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Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05499G, Edge Article
Open Access
Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. Burkart
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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Morphology of Lithium Halides in Tetrahydrofuran from Molecular Dynamics with Machine Learning Potentials

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04957H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marinella de Giovanetti, Sondre H. Hopen Eliasson, Sigbjørn L. Bore, Odile Eisenstein, Michele Cascella
The preferred structures of lithium halides (LiX, with X = Cl, Br, I) in organic solvents have been the subject of a wide scientific debate, and a large variety of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Should you invest in ICICI Prudential Credit Risk Fund?

Credit risk funds, which invest at least 65 per cent of their portfolio in corporate bonds rated AA or below, offer a shot at high accrual returns




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ICICI Prudential Flexicap Fund: A steady outperformer for the long term

ICICI Prudential Flexicap’s performance over the past three years places it in the top-quartile of its category




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Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide

Lab Chip, 2024, 24,4989-4997
DOI: 10.1039/D4LC00715H, Paper
Hanjia Zheng, Fatemeh Keyvani, Sadegh Sadeghzadeh, Dragos F. Mantaila, Fasih A. Rahman, Joe Quadrilatero, Mahla Poudineh
A simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Inertial co-focusing of heterogeneous particles in hybrid microfluidic channels with constantly variable cross-sections

Lab Chip, 2024, 24,5032-5042
DOI: 10.1039/D4LC00479E, Paper
Tianwei Zhao, Peng Zeng, Yuanting Zhang, Jinxia Li, Hui Sun, Imrich Gablech, Honglong Chang, Xichen Yuan, Pavel Neužil, Jianguo Feng
Inertial focusing chips based on hybrid microfluidic channels were presented for high-efficiency heterogeneous particle co-focusing, offering significant applications in microfluidic flow cytometry and single-cell analysis.
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Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition

Lab Chip, 2024, 24,4940-4947
DOI: 10.1039/D4LC00414K, Tutorial Review
Stacey Bacheller, Malancha Gupta
Paper-based microfluidic devices offer a low-cost platform for biological and environmental detection. This tutorial review shows that initiated chemical vapor deposition can be used to modify these devices with functional polymers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Seaplanes have potential to woo high-budget tourists to Kerala: Biju Prabhakar

Aviation Secretary says these amphibious aircraft can link tourism locales in the State. A seaplane will operate a trial service from Kochi International Marina to the Mattupetty dam in Munnar on Monday




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Action initiated against units lacking sewage treatment facilities, Environment dept. tells NGT




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Supernatural, Jade and Celestial catch the eye




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Immunotherapy approach shows potential in some people with metastatic solid tumors

A new cellular immunotherapy approach shrank tumors in 3 of 7 patients with metastatic colon cancer, in a small NCI clinical trial. Normal white blood cells from each patient were genetically engineered to produce receptors that recognize and attack their specific cancer cells.




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Egyptians exhume the dead as city development takes over cemeteries in Cairo

Since 2020, thousands of graves have been demolished at the UNESCO-listed World Heritage Site




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A.P. universities undertake novel initiative to introduce students to natural farming

Sri Venkateswara University and Sri Padmavati Mahila Viswa Vidyalayam establish organic vegetable gardens at their respective premises, where vegetables like brinjal, chilli, tomato and lady’s finger, roots like carrot, beetroot, and radish are planted




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The World War I databook : the essential facts and figures for all the combatants / John Ellis & Michael Cox

London : Aurum, 2001




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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
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Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




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Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




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Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
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Introduction to the themed collection in honour of Professor Christian Leumann

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90039A, Editorial
Marcel Hollenstein, Eugen Stulz
Marcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry




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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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Investing in companies with ‘indicorn’ potential

Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years




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IIT Delhi’s annual Open House shows AI’s potential use in health care, tech




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Pranab’s Presidential years

A matter-of-fact, yet reflective, memoir of a veteran politician




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Demand for petrol cars hits Tiago




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Markets give up initial gains dragged by sharp fall in Kotak Bank, unabated foreign fund outflows

Equity markets open strong but later decline; HDFC Bank gains, Kotak Mahindra Bank falls, global markets mixed




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Police women under the ‘Police Akka’ initiative, to reach out to schoolgirls in Pudukottai district

Policewomen nominated under this initiative will visit schools and colleges every 15 days to ascertain concerns and grievances of students and render assistance




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Deputy Chief Minister launches initiatives to support start-up ecosystem in T.N.

