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Low alloy steel for geothermal power generation turbine rotor, and low alloy material for geothermal power generation turbine rotor and method for manufacturing the same

A low alloy steel ingot contains from 0.15 to 0.30% of C, from 0.03 to 0.2% of Si, from 0.5 to 2.0% of Mn, from 0.1 to 1.3% of Ni, from 1.5 to 3.5% of Cr, from 0.1 to 1.0% of Mo, and more than 0.15 to 0.35% of V, and optionally Ni, with a balance being Fe and unavoidable impurities. Performing quality heat treatment including a quenching step and a tempering step to the low alloy steel ingot to obtain a material, which has a grain size number of from 3 to 7 and is free from pro-eutectoid ferrite in a metallographic structure thereof, and which has a tensile strength of from 760 to 860 MPa and a fracture appearance transition temperature of not higher than 40° C.




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Hot-rolled steel sheet and method for producing same

Provided is a hot-rolled steel sheet that has a chemical composition including, by mass %: C: 0.060% to 0.150%; Si: 0.15% to 0.70%; Mn: 1.00% to 1.90%; P: 0.10% or less; S: 0.010% or less; Al: 0.01% to 0.10%; N: 0.010% or less; Nb: 0.010% to 0.100%; and the balance including Fe and incidental impurities. The hot-rolled steel sheet has a microstructure containing ferrite of 18 μm or less in average grain size by a volume fraction of at least 75% and pearlite of at least 2 μm in average grain size by a volume fraction of at least 5%, the balance being low-temperature-induced phases, the pearlite having a mean free path of at least 5.0 μm.




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Theft-protection system and device, in particular for open pockets

A system and a device for anti-thief protection, especially for open pockets of trousers, bags and the like, includes a mobile protection strip element (1) to be applied on the pockets hooks (12). The aim is attained by superposing the strip (1) on the pocket (T) and blocking the strip (1) using a plurality of hooks (12) in the form of clips located in the lower part (5) of the strip (1), the strip (1) supported by support elements (G), located in the upper part (2) thereof, which insert or hook in the zone overlying the pocket (T) to be protected.




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Tablecloth retainer

A tablecloth retainer includes an elastic band having at least a primary thickness, a width, and a predesigned boundary, wherein the elastic band is stretched around the perimeter edge of a table top to retain a tablecloth, the predesigned boundary being smaller than a range of table top perimeters accommodating the band by virtue of elasticity of the band.




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Day motorcycle cover/blanket

An architecture is presented that provides a lightweight durable cover for a motorcycle or other two-wheeled vehicle that protects the seat, sides, and fuel tank portions of the vehicle when not in use. Friction and/or hook and loop fasteners hold the form fitting cover in place on the motorcycle. The cover may be rolled or folded for convenient storage after removed from the motorcycle.




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Theft protectable carrying bag in particular for portable computers

A carrying bag (10) with a shoulder-strap (22) and a zipper (14) with zipper-rider (16) for closing/opening the bag. The shoulder-strap (22) is provided with a loop (24) at one end and a key-operated locking device (26) at the other end thereof. Means (36) are provided for fastening the loop (24) to an inside wall of the bag. Means (48) are provided for securing the zipper-rider (16) by the locking device (26) to an outside wall of the bag (10) for preventing the un-zipping of the bag.




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Backpack and protective cover for bicycle

A durable yet flexible protective bicycle cover is disclosed. The protective cover having properties of insulation from damage, wear, elements, dust and dirt, and the like. The protective cover further includes means for carrying a bicycle while within the cover, means for pushing a bicycle while within the cover, means for lifting a bicycle to and from a motor vehicle while within the cover, and means for transforming the cover into a backpack.




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Protective cover system for trailer

A protective cover system for a trailer is provided that includes a cover and a line. The line moves relative to the trailer for moving the cover from a lowered position to a raised position. A portion of the line may be located outboard from a side surface of the trailer in a lateral direction and may be located rearward of a front surface of the trailer in a longitudinal direction.




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Stowable motorcycle cover

A system for storing a cover for a motorcycle comprises a storage case mounted to a motorcycle, wherein the storage case includes a main housing and a lid, and a storage pouch defining an inner cavity and at least one opening, wherein the storage pouch is configured to be mounted to the lid of the storage case. The system further comprises a cover that is stowable in the inner cavity of the storage pouch in a stowed mode of operation and configured to extend around at least a portion of the motorcycle in a deployed mode of operation, a mounting bracket mountable to an inner surface of the lid of the storage case, and a retaining member including a first portion mountable to the mounting bracket and a second portion mountable to the main housing of the storage case.




