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Opioid and Hedgehog signalling pathways converge to modulate OA




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Hospitalization for infection on the rise in gout




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Adenomyoepithelial tumors of the breast: molecular underpinnings of a rare entity




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Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast




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An analysis of the effect of mu-opioid receptor gene (<i>OPRM1</i>) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence




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Publisher Correction: ASPI: a public–private partnership to develop treatments for autism




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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform




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Picking away at fossilized skeletons




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Tunable correlated states and spin-polarized phases in twisted bilayer–bilayer graphene




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Laser spectroscopy of pionic helium atoms




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Mapping the twist-angle disorder and Landau levels in magic-angle graphene




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Podcast: Galileo and the science deniers, and physicists probe the mysterious pion




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Millennial-scale hydroclimate control of tropical soil carbon storage




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Worm brain, ocean giant and soothing Jupiter — April’s best science images




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Smart-technology spies, a final warning on the environment, and the staggering costs of cancer: Books in brief




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Cyber-spinach turns sunlight into sugar




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Apixaban therapy is effective and safe for cancer-associated VTE




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Cardiovascular effects and safety of (non-aspirin) NSAIDs




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Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape




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Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis




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Seeking for Multiple Faculty Positions in Capital Normal University (CNU)

About CNU
Capital Normal University (CNU) was founded in 1954. Being a national “Double-First Class” university and “Province-Ministry Co-sponsored” (Beijing and the Education Ministry) university, CNU has extensively broad disciplines including literature, sciences, engineering, management, law, education, foreign languages and arts. For over 60 years, CNU has cultivated more than 200 thousand graduates specializing in various fields. Currently, CNU is an important talent training base of Be…




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Recruitment for director and research principal investigators of Shanghai Key Laboratory of Tissue Engineering Research, at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University

Position
Laboratory director and independent principal investigators

Employer
Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine

Location
639 Zhi Zao Ju Rd, Huang Pu District, 200011, Shanghai, China

Discipline
Tissue engineering and regenerative medicine related disciplines including: Stem Cell, Developmental Biology, Biomaterials, Biomedical Engineering

Aim:
Shanghai Tissue Engineering Key Laboratory is among the l…




pi

Seeking for Multiple Faculty Positions in Capital Normal University (CNU)

About CNU
Capital Normal University (CNU) was founded in 1954. Being a national “Double-First Class” university and “Province-Ministry Co-sponsored” (Beijing and the Education Ministry) university, CNU has extensively broad disciplines including literature, sciences, engineering, management, law, education, foreign languages and arts. For over 60 years, CNU has cultivated more than 200 thousand graduates specializing in various fields. Currently, CNU is an important talent training base of Be…




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Clinical and radiographic evaluation of indirect pulp treatment of young permanent molars using photo-activated oral disinfection versus calcium hydroxide: a randomized controlled pilot trial




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Viral contamination in biologic manufacture and implications for emerging therapies




pi

Clinical utility of the exosome based ExoDx Prostate(<i>IntelliScore</i>) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL




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Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




pi

Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




pi

Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




pi

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Inducing senescence sensitizes pancreatic tumours to therapies




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Combining radiolabelled therapies for neuroendocrine neoplasms




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Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why?




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Incidence of acute spinal cord injury in South Korea does not reflect a sizable number of traumatic spinal cord injuries




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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system




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Development of a skin temperature map for dermatomes in individuals with spinal cord injury: a cross-sectional study




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Impact of COVID-19 outbreak on spinal pathology: single center first impression




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Recovery after traumatic thoracic- and lumbar spinal cord injury: the neurological level of injury matters




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Supporting sexual adjustment from the perspective of men living with spinal cord injury




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Spinal Cord




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




pi

A standardized patient-centered characterization of the phenotypic spectrum of <i>PCDH19</i> girls clustering epilepsy




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Activation and targeting of ATG8 protein lipidation




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors