Grup Yorum's Ibrahim Gokcek died two days after suspending his “death fast."

Although Egypt has stopped liquefying and exporting liquefied natural gas due to the global collapse of prices as a result of the coronavirus pandemic, it is still expanding its gas production in the eastern Mediterranean.

Ankara’s haste to reopen shopping malls may be an effort to revive sagging consumption, but it also has to do with a tight nexus between politicians and businesses in the country.

Former Nissan CEO Carlos Ghosn has been living in Lebanon since escaping house arrest in Japan in late December.

The Covid-19 pandemic has increased the importance of implementing China’s agreement to buy US$200 billion of US goods – a key aspect of the interim trade deal between the two sides, sources familiar with the talks have said.US President Donald Trump has threatened to withdraw from the agreement if China fails to live up to its commitment over the next two years.In a phone conversation between the lead negotiators on Friday, Chinese Vice-Premier Liu He and US Trade Representative Robert…

Zoom Video Communications pushed forward on Thursday in its effort to revamp its security, striking a deal with the New York attorney general’s office to protect users’ privacy and purchasing secure messaging start-up Keybase.The company, which has faced backlash for failing to disclose that its service was not fully end-to-end encrypted said it planned to develop tools that will give more controls to meeting hosts and allow users to securely join a meeting and submit them to external review…

Europe marked the 75th anniversary of the surrender of Nazi Germany to Allied forces in low-key fashion Friday because of coronavirus lockdown restrictions across the continent.The big celebrations planned were either cancelled or dramatically scaled back. There were no mass gatherings, no hugging or kissing, but the day of liberation was emotionally charged from Belfast to Berlin. For the few surviving World War II veterans, many living in nursing homes under virus lockdowns, it has been a…

Doctors believe this will revolutionalise medicine, but there are ethical and safety concerns

Hong Kong lawmakers from opposing camps are gearing up for a showdown over control of a key committee in the legislature, with both sides bracing for physical clashes.The opposition camp is expected on Friday to filibuster at the Legislative Council House Committee meetings, using legal opinion obtained from two constitutional law experts. They will accuse pro-Beijing heavyweight Starry Lee Wai-king of conflict of interest in handling council affairs while standing for re-election, slamming her…

A meeting in Hong Kong’s legislature descended into shouting matches and scuffles as 11 opposition lawmakers were thrown out by a pro-establishment leader who took control of a key committee to begin clearing a backlog of bills for review.The pan-democrats walked out of talks on Friday after losing their hold over the House Committee, threatening court action against Legislative Council staff, including legal advisers and security guards, whom they accused of abandoning political neutrality and…

Skills training, civic engagement and youth forums will help young people become active players in society’s shared efforts to grow and improve.

Despite variations across countries on policy mix and timing, a pragmatic focus on sustained growth, poverty reduction, and inclusiveness characterize Asia’s economic rise 

Pacific nations, led by the smallest and least well-off, moved decisively to restrict travel from a fast-growing list of COVID-19 affected countries.

To reduce air pollution, national and city government policy makers, their development partners, academe, and the private sector need to work with young people. 

The Chinese government policy of racial and religious profiling has forced young Uyghurs to leave China and remain in exile.

MCC - Turnkey Touch Host Library V1.0.0

MEC152x Keyboard and Embedded Controller for Notebook PC

The stage seems to be set for the real estate sector to take a turn for good times again. When everyone expected a rate hike in the Reserve Bank of India’s policy review on December 18, the central bank surprised all with a status quo on rates. Another bonanza soon followed: State Bank of India and HDFC, the top two home loan providers, slashed home loan interest rates between 30-50 basis points. Both these unexpected moves have rekindled hopes in the struggling real estate sector at a time when housing demand remained largely stagnant across major urban markets in India. The sector of late has been witnessing end-user perceptions of […]

U.S. Vice President Mike Pence's press secretary, the wife of one of President Donald Trump's senior advisors, has tested positive for the coronavirus, the second White House staffer to be diagnosed with the illness. This report produced by Chris Dignam.

An Englishwoman proves it is possible to manage a business in 21st century Britain and make a modest living, without the use of modern-day technology. Hayley Platt looks at Dani Church's ferry business on the Suffolk coast, which has been in her family for 125 years.

