With social distancing a must, this year's virtual celebration will be long remembered.

The motion picture academy's new museum should include an exhibit of the painful racist images created to maintain a system of dehumanization.

Actor Mena Massoud, who starred in Disney's live-action "Aladdin" film last year, just paid $2.2 million for a modern farmhouse in Encino.

The Saturday Night Passover Seder that aired on YouTube over the weekend brought together dozens of celebrities and raised $2.6 million for the CDC Foundation.

'14-day refund rule is impossible for the majority of companies to stick to,' said the travel association's chief executive, Mark Tanzer

Deborah Borda, now head of the New York Philharmonic, talks leadership in the coronavirus crisis. Her strategy: Invest in a future that people want.

WHY was it the fact that Professor Neil Ferguson couldn't keep it in his pants heralded his sacking not his disastrous doomsday projections that forced this country into a financially crippling lockdown?

THE TRANSFER WINDOW has closed - take a look at how all the deadline day action unfolded.

JOB RESPONSIBILITIES Identify quality oriented process improvement initiatives and technological advancements; identify, plan, lead, and execute research and development activities across all Graniterock products lines including but not limited to Cold-In-Place (CIR) Recycling, Hot Mix Asphalt,

JOB RESPONSIBILITIES Identify quality oriented process improvement initiatives and technological advancements; identify, plan, lead, and execute research and development activities across all Graniterock products lines including but not limited to Cold-In-Place (CIR) Recycling, Hot Mix Asphalt,

Cuộc đời lưỡng quốc nguyên soái Konstantin Rokossovsky nói nhiều về lịch sử khó khăn giữa hai dân tộc Nga và Ba Lan.

WHY was it the fact that Professor Neil Ferguson couldn't keep it in his pants heralded his sacking not his disastrous doomsday projections that forced this country into a financially crippling lockdown?

Kerry Kapaku, owner of DanceWorks Indy, teaches a Saturday ballet class from her home. The studio is offering online content due to coronavirus concerns.

Todd Rokita is running for the Senate with a campaign that could hardly be less senatorial. And that's not a good thing.

The big lesson for the banks from today's decision by the British Bankers Association not to appeal against the high court ruling on Payment Protection Insurance is - funnily enough - very similar to the big lesson from the Great Crash of 2007-8.

In the case of PPI, much of what the banks have now acknowledged to be mis-selling seemed consistent with rules laid down by the regulator, the Financial Services Authority, in its handbook and its source book on the selling of insurance.

But the FSA argued that following the letter of these rules was a necessary but not sufficient guarantee that the banks were behaving property. The FSA argued that the big banks should have been more mindful of its over-arching principles, notably the imperative of paying due regard to the interests of customers and treating them fairly.

The banks appear to have been so seduced by the apparently huge profits available from insuring personal loans, mortgages and credit card debt that they pushed the insurance to all manner of unsuitable customers (the self-employed who could never make a claim for being made redundant, or those with pre-existing health conditions, that would invalidate claims, to name just two common examples).

"It is very difficult to justify how we behaved" said one senior banker. "You can't imagine supermarkets treating their customers in the way we treated ours. I know my colleagues think that so long as we followed what was in the FSA's handbook, we shouldn't be blamed. But my view is that we forgot the cardinal rule, which is that we're there to serve customers, not to shove something down their throats which they don't need".

This departure from the very basics of retailing is costing the banks very dearly indeed. Last week Lloyds - the market leader in PPI and the first of the big banks to say it would provide comprehensive restitution - said that the settlement would lead to a £3.2bn expense.

Today, Barclays has quantified the compensation and related costs at £1bn. There will be a similar charge for Royal Bank of Scotland. And HSBC has just said it is setting aside £274m to meet these costs.

In total for all the big banks, the costs are heading towards £6bn or so - and that's to ignore the compensation bill for hundreds of smaller firms which joined in the PPI mis-selling frenzy.

Now what's striking is that the PPI debacle shares strong cultural characteristics with the behaviour that took many of the world's banks to the brink of bankruptcy less than three years ago. During the boom years before the crisis of 2007-8, you won't need telling that banks lent and invested recklessly - to subprime borrowers, to commercial property, to each other, through off-balance sheet vehicles, in the form of "structured" products which delivered the illusion of quality (inter alia).

And much of this reckless lending and investing took advantage of the global Basel rules that give the official regulators' view of how much risk the banks were taking - and, as we now know, were catastrophically wrong.

But - many bankers belatedly concede - banks should have known better than to make their judgments on how to lend on the basis of the regulators' rules. They should have done what other commercial businesses do, which was to lend and invest on the basis of what would be sustainable and prudent for the long term.

Gaming or playing the Basel rules, and forgetting commercial common sense, led to disaster. It meant that Royal Bank of Scotland, in the autumn of 2008, looked like a sound bank as measured by the Basel rules, when to all intents and purposes it was bust.

