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Bronchiectasis is a chronic lung condition which is characterised by recurrent chest infections, chronic sputum production and cough, and limited exercise tolerance. While bronchiectasis may be caused by various aetiologies, these features are shared by most patients with bronchiectasis regardless of the cause. This review consolidates the existing evidence on patient-managed interventions for adults with bronchiectasis, while also outlining areas for future research. Airway clearance techniques and hyperosmolar agents are key components of the bronchiectasis management and consistently recommended for clinical implementation. Questions around their prescription, such as optimal sequence of delivery, are still to be answered. Pulmonary rehabilitation and exercise are also recommended for patients with bronchiectasis. Relatively strong evidence underpins this recommendation during a clinically stable stage of the disease, although the role of pulmonary rehabilitation following an exacerbation is still unclear. Additionally, self-management programmes feature prominently in bronchiectasis treatment, yet the lack of consensus regarding their definition and outcomes presents hurdles to establishing a cohesive evidence base. Moreover, cough, a cardinal symptom of bronchiectasis, warrants closer examination. Although managing cough in bronchiectasis may initially appear risky, further research is necessary to ascertain whether strategies employed in other respiratory conditions can be safely and effectively adapted to bronchiectasis, particularly through identifying patient responder populations and criteria where cough may not enhance airway clearance efficacy and its control is needed. Overall, there is a growing recognition of the importance of patient-managed interventions in the bronchiectasis management. Efforts to improve research methodologies and increase research funding are needed to further advance our understanding of these interventions, and their role in optimising patient care and outcomes.

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ABSTRACTIntroduction: Nigeria has the highest number of children who have not received any vaccines in Africa. The training-of-trainers (TOT) model used to train program managers (PMs) and health care workers (HCWs) is ineffective for adult learning and limits immunization programs’ success. We incorporated adult learning principles (ALPs) in designing and delivering TOT for immunization PMs and HCWs to use data to engage communities for tailored immunization strategies.Methods: Our study was implemented in 3 local government areas (LGAs) of the Federal Capital Territory, Nigeria. A training curriculum was developed, integrating ALPs and technical and operational content based on best practices in delivering immunization training and the training needs assessment findings. State PMs (n=10), LGA PMs (n=30), and HCWs (n=42) were trained on the human-centered design for tailoring immunization programs (HCD-TIP) approaches using ALPs. We used interviews and surveys with purposively and conveniently sampled PMs and HCWs, respectively, and observations to assess participants’ satisfaction, knowledge and competence, behavior changes, and results. The interviews were analyzed thematically, and surveys were statistically.Results: There was a high level of satisfaction with the training among LGA PMs (100%), state PMs (91%), and HCWs (85%), with significant knowledge and competence improvements post-training (P<.001). The trained participants conducted 2 HCD sessions with 24 undervaccinated communities and co-designed 24 prototype solutions for testing. Results showed increased coverage of the pentavalent vaccine first dose (54%) and third dose (188%) across 12 participating communities. Improved community colaboration, communication skills, and data-driven approaches were the most cited behavior changes in practice.Conclusion: The application of ALPs in training, use of HCD-TIP approaches and tools, and supportive supervision enhanced PMs’ and HCWs’ capacity for tailored interventions. Countries should consider adopting a holistic approach that focuses on using these approaches in immunization programs to strengthen the health system for equitable vaccine coverage.

Affibody molecules are small, robust, and versatile affinity proteins currently being explored for therapeutic, diagnostic, and biotechnological applications. Surface-exposed residues on the affibody scaffold are randomized to create large affibody libraries from which novel binding specificities to virtually any protein target can be generated using combinatorial protein engineering. Affibody molecules have the potential to complement—or even surpass—current antibody-based technologies, exhibiting multiple desirable properties, such as high stability, affinity, and specificity, efficient tissue penetration, and straightforward modular extension of functional domains. It has been shown in both preclinical and clinical studies that affibody molecules are safe, efficacious, and valuable alternatives to antibodies for specific targeting in the context of in vivo diagnostics and therapy. Here, we provide a general background of affibody molecules, give examples of reported applications, and briefly summarize the methodology for affibody generation.

BackgroundAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, for which there are effective pharmacological treatments that improve symptoms and reduce complications. Guidelines published by the National Institute for Health and Care Excellence recommend that primary care practitioners prescribe medication for adult ADHD under shared-care agreements with Adult Mental Health Services (AMHS). However, provision remains uneven, with some practitioners reporting a lack of support.AimThis study aimed to describe elements of support, and their availability/use, in primary care prescribing for adult ADHD medication in England to improve access for this underserved population and inform service improvement.Design and settingCross-sectional surveys were used to elicit data from commissioners, health professionals (HPs), and people with lived experience of ADHD (LE) across England about elements supporting pharmacological treatment of ADHD in primary care.MethodThree interlinked cross-sectional surveys were used to ask every integrated care board in England (commissioners), along with convenience samples of HPs and LEs, about prescribing rates, AMHS availability, wait times, and shared-care agreement protocols/policies for the pharmacological treatment of ADHD in primary care. Descriptive analyses, percentages, and confidence intervals were used to summarise responses by stakeholder group. Variations in reported provision and practice were explored and displayed visually using mapping software.ResultsData from 782 responders (42 commissioners, 331 HPs, 409 LEs) revealed differences in reported provision by stakeholder group, including for prescribing (95% of HPs versus 64% of LEs). In all, >40% of responders reported extended AMHS wait times of ≥2 years. There was some variability by NHS region – for example, London had the lowest reported extended wait time (25%), while East of England had the highest (55%).ConclusionElements supporting appropriate shared-care prescribing of ADHD medication via primary care are not universally available in England. Coordinated approaches are needed to address these gaps.

BACKGROUND

For many patients with post–COVID-19 condition (long COVID), primary care is the first point of interaction with the health care system. In principle, primary care is well situated to manage long COVID. Beyond expressions of disempowerment, however, the patient’s perspective regarding the quality of long COVID care is lacking. Therefore, this study aimed to analyze the expectations and experiences of primary care patients seeking treatment for long COVID.

Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging.

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Congested Kelley goes HONK! Chris runs over old people in GTA while distracting Anna Marie with Octopath. RPGamer tip of the week: If your game has more than 12 currencies, it's main stream.

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This is a sponsored article brought to you by Khalifa University of Science and Technology.

A total of eight intense competitions to inspire creativity and innovation along with 13 forums dedicated to diverse segments of robotics and artificial intelligence will be part of the 36th edition of the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024) in Abu Dhabi.

These competitions at the Middle East and North Africa (MENA) region’s first-ever global conference and exhibition from 14-18 October 2024 at the Abu Dhabi National Exhibition Center (ADNEC) will highlight some of the key aspects of robotics. These include physical or athletic intelligence of robots, remote robot navigation, robot manipulation, underwater robotics, perception and sensing as well as challenges for wildlife preservation.

This edition of IROS is one of the largest of its kind globally in this category because of active participation across all levels, with 5,740 authors, 16 keynote speakers, 46 workshops, 11 tutorials, as well as 28 exhibitors and 12 startups. The forums at IROS will explore the rapidly evolving role of robotics in many industry sectors as well as policy-making and regulatory areas. Several leading corporate majors, and industry professionals from across the globe are gathering for IROS 2024 which is themed “Robotics for Sustainable Development.”

“The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.” —Jorge Dias, IROS 2024 General Chair

Dr. Jorge Dias, IROS 2024 General Chair, said: “Such a large gathering of scientists, researchers, industry leaders and government stakeholders in Abu Dhabi for IROS 2024 also demonstrates the role of UAE in pioneering new technologies and in providing an international platform for knowledge exchange and sharing of expertise. The intense robotics competitions will inspire creativity, while the products on display as well as keynotes will pave the way for more community-relevant solutions.”

The competitions are:

• 2nd AI Olympics With RealAIGym: Is AI Ready for Athletic Intelligence in the Real World? focusing on the physical or athletic intelligence of robots

• The Earth Rovers Challenge on remote robot navigation

• Robotic Construction Challenge and the euROBIN Manipulation Skill Versatility Challenge (MSVC) on robot manipulation

• Underwater Robotics Challenges on innovation and problem-solving in underwater robotics and artificial intelligence

• ROAD-IROS: Automatic Data Annotation Challenge for ROAD Dataset on perception and sensing

• 21st F1Tenth Autonomous Racing Competition

• IEEE RAS Quadruped Robot Challenge (QRC), focusing on navigation

In addition to these competitions, the Falcon Monitoring Challenge (FMC) will focus on advancing the field of wildlife tracking and conservation through the development of sophisticated, noninvasive monitoring systems.

Khalifa University

IROS 2024 will also include three keynote talks on ‘Robotic Competitions’ that will be moderated by Professor Lakmal Seneviratne, Director, Center for Autonomous Robotic Systems (KU-CARS), Khalifa University. The keynotes will be delivered by Professor Pedro Lima, Institute for Systems and Robotics, Instituto Superior Técnico, University of. Lisbon, Portugal; Dr. Timothy Chung, General Manager, Autonomy and Robotics, Microsoft, US; and Dr. Ubbo Visser, President of the RoboCup Federation, Director of Graduate Studies, and Associate Professor of Computer Science, University of Miami, US.

The forums at IROS 2024 will include:

• Robotics in Africa Forum

• Marine Robotics in Ocean Decade Initiative for Sustainable Development

• Robots for Sustainability and Sustainable Robots

• Government Forum: Funding for Robotics Research, Human-Avatars Symbiosis: Can you imagine a future society where you can remotely control multiple avatars?

• Moonshot R&D Program Goal 3 Forum. Envisioning a Future of Human-Robot Co-living: Potential for Robotics to Transform Human Lives

Other forums include:

• Sustainable Medical and Surgical Robotics

• Empowering Diverse Voices in Robotics, Robotics & AI in the UAE: Research Innovation and Entrepreneurship

• Europe Regulates Artificial Intelligence: the Challenge for Robotics, Industrial Opportunities and Socio-Economic Impact of Medical Robotics

• The Future of Work: AI-Enhanced Robotics and Human Interaction Research in M3S

• Robots for a Better Tomorrow: Wellbeing Through Advanced Technology.

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas about the latest advances in intelligent robots and smart machines. A total of 3,344 paper submissions representing 60 countries, have been received from researchers and scientists across the world. China tops the list with more than 1,000 papers, the US with 777, Germany with 302, Japan with 253, and the UK and South Korea with 173 each. The UAE remains top in the Arab region with 68 papers.

One of the largest and most important robotics research conferences in the world, IROS 2024 provides a platform for the international robotics community to exchange knowledge and ideas.

For eight consecutive years since 2017, Abu Dhabi has remained first on the world’s safest cities list, according to online database Numbeo, which assessed 329 global cities for the 2024 listing. This reflects the emirate’s ongoing efforts to ensure a good quality of life for citizens and residents. With a multicultural community, Abu Dhabi is home to people from more than 200 nationalities, and draws a large number of tourists to some of the top art galleries in the city such as Louvre Abu Dhabi and the Guggenheim Abu Dhabi, as well as other destinations such as Ferrari World Abu Dhabi and Warner Bros. World™ Abu Dhabi.

Because of its listing as one of the safest cities, Abu Dhabi continues to host several international conferences and exhibitions. Abu Dhabi is set to host the UNCTAD World Investment Forum, the 13th World Trade Organization (WTO) Ministerial Conference (MC13), the 12th World Environment Education Congress in 2024, and the IUCN World Conservation Congress in 2025.

IROS 2024 is sponsored by IEEE Robotics and Automation Society, Abu Dhabi Convention and Exhibition Bureau, the Robotics Society of Japan (RSJ), the Society of Instrument and Control Engineers (SICE), the New Technology Foundation, and the IEEE Industrial Electronics Society (IES).

More information at https://iros2024-abudhabi.org/

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