket. A rotation reduction gear is coupled to the motor, the rotation reduction gear transmitting rotary force to the socket and increasing a torque. A USB and a battery for supplying uniform power to the motor are added.

A ratcheting device includes a handle member including a first end and an opposed second end, a ratchet head pivotably connected to the first end of the handle member, and a ring grip pivotably connected to the second end of the handle member.

A set of sewing disks for controlling the movement of a piece of fabric over the free arm and under the needle of a sewing or quilting machine. Each disk is flat and has an oval or circular configuration and comprises three registered, stacked adhesively attached layers—a first contact layer made of open cell foam, a semi-rigid intermediate stiffener member, and a second contact layer made of closed cell foam. When each disk is placed over a piece of fabric with the lower contact layer is placed adjacent thereto, the individual's fingers are exposed at all times and placed over the opposite contact layer. The intermediate stiffener layer spreads and evenly dissipates the forces exerted by the fingers to the top contact layer to the lower contact layer. Because the finger tips are not in contact with the fabric, soiling of the fabric by the finger tips is prevented.

Method for creating a crystal/rhinestone template utilizing a sewing/embroidery machine to perforate a medium in a desired pattern. In the case of a multiple-needle sewing/embroidery machine, the machine's needle is replaced by a perforator blade and perforator blade holder which are attached to machine's needle bar. Machine's needle plate is replaced by perforator plate and waste holder. With a single-needle sewing/embroidery machine, machine's needle is replaced by a pressing tool attached to the machine's needle bar. A contact point, a spring, and an arm are attached to machine's presser foot. Machine's needle plate is replaced by perforator plate. A template medium is placed on a work surface of machine. Machine is operated by software that reads a user-specified pattern/motif outline for filling stones in vector form, using innate rules to move machine frame and control hole placement.

A direct drive cloth feeding mechanism of a sewing machine includes a cloth feeding structure, a vertical driving structure and a direction adjustment structure. The cloth feeding structure includes a swing shaft and a cloth feeding teeth member. The vertical driving structure includes an eccentric shaft connected to the cloth feeding teeth member, and an eccentric cam disposed on the eccentric shaft. The direction adjustment structure includes a stepping motor, and a rotating shaft driven by the stepping motor to rotate and switch between a first position and a second position. When the stepping motor directly drives the rotating shaft to the first position, the cloth feeding teeth member performs a forward feeding process. When the stepping motor directly drives the rotating shaft to the second position, the cloth feeding teeth member performs a reverse feeding process.

The invention relates to the use of a hot-melt adhesive having high hardness for adhesive bonding of metal films or foils, paper films or foils, and/or plastic films or foils. The invention further relates to a method for adhesively bonding a metal film or foil, paper film or foil, and/or plastic film or foil onto a substrate.

The steps of the irrigation method include: flowing a stream of water having input and output and intermediate location; interposing a feeding device into the stream of water at the intermediate location, the feeding device having input and output ends; inserting a quantity of nutrient fertilizer into the feeding device; converting the nutrient fertilizer from the viscous state to the less viscous state through the flow of water through the feeding device; and intermixing the viscous nutrient fertilizer with the water entering the feeding device whereby the water leaving the device to plants and soil will include a fertilizer.

A composition of matter comprising: a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi that is placed in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root; and a method for increasing plant yield comprising: placing a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root.

A navigation system includes at least one inertial sensor configured to detect motion of the system and generate inertial data; at least one aiding device configured to generate aiding device measurement data; at least one processing unit configured to generate an un-smoothed navigation solution inclusive of navigation state variable error resets based on the inertial data and the aiding device measurement data; wherein the at least one processing unit is further configured to sum the state variable error resets into a cumulative sum of the state variable error resets; wherein the at least one processing unit is further configured to high pass filter the cumulative sum of the state variable error resets; and wherein the at least one processing unit is further configured to subtract the high pass filtered cumulative sum of the state variable error resets from the un-smoothed navigation solution to generate a smoothed navigation solution.

A remotely controlled motile device system comprises a remotely controlled motile device, and a mobile smart device that comprises a data processor operatively connected to a display screen, a memory, a user input interface, a camera, and a wireless transceiver. The memory stores computer-readable instructions that, when executed by the data processor, cause the mobile smart device to capture images of an optical reference background and the remotely controlled motile device, present the images on the display screen, register a target position relative to the optical reference background and entered via the user input interface, determine a pose of the remotely controlled motile device relative to the optical reference background, and transmit commands to the remotely controlled motile device to move to the target position.

