Background:

Incentive payments for chronic diseases in British Columbia were intended to support primary care physicians in providing more comprehensive care, but research shows that not all physicians bill incentives and not all eligible patients have them billed on their behalf. We investigated patient and physician characteristics associated with billing incentives for chronic diseases in BC.

Omadacycline is a broad-spectrum aminomethylcycline approved in October 2018 by the U.S. Food and Drug Administration for treating acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous once-daily formulation. In this report, the activities of omadacycline and comparators were tested against 49,000 nonduplicate bacterial isolates collected prospectively during 2016 to 2018 from medical centers in Europe (24,500 isolates, 40 medical centers [19 countries]) and the United States (24,500 isolates, 33 medical centers [23 states and all 9 U.S. census divisions]). Omadacycline was tested by broth microdilution following the methods in Clinical and Laboratory Standards Institute document M07 (Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard, 11th ed., 2018). Omadacycline (MIC_50/90, 0.12/0.25 mg/liter) inhibited 98.6% of Staphylococcus aureus isolates at ≤0.5 mg/liter, including 96.3% of methicillin-resistant S. aureus isolates and 99.8% of methicillin-susceptible S. aureus isolates. Omadacycline potency was comparable for Streptococcus pneumoniae (MIC_50/90, 0.06/0.12 mg/liter), viridans group streptococci (MIC_50/90, 0.06/0.12 mg/liter), and beta-hemolytic streptococci (MIC_50/90, 0.12/0.25 mg/liter), regardless of species and susceptibility to penicillin, macrolides, or tetracycline. Omadacycline was active against all Enterobacterales tested (MIC_50/90, 1/8 mg/liter; 87.5% of isolates were inhibited at ≤4 mg/liter) except Proteus mirabilis (MIC_50/90, 16/>32 mg/liter) and indole-positive Proteus spp. (MIC_50/90, 8/32 mg/liter) and was most active against Escherichia coli (MIC_50/90, 0.5/2 mg/liter), Klebsiella oxytoca (MIC_50/90, 1/2 mg/liter), and Citrobacter spp. (MIC_50/90, 1/4 mg/liter). Omadacycline inhibited 92.4% of Enterobacter cloacae species complex and 88.5% of Klebsiella pneumoniae isolates at ≤4 mg/liter. Omadacycline was active against Haemophilus influenzae (MIC_50/90, 0.5/1 mg/liter), regardless of β-lactamase status, and against Moraxella catarrhalis (MIC_50/90, ≤0.12/0.25 mg/liter). The potent activity of omadacycline against Gram-positive and -negative bacteria indicates that omadacycline merits further study in serious infections in which multidrug resistance and mixed Gram-positive and Gram-negative bacterial infections may be a concern.

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Nine hundred Haemophilus influenzae clinical isolates from 83 U.S. and European medical centers were tested for susceptibility by reference broth microdilution methods against ceftolozane-tazobactam and comparators. Results were stratified by β-lactamase production and infection type. Overall, ceftolozane-tazobactam MIC_50/90 values were 0.12/0.25 mg/liter, and 99.0% of isolates were inhibited at the susceptible breakpoint of ≤0.5 mg/liter; the highest MIC value was only 2 mg/liter. Our results support using ceftolozane-tazobactam to treat H. influenzae infections.

In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.

In Céline Sciamma’s Portrait of a Lady on Fire, we finally steer away from seeing intimacy through the male gaze

The portrayal of lesbians in mainstream cinema tends to involve prosthetic vaginas and gratuitous sex scenes; so Céline Sciamma’s Portrait of a Lady on Fire comes as a breath of fresh air. It is the story of the burgeoning relationship between two young women – emancipated artist Marianne (Noémie Merlant), who is commissioned to paint a portrait of sexually repressed Héloïse (Adèle Haenel), leading to a heated romance.

On paper, it looks like the classic lesbian cinematic narrative – there is a buildup of tension, they finally kiss, and then their possibility of a future together seems doomed. However, what makes Portrait of a Lady on Fire different is its heightened self-awareness. The film is constructed with lesbian representation in mind through careful interrogation of the lesbian gaze. There is a lot of looking. Marianne looks at Héloïse because she has to secretly paint her, and Héloïse looks at Marianne out of curiosity. Eventually, there is a shift in the way they start looking at each other – out of desire.

Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes.

A Colombian advertising company is pitching a novel if morbid solution to shortages of hospital beds and coffins during the coronavirus pandemic: combine them. ABC Displays has created a cardboard bed with metal railings that designers say can double as a casket if a patient dies. Company manager Rodolfo Gómez said he was inspired to find a way to help after watching events unfold recently in nearby Ecuador.

'The Real Michael Jackson' aired on BBC2 in March

Valencia midfielder Geoffrey Kondogbia could be available for around €30 million this summer amid reported interest from Tottenham.

Fulham forward Aleksandar Mitrovic says Serbia team-mate Luka Jovic is in crisis at Real Madrid.

Newcastle United are in danger of being used as a "PR tool" by Saudi Arabia if the club's proposed takeover goes through, according to Amnesty International UK.

Amnesty International has written to the Premier League saying it "risks becoming a patsy" unless it takes a serious look at Saudi Arabia's human rights record with regard to the takeover of Newcastle United.

The Premier League has been asked to consider blocking a Saudi-backed consortium's attempt to purchase Newcastle United by one of the league's major broadcast partners.

The Government is not likely to intervene in the proposed Saudi Arabia-led takeover of Newcastle United, according to Culture Secretary Oliver Dowden​.

James Rodriguez has been linked with a sensational switch to David Beckham's MLS franchise, Inter Miami.

