era Controlling CAR-T: How scientists plan to make the engineered T cell therapy safer, and work for more cancers By feedproxy.google.com Published On :: 07 May 2018 05:00:04 +0000 CAR T-cell therapy works wonders for some cancer patients. For others, it is a death sentence. To make the revolutionary therapy work for more people, scientists must devise better ways to control it Full Article
era Lilly boosts immunotherapy pipeline with Armo BioSciences acquisition By feedproxy.google.com Published On :: 11 May 2018 00:22:45 +0000 The drug company will pay $1.6 billion to gain Armo’s IL-10 program Full Article
era Sarepta acquires five muscular dystrophy gene therapies from Myonexus By feedproxy.google.com Published On :: 13 May 2018 11:44:51 +0000 Full Article
era David Liu launches Beam Therapeutics to treat genetic diseases with CRISPR base editing By feedproxy.google.com Published On :: 14 May 2018 10:00:00 +0000 Joined by CRISPR luminaries Feng Zhang and J. Keith Joung, the Harvard chemist raises up to $87 million in funding Full Article
era Can single-cell genomics lead to a new wave of drug targets? Celsius Therapeutics thinks so By feedproxy.google.com Published On :: 15 May 2018 10:30:00 +0000 The start-up, based on the work of Broad Institute scientist Aviv Regev, has raised $65 million to develop therapies for cancer and autoimmune disease Full Article
era El aumento de las emisiones de CFC amenaza la recuperación de la capa de ozono By feedproxy.google.com Published On :: 16 May 2018 21:21:31 +0000 El triclorofluorometano probablemente se origine en fábricas del este de Asia Full Article
era Accent Therapeutics launches to target the epitranscriptomic RNA code in cancer By feedproxy.google.com Published On :: 18 May 2018 09:00:00 +0000 With $40 million series A funding, the start-up will develop inhibitors of proteins that make chemical modifications to RNA Full Article
era EPA revises Obama-era industrial safety regulation By feedproxy.google.com Published On :: 18 May 2018 20:48:37 +0000 Updated following the West, Texas, fertilizer explosion, rule is intended to prevent incidents at facilities handling large amounts of hazardous materials Full Article
era Gilead’s Kite adds cell therapy manufacturing capacity By feedproxy.google.com Published On :: 21 May 2018 05:00:02 +0000 Full Article
era Celsius Therapeutics launches to tap single-cell genomics for drug discovery By feedproxy.google.com Published On :: 21 May 2018 05:00:03 +0000 Full Article
era David Liu launches Beam Therapeutics to treat genetic diseases with CRISPR base editing By feedproxy.google.com Published On :: 21 May 2018 05:00:04 +0000 Joined by CRISPR luminaries Feng Zhang and J. Keith Joung, the Harvard chemist raises up to $87 million in funding Full Article
era Astellas restructures Japan operations By feedproxy.google.com Published On :: 23 May 2018 16:54:54 +0000 Company expects to slim its home country head count by 600 Full Article
era EPA revises Obama-era industrial safety regulation By feedproxy.google.com Published On :: 27 May 2018 14:31:45 +0000 Updated following the West, Texas, fertilizer explosion, rule is intended to prevent incidents at facilities handling large amounts of hazardous materials Full Article
era Experimental cancer cell therapies have nearly doubled in six months By feedproxy.google.com Published On :: 01 Jun 2018 00:36:56 +0000 A new report from the Cancer Research Institute highlights the U.S. and China as cell therapy leaders Full Article
era The difficult search for the right recipe in cancer immunotherapy By feedproxy.google.com Published On :: 01 Jun 2018 14:00:00 +0000 With so many ingredients on hand, can the oncology community figure out how to sensibly and efficiently combine checkpoint inhibitors with other drugs? Full Article
era BridgeBio launches CoA Therapeutics to treat a rare neurodegenerative disease By feedproxy.google.com Published On :: 13 Jun 2018 12:00:00 +0000 The startup is developing allosteric activators to increase levels of the vital metabolic molecule coenzyme A in pantothenate kinase-associated neurodegeneration Full Article
era Alexion partners with Complement Pharma on neurodegenerative therapy By feedproxy.google.com Published On :: 17 Jun 2018 11:15:22 +0000 Full Article
era Sarepta’s Duchenne gene therapy shows promise in small study By feedproxy.google.com Published On :: 20 Jun 2018 23:48:13 +0000 The early peek at data from a Phase I/II study excited families, physicians, and investors Full Article
era Trump proposes U.S. federal government reorganization By feedproxy.google.com Published On :: 23 Jun 2018 13:09:02 +0000 Food regulation, graduate education among changes put forward Full Article