Techniques for navigating semi-autonomous mobile robots are described. A semi-autonomous mobile robot moves within an environment to complete a task. A navigation server communicates with the robot and provides the robot information. The robot includes a navigation map of the environment, interaction information, and a security level. To complete the task, the robot transmits a route reservation request to the navigation server, the route reservation request including a priority for the task, a timeslot, and a route. The navigation server grants the route reservation if the task priority is higher than the task priorities of conflicting route reservation requests from other robots. As the robot moves within the environment, the robot detects an object and attempts to classify the detected object as belonging to an object category. The robot retrieves an interaction profile for the object, and interacts with the object according to the retrieved interaction profile.

Described herein is an onboard vehicle system configured to capture vehicle information and notify an operator of the onboard vehicle system of potentially dangerous vehicles. In some embodiments, the onboard vehicle system may capture image information related to its surroundings. The image information may be processed to identify one or more vehicle identifiers associated with vehicles in the vicinity of the onboard system. The onboard system may provide vehicle identifiers to a service provider computer, which may subsequently query one or more driver behavior databases for anomalous behavior related to the vehicle identifiers. Upon detecting anomalous behavior for a target vehicle, the service provider computer may generate one or more notifications to be presented to the operator of the onboard system with regard to the target vehicle. In some embodiments, the onboard system may present the notification to the operator in an audio and/or visual format.

This application includes a number of embodiments of a spring powered toothbrush for cleaning teeth. A wind-up spring is located in the base of the toothbrush which spring provides power for a gear train including a drive shaft assembly that is designed to bring about rapid movement of the brush portion of the toothbrush to aid in cleaning the teeth. The drive mechanism is controlled by a spring biased push button in the toothbrush housing. In one version the brush portion of the toothbrush includes a rotatable brush section that is gear driven by the drive shaft. In another version the upper portion of the toothbrush is vibrated by an offset weight connected to the drive shaft and in a third version the drive shaft includes an offset weight that acts to oscillate a movable brush section by intermittent engagement between the; weight and brush section.

A mechanical rotational drive has a bar-like torsion element, whereby the torsion element is firmly clamped with a first end in a bearing device. The torsion element can be pivoted with a second free end with respect to the clamped end about the longitudinal axis, forming a rotation axis, of the torsion element between a relaxed position and a tensioned position, whereby the length of the torsion element is reduced with respect to the relaxed position when the torsion element is brought into its tensioned position. A device for transmitting a torque into the torsion element or out of the torsion element is provided in the area of the free end, and a damping device is arranged in the axial direction of the torsion element at a fixed distance from the bearing device and adjacent to the free end of the torsion element, and a damping part is provided on the torsion element in the area of the free end of the torsion element, which damping part in the relaxed position is in friction engagement with the damping device and which in the tensioned position is not engaged with the damping device.

A motor mounted on a structural support with a pivot at its center line which comprises a cylindrical vessel for holding a fluid in a closed system and in which a buoyant cylinder containing a lighter fluid is allowed to free float so that a cable attached to either end of the buoyant cylinder may be used to transfer energy to a energy storage unit, a crank or a generator. Two moment arms having a weight attached at the exterior end and inside attachably connected to the surface of two drive pistons that operate in pressure tanks which force a compressed gas against the pistons through pre-sequenced automatic activated valves to extend or retract the moment arms at the end of a cycle. The motor then becomes top heavy and rotates 180 degrees by gravity and relocks in place to repeat the cycle.

Disclosed is an apparatus and method for generating energy through oscillatory motion requiring little input. Oscillatory motion is generated using a substantially circular trough containing a liquid, inflatable bags positioned below the trough and a movable weight. The trough is pivotally connected to a central point about which it oscillates. Sustained oscillatory motion is encouraged by inflating and deflating the bags in coordination with the movable weight within the trough and a biased member upon which the bags reside. The oscillatory motion may be captured and transferred to rotary motion which may be used to drive a generator.

An inexpensive apparatus for powering a toy plane including a rubber band motor which is connectable to the plane's propeller and to a winding mechanism, including a gear mechanism which is activated by a handle. As the handle is repeatedly squeezed and released by the user, the motor is wound up. An anti-reversing ratchet is coupled with the motor to prevent unwinding until the user wishes to launch the plane.

A linear recliner assembly in use with a seat having a seat back pivotally engaged relative to a seat bottom. A housing exhibits a communicating interior between a first and second ends. A drive rod is supported in linearly displaceable fashion from the first end and is secured to the seat bottom. The second end pivotally engages the seatback spaced from its pivot point. A rotatable gear located at a fixed lineal position within the housing receives the drive rod in threadably inter-engaged fashion. A trigger mechanism pivotally secured to the housing exhibits a downwardly biased detent communicating through an opening in the housing to seat between succeeding teeth of the gear. A spring supported within the housing contacts the drive rod. Upon release of the detent, a reclining force applied to the seatback results in displacement of the housing against the drive rod to bias the spring. The spring influencing the drive rod in a reverse direction such that, upon release of said detent when the seatback is in the reclined position, the spring influences the seatback to reverse pivot to a returned upright position.

A drive mechanism for a device with two operating parts, which are connected so as to be pivotally displaceable relative to each other between a first position and a second position about a common axis of rotation. The drive mechanism has a driving mechanism such that a movement from the first position to the second position can be initiated initially by a slight movement and the additional movement is then effected automatically through spring force (F) until the second position has been reached. The movement out of the first position into the second position is possible in either a clockwise and counterclockwise movement. The driving mechanism comprises a driven part, one operating part and two drives that are in the form of a force storing device The force storing devices interact with the driven part in opposing directions in such a manner that only the one for storing device is in driving connection with the driven part while the other force storing device is retained in its starting position.

A device for generating rotational movement which includes an output shaft supported for rotational movement and at least two one-way clutch mechanisms attached to the output shaft. An inflatable piston (“infton”) assembly is associated with each one-way clutch mechanism and includes a weighted member, an inflatable bladder associated with the weighted member, at least one inlet valve associated with an interior of the inflatable bladder, at least one outlet valve associated with the interior of the inflatable bladder, and a chain associated with the weighted member and extending over and drivingly engaging the respective one-way clutch mechanism. A source of filling fluid supplies each inlet valve. The filling fluid has a density less than that of a buoyancy fluid surrounding the infton assembly. A control system is configured to control the inlet and outlet valves to facilitate filling and discharging of the inflatable bladders.

A spring motor and drag brake for use in coverings for architectural openings.

A method for ascertaining a rotational speed parameter for determining a setpoint torque for driving a drivetrain. The drivetrain comprises a first and at least one second drive assembly for driving a hybrid vehicle. The first drive assembly can be coupled to the drivetrain by means of a clutch. The second drive assembly is mechanically coupled to the drivetrain. When the hybrid vehicle is being driven by means of at least the first drive assembly, the rotational speed parameter corresponds to the value of a shaft rotational speed. When the hybrid vehicle is being driven only by means of the second drive assembly, the rotational speed parameter corresponds to the value of a determined rotational speed.

A linear recliner assembly in use with a seat having a seat back pivotally engaged relative to a seat bottom. A housing exhibits a communicating interior between a first and second ends. A drive rod is supported in linearly displaceable fashion from the first end and is secured to the seat bottom. The second end pivotally engages the seatback spaced from its pivot point. A rotatable gear located at a fixed lineal position within the housing receives the drive rod in threadably inter-engaged fashion. A trigger mechanism pivotally secured to the housing exhibits a downwardly biased detent communicating through an opening in the housing to seat between succeeding teeth of the gear. A spring supported within the housing contacts the drive rod. Upon release of the detent, a reclining force applied to the seatback results in displacement of the housing against the drive rod to bias the spring. The spring influencing the drive rod in a reverse direction such that, upon release of said detent when the seatback is in the reclined position, the spring influences the seatback to reverse pivot to a returned upright position.

A method for printing a digitally-stored image on the surface of a cylindrical object comprises the steps of axially moving the object along a line of travel that is aligned with the object's long axis until it is underneath one or more printheads, each of which have a plurality of ink nozzles that may be arranged in one or more columns while simultaneously rotating the object with respect to the printheads and simultaneously causing a pre-determined number of nozzles to eject ink onto the surface of the object.

The invention provides a carry-on wheeled luggage (1) for photographic equipment that has an interior compartment (80) deep enough to accommodate a large article of photographic equipment such as at least a 400 mm 2.8 f-stop aperture telephoto lens.

A case for a portable electronic device such as cell phones, cameras, MP3 players and PDAs wherein said case includes material at the corners to provide protection to the electronic device. To reduce bulk at the corners and allow the material forming the case to conform with the contours of the device, the protection at the corners includes strips of material defining apertures there between. The apertures provide reduction in bulk and allow the case to conform to the corners of the device therein. Alternately, the protection at the corners can be provided by other structures co-molded into the corners of the cases. Such structures include material that is of a reduced thickness than other material used in the case, or structures that are formed to conform to the corners of the case. Such structures can be joined to the material forming the panels of the case by co-molding.

A protective cover for handbags and like objects is provided, which comprises a portable and self-contained storage pouch. The protective cover can be attached to the exterior of a handbag by various mechanisms and can comprise one or more carrying straps. The protective cover can be made from a durable, water resistant and germ resistant material capable of preventing dirt, moisture and harsh chemicals from reaching the handbag. This protective cover can also prevent germ contamination of the handbag or other surfaces by removing it from the handbag and washing it after use.

