Several women told local newspapers that Pennsylvania state board chair Larry Wittig pursued sexual relationships with them when they were teenagers.

Coronavirus is disrupting every facet of American life, including millions of students who will be out of school for several weeks.

[Edinburgh?] : [publisher not identified], 1840.

Birmingham : printed by M. Billing, 1847.

Mitau : G.A. Reyher, 1848.

Stuttgart : F. Enke, 1878.

Berlin : A. Hirschwald, 1870.

Berlin : J. Springer, 1897.

Berlin : J. Springer, 1894.

Jena : G. Fischer, 1893.

Leipzig : Vogel, 1904.

London : published by S.W. Fores, 1795.

In Tuesday night's Republican primary in West Virginia, Robert Karnes, a West Virginia Republican state senator who lashed out at teachers during their nine-day strike, lost to pro-labor candidate Bill Hamilton.

State Education Secretary Rebecca Holcombe has been officiating over the state's politically thorny district consolidation process, and many are asking for it to be placed on hold until the state board replaces her.

([Rome] : Raffaelle Jacomini impresse)

[London] : [Wellcome Trust], [2009]

London : European Collaborating Centres in Addiction Studies, 1998.

Didier Chételat, Martin T. Wells.

Source: The Annals of Statistics, Volume 47, Number 5, 2639--2670.

Abstract:
We study the behavior of a real $p$-dimensional Wishart random matrix with $n$ degrees of freedom when $n,p ightarrowinfty$ but $p/n ightarrow0$. We establish the existence of phase transitions when $p$ grows at the order $n^{(K+1)/(K+3)}$ for every $Kinmathbb{N}$, and derive expressions for approximating densities between every two phase transitions. To do this, we make use of a novel tool we call the $mathcal{F}$-conjugate of an absolutely continuous distribution, which is obtained from the Fourier transform of the square root of its density. In the case of the normalized Wishart distribution, this represents an extension of the $t$-distribution to the space of real symmetric matrices.

Integration software. Middleware is the term coined to describe software that connects other software together. In the early days of computing, each software system in an organization was a separate 'stovepipe' or 'silo' that stood alone and was dedicated to automating a specific part of the business or its IT operations. Middleware aims to connect those individual islands of automation, both within an enterprise and out to external systems (for example at customers and suppliers). For a long while, middleware has either been custom coded for individual projects or has come in the form of proprietary products or suites, most notably as enterprise application integration (EAI) software. The emergence of industry-agreed web services specifications is now enabling convergence on standards-based distributed middleware, which in theory should allow all systems to automatically connect together on demand.

Scott Marion, who consults states on testing, talks about why it's important for vendors and public officials to work cooperatively in renegotiating contracts amid assessment cancellations caused by COVID-19.

The post How States, Assessment Companies Can Work Together Amid Coronavirus Testing Cancellations appeared first on Market Brief.

ACT and the American Federation of Teachers are partnering to provide free resources as educators increasingly switch to distance learning amid the COVID-19 pandemic.

The post ACT and Teachers’ Union Partner to Provide Remote Learning Resources Amid Pandemic appeared first on Market Brief.

Boeing CEO Dave Calhoun said the company was aiming to resume production this month, despite the ongoing grounding and coronavirus pandemic.

The New York City police department (NYPD) is conducting an internal investigation into a May 2 incident involving the violent arrests of multiple people, allegedly members of a group who were not social distancing

Keep your feet comfy and your wallet fat.

WD Knowles
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Articles

Jozsef Csicsvari
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WT Newsome
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Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which mediate cell-to-cell inflammatory and trophic signaling, are thought be viable therapeutic targets. We recently showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of function after injury of the primary motor cortex, likely through enhancing plasticity in perilesional motor and premotor cortices. Here, using in vitro whole-cell patch-clamp recording and intracellular filling in acute slices of ventral premotor cortex (vPMC) from rhesus monkeys (Macaca mulatta) of either sex, we demonstrate that MSC-EVs reduce injury-related physiological and morphologic changes in perilesional layer 3 pyramidal neurons. At 14-16 weeks after injury, vPMC neurons from both vehicle- and EV-treated lesioned monkeys exhibited significant hyperexcitability and predominance of inhibitory synaptic currents, compared with neurons from nonlesioned control brains. However, compared with vehicle-treated monkeys, neurons from EV-treated monkeys showed lower firing rates, greater spike frequency adaptation, and excitatory:inhibitory ratio. Further, EV treatment was associated with greater apical dendritic branching complexity, spine density, and inhibition, indicative of enhanced dendritic plasticity and filtering of signals integrated at the soma. Importantly, the degree of EV-mediated reduction of injury-related pathology in vPMC was significantly correlated with measures of behavioral recovery. These data show that EV treatment dampens injury-related hyperexcitability and restores excitatory:inhibitory balance in vPMC, thereby normalizing activity within cortical networks for motor function.

SIGNIFICANCE STATEMENT Neuronal plasticity can facilitate recovery of function after cortical injury, but the underlying mechanisms and efficacy of therapeutic interventions promoting this plasticity in primates are not well understood. Our recent work has shown that intravenous infusions of mesenchymal-derived extracellular vesicles (EVs) that are involved in cell-to-cell inflammatory and trophic signaling can enhance recovery of motor function after injury in monkey primary motor cortex. This study shows that this EV-mediated enhancement of recovery is associated with amelioration of injury-related hyperexcitability and restoration of excitatory-inhibitory balance in perilesional ventral premotor cortex. These findings demonstrate the efficacy of mesenchymal EVs as a therapeutic to reduce injury-related pathologic changes in the physiology and structure of premotor pyramidal neurons and support recovery of function.

Built nearly 4,700 years ago as a tomb for the pharaoh Djoser, the structure underwent more than a decade of on-and-off restorations

Lead decontamination policies enacted in August are now in conflict with measures to prevent spread of COVID-19

The Library Street Collective's "We All Rise" coloring book features drawings by around 30 contemporary artists

Delaying the Games for a year is considered by many to be the best course of action for public health

Titles related to "home-life" subjects—like preserving and canning—have also experienced a boost in sales

The country has shut down its museums and archaeological sites in an effort to slow the spread of coronavirus

Illustrators are sharing artwork of Amabie, a spirit first popularized during the Edo period, on social media

The nearly 2,800-mile-long walking route runs all the way around the English coast

Stay-at-home orders have inspired those with ample free time to pick up hands-on projects

In April alone, the Sturminster Newton Mill ground more than one ton of wheat

In an official statement, the Institution announced temporary closures beginning Saturday, March 14

A newly discovered pyramid yields a baffling mystery: A royal tomb, usually reserved for kings, is found to contain a mystery woman. Who was she and why was she given such a great honor?

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Fifty thousand jobs were lost in Nova Scotia in April, reflecting the devastating economic impact of the first full month of public health orders to prevent the spread of COVID-19.

Soccer's international governing body says it will maintain funding for women's soccer despite concerns about the impact of the coronavirus pandemic.

Acclaimed jigger Ryan Richard, from Sandy Bay First Nation, is calling all dancers to showcase their skills in an online jigging competition.

Carving out a section of low-hanging basement ceiling was a small price to pay to give Travis Bondy the space he needed to play in the Isolation Dart League.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

McMaster University is planning for fewer international students, more deferred acceptance offers and online teaching for the thousands who are attending as the start of a new school year looms in the near future and in the middle of the COVID-19 pandemic.