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Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1

Food Funct., 2024, 15,11083-11095
DOI: 10.1039/D4FO03543G, Paper
Wenshan Nan, Jialin Yin, Wenhao Hao, Huali Meng, Junduo Wu, Xiao Yin, Hao Wu
Cardamonin inhibited macrophage M1 polarization in diabetic cardiomyopathy by binding to KEAP1, leading to the dissociation of NRF2 from KEAP1. This promoted NRF2 nuclear translocation and antioxidant gene expression in M1 polarized macrophages.
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Dietary supplementation of pterostilbene, a major component in small berries, prevents alcohol-induced liver injury associated with lipid accumulation and inflammation

Food Funct., 2024, 15,11206-11219
DOI: 10.1039/D4FO03898C, Paper
Jia-Yi Dou, Sai-Hu Liu, Jia Guo, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu
Pterostilbene (PTE), a natural stilbene found in small berries, exhibits multiple pharmacological activities, particularly antioxidant and anti-inflammatory activities.
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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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Exosome-like nanoparticles from Arbutus unedo L. mitigate LPS-induced inflammation via JAK-STAT inactivation

Food Funct., 2024, 15,11280-11290
DOI: 10.1039/D4FO03646H, Paper
Cristian Martínez Fajardo, Lucía Morote, Elena Moreno-Giménez, Susana López-López, Ángela Rubio-Moraga, María José M. Díaz-Guerra, Gianfranco Diretto, Alberto J. López Jiménez, Oussama Ahrazem, Lourdes Gómez-Gómez
Exosomes have garnered attention as a potential cell-free therapy for inflammatory diseases due to their immunomodulatory and anti-inflammatory properties.
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Effects of vegetarian diets on blood lipids, blood glucose, and blood pressure: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03449J, Review Article
Xin Xia, Jinkai Zhang, Xinfang Wang, Ke Xiong, Zhaobao Pan, Jinyu Wang
Our systematic review and meta-analyses showed that vegetarian diets significantly reduced blood lipids and blood glucose and had null effects on blood pressure.
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Maternal n-3 fatty acid supplementation has an immediate impact on the human milk fatty acid composition

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02548B, Paper
Yannan He, Lin Chen, Miao Miao, Yongmei Dai, Li Qin, Jing Lin, Yumei Qi, Huijuan Xiao, Yajun Qiu, Xiaohong Zhang, Hailan Sun, Jianing Wang, Meng-yan Xu, Ping Tan, Bo Yang, Guiju Sun, Feng Zhao, Duo Li
Fatty acids are essential components in breast milk with mutable characteristics.
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Alleviating effect of whey protein supplementation on oxidative stress in hypothyroidism

Food Funct., 2024, 15,11158-11168
DOI: 10.1039/D4FO03186E, Paper
Ann Liya Sajan, Jenat Pazheparambil Jerom, Bhagyasree Rajasekharan Nair, Devanandana Dileep Kumar Sajitha, Reshma Soman, Ajmal Jalal, Raveendran Harikumaran Nair
Supplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.
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Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper
Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
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Association between olive oil consumption and all-cause, cardiovascular and cancer mortality in adult subjects: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04161E, Paper
Andrea del Saz-Lara, Alicia Saz-Lara, Iván Cavero-Redondo, Carlos Pascual-Morena, Carmen Mazarío-Gárgoles, Francesco Visioli, María-Carmen López de las Hazas, Alberto Dávalos
Fourteen studies were systematically reviewed and seven were included in the meta-analysis. Consumption of OO is associated with a reduction of cardiovascular mortality (16%), all-cause mortality (15%) and cancer mortality (11%) in adult population.
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Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04381B, Paper
Yaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun Jiang
Lacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...
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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
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Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03468F, Paper
Open Access
Zeyu Cui, Te Liu, Yichao Wen, Weihao Li, Jianghong Xu, Yingjuan Chen, Danping Chen, Ying Zhu
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
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Editorial. India needs a stable population, not more children

Southern States’ concerns need to be addressed by the Finance panel




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Editorial. India needs to focus on being a global AI power

The country’s vast pool of skilled professionals in engineering, data science and software development puts it in a position to become a global AI hub




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Editorial. BRICS’ financial ambitions cannot be wished away

BRICS countries have expressed the need for developing a platform where central bank digital currencies can be linked. This will reduce intermediation costs




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Electric truck initiative off to a good start

Incentives under PM E-DRIVE must be backed by tighter fuel consumption rules, charging infra and demand creation




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Editorial. FMCG firms should look within for falling performance

FMCG multinationals seem to be hurt more by sector-specific disruptions that they have failed to foresee, than any economy-wide distress




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Which States are leading the race towards renewables in India?

