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25YT_DRAWINGS FROM INDIA part I




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25YT_DRAWINGS FROM INDIA part II




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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00177J, Paper
Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
Synthesis of a series of new donor–acceptor dyes based on 2-pyridone and the study of the effect of the position of the donor group, the type of π-linker and the acid–base characteristics of the medium on their photophysical properties.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Copper-catalyzed ortho-thiocyanation of aromatic amines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00137K, Communication
Monak Patel, Nitish Kumar, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
Here, we described an efficient ortho- C(sp2)-H thiocyanation of anilines for the synthesis of aryl thiocyanates. This protocol tolerates a variety of aromatic amines to provide the desired products in good to excellent yields.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00472H, Communication
Wen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang Xu
A diaminodiacid (DADA) containing an amide bond can be used in Fmoc solid-phase peptide synthesis (SPPS) of an Asp-based lactam cyclic peptide with no aspartimide formation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Hydrosilylation of nitriles and tertiary amides using a zinc precursor

Org. Biomol. Chem., 2024, 22,3053-3058
DOI: 10.1039/D4OB00161C, Paper
Ravi Kumar, Rohan Kumar Meher, Himadri Karmakar, Tarun K. Panda
A competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by zinc bis(hexamethyldisilazide) [Zn(HMDS)2] under solvent-free and mild conditions are reported, as a sustainable and desirable alternative to existing methods.
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Albumin–ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group

Org. Biomol. Chem., 2024, 22,2992-3000
DOI: 10.1039/D4OB00234B, Paper
Kimberly S. Taylor, Madison M. McMonagle, Schaelee C. Guy, Ariana M. Human-McKinnon, Shumpei Asamizu, Heidi J. Fletcher, Bradley W. Davis, Takashi L. Suyama
An organo–ruthenium catalyst conjugated to albumin efficiently unmasks an alloc group under physiologically relevant conditions.
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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Additive-free oxychlorination of unsaturated C–C bonds with tert-butyl hypochlorite and water

Org. Biomol. Chem., 2024, 22,3080-3085
DOI: 10.1039/D4OB00003J, Paper
Duyi Shen, Chaoyue Sun, Yun Han, Zhen Luo, Ting Ren, Qin Zhang, Wenting Huang, Jianru Xie, Ying Jia, Mianran Chao
A facile oxychlorination of various alkynes and alkenes with tBuOCl as an alternative chlorine source and H2O as a green oxygen source.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00240G, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. Falconer
Herein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.
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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
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Built-in Browser Support for Responsive Images

Take advantage of the new element and new features of in your next responsive website.




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Getting Started with CSS Shapes: Wrapping content around custom paths

Using CSS Shapes we can create experiences that we have never been able to create on the web before.




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The Hobbit Experience 2014: Adding WebRTC gameplay to the Hobbit Experience

Learn how North Kingdom built an immersive multimedia experience optimized for modern mobile browsers using Web RTC




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Rolling out Public Key Pinning with HPKP Reporting




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Walking through a new airport experience

Automation and biometrics will be the norm rather than the exception at leading airports in the pandemic world




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India ahead in tech to make airports safer

Airports are also keeping pace to ensure safe, touchless and seamless journeys




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Greenfield airports on a slippery runway

The success of these new airports is contingent on the ability to attract international traffic




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Start-up founders onboard pvt jets

JetSetGo in talks with VCs, PEs to raise additional $50 million




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As India builds its newest airports, it needs robust, fail-proof SOPs

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh




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Short-haul flights redefining air travel

 While the growth of international flights remains muted, demand for narrow-bodied aircraft witnesses a renewed surge 




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The art of avoiding accidents in air

Flying distance may vary based on flight phases, altitudes and regions




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




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OpenAI chair's AI startup Sierra gets $4.5 billion valuation in latest funding round

One-year-old Sierra focuses on selling artificial intelligence-powered customer service chatbots to enterprises




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Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




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Elon Musk's xAI in talks to raise funding valuing it at $40 billion: Report

Earlier in October, OpenAI raised $6.6 billion in funding from investors which could value the company at $157 billion




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ChatGPT will now work as a search engine as OpenAI partners with some news outlets

OpenAI is launching a ChatGPT-powered search engine that could put the artificial intelligence company in direct competition with search giant Google




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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




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Amazon won’t release new Alexa until 2025: Report

Until sometime ago, users were able to access the beta version of Alexa using an Echo but that has been cut off now




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Karnataka government plans to start 11 medical colleges under contentious PPP model

As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts




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WHO certifies Egypt as malaria-free; calls it ‘historic feat’ ending ancient scourge

Globally, 44 countries and one territory have now been certified as malaria-free




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Roll back approval to import used medical devices, med-tech industry urges PM

The group said the move puts at risk patient safety and undermines the domestic med-tech sector. It said that refurbished machines are not subject to stringent quality checks applicable to new devices.




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COVID-19 resulted in nearly half a million excess deaths, WHO’s global TB report states

Thirty high TB burden countries accounted for 87% of the world’s TB cases in 2022 and two-thirds of the global total was in eight countries including India




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World Stroke Day: NIMHANS study finds that part of sleep apnoea burden is a consequence of stroke

Most patients with stroke are not evaluated for sleep apnea; this is an issue that needs to be addressed by the scientific community, doctors at NIMHANS, Bengaluru said




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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Malaria elimination: Egypt’s success and a roadmap for India’s WHO certification

India has made remarkable strides in reducing malaria, with reported cases dropping over the years; however, there is a long journey ahead, with climate change raising the potential for malaria transmission in areas that have already achieved elimination




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Wellness retreat that King Charles and Queen Camilla visited in Bengaluru to soon expand to Portugal 

King Charles III and Queen Camilla, who left the retreat after a three-day rejuvenation session, are happy with the expansion plans as this would be closer to the UK, says holistic health practitioner Issac Mathai, who runs the facility




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Third phase of polio vaccination campaign to resume in northern Gaza: WHO-UNICEF

“Despite the lack of access to all eligible children in northern Gaza, the Polio Technical Committee for Gaza has taken the decision to resume the campaign,” a joint statement by UNICEF and WHO said




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Bengaluru start-up strives to bridge India’s genomics data gap to aid precision oncology

The company, 4baseCare, has come up with a gene panel for the Indian population after extensive research. This, according to the founders, will allow doctors to provide more evidence-based and data-backed treatment for cancer patients in the country




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Osteoporosis can shorten your life − here’s how to prevent fractures and keep bones healthy

The key to having healthy bones for a lifetime is to take some simple preventive measures – and the earlier, the better




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National Task Force files interim report on safety measures for hospital staff

NTF report has suggested short term, medium, and long term measures to protect doctors and medical staff in their workplaces.




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Can mid-level healthcare providers compensate for physician shortages in rural India?

To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine 




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Severe staff shortage leaves Tamil Nadu’s obstetricians and gynaecologists overworked

Doctors are forced to take turns doing frequent 24-hour shifts — in some cases two to three 24-hour shifts a week. Inquiries with government OB-GYNs reveal that several health facilities have been short-staffed for years, and vacant posts remain unfilled




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'Rituraj was the life of the party'

'One day, just like that, without even saying goodbye, he was gone.'




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'Mission to abrogate Article 370 is...'

'I was emotional when the decision took place on August 5, 2019.''I made the film with clear intentions of projecting the truth.'




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'I've lost out on parts because...'

'People had a perception that I may be angry as a person.''Or I'm older than I really am.''Or I can't speak in English because of the characters I've done at the beginning of my career.'