era Cellulose derivative accelerates organic chemistry in water By feedproxy.google.com Published On :: 24 Jun 2018 11:29:34 +0000 Additive facilitates numerous pharmaceutically relevant reactions through unknown mechanism Full Article
era Gene therapy start-up Freeline Therapeutics raises $116 million By feedproxy.google.com Published On :: 24 Jun 2018 13:02:32 +0000 Full Article
era BridgeBio licenses compounds from NeuroVive and launches Fortify Therapeutics By feedproxy.google.com Published On :: 24 Jun 2018 13:03:02 +0000 Full Article
era Theracos becomes increasingly reliant on contract manufacturing as its drug advances By feedproxy.google.com Published On :: 24 Jun 2018 13:18:00 +0000 Piramal sites on different continents have become involved in producing Theracos’s diabetes treatment Full Article
era AbbVie invests in switchable CAR-T therapies for cancer By feedproxy.google.com Published On :: 25 Jun 2018 11:01:02 +0000 The drug company is partnering with Calibr to develop universal CAR T-cells directed to different tumors via antibody switches Full Article
era Celgene partners with Skyhawk Therapeutics to drug RNA with small molecules By feedproxy.google.com Published On :: 26 Jun 2018 21:57:43 +0000 Skyhawk will receive $60 million up front to develop drug candidates that target RNA in neurological diseases Full Article
era AbbVie invests in switchable CAR-T therapies for cancer By feedproxy.google.com Published On :: 30 Jun 2018 13:13:07 +0000 The drug company is partnering with Calibr to develop universal CAR T cells directed to different tumors via antibody switches Full Article
era Organic photovoltaic window device generates electricity and blocks heat By feedproxy.google.com Published On :: 06 Jul 2018 19:10:59 +0000 Improvements to device may eventually cut external power demands for buildings by 50% Full Article
era Carisma Therapeutics raises $53 million for CAR-T alternative using macrophages By feedproxy.google.com Published On :: 08 Jul 2018 13:06:02 +0000 Full Article
era Nanostructures help chemists generate hydrogen in microgravity By feedproxy.google.com Published On :: 11 Jul 2018 20:25:03 +0000 Textured catalyst prevents gas bubbles from clinging to surfaces Full Article
era Genes found in the desert inspire drought-tolerant crop trial By feedproxy.google.com Published On :: 11 Jul 2018 21:20:51 +0000 PlantArcBio, an Israeli start-up, will try out its new soybean genes at the University of Wisconsin Full Article
era Compass Therapeutics debuts with $132 million in funding By feedproxy.google.com Published On :: 13 Jul 2018 15:32:00 +0000 Full Article
era FTC takes Tronox and Cristal to federal court By feedproxy.google.com Published On :: 13 Jul 2018 15:35:00 +0000 Full Article
era Fetal gene therapy could treat genetic diseases in the womb By feedproxy.google.com Published On :: 16 Jul 2018 17:32:48 +0000 Researchers are working to fix genetic conditions like Gaucher disease before birth by testing experimental therapies on fetal animals Full Article
era HotSpot Therapeutics debuts with $45 million to pursue allosteric inhibitors By feedproxy.google.com Published On :: 17 Jul 2018 11:01:12 +0000 The company claims its technology will allow it to access previously undruggable targets Full Article
era Bill Gates backs Alzheimer’s diagnostics with new Diagnostics Accelerator venture fund By feedproxy.google.com Published On :: 20 Jul 2018 16:15:55 +0000 Full Article
era Supramolecular complex liberates lithium By feedproxy.google.com Published On :: 21 Jul 2018 13:06:04 +0000 Cation gets a conductivity boost by capturing its counterion Full Article
era HotSpot Therapeutics debuts with $45 million to pursue allosteric inhibitors By feedproxy.google.com Published On :: 23 Jul 2018 05:00:19 +0000 The company claims its technology will allow it to access previously undruggable targets Full Article
era PTC buys gene-therapy-focused Agilis By feedproxy.google.com Published On :: 27 Jul 2018 14:04:06 +0000 Full Article
era Sangamo acquires TxCell for cell therapy By feedproxy.google.com Published On :: 27 Jul 2018 14:05:00 +0000 Full Article
era Canada issues scientific integrity guidance for federal researchers By feedproxy.google.com Published On :: 03 Aug 2018 13:23:29 +0000 Full Article
era Overall, Porsche Cayenne Coupe is a great package By www.rediff.com Published On :: Fri, 08 Nov 2019 10:48:57 +0530 This coupe SUV has all the elements that make a Porsche both aesthetically and dynamically poised. Full Article SUV BMW Porsche Cayenne Coupe