A protective bag, such as for a handbag, has configurable dimensions so that the protective bag can be conformed to the shape and size of the handbag. The width, depth, height and silhouette of the protective bag can be separately configured. The protective bag may have a rim that can be independently configured. Accessory pockets and removable carriers such as a shoulder strap or a pair of handles may be part of the protective bag.

The present invention employs a photoacoustic measuring apparatus including: a laser light source; a forming unit for forming a second light beam by dividing or deforming a laser light beam; an optical member for guiding the second light beam to the surface of a subject; a probe for obtaining a photoacoustic wave generated when the subject is irradiated with the second light beam; and a buffering member that contacts the surface of the subject and transmits light, wherein the optical member overlaps areas of the second light beam having a small light intensity on the surface of the subject, the probe and the optical member are positioned on an identical side of the buffering member relative to the subject, and the optical member refracts the second light beam such that the second light beam enters the subject through the buffering member while avoiding the probe.

A kiosk apparatus that may select for a person a recommended footcare product based on pressure measurements collected from pressures sensors or calculated biomechanical data estimates. Pressure measurements and calculated biomechanical data estimates may be used to determine if a foot is unshod on the pressure sensor and also group a person into a classified subgroup. The pressure measurement and calculated biomechanical data estimates may also be used to select a recommended footcare product.

Remotely readable valve position indicators and related methods are described. An example apparatus in accordance with the teachings of this disclosure includes a valve body, a valve stem and a fluid flow control apparatus coupled to the valve stem. The fluid flow control apparatus is longitudinally displaceable between a first position and a second position to control fluid flow through a flow aperture of the valve body. The apparatus also includes a valve position indicator including an identifier device coupled to the valve stem. In the first position, the wireless identifier device associated with a first value indicative of the first position of the fluid flow control apparatus. In the second position, the wireless identifier device associated with a second value indicative of the second position of the fluid flow control apparatus.

A vessel includes a hull and a deck, a substantially cylindrical rotor having a peripheral wall rotatable with respect to the deck around a longitudinal center line, the rotor being at a lower end connected to the deck and including an upper end plate, the rotor being mounted on the deck in such a manner that in an operational state the rotor is substantially vertically oriented and in an inoperational state the upper end plate is situated in the vicinity of the deck, the end plate extending transversely to the longitudinal center line, wherein the end plate is provided with movable edge segments that in the operational state of the rotor extend radially outwardly from the peripheral wall to an extended position and in the inoperational state of the rotor are moved to a retracted position that is situated closer to the peripheral wall than the extended position.

A boat protection device includes a boat fender having a cushion, a first attachment element and a second attachment element. The first attachment element has a first keyhole aperture. The first keyhole aperture has a first slot and a first passage contiguous with the first slot. The second attachment element has a second keyhole aperture. The second keyhole aperture has a second slot and a second passage contiguous with the second slot.

An equipment complex for deploying and recovering marine geophysical seismic or electric-survey bottom stations is mounted on a ship. The complex includes—a powered capstan, —rotatable turntables and rolls, —load-bearing units connected to the bottom stations by various fasten means and capable of winding onto the capstan and turntables, a work platform supporting a bottom station placed thereon, —an indicator for registration of the bottom stations' coordinates, mounted on the platform, —a limit switch mounted on the platform, switching ON when the bottom station is placed on the work platform, and OFF when it's removed therefrom providing for operation of the indicator. The complex may include floating buoys, damping loads, and halyards for deploying the stations. Methods for deploying and recovering the bottom stations using the equipment complex are described. Some recovering methods contemplate winding the load-bearing units onto the capstan, while switching the turntables for each subsequent load-bearing unit.

A vessel includes a hull, a propeller for propulsion of the vessel and at least one rotatable cylinder which in its operational state is vertically mounted on the vessel, the cylinder having a rigid outer surface, a motor drive for rotating the cylinder around a longitudinal axis and a displacement member for displacing the cylinder to an inoperational position, wherein the motor drive is situated inside the cylinder.

A boat protective extension platform apparatus for use in connection with watercraft lifting platforms is provided. The extension platform is preferably attached to the stern of a boat and serves to at least partially cover a gap created between the boat and the lifting platform when the lifting platform is in a lowered position. The extension platform can include a retractable screen that is removably attachable to the lifting platform such than when said screen is extended, the aforementioned gap is further covered, thus preventing items carried by passengers and crew from falling or rolling into said gap and being lost or damaged.