Brighton and Hove Albion have designed a special shirt to pay tribute to the NHS and key workers during the coronavirus pandemic.

BIA also dropped a quick quarantine verse to keep us going.

California state agencies argue that women who worked at the video game company could deserve up to $400 million. The company—and the lawyers for women who worked there—strongly disagree.

Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes.

A Colombian advertising company is pitching a novel if morbid solution to shortages of hospital beds and coffins during the coronavirus pandemic: combine them.ABC Displays has created a cardboard bed with metal railings that designers...

Despite more relaxed coronavirus restrictions in South Australia and Western Australia, the AFL says it does not want clubs from those states training in bigger groups until Victorian teams are allowed to do so.

Shares of US biotech Akebia Therapeutics were up more than 35% at $11.72 by early afternoon today, after…

Positive Phase III data for Recarbrio (imipenem/cilastatin/relebactam) have been announced by New Jersey,…

A fish wholesaler, its owner and an employee have all pleaded guilty in U.S. District Court for the District of Columbia for the illegal purchase and sale of striped bass from the Chesapeake Bay and Potomac River from 2003 through 2007.

Miguel Angel Mejia-Munera, a/k/a “El Mellizo,” was extradited today from Colombia to the United States to face narcotics trafficking charges. According to the indictment, Miguel Angel Mejia-Munera, together with his twin brother Victor, led a major Colombian narcotics trafficking organization known as “the Twins” or “Los Mellizos” Organization.

A Fairfield, Calif., couple was indicted today by a federal grand jury in Sacramento, Calif., on federal civil rights charges related to an alleged bias-motivated assault on an Indian-American couple. The two-count indictment alleges that on the evening of July 14, 2007, Joseph and Georgia Silva committed a bias-motivated assault on another couple at a public beach in South Lake Tahoe, Calif.

A 32-year-old Colombian citizen, Luz Mery Gutierrez Vergara, who was extradited from the Republic of Colombia on Thursday, made her initial appearance today in federal court in Washington, D.C., to face charges for allegedly participating in a conspiracy to provide material support to the Fuerzas Armadas Revolucionarias de Colombia, commonly known as the “FARC.”

"Graduates, as you dive head first toward tomorrow, I call upon you to never loosen nor lose your grip on hope. The optimism that seems to come naturally with youth need not be lost as the years pass."

Three Colombian nationals have been arrested in Colombia on charges of conspiracy to commit alien smuggling for profit, alien smuggling for profit, and conspiracy to commit visa fraud in connection with their alleged roles in an extensive and sophisticated visa fraud scheme against the U.S. Embassy in Bogotá, Colombia.

Willie Borden, a former Washington, D.C., Metropolitan Police Department officer, pleaded guilty today to a criminal tax charge before U.S. District Court Judge James Robertson.

Three Saudi nationals were transferred today from the detention facility at Guantanamo Bay to the Kingdom of Saudi Arabia under appropriate security measures.

Diego Montoya Sanchez, 48, one of the leaders of the Norte Valle Colombian drug cartel and a former FBI Top Ten Fugitive, pleaded guilty today in Miami to drug trafficking, murder and racketeering charges.

Febe Durango-Rueda, 52, a Colombian national, pleaded guilty on Nov. 20, 2009, to participating in a scheme to defraud the Export-Import Bank of the United States (Ex-Im Bank) of more than $1 million.

A Washington, D.C., fish wholesaler and two of its employees have been charged in U.S. District Court in Maryland for the purchase of illegally harvested striped bass, commonly referred to as rockfish, from the Potomac River from 1995 through 2007.

"To return today, as our Nation’s Attorney General, to the place where I first studied the law, where I first dreamed of both serving the cause of justice and our country’s Department of Justice, is an extraordinary privilege," said Attorney General Holder.

Pedro Antonio Bermudez, also known as “El Arquitecto,” was arraigned Wednesday in U.S. District Court in Brooklyn, N.Y., following his extradition on June 15, 2010, from Mexico to the United States on charges of participating in an international drug trafficking conspiracy.

"With your help and engagement, we’re working to ensure that the Justice Department lives up to its responsibility to provide a work environment where every employee is respected and given an equal opportunity to thrive," said Attorney General Holder.

"Over the last decade, you have redefined statistics, expectations, and, most importantly, possibilities for students across this city," said Attorney General Holder.

Following a five-week trial, a fish wholesaler and two of its employees were found guilty with purchasing illegally harvested striped bass, known locally as rockfish, from the Potomac River in Virginia and Maryland from 1995 through 2007.

Three Colombian nationals have been extradited from Colombia to the United States on charges of conspiracy to smuggle aliens for profit, alien smuggling for profit, and conspiracy to commit visa fraud in connection with their alleged roles in an extensive and sophisticated visa fraud scheme through which they fraudulently procured visas from the U.S. Embassy in Bogotá, Colombia.

The Justice Department today announced that it has reached agreements with Colorado, District of Columbia, U.S. Virgin Islands and Hawaii officials to help ensure that military service members and U.S. citizens living overseas have an opportunity to participate fully in the Nov. 2, 2010 federal general election.

Three Colombian nationals pleaded guilty today to conspiracy to smuggle aliens for profit and conspiracy to commit visa fraud in connection with their roles in an extensive and sophisticated visa fraud scheme through which they fraudulently procured visas from the U.S. Embassy in Bogotá, Colombia.

Christian Fernando Borda and Alvaro Alvaran-Velez, two narcotics traffickers aligned with the Autodefenses Unidas de Colombia (AUC), were found guilty today in U.S. District Court of conspiring to import ton-quantities of cocaine into the United States.