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Motion greeting cards

The present invention and related disclosure describes greeting cards with moving elements or devices which are operable to create motion in connection with some portion of the greeting card. The greeting card may include a multi-panel greeting card body or a three-dimensional foam greeting card body. At least one movable object is contained upon or within the greeting card body. A sound module having at least one pre-recorded digital audio file saved therein and a motor module are contained and concealed within the greeting card body. One or more switches may be used to activate the sound and motor modules, causing the pre-recorded audio file to play and causing movement of the movable or mobile object.




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Apparatus to support portable electronic devices and other devices or objects

An apparatus to support a device includes a first base; a first support; a first base-support hinge adapted to rotatably couple the first base and the first support along a first axis of rotation; a first swivel slidably connected to the first support and having a first cut-out adapted to receive a first portion of the device; a second base; a second support; a second base-support hinge adapted to rotatably couple the second base and the second support along a second axis of rotation; and a second swivel slidably connected to the second support and having a second cut-out adapted to receive a second portion of the device spaced apart from the first portion of the device.




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Water lamp with rotary structure

A water lamp comprises a main body, a rotary unit, and a base. The main body includes a transparent housing and a transparent bottom plate. The transparent housing is filled with slightly-viscous flowable liquid and sealed by the transparent bottom plate. The rotary unit is located within the transparent housing and includes an aesthetic object, a fixing block, a passive disk, and a central part. The passive disk is rotatably fitted over the central part and provided with a magnet. The base is provided with a lighting component, an active disk having one magnet corresponding to the magnet of the passive disk, and a driving device. The lighting component can emit light into the transparent housing. The driving device can rotate the active disk, which in turn can rotate the passive disk by using mutual attraction between the magnet of the active disk and the magnet of the passive disk.




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Side edge cleaning methods and apparatus for thin film photovoltaic devices

Methods for cleaning a side edge of a thin film photovoltaic substrate utilizing a laser are provided. The method can include transporting the substrate in a machine direction to move the substrate past a first laser source, and focusing a first laser beam generated by the first laser source onto the side edge of the substrate such that the laser beam removes the thin film present on the side edge of the substrate. An apparatus is also generally provided for cleaning a first side edge and a second side edge of a thin film photovoltaic substrate.




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Fluid screen for pot and pan washing machine

A fluid screen for a washing machine, and a washing machine including a fluid screen, is provided. The fluid screen includes a generally planar member including a first end and a second end extending from the first end. The first end is mounted within the wash tank of the washing machine at a location generally in proximity to an operating fluid level within the wash tank. During operation of the washing machine, fluid circulates within the wash tank to create a rolling wash action and the second end of the fluid screen extends from the first end generally in the direction of fluid flow across the surface of the wash tank.




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Domestic appliance having a surface which comprises a photocatalyst

A domestic appliance includes at least one component having a surface that can become laden with organic dirt. The surface includes a photocatalyst and is made from a primary-formed first material in which the photocatalyst is dispersed. A photoradiation source is provided for irradiating the photocatalyst with an activating electromagnetic radiation.




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High molecular weight polyacrylates for aluminum protection in warewash applications

A warewashing detergent composition is provided for use for in cleaning of alkaline sensitive metals such as aluminum or aluminum containing alloys. The compositions include alternatives to sodium tripolyphosphate and/or other phosphorous containing raw materials, while retaining cleaning performance and corrosion prevention. According to the invention, high molecular weight polyacrylates (polyacrylic acid homopolymers) with a molecular weight of at least about 5000 are used as corrosion inhibitors and can be included for aluminum protection in a number of different detergent compositions.




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Dishwasher comprising at least one rotatable spray arm

A dishwasher includes a dishwashing compartment and a rack provided in the dishwashing compartment for holding items to be cleaned. A rotatable spray arm is associated with the rack for applying water or wash liquor liquid upon the items. Water or wash liquor liquid is supplied to the spray arm via an upright supply tube having at least one region which flares in a direction of the spray arm and a peripheral terminal end facing the spray arm. The terminal end of the supply tube is configured to project into the cavity and thereby is extended into the spray arm.