A hull robot is disclosed for operation on a surface of a hull of a vessel. The robot can include a drive subsystem onboard the robot for driving and maneuvering the robot about the hull. A sensor subsystem onboard the robot can sense an attachment state of the robot to the hull. The attachment state can include at least one of attached and detached. A signal generation subsystem onboard the robot can emit a distress signal when the attachment state is detached.

A rack of the type for circulating air interiorly for drying multiple pairs of boots and/or gloves, where the articles to be dried are sprayed with a liquid sterilizing agent while on the rack. The blower housing, manifold and hollow members of the rack have no exterior horizontal surfaces to prevent pooling of the sterilizing agent. In addition, drain holes are provided in the blower housing, rack tubes and manifold to prevent interior trapping of sterilizing agent or moisture from condensation. In one version intended for sterilizing with power connected, a conduit in the manifold drains any liquid in the blower housing directly into the rack tubes. Another lower cost version is intended for sterilizing after electrical power has been externally disconnected and has liquid/moisture drain holes in the blower housing. Either version may be wall mounted or arranged as portable free standing single or double sided rack drying systems.

Energy efficiencies are achieved in a dryer or washer/dryer by selectively varying temperature ranges, time periods, heater power levels, and air flow rates. Efficiency improvements on the order of 16% were obtained over typical constant power, constant temperature, timed drying cycles by varying one or more of these parameters. Efficiencies can also be improved by drawing air from alternative warm sources such as an attic or warm external environment, or by heat recovery from dryer exhaust passages.

A robot system according to one aspect of an embodiment includes a robot and an instructing module. The robot holds one of a plurality of feed materials used for processing a workpiece. The instructing module gives instructions to the robot, when the feed materials are used for processing the single workpiece, for an operation in which the feed material held last in the previous round of processing a workpiece is used first in the subsequent round of processing a workpiece.

A centrifugal pellet dryer with a self-cleaning rotor seal, replaceable wear plates, and a fluid powered dewatering tower is presented. The self-cleaning rotor seal includes a plurality of grooves that are structured to eject pellet debris that migrates into between the seal and the housing for the rotor. The replaceable wear plates are secured to the rotor at locations such that they contact pellets that are entering the rotor housing. The dewatering tower includes a helical augur that dewaters a pellet slurry and delivers partially dried pellets to the rotor housing.

A clothes dryer has a cabinet forming a drying chamber and a drying rack slidably mounted to the cabinet and movable between a retracted position where the drying rack is within the drying chamber and an extended position where the drying rack is exteriorly of the cabinet. A removable dividing panel is retained by the drying rack and divides the drying chamber into two horizontal and vertically extending drying chambers. A control system associated with the dryer has selectable modes to operate the divided drying chambers independently or concurrently as a single large drying chamber. A recycle system associated with the dryer permits recycling of heat air to increase drying efficiency.

A clothes treatment apparatus and a method for controlling a clothes treatment apparatus are provided. The clothes treatment apparatus may include a drying duct, a first blower fan located in the drying duct that circulates interior air within the drying duct, and a filter located in the drying duct. The method may include sensing clogging of the filter, and switching a flow of air passing through the filter from a first direction to an opposite second direction if clogging of the filter is sensed. The method may further include a washing cycle for washing clothes, and a drying cycle for drying the clothes. An implementation time of the washing cycle may be less than an implementation time of the drying cycle.

An expandable and collapsible enclosure is provided for a garment refreshing appliance. The appliance has at least either a top or a bottom rigid housing structure. The enclosure comprises a wall structure extending substantially an entire height of the enclosure. The wall structure is made of a flexible material. An opening is provided in the wall structure through which garments can be introduced into or removed from the enclosure. A zipper is attached at the opening to selectively open and close the opening. A snap attachment mechanism is located at either or both of the top and a bottom of the wall structure for securing the wall structure to the top and/or bottom rigid housing structures.

Vaporizable material is supported within a vessel to promote contact of an introduced gas with the vaporizable material, and produce a product gas including vaporized material. A heating element supplies heat to a wall of the vessel to heat vaporizable material disposed therein. The vessel may comprise an ampoule having a removable top. Multiple containers defining multiple material support surfaces may be stacked disposed within a vessel in thermal communication with the vessel. A tube may be disposed within the vessel and coupled to a gas inlet. Filters, flow meters, and level sensors may be further provided. Product gas resulting from contact of introduced gas with vaporized material may be delivered to atomic layer deposition (ALD) or similar process equipment. At least a portion of source material including a solid may be dissolved in a solvent, followed by removal of solvent to yield source material (e.g., a metal complex) disposed within the vaporizer.