era Federal Tax Practice By www.cch.ca Published On :: Wed, 05 Sep 2007 13:57:31 GMT With a practical combination of portability and relevant content, the Federal Tax Practice makes an ideal companion for the tax litigation and tax administration practitioner. It contains all the information you'll need to navigate through tax appeal procedures. And it's portable enough to take along for quick reference in the courtroom or in the boardroom. It features an annotated legislation and other valuable information, including: Tax Court of Canada Act and Rules Relevant portions of income tax and GST legislation Tax Court Practice Notes How to prepare income tax and GST objections Case annotations Taxpayer relief provisions (formerly Fairness Package) Matters under other statutes (EI, CPP, etc.) Forms Flowcharts and checklists Relevant Bulletins and Circulars Traditional 3-ring reference materials can be awkward and impractical. The Federal Tax Practice provides just the right amount of the content without the bulk. With very simple navigation, it's designed to save you time. No more flipping between binders to find out what you're looking for. The content required for preparing for tax audits and assessments, objections and appeals, and dealing with trial issues is all contained in one convenient volume. You won't find anything on the market today that offers the same combination of essential information and portability. For practical guidance and ultimate convenience, it's simply indispensable. Table of Contents (abbreviated) Chapter 1: Canadian Federal Courts General commentary on Canadian court system with respect to tax issues Chapter 2: Flowcharts and Checklists General and Informal Procedure for Income Tax Act appeals General and Informal Procedure for Excise Tax Act appeals Appeals procedure respecting the Employment Insurance Act Appeals procedure respecting the Canada Pension Plan Chapter 3: Annotated Tax Court of Canada Act Chapter 4: Annotated Selected Income Tax Act Provisions Sections 152 through 179.1, 225.1, 225.2 Chapter 5: Annotated TCC Rules: General Procedure Chapter 6: Annotated TCC Rules: Informal Procedure Chapter 7: GST Appeals Chapter 8: Appeals Under Other Statutes Section A: Canada Pension Plan Section B: Employment Insurance Act appeals Section C: Old Age Security Act (OASA) references Section D: War Veterans Allowance Act and Civilian War-related Benefits Act Chapter 9: Appeals to the Federal Court of Appeal and the Supreme Court of Canada AppIf you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Federal Master Tax Basics By www.cch.ca Published On :: Fri, 12 Jan 2007 14:00:19 GMT A cost-effective reference bundle for all your basic tax questionsFederal Master Tax Basics gives you all the core tax information you need from a single online source. A $1,500 value if purchased separately, these resources include the Income Tax Act and common government documents from the CRA, bundled at a special price so every practitioner can stay up-to-date. With these easy-to-use resources at your fingertips you can get started on any federal tax research question. Materials are linked for quick navigation throughout all your content, which includes: Income Tax Act and Regulations, richly annotated detailed history notes to track changes to the legislation editorially-created references (related matter) to provide hints on other documents to consult to complete your research full text of proposed amendments – essential for tax planning and compliance Access to the full text of all tax treaties, including the Canada-US treaty All income tax forms and guides Other CRA documents Canadian Master Tax Guide commentary – an online version of our trusted reference book, updated annually covers a wide range of topics including employment income, business and property income, capital gains, inclusions and deductions from income, and much more includes extensive annotations and cross-references Best-selling guides Preparing Your Income Tax Returns and Preparing Your Corporate Tax Returns Bonus features: News Tracker brings you up-to-the-minute information on the latest tax developments. You choose the topic and how frequently you want to be updated. Convenient charts and rate tables for quick reference Free training and technical supportWolters Kluwer CCH research subscriptions deliver the most timely, relevant and reliable tax information and commentary to Canada's tax professionals, significantly reducing research time. If you would like more details about this product, or would like to order a copy online, please click here. Full Article
era The Federal Budget 2011 By www.cch.ca Published On :: Fri, 09 Jan 2009 12:21:18 GMT This Special Report contains the full text of the 2011 Federal Budget announced on March 22, 2011. In addition this report contains commentary written by Fraser Milner Casgrain LLP and other members of CCH Canadian’s Editorial Board.. Shipping March 23, 2011 If you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Federal Income Taxation: Fundamentals, 4th Edition By www.cch.ca Published On :: Tue, 14 Jul 2009 10:40:42 GMT Please note that new editions will be available by mid August, 2011 The Federal Income Taxation: Fundamentals, 4th Edition is the book of choice for the Certified General Accountants Association of Canada Taxation 1 course. This book is intended for students taking: Business Economics Taxation Law This textbook has been structured to meet the specific needs of students enrolled in the following programs, or related introductory courses: CGA CMA CA Student Friendly CCH has re-mastered and modified this resource to improve accessibility and increase student comprehension. Covers the fundamental federal income taxation curriculum with a narrow scope and topical coverage Study Guide and supplemental material for students and instructors makes learning even easier Review Questions, Multiple Choice Questions and Exercises are provided at the end of each chapter The proprietary, adjusted learning model employed in this text facilitates understanding and the application of knowledge Practical examples and applications are designed to anchor and integrate learning References to the Income Tax Act are incorporated throughout the text, with all key topics covered Includes two extra appendices: Individual Tax Facts and Withholding Tax Robert E. Beam, F.C.A., is a Professor Emeritus in the School of Accounting and Finance, University of Waterloo. He was associated with Ernst & Young, Chartered Accountants, Toronto. From 1972 to 1998, he was Coordinator of the Tax Section of the School of Accountancy, Institute of Chartered Accountants of Ontario. In September 2002, Mr. Beam became the first recipient of the Canadian Institute of Chartered Accountants Award for Excellence in Tax Practice and Education. His articles have appeared in the Canadian Tax Journal. Stanley N. Laiken, Ph.D., is the Deloitte Professor in the School of Accounting and Finance, University of Waterloo. He has taught taxation to students in professional programs, both at the university and post-university levels, since 1972. He is a recipient of the Distinguished Teacher Award at the University of Waterloo and the Canadian Academic Accounting Association’s L.S. Rosen Award in recognition of outstanding contributions to Canadian accounting education. His articles have appeared in the Canadian Tax Journal. He is also the Director of the Deloitte Centre for Tax Education and Research at the University of Waterloo. James J. BarnetIf you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Oil and Gas: U.S. Federal Income Taxation (2011) By www.cch.ca Published On :: Fri, 14 Nov 2008 10:59:13 GMT The taxation of natural resources is one of the more complicated areas of the U.S. federal income tax system. From the acquisition of the mineral rights, to the exploration and development of the property, to the ultimate production of the mineral, there are unusual and challenging tax aspects along every step of the way. Oil and Gas: Federal Income Taxation (2011) is an invaluable single-source handbook for accounting, tax and legal practitioners concerned with financial issues related to oil and gas industry tax law. Updated and revised by noted oil and gas taxation authority and educator, Patrick A. Hennessee, Ph.D., CPA , this detailed reference is divided into six main sections: Introduction to Oil and Gas Taxation Acquisition of Interests The Exploration Period The Production Period Dispositions Other Areas The text begins with a discussion of the nature of oil and gas reserves in order to gain a better understanding of the industry. The material following is organized in a logical sequence of events which traces the normal industry pattern for developing oil and gas reserves. Special features include: A special ''Highlights of New Developments'' section provides a convenient, at-a-glance summary of recent tax legislation, case law, rulings, position papers, etc., as they relate to the oil and gas industry, and it tells readers where in the volume they can find additional information on the specific topics. Reflects all the recent developments in place, including new legislation, regulations and case law changes impacting this area since the previous edition published, allowing tax and legal professionals to stay current on this