He also presents sanction letters for pre-incubation centres, which aim to support innovative business ideas in their initial stages




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Long range signature of liquid's inertia in nanoscale drainage flows

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01006J, Paper
Nathan Bigan, Mathieu Lizée, Marc Pascual, Antoine Niguès, Lydéric Bocquet, Alessandro Siria
In confinement, liquid flows are governed by a complex interplay of molecular, viscous and elastic forces.
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Chemo-mechanical model of cell polarization initiated by structural polarity

Soft Matter, 2024, 20,8407-8419
DOI: 10.1039/D4SM00800F, Paper
Hexiang Wang, Zhimeng Jia, Yuqiang Fang
We establish a multiscale model of a cell to explore the chemomechanical mechanisms of cell polarization initiated by structural polarity. The two-dimensional vertex model is built by coupling the cytoskeletal reorganization and the Cdc42 activation.
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Active nematic coherence probed under spatial patterns of distributed activity

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00651H, Paper
Ignasi Vélez Cerón, Jordi Ignes-Mullol, Francesc Sagues
A photoresponsive variant of the paradigmatic active nematic fluid made of microtubules and powered by kinesin motors is studied in the conventional two-dimensional interfaced form when forced under blue-light illumination....
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Editorial. Overall rain surplus but spatial, temporal spread concerning

While the IMD has strived to improve its predictive models, global warming is the wild card factor




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ICICI Prudential Multi asset completes 22 years

A lump sum investment of ₹10 lakh at the time of inception in October 31, 2002 will be worth about ₹7.26 crore given compounded annual growth rate of 22 per cent



  • Money & Banking

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IG orders departmental inquiry into ‘preferential treatment’ to Borugadda Anil Kumar

The events came to light after a video clip went viral on social media on Saturday, in which police can be seen offering him a table, bed sheet and allowing him to sleep outside the lock up, but within the station




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Good potential for cosmetic, textile, food processing sectors in Andhra Pradesh: South Korean diplomat

South Koreans are familiar with Andhra Pradesh and since Kia Motors is here, more Korean companies may wish to come too, says Sangwoo Lim




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Essential business priorities in a changing world

In advanced and emerging economies, inclusive growth and development can become a reality if there is a focus on key policy actions that have been identified




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Karnataka’s untapped tourism potential

The State has not capitalised on its rich cultural, religious, and natural heritage




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What is clicking on the U.S. presidential campaign trail

Kamala Harris’s campaign is leveraged on a diminishing statistic while Donald Trump’s is the opposite




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The essential skill of ‘media and information literacy’

The complex digital environment poses governance challenges, making it important to create an ‘Internet of Trust’ for a safe digital world




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Probability and partial differential equations in modern applied mathematics [electronic resource] / Edward C. Waymire, Jinqiao Duan, editors

New York : Springer, [2005]




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On the RiseUp4Peace initiative by the UNODC

This initiative works towards educating children about current social problems and creating a just and inclusive society




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Aurobindo Pharma Q2 net rises 8.6% year-on-year to ₹816.9 crore, declines 11% sequentially on higher revenue




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As its industry struggles, Germany services sector offers untapped growth potential




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‘Mem Famous’ movie review: Sumanth Prabhas makes a promising debut in this partially engaging coming-of-age story

Newcomers led by Sumanth Prabhas get the carefree rural Telangana vibe right in the Telugu film ‘Mem Famous’, which shines in a few segments but falls short of being a roller coaster fun ride




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Bengaluru residential property micromarkets witness record hike in prices: Report

Prices in Bagaluru in North Bengaluru have surged by nearly 90 per cent in the past five years, while Whitefield has seen an 80 per cent rise in prices




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Godrej Properties wins ₹515 crore bid for two residential plots in Gurugram

The company also won auctions for two land parcels in Greater Noida in the current quarter