Two lineages of ancient monkey migrated from Africa to South America more than 30 million years ago. But we’re not sure which ones got there first

Notorious for making us sick, viruses are weird, undead organisms – but new insights are revealing they may have created life's glorious complexity in the first place

U.S. Vice President Mike Pence's press secretary, the wife of one of President Donald Trump's senior advisors, has tested positive for the coronavirus, the second White House staffer to be diagnosed with the illness. This report produced by Chris Dignam.

U.S. Vice President Mike Pence's press secretary, the wife of one of President Donald Trump's senior advisors, has tested positive for the coronavirus, the second White House staffer to be diagnosed with the illness. This report produced by Chris Dignam.

Many countries are focusing coronavirus testing on people who have covid-19 symptoms. But regularly testing all essential workers would have more of an impact

U.S. Vice President Mike Pence's press secretary, the wife of one of President Donald Trump's senior advisors, has tested positive for the coronavirus, the second White House staffer to be diagnosed with the illness. This report produced by Chris Dignam.

Title: Kids' 'Microbiome' May Play Key Role in Asthma
Category: Health News
Created: 12/24/2019 12:00:00 AM
Last Editorial Review: 12/24/2019 12:00:00 AM

Title: Fitness Key to Long-Term Weight Loss Success
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Title: Hospital Computer Keyboards May Spread Danger
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Title: Is Drinking Wine a Key to Antiaging?
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ABSTRACT

Microbes affect vertebrates on timescales from daily to evolutionary, and the cumulative effect of these interactions is immense. However, how microbiomes compare across (host) species is poorly understood, as most studies focus on relatively few species. A recent mBio article by S. J. Song, J. G. Sanders, F. Delsuc, J. Metcalf, et al. (mBio 11:e02901-19, 2019, https://doi.org/10.1128/mBio.02901-19) expands our collective understanding of the vertebrate microbiome by analyzing ~900 species. They demonstrate that patterns within mammals contrast with those within birds. Their results suggest many hypotheses about the role of host ecology and evolution on microbiome variation. Bats, the only volant mammals, appear to contradict many of the general mammal microbiome trends, in some ways resembling birds. What role has powered flight, and the evolution thereof, played in microbiome structure and function? Comparative methods, mechanistic hypotheses, and theory will elucidate this exciting question (and others) that we can ask using Song, Sanders et al.’s data and results.

The Bcl-2 (B cell lymphoma 2)-related protein Nr-13 plays a major role in the regulation of cell death in developing avian B cells. With over 65% sequence similarity to the chicken Nr-13, herpesvirus of turkeys (HVT) vNr-13, encoded by the HVT079 and HVT096 genes, is the first known alphaherpesvirus-encoded Bcl-2 homolog. HVT-infected cells were reported to be relatively more resistant to serum starvation, suggested that vNr-13 could be involved in protecting the cells. Here, we describe CRISPR/Cas9-based editing of exon 1 of the HVT079 and HVT096 genes from the HVT genome to generate the mutant HVT-vNr-13 to gain insights into its functional roles. Overall, wild-type HVT and HVT-vNr-13 showed similar growth kinetics; however, at early time points, HVT-vNr-13 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2-fold-lower growth of cell-free virus. In transfected cells, HVT vNr-13 showed a mainly diffuse cytoplasmic distribution with faint nuclear staining. Further, vNr-13 localized to the mitochondria and endoplasmic reticulum (ER) and disrupted mitochondrial network morphology in the transfected cells. In the wild-type HVT-infected cells, vNr-13 expression appeared to be directly involved in the disruption of the mitochondrial network, as the mitochondrial network morphology was substantially restored in the HVT-vNr-13-infected cells. IncuCyte S3 real-time apoptosis monitoring demonstrated that vNr-13 is unequivocally involved in the apoptosis inhibition, and it is associated with an increase of PFU, especially under serum-free conditions in the later stages of the viral replication cycle. Furthermore, HVT blocks apoptosis in infected cells but activates apoptosis in noninfected bystander cells.

IMPORTANCE B cell lymphoma 2 (Bcl-2) family proteins play important roles in regulating apoptosis during homeostasis, tissue development, and infectious diseases. Several viruses encode homologs of cellular Bcl-2-proteins (vBcl-2) to inhibit apoptosis, which enable them to replicate and persist in the infected cells and to evade/modulate the immune response of the host. Herpesvirus of turkeys (HVT) is a nonpathogenic alphaherpesvirus of turkeys and chickens that is widely used as a live vaccine against Marek’s disease and as recombinant vaccine viral vectors for protecting against multiple avian diseases. Identical copies of the HVT genes HVT079 and HVT096 encode the Bcl-2 homolog vNr-13. While previous studies have identified the potential ability of vNr-13 in inhibiting apoptosis induced by serum deprivation, there have been no detailed investigations on the functions of vNr-13. Using CRISPR/Cas9-based ablation of the vNr-13 gene, we demonstrated the roles of HVT vNr-13 in early stages of the viral replication cycle, mitochondrial morphology disruption, and apoptosis inhibition in later stages of viral replication.

Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like protein 1 (FHL-1) to self-ligands or altered self-ligands (e.g.,...

To identify genomic alterations contributing to the pathogenesis of high-risk chronic lymphocytic leukemia (CLL) beyond the well-established role of TP53 aberrations, we comprehensively analyzed 75 relapsed/refractory and 71 treatment-naïve high-risk cases from prospective clinical trials by single nucleotide polymorphism arrays and targeted next-generation sequencing. Increased genomic complexity was a hallmark of relapsed/refractory and treatment-naïve high-risk CLL. In relapsed/refractory cases previously exposed to the selective pressure of chemo(immuno)therapy, gain(8)(q24.21) and del(9)(p21.3) were particularly enriched. Both alterations affect key regulators of cell-cycle progression, namely MYC and CDKN2A/B. While homozygous CDKN2A/B loss has been directly associated with Richter transformation, we did not find this association for heterozygous loss of CDKN2A/B. Gains in 8q24.21 were either focal gains in a MYC enhancer region or large gains affecting the MYC locus, but only the latter type was highly enriched in relapsed/refractory CLL (17%). In addition to a high frequency of NOTCH1 mutations (23%), we found recurrent genetic alterations in SPEN (4% mutated), RBPJ (8% deleted) and SNW1 (8% deleted), all affecting a protein complex that represses transcription of NOTCH1 target genes. We investigated the functional impact of these alterations on HES1, DTX1 and MYC gene transcription and found derepression of these NOTCH1 target genes particularly with SPEN mutations. In summary, we provide new insights into the genomic architecture of high-risk CLL, define novel recurrent DNA copy number alterations and refine knowledge on del(9p), gain(8q) and alterations affecting NOTCH1 signaling. This study was registered at ClinicalTrials.gov with number NCT01392079.

Type 2 diabetes (T2D) is caused by loss of pancreatic β-cell mass and failure of the remaining β-cells to deliver sufficient insulin to meet demand. β-Cell glucolipotoxicity (GLT), which refers to combined, deleterious effects of elevated glucose and fatty acid levels on β-cell function and survival, contributes to T2D-associated β-cell failure. Drugs and mechanisms that protect β-cells from GLT stress could potentially improve metabolic control in patients with T2D. In a phenotypic screen seeking low-molecular-weight compounds that protected β-cells from GLT, we identified compound A that selectively blocked GLT-induced apoptosis in rat insulinoma cells. Compound A and its optimized analogs also improved viability and function in primary rat and human islets under GLT. We discovered that compound A analogs decreased GLT-induced cytosolic calcium influx in islet cells, and all measured β-cell–protective effects correlated with this activity. Further studies revealed that the active compound from this series largely reversed GLT-induced global transcriptional changes. Our results suggest that taming cytosolic calcium overload in pancreatic islets can improve β-cell survival and function under GLT stress and thus could be an effective strategy for T2D treatment.

Purpose:

KEYNOTE-158 (ClinicalTrials.gov identifier: NCT02628067) investigated the efficacy and safety of pembrolizumab across multiple cancers. We present results from patients with previously treated advanced well-differentiated neuroendocrine tumors (NET).

This unusual contraption recreates the sounds of an old-school mechanical typewriter on a modern keyboard.

"This government has failed to show any self-criticism whatsoever, when it is glaringly obvious to everybody that big mistakes have been made."

In light of the newly declassified documents, it is clear that understanding what happened in that January 5 Oval Office meeting is essential to understanding the corrupt operation against the Trump administration.