highly specialized area of tax law. Enables understanding of the myriad technical aspects of oil and gas taxation by thoroughly discussing the critical issues of: economic interests lease and purchase arrangements royalties working or operating mineral interest production payments net profits arrangements geological and geophysical expenses intangible drilling and development costs sharing arrangements and carried interests depletion gross income from property taxable income from property unitizations disposition of interests nontaxable exchanges losses and abandonments types of ownership alternative minimum tax nonconventional fuel credit depreciation aIf you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Introduction to Federal Income Taxation in Canada, 32nd Edition By www.cch.ca Published On :: Tue, 14 Jul 2009 10:39:20 GMT Introduction to Federal Income Taxation in Canada, 32nd Edition gives you a smart learning advantage – here’s how: Each chapter includes examples, problems, multiple choice questions, and exercises designed to reinforce the material and text comprehension – with solutions provided for the student Review questions throughout the textbook include discussion notes at the end of the book Assignment problems and advisory cases have solutions provided in the Instructor’s Solutions Manual Student DVD includes extra problems and solutions for self-study CCH research software and CANTAX software also included on DVD New this year – Student Study Guide: This guide contains the solutions to the Review Question, Multiple Choice Questions, and Exercises, as well as additional study material and a glossary. Income Tax Act compliant Students dedicated to taxation and students interested in developing a solid general understanding of federal tax law will benefit from this resource. The contents are arranged in a sequence that follows the organization of the Income Tax Act for easy cross-referencing. Reality checked We know accuracy is critical and we pride ourselves on providing the most accurate and current content. Updated annually to reflect Budget and other legislative changes to income tax provisions All assignment materials have been carefully prepared and tested Robert E. Beam, F.C.A., is a Professor Emeritus in the School of Accounting and Finance, University of Waterloo. He was associated with Ernst & Young, Chartered Accountants, Toronto. From 1972 to 1998, he was Coordinator of the Tax Section of the School of Accountancy, Institute of Chartered Accountants of Ontario. In September 2002, Mr. Beam became the first recipient of the Canadian Institute of Chartered Accountants Award for Excellence in Tax Practice and Education. His articles have appeared in the Canadian Tax Journal. Stanley N. Laiken, Ph.D., is the Deloitte Professor in the School of Accounting and Finance, University of Waterloo. He has taught taxation to students in professional programs, both at the university and post-university levels, since 1972. He is a recipient of the Distinguished Teacher Award at the University of Waterloo and the Canadian Academic Accounting Association’s L.S. Rosen Award in recognition of outstanding contributions to Canadian accounting education. His articles have appeared in the Canadian Tax Journal. He is also the Director of the Deloitte Centre for Tax Education and Research at the University of Waterloo. <If you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Federal Tax Course (U.S.): A Guide for the Tax Practitioner (2011) By www.cch.ca Published On :: Wed, 10 Nov 2010 15:00:56 GMT Federal Tax Course: A Guide for the Tax Practitioner offers the knowledge and know-how needed to deal effectively with all current developments in federal tax. This easy-to-use guide is written by Susan Flax Posner, one of today's most effective communicators on the tax law. The Guide presents a complete picture of the federal tax law for today's busy practitioners with clear and easy-to-understand explanations. It discusses hundreds of tax strategies and uses real-world examples to illustrate application of tax principles. This comprehensive manual provides more than 2,300 pages of completely updated material, which has made it an essential and necessary reference for thousands of tax return preparers, business planners, legal advisors or business owners. The Guide is the tax reference of choice for so many practitioners because it covers taxes in a uniquely approachable and understandable way and it helps readers avoid costly tax traps and keep tax bills at their rock-bottom minimum. Simply written and illustrated, yet comprehensive, the Guide provides: Eight chapters on figuring