Of course it is reasonable to blame the regulators for framing the rules badly. But many would say that the banks were more at fault for mindlessly running their businesses on the basis of what the rules allowed.

So what's the big lesson of both PPI and the 2007-8 crash? Well, it is probably that banks need to base everything they do on what is good for customers, shareholders and creditors in a fundamental sense - and not on what the rules allow them to do.

PS Apart from the banks, another group of firms - the claims management firms - look set to be burned by the banks' decision to chuck in the towel and pay compensation to 2.75m or so individuals who were mis-sold PPI insurance.

The banks will now set up operations to speedily process claims for compensation. So they would argue that there is no point in their customers using the services of claims management firms, because in doing so those customers would not gain any additional compensation but would have to pay commission to the claims handler.

Para Luis Alberto Moreno, pandemia deixou ainda mais evidente a desigualdade da América Latina e mostrou necessidade de se investir na saúde pública regional.

Especialistas apontam que propagação de vírus pode ter começado antes de 25 de fevereiro, quando primeiro paciente foi diagnosticado com a covid-19.

Recuperação pode ser um processo lento, dependendo da gravidade do quadro.

Em entrevista à CNN Brasil, secretária Especial da Cultura diz que optou por mandar mensagens privadas às famílias, em vez de fazer homenagens públicas.

Há milhões de pessoas que não lavam as mãos infiltradas entre nós, mesmo com acesso a água encanada e sabão. Mas por que elas não incorporam esse simples hábito de higiene, e como podemos mudar suas cabeças?

BBC preparou lista de perguntas e respostas sobre covid-19.

Investigamos centenas de histórias enganosas durante a pandemia. Isso nos deu uma ideia sobre quem está por trás da desinformação - e o que os motiva. Aqui estão sete tipos de pessoas que iniciam e espalham falsidades.

While McCulley became a key part of Lawrence North's run in basketball, there is no doubt that his collegiate future is in football.

While McCulley became a key part of Lawrence North's run in basketball, there is no doubt that his collegiate future is in football.

Lawrence North, Silver Creek, Fort Wayne Blackhawk, Greenwood Christian on top of my ballot this week

Shenandoah moves up to No. 1 in Class 2A and Greenwood Christian No. 1 in Class A

Bloomington South No. 1 on my Class 4A ballot this week

Bloomington South, Silver Creek, Shenandoah, Greenwood Christian are No. 1 teams this week

Bloomington South, Lawrence North, Lawrence Central top three on my Class 4A ballot this week

Linton-Stockton new No. 1 this week in Class 2A

Bloomington South, Silver Creek, Fort Wayne Blackhawk, Greenwood Christian on top of my ballot

Bloomington South, Silver Creek, Shenandoah, Greenwood Christian on top of polls this week

Bloomington South, Silver Creek, Fort Wayne Blackhawk, Barr-Reeve No. 1 teams on my ballot for this week

Bloomington South, Silver Creek, Shenandoah and Barr-Reeve ranked No. 1 this week

IHSAA basketball: IndyStar's high school insider Kyle Neddenriep ranks boys basketball teams statewide.

Bloomington South, Silver Creek, Shenandoah, Barr-Reeve are No. 1 teams going into tournament

He's interesting, he's intelligent and he's back. The Teacher returns with his hilarious lessons.

The same spirit that now forces us to work together to address the COVID-19 pandemic can be harnessed to address the challenge of climate change.

An overview of the 10-nation regional political and economic grouping

The Japanese island, which initially saw a drop in cases, is now facing a bigger wave of virus cases.

US police say Bing Liu was shot dead by his lover, but conspiracy theorists have other ideas.

Amazon.com said it's temporarily closing a small New York warehouse after one of its associates tested positive for the coronavirus. As Fred Katayama reports, it highlights the operational risk it faces as the disease spreads.

The Amateur Traveler talks to Rease Kirchner about her hometown of St. Louis Missouri. St. Louis is known for its iconic Arch and is known as the gateway to the west. Rease claims that St. Louis has the largest urban park in the U.S., and now boasts about a surprising array of ethnic restaurants including a Little Italy area with toasted ravioli and a Little Mexico around Cherokee street. The city has an art museum made of entirely recycled materials, and Rease’s favorite the City Museum. Rease also tells us where we can find traditional St. Louis food including gooey butter cake and a slinger which she describes as “everything that can kill you all on one plate”. St. Louis is famous for Budweiser and for the associated Busch stadium which is the home of the St. Louis Cardinals, but now also boasts micro-breweries and NFL and NHL teams.

Hear about travel to Kansas City (Kansas and Missouri) as the Amateur Traveler talks to Rob Walch about the Paris of the Plains. Kansas City has that nickname because of the many fountains in the city.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

12 November 2019

2 April 2020

Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension.