Deepika Padukone's Met Gala journey also started in 2018 with Priyanka Chopra Jonas. However, unlike Priyanka Chopra, Deepika Padukone has mostly been criticised by the fashion critics for her costume choices. The critics and fashion enthusiasts did find her

Deepika Padukone is not only a prolific actress, who has been upping her acting game but she is also a saree connoisseur. With her resplendent sarees, the actress has inspired the young ladies of today to drape sarees. In

Kajol's sister and Bollywood-South Indian film actress Tanishaa Mukerji has been doing rounds on the internet these days. She has been treating her fans with her beautiful pictures one after the other and her recent traditional look is what we

Each and every minute detail of Allu Arjun's Pushpa has left the fans super excited, ever since the inception. The movie is said to be an action thriller, wherein Allu Arjun will be seen doing some high-octane action sequences. Well, if

Director Sukumar recently got emotional, as his longtime friend and manager Prasad suddenly passed away due to heart attack last month. His sudden demise literally broke Sukumar and he still hasn't recovered from the shock. Sadly, due to the lockdown, he

An Air India flight landed here from London at 1.30 am on Sunday carrying 239 Indians from the UK who were stranded there due to suspension of commer

The UK is set to modify its Stay At Home social distancing message to curb the spread of coronavirus to Stay Alert as British Prime Minister Boris Joh

The Red Devil linebacker will join the Boilermakers in the fall.

15 October 2013

Invitation Only Research Event

Event participants

HE Professor Kwaku Danso-Boafo, High Commissioner for Ghana to the United Kingdom
Chair: Alex Vines OBE, Research Director, Area Studies and International Law; Head, Africa Programme, Chatham House

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

English Language Community Outreach students from OM Lifehope lend a hand to volunteers at the Black Country Food Bank near Birmingham, UK.

An OM ministry team in the UK has been reaching out to Iranian and Afghan refugees since May 2012 and praying for growth.

An interview with the leaders of MDT UK, an exciting new training programme in Birmingham and London.

Working among the UK's Turkish-speaking communities, an OM worker is witnessing lives being transformed.

The Kid's 'n' Things team visited two churches to run five-day long holiday clubs, with the theme of “Lionheart and the Great Wild West Adventure”.

Nicola Sturgeon has promised to exhaust all options in an effort to keep Scotland in the EU after the country voted by 62 per cent to 38 per cent against Brexit.

A total of 329 people who were stranded in the UK due to travel restrictions arrived here in an Air India flight today morning.

The new 2020 Suzuki Burgman 200 will be available for sale in three colours of white, black and silver.

The Suzuki Gixxer and the SF250 BS6 might be priced Rs 3,000 over the BS4 offerings while the launch will be post lockdown.

The upcoming 2020 Suzuki V-Strom 650 XT will be BS6 compliant. Here's what to expect from the Versys 650 challenger!

One of the prime changes on the new 2020 Triumph Street Triple RS is the engine that offers a better and more solid mid-range now along with better refinement.

The new 2020 Triumph Street Triple RS is now here, in India! Here is what all has changed apart from a BS6 compliant motor.

The BS6 Honda Dio is priced at Rs 59,990 for the standard model and Rs 63,340 for the deluxe variant (both prices mentioned, ex-showroom). 

Few of these bikes hold the promise of performance that will excite college-going kids while some can be entertaining even for the mature riders.

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Suzuki Gixxer, Gixxer SF Review: The 150cc sports-oriented bikes in Suzuki's lineup have gained substantial popularity in India over the years. The two have been updated for the year 2019. But naked or fully-faired. Which one to go for?

There's nothing out there in the market today like the Maruti Suzuki S-Presso so we drove the automatic and manual versions of the car around Jodhpur to find out if it has what it takes to infuse some life into a declining segment and create a niche. 

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Market regulator SEBI, late Thursday night advised Franklin Templeton to focus on returning investor’s money after the fund house decided to wound up six of its debt mutual fund schemes.

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The new dealerships will be known as ARENA and will be well equipped digitally to cater to the demand of the tech savvy customers.

Your digital assets are the building blocks for brand voice. Use them wisely

It noted that the timeliest indicators of UK demand have stabilised in recent weeks, albeit at very low levels, after unprecedented falls during late March and early April.

1 Ugandan Shilling = 0.0071 Ukrainian Hryvnia

1 Salvadoran Colon = 3.0666 Ukrainian Hryvnia

1 Romanian Leu = 6.0265 Ukrainian Hryvnia

1 Ukrainian Hryvnia = 44.3396 Iraqi Dinar

1 Ukrainian Hryvnia = 193.3617 Zambian Kwacha

1 Ukrainian Hryvnia = 0.6838 South African Rand

1 Ukrainian Hryvnia = 9.329 Yemeni Rial

1 Ukrainian Hryvnia = 22.5424 CFA Franc BCEAO