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Rotary dresser

A rotary dresser is provided with a roll having an outer circumferential surface which includes an arc portion or inclined portion differing in diameter in dependence on the axial position thereof, and a plurality of diamond abrasive grains embedded on the outer circumferential surface of the roll. The number of the diamond abrasive grains in the circumferential direction is fixed even at any axial position on the outer circumferential surface of the roll.




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Slot wear indicator for a grinding tool

Wear indicators for abrasive articles are presented. Specifically, indicator marks that are parallel to a bonding edge of a grinding element are presented. Tools comprising a carrier element and one or more grinding elements comprising one or more indicators are also presented.




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Protective cover for a handheld power tool

A protective cover for a handheld power tool, with a tool that is at least partially surrounded by the protective cover, is formed of at least a first wall element and a second wall element, which in order to form a tool space are connected to each other in a parallel-spaced arrangement. The first wall element has a first circumferential section and the second wall element has a second circumferential section. The circumferential sections overlap each other and form a circumferential wall of the protective cover, with at least one opening which is provided in the outer-lying second circumferential section and under which the inner-lying first circumferential section extends.




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Motorized cutter, motorized cutter with wheels, and cutting method

The motorized cutter with wheels (10) comprises a motorized cutter (20) and a carriage (30). The motorized cutter (20) is equipped with an engine (24), a blade (22) rotatably driven by the engine (24), and a light-emitting unit (50) that generates laser light (52) in the same plane as the plane of rotation of the blade (22). A roadbed (90) is then cut along a line (X) drawn on the roadbed (90) by operating the motorized cutter with wheels (10) so that the line (X) is irradiated with the laser light (52). It is possible to remove the motorized cutter (20) from the carriage (30) together with the light-emitting unit (50).




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Method for shaping and slicing ingots using an aqueous phosphate solution

A method for slicing a workpiece into wafers in which a polyphosphate solution is applied to the workpiece during the slicing process. The method comprises the steps of positioning the workpiece, such as a silicon ingot, in the vicinity of a wire saw that can cut through the workpiece without the use of an abrasive slurry; causing an aqueous polyphosphate solution to contact the workpiece; and causing the wire saw to cut into the workpiece while the polyphosphate solution is in contact with the workpiece. After the workpiece has been cut into wafers, the polyphosphate solution is rinsed off of the wafers. Preferably, the wire saw used in this method is a diamond wire saw.




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Systems and methods for connecting an ingot to a wire saw

Systems and methods are disclosed for connecting an ingot to a wire saw with an ingot holder, a bond beam, and a bar. The bar has an angled mating surface that engages a recessed surface formed in a slot of the bond beam. Mechanical fasteners are used to connect the tee bar to the ingot holder. The angle of the mating surface with respect to the recessed surface of the slot prevents deformation of the bond beam and prevents compromising the integrity of the adhesive bond between the ingot and the bond beam.




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Method for manufacturing titanium ingot

The present invention is a method for manufacturing a titanium ingot (30), the method being characterized by comprising: a step of melting a titanium alloy for a predetermined time by cold crucible induction melting (CCIM); a step of supplying molten titanium (6) to a cold hearth (10), and separating high density inclusions (HDIs) (8) by precipitation in the cold hearth (10) while spraying a plasma jet or an electron beam onto the bath surface of the molten titanium (6); and a step of supplying a molten titanium starting material from which the HDIs (8) are separated by precipitation to a mold (20) to obtain the titanium ingot.




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Metal alloy injection molding protrusions

Metal alloy injection molding techniques are described. In one or more implementations, these techniques may also include adjustment of injection pressure, configuration of runners, and/or use of vacuum pressure, and so on to encourage flow of the metal alloy through a mold. Techniques are also described that utilize protrusions to counteract thermal expansion and subsequent contraction of the metal alloy upon cooling. Further, techniques are described in which a radius of edges of a feature is configured to encourage flow and reduce voids. A variety of other techniques are also described herein.




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Method of producing ingot with variable composition using planar solidification

Molten metal of a first composition is fed into a mold cavity, via a first control apparatus, wherein the control apparatus is open, wherein the feeding includes at least flowing out of a first feed chamber. The first control apparatus is closed. A second control apparatus is opened. Molten metal of a second composition is fed into the mold cavity, via the second control apparatus, wherein at least a portion of the metal of the first composition in the mold cavity is sufficiently molten so that an initial feed of molten metal of the second composition mixes with the molten metal of the first composition in the mold cavity, wherein the feeding includes at least flowing out of a second feed chamber, wherein the second composition is different from the first composition. An ingot is removed from the mold cavity, wherein the ingot as a top section, a middle section, and a bottom section, wherein the bottom section is composed of metal of the first composition, wherein the top section is composed of metal of the second composition, wherein the middle section is composed of a mixture of metal of the first composition and the second composition.




