China’s military may have been spared any coronavirus infections, but the global health crisis has slowed the progress of Chinese President Xi Jinping’s plan to transform the People’s Liberation Army into a modern fighting force capable of long-range power-projecting operations, experts say.According to China’s defence ministry, the world’s largest armed force – with about 2.3 million personnel – has had zero confirmed cases of Covid-19. In contrast, the US and Russian militaries, ranked second…

The United States has tightened visa rules for Chinese journalists as the tit-for-tat war on the media between the two sides escalated.The rules, which will take effect on Monday, limit visas for Chinese passport holders to 90 days with the option for an extension, the US Department for Homeland Security said on Friday.Journalists with passports from Hong Kong or Macau will not be affected.“The department is issuing this rule to address the actions of the PRC [People’s Republic of China]…

Many individuals with disabilities have been hard hit due to loss of income.

The International Criminal Court (ICC) on Tuesday highlighted crimes against humanity and grave mismanagement of the law in Libya during a release of their latest report on the North African nation.  Fatou Bensouda, Chief Prosecutor of the ICC, said enforced disappearances, arbitrary detentions, hate speech, and severe maltreatment of detainees remains a massive concern in […]

The post Enforced Disappearances, Arbitrary Detentions, Hate Speech & Attacks on Civilians – ICC Report on Libya appeared first on Inter Press Service.

ISLAMABAD: Senate Chairman Muhammad Sadiq Sanjrani Friday condoled the passing away of the mother of Senator Faisal Javed, who is also chairman of the Senate Standing Committee on Information and...

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PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province...

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Disaster-related displacement is often negative, but can result in more resilient communities under the right circumstances. This can include better management of remittances sent to family members in the disaster zone.

Here’s why the perception that skilled migration damages the source country is wrong.

Bài viết giải thích tại sao nhận thức cho rằng sự di cư của lao động có kỹ năng nghề làm tổn hại nguồn lực quốc gia là sai lầm.

India is one of the world’s most vulnerable countries to disasters and it has a lot to share when it comes to preparing for them.

Global supply chains link the welfare of disaster-hit companies and their surrounding communities to a network of corporations that have an economic incentive to help them bounce back. 

Simmering trade disputes are decreasing the beneficial effects of free trade and could in the long-term damage the rules-based order upon which global commerce is based.

The cost of disasters far outweighs the resources available for recovery. Microfinance could be one way to fill the funding gap.  

Governments in the region need to invest more in prevention and response to the long-term impacts of disaster displacement.

A meme based on an image from a video clip of Lisa, a member of K-pop girl group Black Pink, has gone viral among global celebrities on Twitter. Lisa uploaded the 1 minute, 20 second video, which shows her performing a sexy dance routine, on her personal YouTube channel on April 20. Hollywood celebr...

Grant agreements outline the terms of an agreement for a grant. This document dated 7 May 2020 is provided for the ADB project 54229-001 in Fiji.

Bu nəşrdə Azərbaycanda şaxələndirilmiş, inklyuziv və dayanıqlı artım naminə Asiya İnkişaf Bankı (AİB) və Azərbaycan Hökuməti arasında əməkdaşlığın və birgə səylərin xülasəsi təqdim edilir.

This policy dialogue session on water-related disaster resilience with various public scientific agencies, ministries and Senior public works department officials from Japan and developing countries in Asia.

A major focus of the Phuentsholing Township Development Project is to provide a safer space in which the town can grow by helping develop a new urban center with raised ground levels in an area sheltered by the embankments.

The three-body problem has vexed mathematicians and physicists for 300 years, but AI can find solutions far faster than any other method anyone has come up with

A study of what will happen to glaciers in the Alps under various climate scenarios suggests they will almost completely disappear if we keep pumping out carbon dioxide

The United States issued a new rule on Friday tightening visa guidelines for Chinese journalists, saying it was in response to the treatment of U.S. journalists in China, a shift that comes amid tensions between the two nations over the coronavirus global pandemic.