the individual tax that clearly explain all the rules and concepts involved Six chapters on deductions and exemptions that painstakingly present the detail in clear language Five chapters on withholding, AMT and tax accounting that cut through the complexity for better understanding Six chapters on taxation of corporations, S corporations, partnerships, and estates and trusts that plainly explain the rules Five chapters on returns, payments, foreign income and estate and gift that crystallize the issues The new 2011 Edition reflects the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act of 2010, and the Hiring Incentives to Restore Employment (HIRE) Act, as well as recent regulations, rulings and case law that impact the many topics covered. CONTENTS: Key Tax Return Filing Facts Excise Tax Rates 2011 Federal Tax Calendar Figuring the Individual Tax 1. Individuals Filing Status, Personal Exemptions, Standard Deduction and Rates 2. Gross Income Inclusions 3. Retirement Plans 4. Employee Fringe Benefits 5. Gross Income Exclusions 6. Gain or Loss Basis Recognition 7. Gain or Loss, Sale of Residence, Casualty, Theft, Condemnation 8. Capital Gains and Losses of Individuals Maximizing Deductions and Credits 9. Personal Deductions 10. Travel and Entertainment Deductions 11. Depreciation 12. Business Deductions 13. Losses and Bad Debts <If you would like more details about this product, or would like to order a copy online, please click here. Full Article
era 2013 Canadian Federal Budget Plan: CCH Special Report By www.cch.ca Published On :: Mon, 21 Dec 2009 10:36:34 GMT This Special Report contains the full text of the 2013 Canadian Federal Budget Plan with in-depth Budget analysis prepared by experts from Dentons and by Joseph Frankovic LL.B., LL.M., Ph.D., CFA. The commentary written for this report describes each income tax proposal contained in the Budget as well as proposals relating to GST/HST. If you would like more details about this product, or would like to order a copy online, please click here. Full Article
era Oil and Gas: Federal Income Taxation (2012) (U.S.) By www.cch.ca Published On :: Thu, 03 Nov 2011 11:47:11 GMT Available: November 2011 This book is an invaluable single-source handbook for accounting, tax and legal practitioners concerned with financial issues related to oil and gas industry tax law. Updated and revised by noted oil and gas taxation authority and educator, Patrick A. Hennessee, Ph.D., CPA , this detailed reference is divided into six main sections: Introduction to Oil and Gas Taxation Acquisition of Interests The Exploration Period The Production Period Dispositions Other Areas The text begins with a discussion of the nature of oil and gas reserves in order to gain a better understanding of the industry. The material following is organized in a logical sequence of events which traces the normal industry pattern for developing oil and gas reserves. Special features include: A special "Highlights of New Developments" section provides a convenient, at-a-glance summary of recent tax legislation, case law, rulings, position papers, etc., as they relate to the oil and gas industry. Reflects all the recent developments in place, including new legislation, regulations and case law changes impacting this area since the previous edition published. Enables understanding of the myriad technical aspects of oil and gas taxation by thoroughly discussing the critical issues of: 1. Introduction to Oil and Gas Taxation 2. Economic Interest 3. Lease and Purchase Arrangements 4. Royalty and Overriding Royalty 5. Minimum Royalties 6. Working Interest (or for Operating Mineral Interest) 7. Production Payments 8. Net Profits Arrangements 9. Geophysical Expenses 10. Intangible Drilling and Development Costs 11. Sharing Arrangements and Carried Interests 12. Depletion Deduction – General 13. Allowance or Disallowance of Depletion 14. Property for Depletion Purposes 15. Cost Depletion 16. Gross Income from the Property 17. Taxable Income from the Property for Depletion Purposes 18. Limitations on Percentage Depletion 19. Unitizations 20. Disposition of Interests – Lease (or Sublease) and Sale 21. Nontaxable Exchanges 22. Losses and Abandonments 23. Associations Taxable as Corporations 24. Partnerships 25. Selected Corporate Issues 26. Alternative Minimum Tax (AMT) 27. Special Provisions Affecting the Determination of Tax 28. Tax Credits 29. Depreciation 30. Application of Accounting Methods 31. Oil and Gas International Provisions Case Table Finding Lists If you would like more details about this product, or would like to order a copy online, please click here. Full Article