India with 300 days of sunshine each year, possesses vast solar energy potential. The National Institute of Energy estimated the country’s solar potential at 748 GW, assuming solar PV modules cover 3% of the geographical surface. Solar energy is expected to be the main driver pushing India closer to its renewable energy targets. Diving deep into the state-wise push towards solar energy. Rajasthan, Gujarat, Tamil Nadu and Karnataka are the leading States in India, both in terms of installed capacities and power generation, in the solar segment. Also, with respect to solar energy projects, Rajasthan and Gujarat lead in terms of the capacities added since FY22 and projects in pipeline




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Editorial. German Chancellor’s visit can boost multi-level engagement

Germany’s overtures to India are significant on various counts — geo-politics, technology sharing, immigration and trade talks




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Editorial. Structural issues leading to DAP shortage need fixing

With the government holding the selling price of DAP at a fraction of production costs, producers depend on subsidies to make ends meet.




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Librarians’ vital role in the world of academics

Their part in fostering knowledge is invaluable




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Editorial. Eye on debt

Centre, States should augment revenue to bring down debt




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Editorial. Regulating NFOs

Time limit for MFs to invest NFO funds not a good idea




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Editorial. Subdued performance

Q2 earnings point to challenges in many sectors




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Trump 2.0: A new era for India-US relations?

Modi and Trump have the potential to redefine bilateral ties based on mutual economic growth, security, and strategic interests in an increasingly complex global landscape




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Copper’s role in India’s solar, wind energy plans

For every tonne of copper used in renewable energy systems, carbon emissions are reduced by 100 to 7,500 tonnes over the system’s lifecycle




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Editorial. Triumphant Trump

Trump may end existing animosities, start new ones




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What Indian trade can expect from Trump 2.0

India could well face higher tariffs on exports like textiles, chemicals, pharma and auto/engineering products




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Editorial. Growing rice acreage points to need for PDS reform

A household of five individuals does not need 25 kg of free grain per month. Instead, with the same level of food subsidy, pulses and oils can be introduced, where they don’t find a place in the PDS already




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Editorial. Property rights

SC ruling curtails untrammelled State powers




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India on road to achieving 500 GW of RE

Renewable energy is a sector where there is strong alignment and co-operation between the Centre and the States. Public sector units and the private sector must now deliver




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Editorial. Turbulent passage ahead for climate talks

The developed world has been implicitly arguing that China and India should contribute to the climate kitty rather than receive monies from it




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Editorial. Trump factor adds to monetary policy uncertainty

While the monetary policy normalisation is proceeding on expected lines, the change in regime in the US, following the Presidential elections is likely to pose currency related issues in particular for global central banks




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The Crown Review: Appropriate Finale

After the debacle of the first episodes of Season 6, the latter half give an even-handed treatment to intriguing not-so-well-known events of Queen Elizabeth II's reign, observes Vaihayasi Pande Daniel.




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Indian Police Force Review

Rohit Shetty's strengths have been action and humour; the former he delivers in spades, but the latter is totally lacking in Indian Police Force, observes Deepa Gahlot.




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All India Rank Review

All India Rank achieves a fine balance of authenticity and sensitivity in the fine portrayals of its young actors and old.




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Fairy Folk Review: Marriage Story With A Twist

For all its oddball energy and earnest ambition, Fairy Folk cannot be missed, applauds Mayur Sanap.




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The Great Indian Kapil Show Review

Stand-up comedian Kapil Sharma is back with his show and while the set is bigger and the look is grander, the gags are still the same, feels Namrata Thakker.




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Luv Ki Arrange Marriage Review

If this were a French farce, nobody would have batted an eyelid if the father of the groom and mother of the bride fell in love and wanted to marry. But here, some crude comedy is generated with a dash of melodrama, feels Deepa Gahlot.




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Malayalee From India Review

Malayalee From India is trapped within its self-serving corniness and refuses to break free in the process, observes Arjun Menon.




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Indian 2 Review

The saving grace of Shankar's expanded universe is the masterful precision with which Kamal Haasan drops himself into a messy setup, only slightly to elevate the pulpy tendencies of Shankar's vision, observes Arjun Menon.




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The Diary Of West Bengal Review

How can a film that has a character declare that secularism is an illness be taken seriously, asks Deepa Gahlot.





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1,393 farm fires detected in Punjab, 874 FIRs registered: Special DGP




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Debating the ‘healthy longevity initiative’

The divide between the real world and the strategy to be adopted in the healthy longevity initiative is too wide to be ignored




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Stop the free fall: On India-Canada ties

India and Canada must not allow ties to deteriorate further 




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A mixed report card for the India-Middle East-Europe Corridor

Implementation on the northern part of the corridor, which is mostly in West Asia, is going to move slowly until the conflict subsides, while progress is faster on the eastern leg connecting the UAE and Indian ports




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Shruthi clinches crown in Women’s World Billiards Championship Title

Shruthi arrived at the Landywood Snooker Club as the lowest-ranked of the seven competitors, representing five nations




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Mercedes-Benz India introduces sportscar AMG C 63 S E at ₹1.95 crore

The Mercedes-AMG C 63 S E Performance’s hybrid powertrain merges a 2.0-litre AMG turbo engine with an Electric Drive Unit (EDU)