The mysterious Liangzhu civilisation was a neolithic "Venice of the East", rivalling ancient Egypt and Mesopotamia with its engineering marvels

Christiana Figueres and Tom Rivett-Carnac led the 2015 Paris climate negotiations. They tell us why they’re hopeful for the future, and explain how fighting climate change is “the most exciting experiment in history”

The mysterious Liangzhu civilisation was a neolithic "Venice of the East", rivalling ancient Egypt and Mesopotamia with its engineering marvels

Title: Preemies' Increased Survival Comes With No Rise in Disabilities: Study
Category: Health News
Created: 4/30/2013 12:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: Even Routine Housework May Help Stave Off Disability
Category: Health News
Created: 4/30/2014 9:35:00 AM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: Bystander CPR Not Only Saves Lives, It Lessens Disability: Study
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM

Title: Skyrizi (risankizumab-rzaa)
Category: Medications
Created: 4/20/2020 12:00:00 AM
Last Editorial Review: 4/20/2020 12:00:00 AM

Title: Menopause May Someday Disappear as Women Postpone Pregnancy: Study
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

Title: Many Seniors Leave Hospital With New Disabilities
Category: Health News
Created: 3/2/2020 12:00:00 AM
Last Editorial Review: 3/3/2020 12:00:00 AM

ABSTRACT

A microfluidic system coupled with fluorescence microscopy is a powerful approach for quantitative analysis of bacterial growth. Here, we measure parameters of growth and dynamic localization of the cell division initiation protein FtsZ in Bacillus subtilis. Consistent with previous reports, we found that after division, FtsZ rings remain at the cell poles, and polar FtsZ ring disassembly coincides with rapid Z-ring accumulation at the midcell. In cells mutated for minD, however, the polar FtsZ rings persist indefinitely, suggesting that the primary function of the Min system is in Z-ring disassembly. The inability to recycle FtsZ monomers in the minD mutant results in the simultaneous maintenance of multiple Z-rings that are restricted by competition for newly synthesized FtsZ. Although the parameters of FtsZ dynamics change in the minD mutant, the overall cell division time remains the same, albeit with elongated cells necessary to accumulate a critical threshold amount of FtsZ for promoting medial division. Finally, the minD mutant characteristically produces minicells composed of polar peptidoglycan shown to be inert for remodeling in the wild type. Polar peptidoglycan, however, loses its inert character in the minD mutant, suggesting that the Min system not only is important for recycling FtsZ but also may have a secondary role in the spatiotemporal regulation of peptidoglycan remodeling.

IMPORTANCE Many bacteria grow and divide by binary fission in which a mother cell divides into two identical daughter cells. To produce two equally sized daughters, the division machinery, guided by FtsZ, must dynamically localize to the midcell each cell cycle. Here, we quantitatively analyzed FtsZ dynamics during growth and found that the Min system of Bacillus subtilis is essential to disassemble FtsZ rings after division. Moreover, a failure to efficiently recycle FtsZ results in an increase in cell size. Finally, we show that the Min system has an additional role in inhibiting cell wall turnover and contributes to the "inert" property of cell walls at the poles.

Objective

To describe the clinical and molecular genetic findings in a family segregating a novel mutation in the AIFM1 gene on the X chromosome.

The demand for transplantable solid organs far exceeds the supply of deceased donor organs. Patient selection criteria are determined by individual transplant programs; given the scarcity of solid organs for transplant, allocation to those most likely to benefit takes into consideration both medical and psychosocial factors. Children with intellectual and developmental disabilities have historically been excluded as potential recipients of organ transplants. When a transplant is likely to provide significant health benefits, denying a transplant to otherwise eligible children with disabilities may constitute illegal and unjustified discrimination. Children with intellectual and developmental disabilities should not be excluded from the potential pool of recipients and should be referred for evaluation as recipients of solid organ transplants.

OBJECTIVE

No study has reported global disability burden estimates for individual diabetes-related lower-extremity complications (DRLECs). The Global Burden of Disease (GBD) study presents a robust opportunity to address this gap.

The coordinated electrical activity of β-cells within the pancreatic islet drives oscillatory insulin secretion. A recent hypothesis postulates that specially equipped "hub" or "leader" cells within the β-cell network drive islet oscillations and that electrically silencing or optically ablating these cells suppresses coordinated electrical activity (and thus insulin secretion) in the rest of the islet. In this Perspective, we discuss this hypothesis in relation to established principles of electrophysiological theory. We conclude that whereas electrical coupling between β-cells is sufficient for the propagation of excitation across the islet, there is no obvious electrophysiological mechanism that explains how hyperpolarizing a hub cell results in widespread inhibition of islet electrical activity and disruption of their coordination. Thus, intraislet diffusible factors should perhaps be considered as an alternate mechanism.

Current treatments for Acanthamoeba keratitis rely on a combination of chlorhexidine gluconate, propamidine isethionate, and polyhexamethylene biguanide. These disinfectants are nonspecific and inherently toxic, which limits their effectiveness. Furthermore, in 10% of cases, recurrent infection ensues due to the difficulty in killing both trophozoites and double-walled cysts. Therefore, development of efficient, safe, and target-specific drugs which are capable of preventing recurrent Acanthamoeba infection is a critical unmet need for averting blindness. Since both trophozoites and cysts contain specific sets of membrane sterols, we hypothesized that antifungal drugs targeting sterol 14-demethylase (CYP51), known as conazoles, would have deleterious effects on A. castellanii trophozoites and cysts. To test this hypothesis, we first performed a systematic screen of the FDA-approved conazoles against A. castellanii trophozoites using a bioluminescence-based viability assay adapted and optimized for Acanthamoeba. The most potent drugs were then evaluated against cysts. Isavuconazole and posaconazole demonstrated low nanomolar potency against trophozoites of three clinical strains of A. castellanii. Furthermore, isavuconazole killed trophozoites within 24 h and suppressed excystment of preformed Acanthamoeba cysts into trophozoites. The rapid action of isavuconazole was also evident from the morphological changes at nanomolar drug concentrations causing rounding of trophozoites within 24 h of exposure. Given that isavuconazole has an excellent safety profile, is well tolerated in humans, and blocks A. castellanii excystation, this opens an opportunity for the cost-effective repurposing of isavuconazole for the treatment of primary and recurring Acanthamoeba keratitis.

It all boils down to how resilient the region is, says an urban planner and designer based in Manila.

Electric scooters are a nightmare. Rented by the minute, they clog up pavements and are an ungainly eyesore, but we still need them, says Donna Lu

An AI-powered application lets you create real-time deepfakes during video calls, making you appear to be speaking as anyone from Albert Einstein to the Mona Lisa

Michigan can and will recover from the devastating COVID-19 pandemic - but not if Joe Biden wins the presidential election this November. The former vice president's radical policy platform is destined to sabotage America's second economic comeback, dooming the Great Lakes State to a bleak future of perpetual economic stagnation.

Study highlights industry failures and calls for shift in consumer attitudes

The fashion industry needs to fundamentally change in order to mitigate the environmental impact of fast fashion, experts have said.

Clothes rental, better recycling processes, pollution control technology and the innovative use of offcuts are among measures that could help, they said.

The star of M*A*S*H, The Long Goodbye – and more recently, Friends – talks about drugs, his fiery marriage to Barbra Streisand and getting his best reviews from Groucho Marx and Muhammad Ali

The best review ever received by Elliott Gould – renowned actor and star of M*A*S*H and The Long Goodbye; not to mention, Ross and Monica’s dad on Friends – was from Groucho Marx. The two of them had become close in the comedian’s latter years – so close, Gould says, “he used to let me shave him”. One day Marx asked Gould to change a lightbulb in his bedroom. Gould took off his shoes, stood on the bed and replaced the broken bulb. Marx told him: “That was the best acting I’ve ever seen you do.”

Gould, now 81, has been telling the story for decades – but it is clear even in our pixelated video call that it still delights him. “Isn’t that great?” he says, his distinctive nasal, New York baritone now deepened with age. As we speak he is sitting at a computer at a friend’s house in Los Angeles, relaxed in a blue hoodie, with a seemingly bottomless mug of coffee before him. In isolation on either side of the Atlantic, neither of us has anywhere to be. And after more than half a century in Hollywood, in which he went from leading man to exile and, eventually, fixture – Gould could fill days, not just hours, with his stories. Even without his eight-year marriage to Barbra Streisand.

The actor said wearing a fat suit for the 2001 movie taught her what it is like to be humiliated as an obese person. Why are TV and film characters so rarely treated with dignity and respect?

‘Disaster” is how Gwyneth Paltrow has summed up her role in the 2001 film Shallow Hal, which will surprise few people who have actually seen it. Jack Black plays Hal, a man so shallow he has to be hypnotised in order to date a fat woman, who, through his boggled eyes, he sees as a very thin woman.

The nastiness of Shallow Hal, which has long appalled critics and fans alike, was front and centre in the trailer, where Hal’s friend attempts to “rescue” him from speaking to a fat woman, Rosemary, who is, in fact, willowy Paltrow dressed in a fat suit. But because he cannot see what she looks like, he falls for her “inner beauty”. It is an uncomfortable mix – a film that pretends to preach body acceptance while simultaneously inviting laughter at bodies that don’t fit into jeans size six and under. Take the scene where she is called a “rhino”, or the one where she cannonballs into a swimming pool causing a tidal wave. The message built into the script’s DNA is simple: fat is funny; it is OK to laugh at fat people.

"I just couldn't be more proud of you and the prospect of your presidency," Newsom told Biden Friday during a campaign event.

Audio of a private conversation shows the 44th president's unvarnished views about the former national security adviser's case and the White House's COVID-19 response.