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Non-electroslag remelting type clean metal ingot mold

A non-electroslag remelting type clean metal ingot mold includes an ingot mold body and a insulating riser arranged on the ingot mold body; an insulated heating and heat preservation device is vertically arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units; and the cavity units are distributed in two rows in the ingot mold body. Because the insulated heating and heat preservation device is arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units, most of impurities and segregates in liquid metals are enriched in the part in contact with the isolation and heat insulation mechanism during the directional solidification and crystallization of the liquid metals and the enriched alloy segregates, and the impurities can be easily eliminated by utilizing flame or other processing methods.




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Clean metal ingot mold

A clean metal ingot mold comprises an ingot mold body and an insulating riser arranged on the ingot mold body. The bottom mold plate of the ingot mold is provided with at least a ridge connected thereto. The region having a V-shape containing impurities produced during the crystallization process of the liquid metal moves upwards because of the ridge, and then the impurities depart from the center of the cast ingot and the impurities are more centralized. A water-cooling device is arranged in the ridge to allow the temperature of the metal in the ingot mold to decrease rapidly, and the crystallization process of the metal to be rapid.




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Production of die cast rotors with copper bars for electric motors

A rotor core for an electric motor includes a stack of laminations having peripherally spaced openings receiving copper bars with opposite end portions projecting from the stack. The core is mounted on an arbor and is inserted into a mold on a vertical die cast press having a shot chamber. The mold has upper and lower mold members defining annular cavities receiving end portions of the bars. Molten copper or aluminum is poured into the shot chamber and forced upwardly by a shot piston through passages in the lower mold member and into the cavity around the lower end portions of the bars. The pressurized molten metal solidifies and shrinks around the bar end portions to form an endring for the rotor. The core, endring and arbor are inverted and confined in the mold, and the casting steps are repeated to form the opposite endring.




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Bituminous froth inline steam injection processing

An inline bitumen froth steam heater system including steam injection and static mixing devices is provided. The system heats and de-aerates input bitumen froth without creating downstream processing problems with the bitumen froth such as emulsification or live steam entrainment. The system is a multistage unit that injects and thoroughly mixes steam with bitumen resulting in output bitumen material having temperature of about 190° F. The system conditions a superheated steam supply to obtain saturated steam at about 300° F. The saturated steam is contacted with bitumen froth flow and mixed in a static mixer stage. The static mixers provide surface area and rotating action that allows the injected steam to condense and transfer its heat to the bitumen froth. The mixing action and increase in temperature of the bitumen froth results in reduction in bitumen viscosity and allows the release of entrapped air from the bitumen froth.




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Optimizing feed mixer performance in a paraffinic froth treatment process

The invention relates to improved bitumen recovery processes and systems. One process provides for operation of a bitumen froth treatment plant at optimum shear rates in the feed pipe carrying the bitumen froth to the froth settling unit. Another process provides for optimizing the design of a bitumen froth treatment plant by optimizing the diameter of the feed pipe to impart an optimum shear rate to the bitumen froth mixture and further optimizing the volume of the feed pipe to impart an optimum residence time for the bitumen froth stream in the feed pipe. An optimal plant design is also disclosed, the plant including optimal diameter and volume of the feed pipe.




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Rotary sinker, knitting machine, and stitch forming method

A rotary sinker enabling stitch formation by a knitting machine using a rotor for forming a stitch, a knitting machine including the rotary sinker, and a stitch forming method are provided. The ring sinkers as rotating bodies are capable of rotating about a rotation axis independently of each other. The rotation times of the ring sinkers are set to be different from each other. Thus, the rotation times are adjusted to be different between the ring sinker that holds an old loop and the ring sinker that holds a new loop. Adjustment of the rotation times prevents application of a large tension to the knitting yarn made of low stretch fiber, and a stitch can be formed even with a knitting yarn made of non-stretch or low-stretch fiber.




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Knitted component for an article of footwear including a full monofilament upper

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




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Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




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Article of footwear including a monofilament knit element with a fusible strand

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.




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Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




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Turkey fryer with complete splatter protection

A fryer for deep frying a turkey has an outer cooking pot for containing hot oil. A splatter sleeve is telescopically slidable into the pot, the sleeve having a surrounding side wall, an open top surrounded by a top sleeve rim and an open bottom surrounded by a bottom sleeve rim. A lid is sealingly seatable upon the top sleeve rim and has a lid hole. A lid latch latches the lid to the top sleeve rim. A turkey support has a turkey support base, extends upwardly from the base to a handle top end and is insertable through the hole in the lid. When these components and a turkey are assembled, suspended from the handle and lowered into hot cooking oil, the sleeve is sufficiently long that it enters the oil before the turkey thereby assuring a complete splatter barrier.




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Hot-and-cold serving station

A serving station includes a first well and a second well. The wells configured for receiving food pans. The serving station further includes an active cooling system and an active heating system. The active cooling system is configured to independently lower the temperature of either or both of the first and second wells, and the active heating system is configured to independently raise the temperature of either or both of the first and second wells. Both wells may be heated, both wells may be cooled, or one of the first and second wells may be heated while the other is cooled.




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Froth wand for espresso maker

The present invention is a froth wand for an espresso machine that can generate a high velocity stream of steam to foam a beverage at the beverage brewing apparatus. The wand includes an adapter for attaching to the beverage brewing machine at a steam supply outlet, and a conduit for communicating the steam to a steam tube. The steam tube has a cylindrical body with an annular recessed exit, and is surrounded by a cylindrical sheath. The sheath includes a cylindrical plug with a small longitudinal aperture that fits into the outlet of the steam tube. The mating of the sheath's plug and the steam tube forces the steam through the aperture, accelerating the steam at the exit.




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Apparatus and method for preparing ingredients for a baby bottle

An apparatus for preparing infant formula to be supplied to a bottle, and methods and circuits for operating the same, are disclosed. The apparatus includes a housing having a shape for integrating together components of the apparatus. A fluid reservoir for holding fluid and configured to be coupling to the housing is provided. Further provided is a formula disc disposed at a first location of the housing. The first location defined above a dispense location of the bottle, and the formula disc having a top end and a dispense end, the formula disc further includes a plurality of slots for holding the infant formula in a powder state. The apparatus has an end plate that is coupled to the dispense end of the formula disc, and the end plate has a dispense hole, such that the end plate is rotatable relative to the formula disc.




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Bottle top liquid aerator

A bottle aerator of the type having a venturi tube having a constricted section with a narrower cross-sectional section and a fluid inlet section having a wider cross-sectional section, such that the fluid pressure is lower in the constricted section compared to the pressure in the fluid inlet section, and the fluid speed is higher in the constricted section compared to the fluid speed in the fluid inlet section, which is improved by the constricted section being constructed and arranged so that when the bottle aerator is inserted into a bottle, the constricted section is positioned inside the bottle. The air inlet is provided at or below the constricted section, which allows air from outside the bottle to mix with the fluid as it passes through the constricted section, so that the fluid is aerated while still inside the bottle.




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Coffee machine comprising a frothing device and means for cleaning the frothing device and a milk suction line and process for rinsing the milk suction line

A coffee machine comprises a frothing device, wherein an internal milk channel leading to a frothing chamber is provided into which opens a bypass air inlet for operable air supply to the frothing device. A flexible milk suction line connects the frothing device with a milk supply container. Means are provided for cleaning the frothing device and the milk suction line with rinsing water from a continuous-flow water heater of the coffee machine. A controlled valve arrangement is provided which feeds rinsing water from the continuous-flow water heater to the bypass air inlet of the frothing device. A milk suction end of the milk suction line is directly or indirectly, fluid-conductively connectable with a residual water pan of the coffee machine prior to feeding rinsing water to the bypass air inlet.




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FACTOR H BINDING PROTEIN VARIANTS AND METHODS OF USE THEREOF

Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.




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IMMUNOPOTENTIATOR CONTAINING ANTI-ANG2 ANTIBODY

Provided is a method of potentiating immunity or preventing or treating an immune-related disease comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof to a subject in need thereof.




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Immunological Targeting of Pathological Tau Proteins

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.




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NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.




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Human Antigen Binding Proteins That Bind To a Complex Comprising beta-Klotho and an FGF Receptor

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.




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CD123 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.




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BCMA (CD269) SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.




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METHOD OF DETECTING HUMAN MATRIX METALLOPROTEINASE 9 USING ANTIBODIES

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).